Human Geneticist Answers DNA Questions From Twitter | Tech Support | WIRED 

I've said it before and I'll say it again; the producers and creative team at Wired are doing an incredible job finding these experts. Whatever subject matter it is, I find myself intrigued.

How smoothly the man explained the complex concepts. Commendable.

As a biochemist, it's commendable how he makes such complex phenomena so easy to grasp and process.

You can tell if someone is really knowledgeable in their field if they can explain it in terms everyone can understand

This geneticist was the entire reason why I'm studying genetics in undergrad at the moment. I remember his video on CRISPR-Cas9, the one about explaining the concept at 5 different levels wayyy back in middle school and it just stuck haha

The way this guy speaks just shows how intelligent he is. I'm baffled by his clear and elaborate answers.

Dude hitting on the ethics at the end! All new technological developments should pass the Ian Malcolm test: "Your scientists were so preoccupied with whether or not they could, they didnt stop to think if they should". Just because you can, that doesnt mean you should.

As a biotechnology Engineer , I wish I had this man as a teacher back when I was in uni

I love seeing people talk about something their passionate about and it’s amazing that this series allows people to gain exposure to certain topics they otherwise wouldn’t come across

Please do one for cell biology! Cell support! We have a lot of genetics and neurobiology but never have one for cell biology, which arguably one of the most diverse field in biology.

I did a report on CRISPR in college for an ecology class and how it could be used, along with eliminating or at the very least be used to design substantial treatment of human diseases, it can be used to do the same in wildlife diseases that unfortunately ravage different species. The specific examples I used is the facial tumor disease which is a cancer disease that affects Tasmanian Devils.

This man reminds me of a real-life Spock, he has an almost flat affect but you can clearly see his excitement in describing scientific advencements in genetics, and even delivers a couple little quips that almost slip by unless you're paying attention. People like this are some of the best teachers I've ever had.

I still don't understand why our jeans are so important to this guy.

As someone who hasn't studies genetics and molecular/cell biology for a number of years, this brought back memories. Glad to hear about how Dr Sanjana's lab is using CRISPR to create more effective cancer-fighting T-cells. What's more, Dr Sanjana is an outstanding science communicator - one of the best I've ever come across. Also loved his clarity and ethical approach to answering questions about using CRISPR in a 'eugenics'/'creating better humans' context.

He reminds me of why I was interested in genetics in the first place. Unfortunately, I was terrible in the class. But this was awesome and well explained!

Here we go again, having to convert degrees Fahrenheit to Celsius: - DNA breaks at temperatures above 204°C - cremation happens around 815°C - 1093°C You're welcome, world (I didn't convert the unities of distance because he gives examples of that distance and it is less important) :P (Really cool video though, you guys are AMAZING ♡♡)

Wow. This is the best speaker I've ever heard to explain this material. I worked in science for 30 years.

0:21: 🧬 Geneticist explains diverse traits, DNA testing, and gene mutations. 3:09: 🧬 Mutations can have both positive and negative effects on our health, including stronger bones, protection against diseases, and the development of cancer. 6:26: 🧬 CRISPR technology uses the Cas9 protein to edit DNA and has the potential to treat genetic diseases. 9:21: 🧬 Genome engineering focuses on genetic diseases, DNA replication, and alcoholism. 12:14: 🧬 The epigenome and genome are constantly changing, and CRISPR is being used to develop better cancer therapies. Recap by Tammy AI with useful time stamps =)

Dr. Sanjana did such a wonderful job at explaining each question not only smoothly, but in simple to understand way that enables a person to understand even the most complex answer. Sometimes a question might seem not too bad, but actually has quite a complex answer, and he was fantastic.

Dr. Neville is wonderful. charming and informative. thanks for these shows 🤩

Man you guys do such a great job of finding these specific experts. They are always so in love with their field and it’s contagious

Bravo Dr. Neville! I wish I had a professor like you when I were in college.

Is it just me or these people teach better than my teachers

A good use of RU-vid - conveying real knowledge.

this guy is absolutely incredible at explaining things simply, I understood almost everything he said here, what an incredible talent to have

That final question and answer is so unbelievably important for human development. Far more than chasing everlasting beauty, youth or "improvements"

experts that can clearly explain complex concepts are my favorite! i could listen all day

Watching this while doing my genetics assignment. what a coincidence

Well refined, super well delivered, A's around the board for Dr. Sanjana!

