@@MedicosisPerfectionalis at the minute 24:08 , gastric acid secretion is by Gs coupled ? Should not be by muscarinic receptor M3 Gq coupled ?! I am confused with Histamine functions!
ı never have the tolerance to listen to my professors for 20 mnts😂 but ı can sit the whole day watching and listening to your vedios, hilarious and gifted😊
diction and voice 100% Explanation and simplification of the information 100% writing, drawings and colors 100% sense of humor 😂 100% Great Thank to you good luck Keep up 👌👍
Perfectly explained. I've been rereading my textbook for ages, but it only clicked when I could visualise the processes through your drawings. Many thanks!
The reason your content is so amazing is because although it gets really specific, so we can understand in a reasonably deep way these biochemical mechanisms, it doesn't go unnecessarily deep, like what we can find by reading Goodman and Gilman's (I mean I love it but the text is just too long), you give exactly what I need to study for the masters entry exam I'm preparing for. Thank you so much!
Coming here to learn abt GPCR’s after I have been dealing w hellish Long Covid for 16 months now..some think GPCR’s are involved in this and there’s a clinical trial using an aptamer to act on GPCR’s. Hoping for the best
Hey, thank you for your awesome videos i have a question, hope you can help me: 1. β1 stimulation :: Gs :: ⭡ cAMP & PKA :: ⭡ Ca in myocytes :: ⭡ Contractility of (cardiac) muscle Q1. so as β receptor stimulate Gs, does it mean all β receptors (β1,β2,β3) would ⭡ Ca in the effected tissue? for instance, due to Gs pathway, β1 stimulation makes ⭡ Ca in myocytes. so does β2 stimulation makes ⭡ Ca in vascular smooth muscle too, as it use the same Gs pathway? in the video you had written β2 stimulation would "inhibit myosin light chain" in VSMCs. i know the fact that β1 is dominant receptor in heart & β2 is dominant receptor in VSMCs, but my question is when they (β1&β2) both use Gs::cAMP::PKA, how does one receptor knows to make "⭡Ca" and another knows to "inhibit myosin light chain" in the cell? Do their Gs differ or do their PKA differ from each other? i hope you can help me to know what i am missing here best regards
Hi! Thank you so much for your amazing content! What is a good source of information for categorizing drugs that act on Gq vs Gs vs Gi receptors? I appreciate the ones you mentioned, but I was wondering where I could find more. Thank you!
thanks for real life saver professional better than school professor's goddess on youtuber make textbook into less than half hr vdo and immediately connecting whole pic that helps us get connected with all the critical concepts! thanks for make everything so clear! watching your vdo once is saving me reading my teachers books for days and still messy not sure what they try to deliver as key point or larger scope concept! and btw 15:32 the GDP was replaced by whole GTP not just Pi.
I’ve been trying to restudy physiology, patho and pharmacology (for an embarrassing amount of time) and been working for a while to get all the G-protein receptors down because I know they are so key. You just did it so well and made it so simplified. Bravo to you! I will likely be subscribing to your content. Thank you!
@@MedicosisPerfectionalis thank you so much your videos they are very helpful, here is the feed back of last semester i got "A" in microbiology and "A" in biochemisrty because of your Toutorials. again thank you so much and be blessed...😊😊😊
Thank you so much for your video! This makes so much sense! I was wondering if @19:52 you meant to write M2 and M4 are Gi --> which inhibit the sympathetic system because in the video it says that it inhibits the parasympathetic system?
btw thanks a lot, I have a question about gastric acid secretion, of course, Gs is a cause of vasodilation and also smooth muscle relaxation then it means the mechanism of H2 cannot contract the smooth muscle of the gland which releases gastric acid now how to release gastric acid without contraction of the smooth muscle
Thank You for the great well explained videos .I was looking for a video that explains G-Proteins. Can you please make a video on Arsenic poising and how it affects the TCA cycle?also on mercury poisoning and its affects on the enzymes? Can you also please make a video that revises TCA cycle and Glycolysis and gluconeogenesis?
From my PhD experience in Biochemistry Yes that’s true. Ribozymes , Ribonuclease P are example of enzymatic RNAs that are made of RNA and there are very few non proteinous enzymes like this the majority of enzymes are made of proteins after translation.
