EVERY SINGLE METABOLIC PATHWAY YOU NEED TO KNOW FOR BIOCHEMISTRY MCAT IN 30 MINUTES!!! 

I've taken biochem, sat in on biochem classes, and have been in an MCAT prep course and this was the BEST EXPLANATION I have ever had on these processes. I knew bits and pieces but this guy explained them in a way that had everything just click. I feel so empowered now! Biochem is amazing!

I can't believe you don't have more followers. This was better than Khan academy.

I watch this once a week as part of my MCAT studying. Thank you for this gem

“So that’s pretty Cool!” Never change brother, you’re saving everyone in bio chem!

Amazing summary, this approach should be the first class of every biochemistry class, unfortunately they dive into details and never give us the big picture. Essential video for first learners!

This might be the best explanation I have ever seen. Someone hire this guy. I mean seriously. Not only does he explain everything like a tenured professor at Harvard, but relates everything to the holistic vision of biochemical processes in our bodies. Unreal. Thank you!

0:00 - Glycolysis 0:29 - Pyruvate to Acetyl-CoA by PDC (pyruvate dehydrogenase complex) 0:43 - Krebs Cycle, Citric Acid Cycle 1:11 - Central Metabolism 1:29 - Why go through central metabolism? ATP!! 1:53 - Reduced cofactors (more ATP through ETC) → ATPs for cells to survive 2:19 - Other monosaccharides can enter central metabolism 2:57 - What about Proteins (amino acids)? Glucogenic & Ketogenic AAs 4:23 - Excess nitrogens → Urea Cycle (in Liver) 5:58 - What about Fatty Acids? Beta-Oxidation (reduced cofactors & acetyl-CoA produced) 7:13 - Reversible Glycolysis → Gluconeogenesis 7:35 - Irreversible Reaction: Pyruvate to Acetyl-CoA 7:52 - Gluconeogenesis (genesis of new glucose molecules) 8:15 - Sources of carbons for glucose (for gluconeogenesis): lactate, glycerol 9:00 - Alpha-keto acids as a source of carbons for glucose? NOPE (Acetyl-CoA enters TCA cycle) 9:31 - Can we take proteins/amino acids to form glucose? Depends (Glucogenic vs. Ketogenic AAs) 12:05 - Using fatty acids to form glucose? Acetyl-CoA? No, BUT last 3-carbon molecules can be converted to glucose 12:40 - Importance of Acetyl-CoA (for fatty acid synthesis, phospholipids, triacylglycerides) 13:37 - Fed State (excess carbs & proteins stored as triacylglycerides) 15:04 - Serine + Palmitic Acid → sphingosine backbone → cerimide → sphingomyelin/cerebroside/ganglioside) 16:05 - Fasted State (breakdown of triacylglycerides) 16:54 - Fasted State (ketogenesis in liver): 3 Acetyl Co-A molecules converted to HMG-CoA 17:33 - Why forming ketoacids? (ketolysis: ketoacids to acetyl-CoA to enter TCA Cycle) 18:15 - HMG-CoA can be converted to Isoprene → build larger molecules (Fed State) 19:07 - Biosynthesis of Cholesterol 19:26 - Cholesterol used to create hormones 20:16 - Biosynthesis of amino acids 22:09 - Importance of Serine (Folate cycle, Methionine cycle; SAM - universal methyl donor) 23:20 - PAPS (universal sulfur donor) 23:55 - Glycosylation (monosaccharides from intermediates of glycolysis) 25:32 - Pentose Phosphate Pathway (PPP) 25:50 - NADPH cofactors - electron donor to build bond during anabolism 26:14 - Reduced glutathione (endogenous anti-oxidant) 27:21 - Free radicals produced from ETC 28:46 - Biosynthesis of nucleic acids 30:02 - Degradation of nucleic acids 30:47 - Biosynthesis of nuerotransmitters 32:05 - Biosynthesis of porphyrin ring (used for hemoglobin, myoglobin, cytochrome, ETC) 32:44 - Big picture - see the forest! (links in the description box for each pathway in detail) 33:22 - Limitations to central metabolism: Essential Vitamins (must be obtained from diet) 34:04 - Essential Minerals (must be obtained from diet) 34:42 - Our limitations to central metabolism - final note El fin! Now go get that 528 you guys 🏃‍♀️🏃‍♂️

