In 1996, My dad was treated with Interferon-beta for a grawitz tumor in his kidney. 8 inches in diameter, had been labelled terminal. Yet the I-b reduced the tumor to size of a penny. Gave him a couple extra years, after which the cancer returned in the bones. Unfortunately I-b was ineffective in hard tissues. He passed in 2004.
I got diagnosed with hep c a couple years after this drug was approved by the FDA. I remember the big sigh of relief I experienced when my doctor told me that it seems like it cleared on its own and no further treatment is needed after further and subsequent retestings. Apparently about 20% to 35% of those infected with hep c can spontaneously recover. I consider myself very lucky.
Same here. My Hep C cleared itself and was told the same thing from my doctor that I should count myself incredibly lucky. Thank the universe that I didn't get HIV or AIDS or something like that.
I kinda forgot, mostly because headlines were like "cure found, it costs $100k, not a joke or typo", nobody brought it up again so promptly forgot as effectively there was no cure at that price point.
If your in a blue state the ACA covers it and the price went way down once there were more treatment options. If your in a red state well thats death cults for ya. Sorry. Really.
I lost my mom 4 years ago to hep-C related cancer. She got it from a blood transfusion right after I was born, before they developed the detection methods you talked about. I really hope this cure becomes widespread and cheap enough that hep-C can go the way of smallpox.
My condolences to you and your family poseidon, it makes me wonder what other things in blood transfusions could cause other problems, since 1976s we've discovered more and more which allows us to purge things like this.
Being recommended to Dr Abiola on RU-vid was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
I recently Was treated for Hep C... after 6 weeks of treatment no more virus was detected in my blood, treatment continued for another 6 weeks... I am so grateful that there are really smart people in this world that figure these things out!❤️
Me too! I had it for 12 years or so and then Finnish government decided to eradicate it from our country and offered the treatment for free to everyone affected. I had the Glecaprevir/pibrentasvir one
Being recommended to Dr Abiola on RU-vid was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
Thank you so much for this video, my parent contracted HepC a year before I was born. All my childhood I was worried about it. Once the cure came out I was super excited, but later got very depressed once I learned about that it's only available for late stage HepC in most of Europe. I almost encouraged my parent to seek for the cure nevertheless. A few years passed and suddenly health insurance would finally cover it, my parent was yet very skeptical about the actual benefit, couldn't believe what the doctors said. Now my parent is cured, first few months after healing they got a lot of energy, but eventually the energy levels dropped again - apparently a common thing for those who received the cure.
Being recommended to Dr Abiola on RU-vid was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
I find the Asianometry topics of choice for video exposition are uncannily aligned with my own interests. I followed the trials and lead up to approval of this compound very closely when it happened a decade ago. Also, I recall Kalydeco (ivacaftor), the cure for a very specific type of cystic fibrosis, was also of particularly intense fascination and wonder what the long term status of the treatment's efficacy is today.
Being recommended to Dr Abiola on RU-vid was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
India, I believe, challenged Gilead on its pricing and threatened to make the drug themselves despite the obvious patent infringements. Does anyone know how that situation panned out?
They denied Gilead's patent request, & began indigenous production. It's created an ongoing medical tourism to India, where traveling halfway across the planet is more affordable than buying a pill at home.
@@TrollOfReason Thank you. That certainly is a great work around to help their own people. I guess Gilead et al are still making bank in the west, especially in the U.S. despite the decline of the disease.
@@conor7154you do realise that a lot of drug patents are completely stupid and are completely awarded by manipulating the patent laws for variations? India has a patent system but you can't patent innovative processes for the same drug as in the US (which means the patent never actually expires as the company keeps filing new processes when the patent is about to expire), it has to be a new molecule entirely to award patent
In Mongolia Because of India and egypt creating indigenous production they started selling discount to us as altriustic live saving for developing country scheme which made drug became very affordable.
The (IMO misguided) uproar about the cost of the drug really shouldn't overshadow the fact that curing HCV is one of the biggest medical successes of our lifetime.
