Does Betaseron Actually Work for MS Long-Term [Analysis of 15-year study]

Подписаться 33 тыс.

Просмотров 2,3 тыс.

50% 1

Short term randomized trials showed betaseron reduces relapses, new MRI lesions, and disability progression in MS. But is it actually effective over 15 years? This extension study of the BENEFIT trial in clinically isolated syndrome (people with a first attack of demyelinating disease) seeks to answer that question. We review effects on relapses, MRI lesions, disability, cognitive performance, employment, and quality of life.
Long-term clinical outcomes in patients with CIS treated with interferon beta-1b: results from the 15-year follow up of the BENEFIT trial: link.springer....
11 year follow up of benefit trial: pubmed.ncbi.nl...
Betaseron product label: www.accessdata...
Comment or ask questions below! I would be happy to answer!
Subscribe on RU-vid for more videos every Wednesday!
Make video requests in the comments section!
Check out my book “Resilience in the Face of Multiple Sclerosis” FREE on Amazon: amazon.com/dp/... It's about 5 people with MS who live incredible lives, the science and psychology of resilience, mindfulness, and ho’oponopono. Paperback priced to generate $0 royalty.
Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.
Follow me on twitter: / brandon_beaber
Music: INNER GRACE - Copyright 2018 Wilton Vought Source: Really Really Free Music Link: • Video T
he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.

Опубликовано:

17 окт 2024

Ссылка:

Скачать:

Готовим ссылку...

Добавить в:

Мой плейлист

Посмотреть позже

Комментарии : 40

@martinm8991 4 месяца назад

I'd say that the most relevant result of that study is confirmation, that MS-treatment has to start ASAP. While it might me much better to start with stronger DMD, the timing remains significant.

@naenersable 4 месяца назад

I started Betaseron in 1997 right after my diagnosis but I have progressed since I started menopause at 43 and I’m now 47 and I can’t walk anymore but I will never give up and I know I will walk again.

@EvenSoItIsWell 4 месяца назад

Thanks Dr. Beaber. I appreciate the deep dive into Betaseron. I would love to see a similar video on glatiramer acetate if there is long term data on it as well. I am particularly interested in your thoughts on if it helps with remyelination.

@DrBrandonBeaber 4 месяца назад

I'm not personally aware of a similar study with very long term follow up on glatiramer. I would have to look into this. This study with mean follow up of 6.9 years has favorable results: pubmed.ncbi.nlm.nih.gov/25257663/ I doubt it has any capability of remyelination.

@EvenSoItIsWell 4 месяца назад

@@DrBrandonBeaber thanks so much!

@colleensmith3374 3 месяца назад

Great analysis. It will be great to see long term data on these stronger DMT’s! Hopeful for sure. My 1st symptom was tingling in my foot & saw a neurologist quickly to refer me to a MS specialist . I do believe early intervention may make a difference.

@DrBrandonBeaber 3 месяца назад

It is very hard to do long-term follow up studies and retention is usually bad. Hopefully we will get at least some data.

@zleepyjan 3 месяца назад

I'm on Betaseron since 2010. Should I switch to KESIMPTA B-cell treatment or Any Multiple Sclerosis Pill you recommend?

@Nasty3232 3 месяца назад

In all videos it is said, that dmts are most helpful, when one only begins to have ms. But how to know, if you only started to have it? So I’ve been diagnosed 3 months ago and already had more than 50 lesions, and they all mixed together, so that it’s impossible to count them. So it seems like I have ms for several years already. Does it mean that I missed the time and I will soon get disabled? I’m so scared I want to be healthy until at least I’m 40. I’m 24 right now

@Robin-me8fe 3 месяца назад

Thanks Dr.

@fragariasec 4 месяца назад

I am missing the complete placebo group here. As many pwMS dropped out because of the side effects. 😅

@Ennugia 4 месяца назад

I was also hoping there is a study of that sort since I am kind of angry and very worried for the long run prognosis given that I am still on the low efficacy drug Betaseron

@zoranagavrilovic9403 4 месяца назад

I feel like for what it is, it's not worth stabbing myself with a needle every other day, I'd rather have no treatment than be on betaseron

@DrBrandonBeaber 4 месяца назад

It's definitely not a good option for people who hate needles.

@lillyoliver2056 4 месяца назад

Can people tell if you have MS from an MRI without using contrast? I’m allergic to contrast, but suspect possibility of MS.

@brianguppy7693 4 месяца назад

Yes. You don't need contrast to see MS lesions. The contrast just tells you whether they are "active", i.e., associated with an ongoing attack. There will be more to diagnosis than just the MRI, but if you suspect MS then you should definitely get one.

@50shadesofbeige88 4 месяца назад

It takes too long to get an official MS diagnosis. The gatekeeping is unreal.

@DrBrandonBeaber 4 месяца назад

What do you mean "the gatekeeping"?

