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Fischer esterification | Carboxylic acids and derivatives | Organic chemistry | Khan Academy 

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Fischer esterification of carboxylic acids. Created by Sal Khan.
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Organic Chemistry on Khan Academy: Carbon can form covalent bonds with itself and other elements to create a mind-boggling array of structures. In organic chemistry, we will learn about the reactions chemists use to synthesize crazy carbon based structures, as well as the analytical methods to characterize them. We will also think about how those reactions are occurring on a molecular level with reaction mechanisms. Simply put, organic chemistry is like building with molecular Legos. Let's make some beautiful organic molecules!
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5 окт 2024

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Комментарии : 83   
@katiestadler2278
@katiestadler2278 3 года назад
This guy continues to save my life every time I take an organic chemistry related class. Thank you!!
@divinusnobilite
@divinusnobilite 10 лет назад
This video was extremely well done.
@Ps3COD4Fan
@Ps3COD4Fan 9 лет назад
the easy shortcut that I used without even doing any work is, whenever you have an alcohol and the reactant has an alcohol, the attacking OH steals the H from the molecule, then leaves, leaving O connecting to the remaining chain (CH3CH2).
@norenaventosa3463
@norenaventosa3463 6 лет назад
thank you so much for this
@eightarmedshiva
@eightarmedshiva 9 месяцев назад
This video is doing all kinds of possibilities and is making it confusing for people that are less advanced. The method you speak of is the most realistic approach for sure
@aidanloewen2712
@aidanloewen2712 8 лет назад
"Let's think about what might be happen".
@vetetima1
@vetetima1 12 лет назад
you are great ! i have an exam on monday, you helped me so much !!! thank you thank you a lot !!
@horbergus
@horbergus 12 лет назад
Incredible, I've learned invaluable things from this, thank you!
@Hands4Surgery
@Hands4Surgery 12 лет назад
I don't see how you could have made a Fisher esterification any more complicated, difficult to understand, and long. I'm goong back to my Organic book
@hannahpereira176
@hannahpereira176 9 лет назад
This was such a great help! Thank you!!! I totally understand it now :)
@murtyyalamarty4879
@murtyyalamarty4879 6 лет назад
Very well explained than the other videos out on RU-vid. Thanks Sal
@TheOneTheyCallTurner
@TheOneTheyCallTurner 12 лет назад
i have a test tomorrow on Carboxylic acid derivative reactions as well as reactions involving amines and then the Aldol reactions and the Claisen reactions.
@dynamicdimensions
@dynamicdimensions 10 лет назад
Yes, VERY USEFUL! Thanks!
@MonkeyDLuffy-xr4fl
@MonkeyDLuffy-xr4fl 8 лет назад
Thank you, Sal!
@midnightsilverpuppy
@midnightsilverpuppy 7 лет назад
Mmm, I feel like it's more likely that the hydroxyl group on the right will pick up the hydrogen that you say might be picked up from an ethanol molecule. Then, because water is a good leaving group, the lone pairs will come down, reform the carbonyl, and result in the ester
@rongeetbanerjee5205
@rongeetbanerjee5205 4 года назад
Really this was a very realistic and practical explanation.We are being taught very strict mechanisms . Thanks Sal.
@richardcook8490
@richardcook8490 3 года назад
A gifted teacher who is not highly conversant in organic chemistry. There are better videos on the web.
@weezilla
@weezilla 13 лет назад
Heard you on NPR a while ago :) I was excited because I had seen your videos before. Congrats :) Keep up the good work.
@ArjunSingh-vw4ru
@ArjunSingh-vw4ru 8 лет назад
Pndped, protonated, nucleophillic addition, deprotonate, protonated, eliminate and deprotonate brilliant video really helpful thanks.
@ji-yongahn6527
@ji-yongahn6527 8 лет назад
Thanks Khan! your video lecture helps me alot. A Big Thank You!
@iamlea
@iamlea 13 лет назад
Thanks Khan! I finally get it!!
@mcantele
@mcantele 10 лет назад
11:45-12:00 Why does one of the two hydroxyls have to protonate in step 4? I can't understand why the reaction doesn't stop at the stage of thetraedal (sp3 carbon) intermediate. I mean, of course this has something to do (as always) with overall better molecule stability and lower energy state, but I don't seem to get the point of that H2O elimination.
@carlos16alva
@carlos16alva 10 лет назад
Because when you add a nucleophile to an ester or a carboxylic acid the O cliffs off because the overall compound is highly reactive when it has 3 oxygen atoms attached to the same carbon carbon. if you have a book with you I advice you to look at grignard reactions when they react to esters. Hope this helps.
@kaiveen09
@kaiveen09 9 лет назад
YOU ARE AMAZING SIR! THANK YOU!!!!
@helenaellis5927
@helenaellis5927 6 лет назад
THANK YOU SO MUCH SAL!
@andrepulford7236
@andrepulford7236 8 лет назад
Brilliant, thanks!
@jennymaldives
@jennymaldives 11 лет назад
superb video sal. thank you
@710418oo
@710418oo 13 лет назад
@salamut2202 they don't really bond. Its just the oxygen who likes to hug more electrons, so it takes the hydrogen ones.
@reddustspider5830
@reddustspider5830 Год назад
Saved my extended essay, saved my day :')
@benneven9316
@benneven9316 5 лет назад
Hello, I had to carry out this reaction in practice, and I had to heat the mixture of propanoic acid, sulfuric acid and ethanol in a water bath. My question is, why did I have to heat it, since according to the enthalpies of formation this reaction should be slightly exothermal ?
@Ferrus91
@Ferrus91 14 лет назад
Question: you pointed to the carbonyl saying it was a good leaving group... how is this so? Isn't it the acid catalysed water molecule that eventually forms a good leavin group?
