Yo con Nasus empiezo con la tercera, un ítem básico de magia y la runa de quemar y encerio que quitas mucho además te ayuda mucho a no sufrir en los primeros minutos de partida y ya después te haces la primera y un ítem que tu quieras
terrible player, played 3000 games on a single champion with 0 improvement. Grasp is an early game rune for lane and he got 0 value from it, although nasus realistically can't get much value out of it in this particular matchup. Grasp is decent against tanks and other lanes where you can proc it gor free but if you want damage just go Conqueror. Generally Fleet Footwork is the best tho just to sustain lane even more the recent mana regen buff is also insanely valuable. As for domination rune Gathering Storm on Nasus is absolutely terrible, he has not a single AD ratio in his kit and is already weak early game so the 20 or so AD you'd be getting from it at around 15 minutes will do nothing for him, literally any other rune provides more value, just take Triumph, Weakness or even Scorch whatever. Second Wind is decent (good choice here cuz darius bleed will proc the heal) but make sure you actually need it otherwise it's a wasted rune slot. And the last rune mana is always useful on Nasus otherwise just take the extra gold from plants. Doesn't take a nasus expert to figure this out. Also let's not talk about the ignite. Absolute baby player.
