ESCITALOPRAM Mechanism of Action :- Escitalopram increases intrasynaptic levels of the neurotransmitter serotonin by blocking the reuptake of the neurotransmitter into the presynaptic neuron. Over time, this leads to a downregulation of pre-synaptic 5-HT1A receptors, which is associated with an improvement in passive stress tolerance, and delayed downstream increase in expression of brain-derived neurotrophic factor, which may contribute to a reduction in negative affective biases.
Of the SSRIs currently available, escitalopram has the highest selectivity for the serotonin transporter (SERT) compared to the norepinephrine transporter (NET), making the side-effect profile relatively mild in comparison to less-selective SSRIs.
Escitalopram is a substrate of P-glycoprotein and hence P-glycoprotein inhibitors such as verapamil and quinidine may improve its blood brain barrier penetrability. In a preclinical study in rats combining escitalopram with a P-glycoprotein inhibitor, its antidepressant-like effects were enhanced
ESCITALOPRAM is a type of antidepressant which belongs to the class of selective serotonin reuptake inhibitors (SSRI) and is primarily used in the treatment of depression and other mental health conditions which include anxiety, panic disorder, and obsessive-compulsive disorder. Depression is a mood disorder that affects day to day life of a person. A person may have symptoms such as feeling sad or feeling of loss and might have mood swings. Anxiety is defined as an emotion that is characterized by feelings of tension, worried thoughts, and symptoms like increased blood pressure. Anxiety disorder also includes panic disorder which is characterized by sudden feelings of terror. In Obsessive-compulsive disorder (OCD), a person feels the need to think or perform things repeatedly.
ESCITALOPRAM works by increasing serotonin levels. Serotonin is a chemical messenger in the brain which is responsible for improving the mood and physical symptoms of depression. It is also responsible for relieving symptoms of anxiety, panic attacks, and obsessive-compulsive disorders.
Side Effects of ESCITALOPRAM
Nausea
Headache
Blocked or runny nose (sinusitis)
Increased or decreased appetite
Anxiety
Restlessness
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