I have been on Enbrel, Humira, Xeljanz (pill), and Actemra. But I suffer EXTREME itch rash on my feet and ankles. I have been prescribed Simponi, by my rheumatologist, so I am DESPERATELY waiting my first shot, if there is ANY chance it will stop this rash. My RA has actually been under control due to the Actemra, but she told me Actemra does not treat psoriatic arthritis, but Simponi does, if I have psoriatic arthritis. I had the worst case of psoriasis in my life, even worse than I have now on both feet, for Nov-Dec 2011, and Nov 2012-Jan 2013, completely covered my body with itching sores. Those episodes went away on their own inexplicably.