@@WellBattle6nsulin is extremely difficult to make and only a few companies have the ability to make it. It has never been made by an amateur contrary to what people assume. It's cheaper in Europe as the governments cover most of the cost
@@williamthebonquerer9181 Mass production of insulin has been around since the early 1930s, & even today production is a matter of keeping the bacteria that actually makes it happy & productive. It's so easy to mass produce that it was cheap for much of the history of the drug & why it's still cheap outside America. The issue isn't one of technology or logistics, it's an issue of market manipulation & lack of regulation.
@@williamthebonquerer9181 The issue isn't patents, which have expired long ago, but regulation on insulin. Only one type of insulin is approved because of all the clinical trials and safety requirements, and the company that makes it has a monopoly. There is little regulation on making your own insulin. The open insulin project is a group of biohackers in oakland who engineered bacteria and yeast to make insulin and are trying to make the tech to produce it cheap and widely available, so that everyone can home brew their own in the future.
The problem is RU-vid doesn't recommend related content anymore. The sidebar is full of random crap I might generally enjoy watching regardless of the current topic.
Really great video as always! I love that you are dipping your toes into more biology and biotech focused topics and I look forward to more. There are certainly many interesting stories to cover. I could suggest the discovery of CRISPR Cas9 and the later patent war between The Doudna and the Zhang lab/Broad institute along with the many improvements and innovations being built on it since then. Also the Merck/Vioxx story, or the technology behind flowcytometry and cell sorting machines. Also the stories behind the development of Cryo-EM or Lightsheet Flourescent Microscopy two very cool and cutting edge technologies.
@@rdallas81 rofecoxib (Vioxx) is available again in Canada and you can get Celebrex in the US which is basically the same thing. I think the whole story was a bit overblown. Subsequent studies have shown that most NSAIDs come with an elevated risk of heart attack if taken high dose over long periods (except aspirin which has a protective effect). So Vioxx is probably no worse then ibuprofen in that respect. It was just the first large clinical study that was able to statistically show the effect.
Being recommended to Dr Abiola on RU-vid was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
It's incredible how excellent scientists and physicians were at determining clinical patterns from observation and then discovering the causative agents.
I love the wide, diverse range of topics covered in your videos. Hopefully you'll touch on batteries or more precisely the ones used in BEVs (Battery Electric Vehicles) such as lithium ion batteries or the ones talked about recently by Toyota, the solid state battery.
Such a good video! Sound like virology is not what you’ve an expert in but you did a great job explaining everything simply and correctly. Only shame is that you didn’t ask anyone how to pronounce ‘protease’, which in your video sounds like it’s a tease delivered by a pro 😉 but honestly, great video and here’s to some day you making another one about the success of the hepC vaccine!
P.S. Protease is "pro-tee-ace", not "pro-teez". Most enzyme names end in the suffix "-ase", which is pronounced as its own syllable with a hard S: basically like "ace". E.g. alanine aminotransfer-ase mentioned earlier in the video or RNA polymer-ase. Protease is built of "prote" for protein and "-ase" for enzyme. Sometimes an enzyme name is constructed by [name of substrate]-ase, like protease (protein substrate), lipase (lipid substrate), nuclease (noo-klee-ace, nucleic acid substrate), telomerase (telomere substrate); and sometimes it's just [function]-ase like aminotransferase (transfers amino acids, lol), DNA polymerase (polymerizes/lengthens strands of cDNA from a DNA template), or reverse transcriptase (produces cDNA from an RNA template). After further investigation I found out that the etymology of this "-ase" ending is basically "someone used this once and we stuck with it" lol. A libfix from the name of the first discovered enzyme, diastase. Sorry, having a biochemistry background, hearing "pro-teez" with the subtitle protease just made me giggle really hard lol.
Thank you for saving me the effort to write a post like yours. 😅 That "pro-tease" pronunciation initially made me laugh... but then made my ears "bleed" 🤣
Nice vid! Didn't know there was a cure. Hey man, I hope you can talk about Chimei group one day. About how they became a powerhouse in the plastic industry and the Museum they have in Tainan.
Being recommended to Dr Abiola on RU-vid was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
I used meds Harvoni for Hepatitis C for 12 weeks - first meds Canada / USA in 2013 . I was in experimental group for Layla University , Chicago . Thank you !!!! Hepatitis never come back . Today is August 2023
Being recommended to Dr Abiola on RU-vid was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
Right up my alley! You did a great job covering this. I’d advise anyone interested in science and viruses to check out “This week in virology” podcast (not my podcast, just a listener of it).
