Great video it takes some of the mystery out of the cells and the immune response. Should’ve been taught step-by-step like this in college. It becomes so much clearer when you break down the immense Cellular immune response like this.
I wonder how different the history of MS would have been if general immunosuppressants had become popular treatments in the 70s and 80s. What if cytoxan and imuran were routinely used before betaseron became FDA approved in1993? Would interferons have even been adopted? Why were we so far behind rheumatoid arthritis and other rheumatologic diseases? Were young people with relapsing MS just doing too "well" to consider a long-term immunotherapy?
From one lefty to another, thanks for the great lesson Dr B. I’m currently on Tysabri but switching to ocrevus due to increasing JCV Ab count unfortunately. I was hoping you’d post another video that explains how the immune system works while on an anti CD-20 medication like ocrevus. I’m not excited to have to murder all my B cells but my doctor explained that increased rates of infections are rather rare, with limited exceptions listed as possible side effects. I understand the lack of ability to generate immunity from vaccinations without B cells but not sure how the rates of infection remain low as well. Thanks again for helping the MS community gain more knowledge of what’s happening in our bodies. I personally find it interesting and comforting.
Your videos are incredible. I learn so much every time I watch. I appreciate them so much. I’ve learned the most about my Diagnosis from you and not my own team. Forever grateful.
This is hugely helpful, wow! You take a highly complex topic like this & are somehow able to communicate it in a way that is simple to comprehend. I'm so thankful to you for all the time you take to educate ms'ers you don't even know. I wish you could educate MS Doctors the way you educate us on why it's so important to care for their patients w patience, compassion & education. You are an amazing human.
question though - if lymphocytes are consistently low from a DMT, in the range of 0.6 - 0.7, are the lymphocytes still strong enough to protect us from bad things?
So good to better understand terms that I have heard so many times without really knowing what they were! Plan to rewatch this several times to help all the information sink in.
I loved this too. Will watch it a couple of more times and write the information out so it can sink in to my brain. I understand it perfectly but cannot absorb it all in one go. Thankyou Dr Boster ❤️
I know I said beforehand that i liked this, but I sat down with a pen and paper today to write notes from this video. I've heard these term before and nodded my head without knowing what they actually are. Thank you so much, for shedding light on our immune system, Dr B! Really appreciate it
Dr B, you are a godsend! I loved this presentation! My father was my rock, I knew that no matter what happened in life he would always be there. I always felt safe and always had a sense of security because he was by my side. I lost that when he passed. I got some of that security back by bingeing your videos and knowing that you are just a short flight away. Thank you for that!!! Keep on keeping on. ❤️
Dr. B, you are truly the best for your videos and this one I so much appreciated you doing. You have helped me understand how things work, your compassion and patience is amazing. Love the color coding. Wish I could hug you for it. Consider your self Hugged! Ty so very much 🥰
This was a great presentation of the immune system and I hope you will continue educating the MS community. I did learn about this in college, but most people haven’t. All your videos are informative and I enjoy each and every one. You have given so much time and effort to help us understand as well as improve our lives with MS. Thank you so much.
Good evening and thank you for the wonderful lecture on the immune system. I can’t wait for the upcoming lectures on the immune system regarding ms and covid. Thank you again, Doug coffee in hand from Lyndhurst.
Thanks for teaching me about multiple sclerosis doctor I feel like I had the proper ammo today to talk to my neurologist I feel slightly educated thank you
This is an excellent video. Immunology 101 with great references to help us understand what our body does. Innate immune system vs adaptive immune system. What I wouldn’t give to have that book you just wrote in! Lol 😂 don’t get rid of it. Very very helpful. This was A GREAT VIDEO! #Sharingiscaring this should help many to understand what their body is doing- even as a nurse this was a great refresher and put things in order. Much love 💕 rock on 🤘🏻
Hi Dr B. Loved the vidio I got a lot out of it. I do have interest learning about immunoglobulins from how they're created to what they do. Best Regards
Thanks Dr, had to re-watch in 10 min segments, multiple times - TBH got only a very general idea - If you give a quiz on topic, I most probably will score just 3 or 4 of 10 🤣
good accompaniment to the edutainment immunology anime Cells at Work. Covered different stuff as well as stuff covered by that show... I couldn't help but imagine the cells as they look in that show though. Pretty sure NK cells don't actually look like a badass woman with a knife.
This was super duper informative, I learned a ton. Please do a follow-up talking about how the different cells are acting in the MS setting? I know my Ocrevus knocks out my CD-19 (& CD-20?) B-cells -- presumably because they're making antibodies to my myelin & ogliodendrocytes? Is that what's happening? And are those the B-cells that were originally activated by EB virus? More more more please!!
Maybe I'm missing something but I don't understand why they would synthesize & have us inject interferon (& don't understand how it interfers with MS) if it ramps up the cells of our immune system, which it's my understanding that an overactive immune system (specifically B Cells) are part of the problem & cause of our MS in the first place?
Funny enough, I received a refresher on the immune system as an adult through the anime "Cells at Work" (Was written with medical doctors consultation for accuracy, although with some artistic liberties), but find this stuff fascinating. Have you seen the anime, Dr. Boster & if so what did you think? A caution for others, this show isn't for kids & can be a bit violent & gory when the Monocytes go all Freddy Kruger & zombie-like (phagocytosis) on the invading viruses and bacteria, but over all a fun & interesting show.
So a little side topic - but I’m wondering-what is happening with the specialty colleges? Is there a merging of immunology and neurology? Will we eventually be seeing immunologists and not neurologists? Is there a separation happening where other neuro diseases are splitting away? Are immunologists becoming infectious disease experts mostly? If a resident commits to neurology today, are they actually committing to immunology? I know, lots of questions - just seems like an interesting intersection of issues. Also seems like some neuro conditions clearly don’t “fit” in the same buckets. Tourette’s, with epilepsy, with Parkinson’s, with MS, with NMO, with TBI? No way can someone cover it all.
Clinical Neuroimmunologist (Multiple Sclerosis Neurology) typically completes 1-3 extra years of training after completing undergrad then med school then internship then neurology residency. I talk about it in this video: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-gEcEEUvA8N8.html
Hi Kim, I had the numbness and tingling on my feet, hands and my right cheek and lip for over a decade. I didn't even know for sure that it was from MS, thought maybe it was just a part of life. I took avonex for 1yr, then gilenya for 10yrs before switching to kesimpta. After my first 3 injections I realized all the numb patches had resolved. My Neuro was so happy for me and couldn't wait to tell the kesimpta rep. While my numbness wasn't bad or even constant, it was a nuisance and I'm happy to be rid of it. I hope you feel the same soon. 😘
