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How to interpret AlphaFold structures 

European Bioinformatics Institute - EMBL-EBI
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This webinar will introduce AlphaFold system for prediction and interpretation of protein structures. This webinar is designed for experimental biologists who wish to understand the strengths and limitations of AlphaFold and use the models to guide their experimental studies.
In this webinar we will provide an overview for the AlphaFold method and statistics that can be used to understand the reliability of the models. We will also introduce the AlphaFold Database, which provides hundreds of thousands of ready-made models across the tree of life, as well as highlight the AlphaFold Open Source and Colab notebooks that can be used to generate structures of sequences not yet available within the AlphaFold Database.
We will conclude by demonstrating a range of use cases followed by a question and answer session with all the presenters.
Who is this course for?
This webinar is suitable for lab-based and computational researchers with an interest in structural biology.
This webinar was recorded on 08 September 2021. The slides can be viewed on the EMBL-EBI Training site www.ebi.ac.uk/training/events...
Future webinars are listed here www.ebi.ac.uk/training/live-e...

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7 сен 2021

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Комментарии : 33   
@xinformatics
@xinformatics 2 года назад
Thanks for uploading
@practicalmicrofabrication1858
@practicalmicrofabrication1858 2 года назад
Amazing work! Thanks for sharing
@HelysonLucas
@HelysonLucas 2 года назад
fantastic video lesson!!
@orafurman-schueler1839
@orafurman-schueler1839 2 года назад
Thanks for this very useful webinar! Is it possible to use this material for teaching? Specifically, the description of the different parts of AF are excellent, but the slides say "private and confidential". Thanks!
@5602KK
@5602KK 2 года назад
So helpful
@TALKyLIKEENGLISH
@TALKyLIKEENGLISH 2 года назад
Do u have a course for Alphafold2&Ebi coding?, or bioinformatics in general?
@lolerie
@lolerie 2 года назад
Nice, complexes hack is beautiful indeed. I hope you will do > 2700 human proteins in Molstar viewer, after all Molstar can do even insane Viruses, no problem.
@5602KK
@5602KK 2 года назад
At 5:21, you mention that a large MSA provides sufficient information to do accurate structure prediction (doesn't need template data). What information is supplements template data when an MSA is large?
@ranam
@ranam Год назад
I prefer to sphere pack all those with a spherical formula by implicit equation I know it's not practical to morph the manifolds analytical but it's a piece of cake and a beauty of mathematics can be applied at micro level but applying some 3d morphing computational algorithms which have minimal computational time but a symbolic one would be a work of beauty to unfold these protein cells
@joonyoon7900
@joonyoon7900 2 года назад
Hey folks, beautiful session! I have a question where I ran a local version of the alphafold and want to get the 3D structure, but cannot produce anything. Is there a certain program I should be using to render the images?
@christophohlknecht5905
@christophohlknecht5905 2 года назад
use pymol
@itsagooday
@itsagooday 11 месяцев назад
720p please. sorry but i'm old...my vision's blurry...
@mattarnold8139
@mattarnold8139 2 года назад
Does anyone know how to access PAE metrics when running inferences on a local install of AlphaFold?
@SeriousBartYT
@SeriousBartYT Год назад
Check the FAQ section of the AlphaFold database.
@christophec6992
@christophec6992 2 года назад
I cant see what is on the screen.
@arisioz
@arisioz 2 года назад
480p res explaining how they’ve used computers to fold proteins.
@RavindraThakkar369
@RavindraThakkar369 2 года назад
I have two peptides with 17 residues each, one is head to tail cyclic peptide and the other is stapled peptide. Does alphafold2 work with chemically modified peptides?
@SeriousBartYT
@SeriousBartYT Год назад
No.
@RavindraThakkar369
@RavindraThakkar369 Год назад
@@SeriousBartYT Thanks
@imrannooraddin1876
@imrannooraddin1876 2 года назад
420th like
@shinigamee8367
@shinigamee8367 2 года назад
Upload the video in 720p resolution. Otherwise delete it...
@rajatjha707
@rajatjha707 2 года назад
Lol
@theonettleton3042
@theonettleton3042 2 года назад
how about: go solve your own structures
@lolerie
@lolerie 2 года назад
The original is in 1080p. Somebody still uses 720p?
@MolecularArts
@MolecularArts 2 года назад
@@lolerie Setting on this video gives resolutions up to 480p only.
@lolerie
@lolerie 2 года назад
@@MolecularArts and on original there is 1080p which you can download with youtube-dl.
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