It’s amazing that no matter how much we know there’s always more stuff to learn.

How smoothly the man explained the complex concepts. Commendable.. Dr. Neville is wonderful. charming and informative. thanks for these shows .

The fact that this guy has a chromosome lapel pin makes this video all the more fun to watch. Very well done.

I'm glad he touched on the moral and ethical side of what could be done with CRSPR. Some people don't seem to realize that, specially given how new these technologies are, there are some things as a society that we may be should be aware of. Not everything is fair-game.

Whoa! You were able to clearly answer many questions in an interesting and easy way to understand! Thank you! Looking forward to another one on DNA and Genetics! 🧬

I truly appreciated the last answer. I feel many people have been worried about using this science in that way & his answer was much more ethical.

Don't let money control this tech please. We are already freaked out about AI. A world consensus based on ethics is absolutely necessary for such practices.

CRISPR is so promising. Would we need to understand the genetic basis for diseases like fibro, muscular dystrophy, etc first before being able to effectively cure/prevent them? As in, knowing how they’re written in the genome in the first place? Many genes, so much identifying 🤯

Mad props to Dr. Neville for answering all those questions seriously and succinctly... including the asinine questions.

I think we need a Part 2! 👏👏👏👏

Dr. Neville is wonderful. charming and informative. thanks for these shows . How smoothly the man explained the complex concepts. Commendable..

I love these videos very entertaining thank you for producing this type of content❤😊🎉

Worth noticing that he was so compelling and didactic during the AMA but at the very end. It would be interesting to know how exposed to and/or involved Dr. Neville's been with DNA editing for human enhancement.

Please make a part two with Dr. Neville! Awesome video

Such a great video! Would love to see him come back to answer more questions, especially as new breakthroughs occur.

This was highly informative and very entertaining. Thank you.

Easy to understand and quite informative. Thanks.

I love this channel I've never seen a more diverse yet equally intriguing topics in one place🤩🤩🤩🤩

It's a good sign to see this video because I'm going into school for human genetics in a couple months!

So interesting as always

After my husband was told to put his affairs in order with no cause of his imminent death. We did it 23 in me. The 23 and me, diagnosed my husband's Alpha One Anticipation Disorder. His mutated gene came alive after exposure to burn pits in the war. Currently, he's waiting for two lungs and a liver transplant destroyed by a mutated protein. Until that happens every week he takes an infusion of plasma of other people's non-mutated genes (proteins).

Excellent video. This guy can really explain something hugely complex in an accessible way. Great stuff!

This guy is beyond amazing. A real genius moved by endless passion.

Just learned something. When I eat cilantro by itself it tastes exactly like soap, something I have noticed for a long time. If I eat cilantro as topping on street tacos the soap flavor for the most part blends away.

He carefully shot down eugenics without specifically calling it eugenics. You could tell he was trying to tread very carefully and spoke very deliberately when that kind of thing came up. It really is a fine line there.

Very cool! Thanks for doing this!

Fabulous guest! Plz have him back again!

Best practical genetics lecture on RU-vid

I love that he took every question seriously

I am so thrilled to hear your video on genetics. Genetics has always been one of my favorite fields of science, but I love all fields of science.

The ease this guy explained sequencing is honestly what all of us microbiologists should strive for.

The Name's Bond... Genes Bond.

What a marvellous video. Great information!

thanks so much for explaining this all so well. i needed this in standard 8 (year 10....)

Thank you for even mentioning beta thalassemia! Most of my docs have never even heard of it and I wind up explaining it to them, including having to wave away the harmful and needless retests they try to force on me, I'm going to save this video and let this gentleman explain it for me. It gives me hope that it is being seen and is a candidate for CRISPR.

I wanted someone to ask about the implications of this and eugenics vs ethics in gene therapy.

Fantastic, clear explanations. I feel much smarter!

When the Lenny Kravitz question was asked i genuinely thought he'll talk at length about methylation😂

I'm one of those people of Asian descent that feel sick with alcohol ingestion. It is impossible for me to become an alcoholic because my body can't get used to it.

Phenomenal explanations thank you

Wow, thank you, OCA2! And Doctor Sanjana 😅 I appreciate my eyes and the knowledge

Props to WIRED for bringing education to the desolate rabbit hole that social media can be.