@klburke 4 месяца назад

@@DrBrandonBeaber I think I know what he's getting at. It took me 20 years to be diagnosed as I was waved away from doctors since my late 20's, telling me I'm a hypochondriac, just have anxiety, have migraines, and a myriad of other excuses of my complaints, until any doctor would do any actual tests that got me a MS diagnosis. By then I was 49 years old and so much untreated damage was allowed to happen because of gaslighting and being ignored and insulted by doctors. That is gatekeeping in my mind. Am I bitter and angry? Yes I am.

@andrewreisinger6860 4 месяца назад

Short answer for me: MEH. 53y/o male dxd in 93. Betaseron from 2003-2018. Ocrevus 2018-present. EDSS now 6.5

@DrBrandonBeaber 4 месяца назад

Do you believe you developed progressive MS while taking betaseron? Did betaseron stop relapses and new MRI lesions?

@andrewreisinger6860 4 месяца назад

@DrBrandonBeaber I did move to progressive MS while on Betaseron. I had no clinical attacks while on Betaseron. Just the slow insidious progression.

@Nasty3232 4 месяца назад

Could you please tell me if you had new lesions when doing mri? Or it was just a slow progression without any new of them?

@andrewreisinger6860 4 месяца назад

@anastasiatolipova6909 that is the thing that pisses me off the most about my MS care. I had annual MRIs for YEARS and was always told and read in the report that I had "no interval change" on the images. I finally saw an image with my own eyes about 4 years ago, and it devastated me. I had so many lesions that had basically enlarged and morphed into one another. Very different from the images I saw when I was first diagnosed. I am classic SPMS now. It has been 15 years AT LEAST since I have had a distinct "attack". Just the slow, insidious worsening of symptoms. I am at an EDSS of 6.5 now, which is bilateral support (walker) needed to walk anything more than 20 yards. I have been on Ocrevus for the past 4 years or so. My brain has MASSIVE atrophy now. I honestly do not know how I am not bedridden. Find me on FB if you have any questions or want to talk more.

@roberture5903 4 месяца назад

Good morning Dr Brandon wasn't this the same medication that was one of the first and there was a lottery for it? If so I have a friend who is diagnosed in 1995 and she takes it to this day and is doing very well thank you for an excellent video as always

@DrBrandonBeaber 4 месяца назад

Yes you are correct. Of course I am too young to have practiced medicine during the betaseron lottery, but it did occur. There are certainly some "interferon superresponders" such as your friend.

@roberture5903 4 месяца назад

@@DrBrandonBeaber I wouldn't say that she is a super responder and hear me out on this talk to Brandon because for about a year she was in a wheelchair but if you saw her today you would never know it but that's another story but needless to say she never switched medications and I only got I'm only a couple years older than that her so we're from the same generation but even though I know I've had it longer I was diagnosed later in life. Something you said in one of your previous videos and she even admitted she was lucky

@roberture5903 4 месяца назад

I'm sorry about the typos on the reply but I don't have the strength to write it over Dr Brandon haha hope you can understand and have a great rest of your day my friend

@johnrice4273 4 месяца назад

I remember Betaseron and Avonex as injections into the muscle. I took both. I had multiple injections site necrosis. I’m sure I’m correct no?

@DrBrandonBeaber 4 месяца назад

Betaseron is subcutaneous. Avonex is intramuscular. Both can cause site reactions and in some cases, necrosis.

@johnrice4273 4 месяца назад

@@DrBrandonBeaber I eventually ran out of thigh, butt area. The tissue became difficult to penetrate. Copaxone was a relief. At some time I began a regimen of Novantrone. Although It was recommended to stay at the treatment facility for an hour I’d leave, knowing it was an hour home. Entering the house I became I’ll like I’d never been. Four treatments the same result. Because I’d never stayed at the hospital I assumed that my excruciating Illness was normal. Upon the fifth and final treatment I asked the nurse how it was possible those receiving cancer drug infusions could survive let alone finish the course. It was discovered the infusion had not been authorized to add an anti throw up medicine. Had I stayed it would have been discovered the infusion lacked the anti-throwup medicine. Last time infusion went well.👍now it’s an every six month infusion of Ocrevus. Easy peasy.

@freethinkeralways 4 месяца назад

Thank you! Interferons make life miserable. For me, 5% possible risk reduction is not worth 1.5 yrs of side effects. Video suggestion: italian study about BCG vaccine's positive effect on MS. Thank you!

@DrBrandonBeaber 4 месяца назад

Thanks. I am familiar with the BCG study. It seems bizarre that this vaccine could benefit MS but stranger things have happened.

@freethinkeralways 4 месяца назад

@DrBrandonBeaber Yes! It also inspired research on the reversal of pediatric type 1 diabetes by BCG vaccine, I believe Faustman Lab in Boston s conducting those BCG trials.

@desiredecove5815 4 месяца назад

#SharingisCaring

@odaynedaley7080 Месяц назад

Let us know when you got something actually promising

@josephvered3991 4 месяца назад

Hi from Israel interesting video this data is not relevant to new diagnosed because of the new DMT treatment

@DrBrandonBeaber 4 месяца назад

Yes I understand it is not relevant to many people, but I think it helps us understand how effective early initiation of a low-efficacy DMT is over many years.