There are still many viruses that have been with us for many years but we still don't have a cure. Herpes is one that comes to mind. And then there's newer viruses like the sars cov 2. We'll always need research it seems, and then there's the new resistant bacteria and viruses.
My mom was diagnosed with hepatitis C in mid 00s. She was treated with Russian made Interferon alpha type drugs. It has good results, she recoverd, but in mid 10s she developed cirrhosis and died last year in age of 58.
Being recommended to Dr Abiola on RU-vid was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
This would have been nice to have back when I went through chemo for Hep C. My regimen consisted of a twice weekly shot of Interferon, in tandem w/ Ribavirin, and it was brutal! I lost 50 lbs over a six month period and was experiencing severe bouts of tachacardia, which would make me pass out and I'd wake up to find myself on the floor w/ a bloody nose or big bruise somewhere. smh
My mother contracted Hepatitis C from a blood transfusion in the 1980s. She became acutely ill in 1990, to the degree that the doctors told my dad he needed to start thinking about what to do as a single father. My mom survived the acute phase but dealt with other health issues, including a brain hemorrhage in 1995. She died in the summer of 2013 after being diagnosed with liver failure and being hospitalized for a severe GI bleed, and I read an article in the NYT that fall about Harvoni. I wish she'd taken better care of herself - she finished a bottle of chardonnay every day, which couldn't have done anything good for her liver. I will always wonder whether, if she had stopped drinking, she would have had the chance to take Harvoni and would still be alive today.
Good one! I have friends that went through both interferon and sofosbuvir, and there's no comparison - the side effects of the former were stunning in scope. Also the treatment lasted 12 months or more compared to four for Sovaldi, which as far as I could tell was free of any side effects at all. The use of AI in developing leads in medicinal chemistry will probably speed up the development of new antivirals and other meds significantly - a subject we're hearing a lot about in the pharmacology world. Thank you kindly for covering this - it's quite a success story...
I am a recovering addict and this stuff cured me, 3 months of anti virals, cost the state funded insurance like $30k! The meds are so overpriced and they make you feel so bad. I felt like a grandpa after a month, your bones hurt, your super tired and no amount of caffeine helps, it was worth it tho been cured since! Finished my mechanical engineer bachelors and sober!
What drug did you take? I had Maviret, it's Glecaprevir/pibrentasvir and experienced literally no side effects. Not even the mildest. Nothing. Was completely cured ❤
Being recommended to Dr Abiola on RU-vid was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
Very interesting video! My mom went through Interferon + Ribavarin treatment in early 2010s. The side-effects made it very difficult to be a functional adult with a job, considering the full treatment lasted for about a year. And it was a lot more expensive than 1000 dollars. I'm glad she went though it (still virus-free to this day) but it's good to know that there's a much better alternative these days.
Being recommended to Dr Abiola on RU-vid was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
Considering your usual subject matter revolves around silicon related technologies, this foray into virology / molecular biology / immunology must have stretched your comfort zone a bit. I applaud your bravery as this story is multifaceted and difficult to explain to laypeople. As a medical professional, I will say that your presentation was accurate and covered the principal issues quite well. Overall you have provided an excellent primer on the subject. That said, I will offer two tiny nitpicks. ALT (alanine aminotransferase) is generally pronounced as the individual letters by the medical community and “protease” is pronounced as three syllables (pro-tee-ace). Again, outstanding work on your part to put this summary together. Continued good luck to you and your channel from a longtime subscriber.
Being recommended to Dr Abiola on RU-vid was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
My friend’s mother had a blood transfusion in the early ‘80s, before blood was heavily tested. She got hepatitis C, and she thought it was fatal. She’s still around thanks to this.
Being recommended to Dr Abiola on RU-vid was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
I'm assuming he also got contaminated by Factor VIII from bayer? My uncle also got it, in addition to HIV from it. Unfortunately, after he was cured from his hep, he heard he already had gotten cancer from the hep and died shortly after.
@@DrAugurk something like that. He's very competent (his brother, also but less gravely haemophilic, is a doctor) and can speak at length of drugs and treatments for his condition.
Just for my own purposes, would you be willing to include a pastebin link in your description to a list of sources? I love your content, but I always like to do more reading, especially with something as exciting as this.
