This is a short view that describes the mechanism of disease for myocardial infarction.
This video was created using Google Slides.
ADDITIONAL TAGS:
Substernal chest pain (angina)
-Stable angina: pain with exertion but subsides with rest or nitroglycerin
-Unstable angina: pain at rest
-Vasospastic angina: pain at rest from vasospasm
Atherosclerotic plaque buildup
Plaque acutely ruptures
Decreased perfusion leading to prolonged ischemia
Full thickness (transmural) ventricular wall tissue death and myocyte necrosis
Core concepts
Cellular physiology
Inflammation / cell damage
Social determinants of health
Pharmacologic mechanism
Chronic inflammation pathology
Micronutrients (biochemistry)
Microbial pathogenesis
Gene expression / regulation
Blood pressure physiology
Biochemistry
Flow gradients physiology
Nervous system physiology
Symptoms
Labs / tests / imaging results
Chest pain / STEMI
Substernal chest pain (angina) that does not resolve with rest
Leakage of intracellular ions and proteins from damaged cardiac muscle tissue
Impaired blood flow through coronary arteries
Partial obstruction of vessel diameter (70-90%)
Coronary artery narrowing, spasm
ST segment elevation on EKG
Myocytes leak potassium toward unaffected myocardium and way from EKG recording electrode
Elevated cardiac biomarkers (troponin)
Decreased cardiac output and stroke volume
Myocytes deprived of adequately oxygenated blood
Cardiac myocytes sustain reversible damage
Normal cardiac biomarkers
Ventricular dysfunction
Diaphoresis (sweating)
Baroreceptors sense reduced arterial pressure
Sympathetic nervous system activated, releases acetylcholine
Dyspnea
Pulmonary edema
Increased pulmonary venous pressure
23 июл 2024
