HPLC Maintenance - Replacing the Loop Capillary on an Agilent G4226X/G1367E Agilent HiP Autosampler 

Starting from 0:57 to 1:00 and 10:07 to 1:20 you need to do basically the same as shown by the instructor. No need to unscrew the swagelocks of the red loop capillary! Then you squeeze the blue plastic wings of the needle assembly together and slide it out. When reinstalling the new needle assembly, slide the needle in until it makes a "click" sound

With Agilent Lab Advisor you are able to move the needle into maintenance position. Otherwise the needle will be parked in the needle-seat and you wont be able to work on it properly

Yes u can ...but needle should be in the seating position ....no need of lab advisor...u can adjust loop without it ..no issues