My mother had Hepatitis C, she had it for a long time without knowing about it, At the point of detecting her liver was 75% affected We were very concerned and prepared for the worst. We went to various doctors but we fortunately found a specialist. Now normally we'd have to leave our country for India for treatment and it would cost upwards of 4 crore taka (400,000$) But by the Grace of God, our country just the previous year started preparing the Hepatitis C drug in our country that costs 45lac taka (45,000$) for the full dosage. It's been 6 years now and she is now healthy, by the Grace of God. We were very fortunate and I pray others in a worse situation gets better
Being recommended to Dr Abiola on RU-vid was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
Fascinating! Thank you. My Mum had jaundice and nearly died in hospital in Tehran during the 70s! I'm not sure which Hep she had but I wouldn't be here had she not survived.
I did this treatment or a chemical very similar about 7 years ago. It was $180,000 for 6 months. I think the name of it sounded very similar but it was different than what you mentioned. I was told it was 95% effective when I did the treatment. And I am cured of hepatitis C.
I had it during the '70s and never received any treatment as there was none. Full forward 20 years and I was required to vaccinate against Hep B but never sero-converted, which needed to be investigated with routine testing over several years. All the while, I was asymptomatic. Around 10 years further on, I was declared cured by not showing any select antibody activity over a couple of years. One of the lucky ones who required no treatment.
Was about to post this. The pronunciation seems weird, but it’s because the -ase suffix is used throughout biology and chemistry to indicate a chemical that cuts something else. If you want to name a chemical that cuts a protein, it’s a prote-ase. If you want to cut a nucleotide (like DNA and RNA), then you use a a nuclease (new-klee-ace). And if you want to cut a polymer, you use a polymerase. Chemical nomenclature really likes its suffixes and prefixes.
@@Brighton24601 -- Well, he's not a biochemist, so this little error is forgivable. His videos are always well researched and well presented. He impresses me.
I sold an inferior biotech drug from Amgen in the late 90’s. The name was Infergen. Ribaviron was used as a combination agent along with Interferon to increase its efficacy. These drugs were major failures with many side effects. The main issue was the disease’s ability to mutate. I was absolutely blown away when a cure was discovered. This is why the pharmaceutical/biopharma industry is so important in the discovery of these groundbreaking discoveries.
I work for gilead. I have some gripes with some of their pricing, but 1000 for a CURE is a great deal. With a single-use treatment cost being that low, the failure in this case is government healthcare support for low income patients.
When you said: "...regularly injects drugs.", my mind's eye showed me a hospital, with little, sharp, sparks for every needle. When darkness blinds you, try flipping it, for size.
Having my three middle fingers severed off in 2009 and a heart attack in 2015 and a rigorous heart check in 2017 my Hep C was obviously never detected in all the blond test. In 2021 I moved to a small town I like to call Mexico, Texas. I wonder if there is a connection. I’m glad I haven’t drank booze in 37 years.
I've had hep C twice. Once while getting a random STD screening they told me I had hep C my thankfully my body was fighting the virus off naturally. I got tested a few more times and they took my blood and other samples for research made me awnser some questions and oddly gave me 50$ for each of these 4 testings. Three years later while in the hospital they told me I had very early hep C and was confused. I did the treatment in 2021 thank god its covered in Canada. I wanted to die I felt like shit for months. I know someone who did the old treatment in the 90's, they have so many allergies now and other heath problems. While doing treatment they were constantly in pain, it was like chemo. Hep c is rather scary it can live on surfaces for a long time, the virus has mutated like crazy. And now we're seeing Hep D and other forms pop up. Even A&B infects a bunch of people every year its important to get the vax for hep BOTH OF THEM the second booster is super important without it the vax is worthless. a Its gross how companies are able to charge 50k for treatment, considering much like TB how dangerous hepatitis is. You do not want people having a, b or c and spreading that shit around. "I've heard" people buying it off the darkweb due to India being able to make any medicine with no fucks given about laws(Along with other medications). Its real and much much cheaper, customs can still take it away if they find it tho and even threaten charges on you. Would suck having the government stealing your treatment because you cant afford "their" treatment. I hate American pharma companies, only support euro/japanese ones.
Being recommended to Dr Abiola on RU-vid was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