I HAVE BEEN STUDYING FOR THE MCAT FOR 4 MONTHS. I HAVE WATCHED MANY YT VIDEOS... ON MANY TOPICS (BELIEVE ME). THIS. THIS HANDS DOWN. THIS IS THE MOST INFORMATIVE, WELL-ORCHESTRATED, THOUGHTFUL, AND INTUITIVE VIDEO I HAVE WATCHED ON THIS TOPIC. AND OF ALL TOPICS, THIS HAPPENS TO BE THE HARDEST. YOUR CHANNEL DEFINITELY LIVES UP TO ITS NAME BRAVO

This is an amazing summary. I know everyone is saying it in the comments, but this video should literally have a million views. I have spent 20-30 minutes on just the first couple minutes to outline the steps of glycolysis for myself and man you are amazing. In the first 6 minutes, I am having total brain explosions just from the connections that you are putting together that I never quite got. Thank you so much. I always skip ads but not here

currently on the MCAT grind and praying for everyone here AAAAAA

This 30m video has tied together everything I've learned in all my years of schooling and a TON of my things that I never even thought of. This is gold bra!!

This is hands down the best biochem video I've ever seen

I love this guys enthusiasm. Makes it easy to listen to.

Wow... I never comment on RU-vid videos but this is everything and more that I've been looking for in my MCAT studying! I hope both sides of your pillow are cold at night

Thank you so much for this video! I've been trying to figure out the details of metabolism for the last 2 weeks and you summarized it all so well in just 34 minutes. You are the best!

I've taken biochem in both undergrad and medical school and this is by far the best video I've seen! Keep simplifying the science and make more videos!

I am a non-trad and only took two bio courses after my Eng degree. I got 129 in BB thanks to this channel. Don't know how to thank you. I hope you make videos of more advanced concepts like IC-50 (as you promised, JK😜) or do greater things in medicine-related education. ❤❤🙏🙏🙏🙏

Without exaggeration, this is the best video on biochem I've ever watched.

You are a god. There is no better way to make this kind of video, and I thank you eternally for every bit of energy you put into it. I could go on in detail

Thank you so much, you should have more views. i'm definitely sharing this.

i'm in love with this man he's gonna save my ass on this biochem midterm in two days

I am not skipping ads, this one is by far the best video of metabolic pathways!!!

This is a video with a very well explained biochemistry in 30 mins. Thank you!

AMAZING WAY OF EXPLAINING, THANK YOU!

This is a better explanation than the Princeton review damn I am impressed fr

This is such a brilliant overview of biochemistry. Wow!

never thought I would say this but biochem is so amazing. THANK YOU for your wholesome explanations🔥

absolute must watch video. everything is so clearly explained and logically put together, thank you!

You went straight to the point and had me hooked.

Holy Jesus Bless this man. Years of biochem agony just came to an abrupt end. Bro you make me wanna call you daddy!

Watching this the day before my MCAT. Pray for me

this is the most informative biochemistry video I have ever watched. thank you for this

MAN THIS IS GOLD GOD BLESS YOU THANK YOU SO MUCH!! Prayers to everyone here

Voice is crazy funny but information is condensed and accurate. Cool beans

Great video . Keep up the good work

Holy **** ! The channel should be named "Godly simplified science" ! Thank you, awesome work !

Perfect perfect perfect ! This is exactly what we need, a wholistic view on metabolism to get the big picture, thank you so much !

this video saved me hours of content review, thank you so much for this!!!

YOOO you need 10 million subscribers. I'm not even kidding. But besides that, holy moly, you are incredible at explaining this subject.

This was by far the best video summarizing everything I need in biochemistry. Thank you

This is a biochemistry gem. Thank you for this.

Wow! I have to agree with the other commenters here and say that this really helped. Thank you!

