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Galactose Metabolism and Galactosemia - Review 

Dr.Mungli
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In this video I have explained galactose metabolism along with galactosemia condition. Fate of milk carbohydrate lactose into glucose and galactose and galactose metabolism into glucose 1 phosphate is explained. important enzymes like galactokinase and galactose 1 phosphate uridyl transferase ( GALT) enzyme and their defieicny leading to non-classical galactosemia and classical galactosemia, respectively has been explained. All the signes seen in these disorders like bilateral cataract, mental retardation, jaundice and fasting hypoglycemia has been explained.
You can watch my video on why jaundice is seen in classic galactosemia in the link below
• Why Jaundice is Seen i...
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Key words:
galactose
galactosemia
classical galactosemia
galactokinase
galactose 1 phosphate uridyl transferase
GALT
mental retardation
bilateral cataract
jaundice
hypoglycemia
UDP-glucose
lactose
lactase
lactation
Mungli
Dr Mungli
usmle
step 1
biochemistry

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5 авг 2024

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Комментарии : 49   
@Thirst-4knowledge
@Thirst-4knowledge 3 года назад
Thank you Dr. Mungli! Awesome lectures as usual.
@gereve
@gereve 3 года назад
Awesome video! Very thankful for the explanation.
@rahulsarkar5078
@rahulsarkar5078 7 лет назад
Just amazingly described each things thank you sir for clearing the concept
@DrMungli
@DrMungli 7 лет назад
You are most welcome. Consider SUBSCRIBING to the channel for regular updates.
@BallyBoy95
@BallyBoy95 7 лет назад
This is a very detailed and helpful video, thanks a lot! (Writing my university dissertation on this disease, got a tough year ahead of me aha!).
@DrMungli
@DrMungli 7 лет назад
I'm glad my video on galactose metabolism and galactosemia has been helpful to you. Wish you the best for your dissertation.
@wanyonyisam8445
@wanyonyisam8445 3 года назад
Very well explained pathway. My very best
@royjoseph1498
@royjoseph1498 7 лет назад
This is excellent, thanks a lot
@DrMungli
@DrMungli 7 лет назад
You are most welcome
@jas9729
@jas9729 4 года назад
This video and ur fructose metabolism video only I saw at yet, but I felt really good and experienced ,after saw this video Tnq Dr
@arifjamal6353
@arifjamal6353 4 года назад
Very helpful information👌
@anjanas.krishnan8763
@anjanas.krishnan8763 4 года назад
Awesome explanation sir.Thank you
@DrMungli
@DrMungli 4 года назад
You're most welcome
@dr.faizarafique3901
@dr.faizarafique3901 5 лет назад
superbbbb Sir....
@abdulhaqsuri6109
@abdulhaqsuri6109 7 лет назад
thank you sir,,, its very helpful vedio
@DrMungli
@DrMungli 7 лет назад
You are most welcome. Consider SUBSCRIBING to the channel for regular updates.
@Blesspame
@Blesspame 4 года назад
Thank you so much very2 helpful
@DrMungli
@DrMungli 4 года назад
You're welcome!
@skaushik77
@skaushik77 6 лет назад
Thnxk doctor really helped me
@DrMungli
@DrMungli 5 лет назад
You are most welcome. I'm glad that this video has been helpful to you.
@ziaulrupom1215
@ziaulrupom1215 7 лет назад
thanks sir. from Bangladesh
@DrMungli
@DrMungli 7 лет назад
You are most welcome.
@hawraalsofi4795
@hawraalsofi4795 7 лет назад
thanks doctor for this helpful explain. .I have on Thursday presentation about this topic ,,and I have to make questions on galactose pathway ..what questions can I made on it could u help me 😊
@DrMungli
@DrMungli 7 лет назад
You are very welcome. Hope your presentation went well.
@lraksia9358
@lraksia9358 7 лет назад
Do you have any explanations about the Galactosemia type III which is the GALE deficiency?