@rjsd7
@rjsd7 7 лет назад
11:14 color change from yellow to purple was a bit distracting
@gokula8508
@gokula8508 5 лет назад
Wow Sal, fantastic explanation of Fischer *esturfurcation* !
@montyhorseman4264
@montyhorseman4264 5 лет назад
Noone likes you
@AnveshKumarReddyDasari
@AnveshKumarReddyDasari 10 лет назад
@5.32 Would not the proton from the acid go to the oxygen next to the hydrogen besides attracting towards carbonyl oxygen in the initial carboxylic acid?
@gemyhk4407
@gemyhk4407 6 лет назад
So can we say that in the elimination of water the H comes from ethanol and OH comes from the acid??
@justindegroat8987
@justindegroat8987 9 лет назад
sulphuric?
@tazyboy28
@tazyboy28 8 лет назад
+Justin DeGroat lol sulfuric
@wedfrest
@wedfrest 8 лет назад
English FTW
@MrScarykat
@MrScarykat 11 лет назад
took me almost an hour to understand this.haha
@tizianoalimandi150
@tizianoalimandi150 4 года назад
@11:03 "two three four five six seven doubl...oh actully SINGLE BOND HERE!"
@SirGentleManne
@SirGentleManne 11 лет назад
top-tier nitpicking
@mysefl1
@mysefl1 12 лет назад
here's a suggestion make the courser more VISIBLE. i mean seriously a black background and a tiny courser its just not visible.
@utkarshverma1
@utkarshverma1 5 лет назад
Won't intramolecular H deprotonation be more probable at 12:07?
@rongeetbanerjee5205
@rongeetbanerjee5205 4 года назад
I think this is not the Typical Fischer-Speier Esterification because then Dry HCl gas needs to be used instead of H2SO4.
@avtaras
@avtaras 4 года назад
Sir, can HCl work as a catalyst?
@sarthaktrivedi8180
@sarthaktrivedi8180 4 года назад
Yes it can work but then Cl^- will not be as stable as HSO4^- so the second one is preferred....also proves that sulphuric acid is a better acid.
@snehhrd2
@snehhrd2 11 лет назад
very confusing but now its easy........after watching the video second time
@QuinceyFoxx
@QuinceyFoxx 11 лет назад
Take all the tuition I've ever paid UT.
@pkdababe
@pkdababe 13 лет назад
beast...
@salamut2202
@salamut2202 13 лет назад
How do hydrogen ions bond to water to create hydronium?
@InceptionSolver1
@InceptionSolver1 8 лет назад
I think it's more easily pronounced eh-stair-ification haha
@mabusurrahmansheikh6323
@mabusurrahmansheikh6323 5 лет назад
Can anybody help me to let me know that how to avoid reverse formation of ester to acid??any1 plz
@wedfrest
@wedfrest 8 лет назад
Nice one on the spelling of Sulphur :)
@MonkeyDLuffy-xr4fl
@MonkeyDLuffy-xr4fl 8 лет назад
Actually both spellings are correct. 'Sulfur' is Latin, 'sulphur' has been modified to obey conventions of the English language. Pretty sure he knows more about chemistry than you do :-)
@wedfrest
@wedfrest 8 лет назад
Pretty sure you know absolutely nothing about me whatsoever :)
@MonkeyDLuffy-xr4fl
@MonkeyDLuffy-xr4fl 8 лет назад
Chewie Lewie Of course I don't.
@SOG12341
@SOG12341 8 лет назад
What was the point of this interaction right here? Lmao
@basilfeitknecht6430
@basilfeitknecht6430 2 года назад
12:40 repetition legitimizes
@raheebalsaidi
@raheebalsaidi 8 лет назад
lit
@nilstiemer7177
@nilstiemer7177 7 лет назад
Is there no talking in this video?
@MrGW2fanboy
@MrGW2fanboy 12 лет назад
loool "Screen real estate" XD
@avtaras
@avtaras 4 года назад
Ye dw, he says it all the time. You’ll get used to it, then it won’t be as funny
@MrGW2fanboy
@MrGW2fanboy 4 года назад
@@avtarasit's always nice to revisit a comment from 7 years ago and have no idea why you wrote it. Thanks for taking me back to 2013, good times
@honeykim95
@honeykim95 13 лет назад
@58203ju Canada and America has different spellings
@Tazy010383
@Tazy010383 11 лет назад
pretty sure it's Fischer
@58203ju
@58203ju 13 лет назад
*Sulfuric acid *Fischer Esterification
@7KRexCHAT
@7KRexCHAT 12 лет назад
have you seen the movie limitless?... My conclusion.
@blondedcocaine9339
@blondedcocaine9339 6 лет назад
LETS FIND THE PILL
@vijayvarghese1652
@vijayvarghese1652 6 лет назад
sulFuric acid
@davidkain2464
@davidkain2464 7 лет назад
You went really was on the first example 😔
@honeykim95
@honeykim95 12 лет назад
@tjoseph230 I've seen people with the last name Fischer and Fisher before -__-
@micahsimmermandotcom3525
@micahsimmermandotcom3525 7 лет назад
Jezuz, how much time should it really take to explain this reaction?
@Exercic
@Exercic 10 лет назад
Stop changing color please..
@justindegroat8987
@justindegroat8987 9 лет назад
+Exercic There is a point to the color change.
@BigBadVVolf22
@BigBadVVolf22 4 года назад
Dude you don't have to explain to us how to name an alcohol or why sulfuric acid is an acid.
@sumedhbandivdekar8320
@sumedhbandivdekar8320 8 лет назад
very boring😡😡
@Exercic
@Exercic 10 лет назад
Stop changing color please..
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