I think chemistry and biology is the most facinating thing. It's literally like discovering cheat codes for Life. There is so many layers to the knowledge and outcome of different scientific discoveries. The natural world is facinating.
Another Banger! You surprised me again, I expected learning a little about pharmacokinetics. But the nuanced context of some of the inner workings of the pharmacological industry and by extension public health was unexpected, but very interesting. Well almost as unexpected as boron.
If it's not working, chuck a fluorine in there to tighten stuff up and pull evrything in tight. Never fails to amaze me the increase bioactivity that comes with a safely incorporated F.
Hello, I greatly benefit from your videos; first and foremost, thank you for creating such high-quality content. I have a question: could you make a video explaining how molecules that act as anti-addiction agents, work?
Thank you!! Well there are many different mechanisms depending on the compound. I touch on some of them partially in other videos like the one on ibogaine. But I will keep it in mind for a general video perhaps!
Cool video and channel. Do you have any thoughts on pyrazole chemistry and applications in the pharmaceutical industry? I just found your channel and got to look over your other videos!
@@totalsynthesisI'm an undergrad doing a research project on pnictogen chemistry, and coincidentally I'm using some pyrazole derivatives to make my ligands. (I'm actually applying for pharmacy school and it seems pretty lucky of me to stumble onto your channel lol)
The human remains at that Triangle Park place were the participants that would’ve made the study size a round number. For legal reasons this is a joke.
I work in MedChem. The Brainpower behind just one target is amazing but often after 10s of millions have been spend the target gets cancelled bcs. no molecule that is good enough has been found. And Drugs that are really profitable are also not as common in spite of the company spending billions of Dollars in to pharmaceutical research.
Nice. Absolutely! And on the topic of profitability, funnily enough, sometimes simple "non-innovative" small molecules can drive billions in profit whereas more expensive agents (e.g., gene or cell therapies), commonly creating uproar in broader society upon hearing price points, do not even reach $1bn sales given low addressable patient pool. It definitely is a very complex but transformational field.