@DrMungli
@DrMungli 7 лет назад
The galactose 4-epimerase (GALE) deficiency is similar to GALT enzyme deficiency. GALE deficiency leads to decreased availability of UDP-glucose which will affect the functioning of GALT leading to trapping of Pi as galactose-1-phosphate similar to GALT deficiency. The signs and symptoms of galactosemia type III vary from mild to severe and can include cataracts, delayed growth and development, intellectual disability, liver disease, and kidney problems. GALE deficiency specially in lactating mammary glands could lead to decreased lactation due to decreased availability of UDP-galactose from UDP-glucose to male lactose from lactose synthase.
@aaronmockedtodeath6757
@aaronmockedtodeath6757 7 лет назад
can stem cell therapy Posibally Cure classic glactocemia? I believe there is or will be a cure can the Galt enzyme be reproduced?
@DrMungli
@DrMungli 7 лет назад
In future it could be possible.
@yousefrezaei2979
@yousefrezaei2979 3 года назад
Sir, would you introduce a source regarding your explanation on 9:52 deficiency of inorganic phosphate pool and hypoglycemia...thank you for your nice explanation...
@madheshmahadevan
@madheshmahadevan 6 лет назад
sir ....can u make video in fates of pyruvate????? YOUR VIDEOS ARE SO USEFULL FOR ME....THANK YOU SIR!!!!!
@DrMungli
@DrMungli 6 лет назад
Sure I will do it. Make sure to keep notification on for my channel.
@madheshmahadevan
@madheshmahadevan 6 лет назад
Dr.Mungli thank u sir
@johnaleph9487
@johnaleph9487 4 года назад
Doctor..y don't you develop an app for biochemistry teaching.. I hope it will be very useful
@priyabhadauria5733
@priyabhadauria5733 4 года назад
My son was diagnosed with galactosemia in new born baby screeing test...can you please tell me what all are the symptoms of galactosemia in infants and once they complete 6 months what all to give and what all to avoid other than milk products
@DrMungli
@DrMungli 4 года назад
You need to get it confirmed whether galactosemia is due to galactokinase deficiency or GALT enzyme deficiency. in either case avoiding milk and milk product will greatly help to reduce symptoms and signs.
@wanyonyisam8445
@wanyonyisam8445 3 года назад
Why does galactose 1 phosphate inhibit phosphoglucomutaze
@AlphaCenturyX7
@AlphaCenturyX7 7 лет назад
Nice
@aaykumar-tf6gy
@aaykumar-tf6gy 7 лет назад
I pray to god that u r safe and sound after irma hitting hard at carribian island.
@DrMungli
@DrMungli 7 лет назад
Thank you for reaching out to me Abhay Kumar. Yes hurricane Irma was the second most dangerous hurricane ever recorded in terms of wind speed at 185 mph. Fortunately, we all are safe and back to normal life. Thank you again for thinking about me.
@aaykumar-tf6gy
@aaykumar-tf6gy 7 лет назад
Dr.Mungli ,thanks to god u r safe now sir.
@hvnjart
@hvnjart 3 года назад
May you please give your sources so i may be able ti cite them? XD
@ImranHussain-og1tr
@ImranHussain-og1tr 6 лет назад
Super sir g stay blessed ,mental retardation may b due to the hypoglycemia as brain needs 120 grams of glucose per day , thanks so much....
@DrMungli
@DrMungli 6 лет назад
Could be but still we don't know it for sure.
@harlirose
@harlirose 8 лет назад
I have galacsiosemla
@DrMungli
@DrMungli 7 лет назад
sorry to know. God bless.
@dikshaS301
@dikshaS301 6 лет назад
pehle se he sara likha h. distracting ho jata hai
@DrMungli
@DrMungli 6 лет назад
Yes, I agree, ye mera puraana video hai, ab jo kar rahahoo aise nahi hai, fir bhi feedbacks ke liye sukriya. Jab my future me video banata hu jaroor is feedback ko dhyan me rakta hoo. Kindly check out my recent videos and hope you like them better.
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