I play racing games of all sorts and enjoy watching videos that connect the dots between venues. It makes me feel like a real competitor making the rounds from event to event. Thank you for posting this!
From London into Lisbon it's 2188 km, so you'll have to fill your car 4 times if your car has a capacity of 600 km. 60 litres of petrol in France costs around 35€, in Spain 40 to 50€ and in Portugal... 60 to 70€. Yes, Portugal has some of the highest petrol prices in Europe. In tolls you will pay a lot in France and Spain. For example, between Calais and Paris you'll pay something like 30€, from Paris to Bordeaux 60€ and from there to the border with Spain about 20€, so count with more than 100€ or more in tolls in France. In Spain and Portugal, tolls are much cheaper. From the border with France to Burgos, toll prices were around 7 to 8€ when I passed there in 2018. From Burgos to the Portuguese border the road is free. From the Portuguese border to Lisbon you'll have to pay about 23€ in tolls. Therefore, you are going to pay at least 150€ in tolls. In the total trip you'll pay at least 300€.
I did from London to Povoa de Varzim, fill up in the UK then in France 2 times, but did not stop in Spain, was on red by the time we got home. But to be safe next time will stop in Spain to lol.