I wish this guy was my biology teacher

I love this series. I want to see more of the mortician, he's amazing!

Thank you for your videos.

I love the last answer. Not just can we do something, but should we.

While I kind of wish I did like cilantro, I think it's a bad idea to "fix" these genetic changes. They arose due to some form of evolutionary pressure. To assume this change is "broken" in the first place is a fundamental mistake in the logic. Basically, as mentioned in the beginning of the video, we don't want to homogenize our genome because it opens us up to the reemergence of the original pressure that caused this genetic quirk. For example, the current theory on this cilantro aversion is that there is a parasitic insect that lived/lives in our bedding. The people who developed the cilantro aversion gene picked it up because this parasitic bug emits a chemical that's unfortunately shared within the flavour/aroma profile of cilantro as well. The interesting thing about the quirk too is that the people who like cilantro cannot detect the smell, and by that I mean, they're incapable of smelling or tasting the component. The people who you want to "fix" have the ability to detect the chemical. If anything perhaps the solution is to "fix" the cilantro to remove the component that "normal" cilantro loving people can't even tell is there? Of course now we have a paradox, do we risk humanity for the sake of cilantro of risk cilantro for the sake of humanity? If a choice had to be made between the two, I'd think perhaps we would risk cilantro for the sake of humanity because we likely could maintain two branches of the cilantro species in one of several capacities without genetically putting cilantro at risk as we would continue to cultivate and protect it.

bro im doing bio and its just so exciting to point out all the stuff that ive learnt in this video like "omg i learnt about insulin production and genetical modifications before" it's somehow very affirming

I love the video It was very entertaining and easy to understand for complex concepts

I've been rewatching _SeaQuest DSV_ recently, and that last question sounded like it came straight out of the Season 2 premiere, which introduced a hominin race of genetically engineered life forms (GELFs) who, due to their engineered genes, could survive and thrive in a low-oxygen environment; due to the destruction of rainforests, the use of machines that capture CO2 to sequester carbon and generate oxygen to keep our air breathable, and a fully implemented SDI system (ask your parents about that last one, kids), this was a crucial plot point. Unfortunately, Spielbergian pseudoscience woo tanked the plot, not just for the premiere, but for the rest of the series.

Can you do a video about gene or DNA involvement about curly hair? My mother has it too (we're Caucasian). But, we both had straight hair until puberty.

This was super interesting, And the expert explained concepts very clearly.

That was facinating! Dr. Sanjana is an excellent science communicator.

Could you add units in celsius(, kilograms and such if the subject has these units) in these videos too I don’t know fahrenheit and don’t always want to google whenever I see those units

genes were always the most interesting part of biology

Wonderful easy to understand explanation. Thank you.

I’d read his book. So eloquent and precise.

Please do one with a Pharmacist!!!

Question #1 already had me laughing 🤣

it was truuuuuly amazing. I wanted to keep listening like wow, great great greaaaaat one

Thank you Dr. Neville !!

It would’ve been interesting to hear more about eye colours

So I have me/cfs and the MTHFR gene mutation which means I have a 60-70% reduced methylation capacity. I'd really love it if the crispr technology could fix that genetic mutation and hopefully all the biological process that currently don't function properly could be improved. I'd love to stop being severely disabled and be able to rejoin the workforce and have a social life again.

I can’t wait to learn more about this. I love biology

Great video!

I have the gene for brown eyes, but have blue eyes due to the other genes. I'm fascinated to see if my baby will inherit that other gene or not, or if my husband (who also has blue eyes) and I will end up with a brown-eyed baby.

Gattaca is a great film about the consequences and potential problems with genetic editing to weed out ‘undesirable’ genetic traits in favor of ‘enhancing’ humanity.

this is an awesome series

beautifully explained. Thanks

I'd guess that the answer to the 'taste like soap'-question is Yes Questions head on genetic alteration which doesn't discuss extreme deceases is still worth answering, in my opinion. It spreads awareness in a way that widens the emotinal spectra associated to the science which in practice focus on important things, and drives the interest further than only talking about the most urgent issues.

I wonder what mutations were missed out on because that person did not reproduce Edit: 23&me will also replace expired kits. I had a kit that expired in 2020 and got it replaced a few months ago. It was lost during a move but found after another. Pretty good service