We like to pin important comments to address issues or clarifications in our videos. We promise the read is worth expanding! :) We greatly appreciate a commenter who revealed to us that there is an inconsistency in introductory biology sources for non-competitive inhibition. The peer-reviewed source we like to use as our main factual reference is Openstax where they have "In noncompetitive inhibition, an inhibitor molecule binds to the enzyme in a location other than the active site, called an allosteric site, but still manages to *prevent substrate binding* to the active site." Direct Link: openstax.org/books/biology-ap-courses/pages/6-5-enzymes However, in the popular Biology "Campbell" book used by introductory biology courses, the 11th edition states that the substrate can *still bind* but the "active site functions much less effectively." So which is it? After looking at more sources and conversing with some science communicators online and in a biology group Pinky is in, what we are hearing is that while the non-competitive inhibitor alters the enzyme's conformation, sometimes the substrate *can* still bind - and sometimes the substrate *cannot* bind - it depends on the non-competitive inhibitor type and enzyme. Thus, focusing on the binding can be problematic since substrates may still bind so we have now included this sentence *"if the substrate still binds, the enzyme's active site might not function well. Or at all."*
Hello @AmeobaSisters! Your videos helped me alot during my home-education. I watched most of your videos and I understand the topics better. I know that you both have you own children and you are still working hard to making these videos. Are you going to continue to make videos on Advanced biology (College Level), or do you think you might need to have a break before coming back to making videos? I don't want to push you to much, but if you could, it would be great :)
I'm always curious now because of you. I'm watching this at 03:00 AM (South Africa). Thank you, amoeba sisters I wouldn't be able to pass my science class without you guys. I'm now majoring in biology because you made me love science thank you guys ; )
uni student here, my bio professor got fired since he was kind of awful so my in-person class got switched to online, & now i learn everything through your videos. it all makes 200x more sense than anything my old professor said. amazing videos!
So, nobody's going to mention about how they rickrolled us by the last part 🤣🤣🤣 You got us there Amoeba Sisters! How entertaining yet informative at the same time! Very great job! 💯✨
The fact that I've been watching your videos since grade 9 and now I've graduated and am in University. Truly shows how good your videos are, can be watched by all age groups
i'm starting 9th grade, and it's so hard to get over that hill. I just want to say you guys have helped so many people and you NEED to understand that, without you, people could have not even passed there own grades! Your videos are the ONLY videos I can understand, so thank you! TYSMMMMMMMMMMMM
i love you guys fr doing this. i went to a public school that didn't teach biology and i am now an adult falling in love with the topic. videos like yours are what's helping me with some huge gaps i have in my knowledge. thank you thank you thank you!
Hi sisters, I just wanted to let you know that your videos have helped me so much. You have made me realize that learning really can be fun. My grades have improved and so has my love for you guys. Thanks so much for your help!!
Just wanted to come on and say, thank you for these videos!! My biology teacher used your videos to help us understand the topics she thought us and you two have really helped me pass my biology class 💜
Wow! This is the first video I've watched that is very recent (just 1 month ago). All of the videos I've watched from this channel were way back 3-5 years ago and I'm very happy that until now, this channel is still active! ✨ Keep it up Amoeba Sisters! You have helped me get through this online/modular class amidst pandemic. I'm currently in the 12th Grade and by next year, I'm going to graduate from my Senior High and take another step further into College! I will still go back here to your channel because I will take a Biology Course! 🦋 If I graduate from my college and become a doctor of any type, I promise that I will again comment here or any of your videos! I'm reaching my dreams and you're one of the stepping stones that will help me through it! God Bless 💖
I waited along for this video only from amoeba sisters animation make me easier to study the basic concepts , Thank you so much ....it's too helpful for making short notes.
I wanted to thank both of you from the core of my heart! Since, the time I came across your channel - I began to fall in love with Biology! It helped me a lot in my junior years and currently the videos are helping me as a middle schooler as well! The videos has inspired me to go beyond the books and my curriculum! Thanks a lot - I am from Japan (13 years :) )
A GREAT video for helping to explain regulation of cell processes. This is Advanced Placement Biology content all the way, but it is also still very useful for general bio. Outstanding explanations! This helps my students a lot! Sincere Thanks!
just in time !!! i have my final on 12 september and was really confused about coenzymes and cofactors,now i understand them more clearly,thank you so much
Literally watching your videos is the only way i can make information stick. I sometimes watch the videos outside of learning just for the illustrations and jokes
Finally! It's another late-time production, for another biological science subject! I hope you've done a great job there... Also, I gratefully wish to acknowledge you for enhancing my biological science experience!
Amoeba Sisters+ Freesciencelessons+ Biological Science+ Functional Approach =🥳🥳🥳🥳🥳🥳. Tbh, amoeba sisters should be called interesting biology. thank you so much😭😭😭😭😭
i´m a med student and these videos help me A LOT finally a funny way of learning... i´ve get an F from the feedback inhibition, cause I had no idea what it was, I thought it´s complicated as hell, but thanks to you I discoverd it´s not that bad.. I owe you my future degree :DD
These videos are going to put me and all other biology teachers out of a job! Or rather, competitively inhibit our usefulness. Still though, they're incredible and I would do my students a disservice by not sharing them! Thanks, Amoeba Sisters!
Oh! I just found your channel, my highschool biology teacher shows us your vidoes about membranes and plant cells,animal cell, all that stuff that I will forget in my adulthood
I just realized,,, I got rickrolled at the end 💀 but anyway, thx you for your videos!! I have the bio EOC in a few days and your videos are better than out crusty textbooks. 💚💙💚💙