When the drug reaches the kidneys, they are tasked with the responsibility of removing it from the blood stream If the drug is taken in overdose, the kidneys can get damaged in an attempt to remove it from the bloodstream
@@nickolazcartersYes and importantly when you are prescribed a medicine over the long-term, the doctor will regularly check your kidney filtration rate via taking a bit of your blood. That checks how well your kidneys are doing
The long time the drugs stay in your system, is whats making it possible for there side effects to harm you negatively so before you climate blablabla make drugs that are easily excreted from the body.