Great level of hardwork has gone in here 💪

I love how you keep it simple cause I need that lol. Thanks so much for this vid

omg this is the best explanation ever. thank you so much!

thank you sooo much for this! my life has changed))

Thank you so much. This overview is what I needed

this was beautiful!!!! thank you!!

Wow! That was a great, amazing summary of biochemistry course.

Wow, really hands down. Super awesome

There should really be a "But wait! There's more!" somewhere in this video. ;) Excellent job, thank you for the help!

wow you've done an amazing job here. thanks a ton

Wow this was so great! Is it suffice to just watch this 1 video and take detailed notes? or should I also watch all the separate videos you made? (first time learning metabolism)!

This video is amazing! Thank you

I still don't understand why acetyl-CoA can't be converted back into glucose once it goes through the krebs cycle and becomes oxeloacetate Also, love the videos bro. This is the second one I'm watching of yours because they don't put me to sleep like everyone elses. Keep up the good work man! We all appreciate you tons

This is insane. Bravo

Based on KEGG, oxaloacetate can be converted to phosphoenolpyruvate, and then enter in gluconeogenesis.

THIS WAS GREAT! Thank youuu!!!

thanks, the best explanation i've ever seen!

good stuff! kind of a beautiful process actually:)

I have to take notes on this for Biology and its burning a hole in my brain.

Please do videos on nucleotide metabolism we love you sir

There are a few errors I’ve noticed in the first 10 minutes of this video- there are irreversible steps during glycolysis (Steps 1, 3, and 10) that must be circumvented for gluconeogenesis to take place. Additionally, at 11:25 , acetyl-CoA goes through the cycle two times before it’s lost as CO2 during the third time (as proven by isotopic studies). I haven’t watched the entire video, but don’t you think it would be helpful to include the enzyme names?

this is such a great video

Feel like some things aren’t specified properly, the nitrogen group on the amino acids for urea cycle are ammonia. Which is important as this gives understanding to the enzymes involved and what deficiencies within the cycle will cause

You are AMAZING

this video is great, thank you!

Amazing

One question. Do anaerobic organisms still use fatty acids as a form of energy reserve? Beta oxidation only makes sense if the FADH2 and NADH can enter Krebs cycle. There sure must be other way they recycle lipids or do they just discard fatty acids?

Dr can you put the slides in the description?

IDK who you are sir, but THANK YOU!

God level. Thank you.

PURE EXCELLENCE!

Amazing! Such important to have a general vision of this. Very useful!!

Great vid.

Doesn’t oxaloacetate get converted to phosphoenolpyruvate by PEPCK, not to pyruvate directly? 10:23

can you do more kidney, digestive system, cardio etc for mcat prep

brilliant...absolutely brilliant

great video. thanks!

I feel as though someone took a fire hose of knowledge and blasted my face. very helpful

this is too advanced for me anyone have advice on where to start?

Much love. Preciate this

Great video!

I'm writing an exam tomorrow and only discovered this video now 😂

You are a god.

u r amazing!!!!!!

WOW!!!🤯

Thank you a ton

"can't we take acetyl-COA to go in this direction to form this guy to then be used to make glucose?" "well nOoOoOOO!"

are we expected to know the exact structure of each of the biomolecules on the MCAT?

Can someone please tell me the name of the software that he uses for drawing these amazing structures?

ILY

Do I have to memorize all of it?

Cordycepin?

❤❤❤ woow nevveer ever been too eaay

This guy is a baller

Hey just wanted to thank you for this spectacular video, you are really saving me for the MCAT! I had a question though, more out of my own curiousity. Around the 17:28 mark you talk about acetyl coA being used to create HMG coA which creates ketone bodies which then create acetyl coA for the Krebb's cycle. I was just wondering why this occurs. Wouldn't it be easier for the acetyl coA to entire the Krebb's cycle directly? (Again I may have completely missed something and mean no disrespect by this question!) Thank you again @Science Simplified

❤

my biochem exam is in 8 hours wish me luck

Bro, please speak a bit slower, just so I don't need to play you at .75 speed😂👌