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Imprinting and Uniparental Disomy for the USMLE Step 1 

Physeo - USMLE Library
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Imprinting and Uniparental Disomy for the USMLE Step 1, beautifully distilled.
In this video we demystify the two complicated genetic terms: imprinting and uniparental disomy. We cover the clinical significance of these terms and how they can cause Prader-Willi syndrome and Angelman syndrome. We wrap up the video with a couple of high-yield questions to solidify the information.
Come watch the rest of our biochemistry library at physeo.com/
Keep calm and watch Physeo #kcwp

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13 май 2019

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Комментарии : 72   
@telatti
@telatti 4 года назад
the best video on uniparental disomy i've found! thank you so much :)
@physeo-USMLE
@physeo-USMLE 4 года назад
Thanks for the support! We're glad you like it!
@telatti
@telatti 4 года назад
@@physeo-USMLE thank you for helping me learn :) struggling med student from czech republic
@physeo-USMLE
@physeo-USMLE 4 года назад
@@telatti You've got this!
@vineshmanohar2060
@vineshmanohar2060 4 года назад
Can’t get any clearer than this. Thank u so much :)
@physeo-USMLE
@physeo-USMLE 4 года назад
❤😎
@faiziiiiii
@faiziiiiii 3 года назад
love you, just in the first 2 minutes you explained what I've been trying to understand for years. I am beyond greatful for this! Thank you again!
@Alexandra-sd4yy
@Alexandra-sd4yy 4 года назад
My colleagues need to know about this channel! Thank you for the beautiful teaching!
@pawandeepkour544
@pawandeepkour544 Год назад
Best video on Imprinting and Uniparental disomy I have come across.👌🏼
@ashozy1003
@ashozy1003 4 года назад
Excellent video which is underrated.. I'm not a native speaker or from US, but sir I loved your video it's very helpful. Thank you !
@batol5361
@batol5361 3 года назад
You are such a legend. Thank you helped a lot truly! Keep up the good work!🥰
@amiramadhi2074
@amiramadhi2074 2 месяца назад
Best video on uniparental disomy thank u so much 🌸
@sadmanchowdhury9823
@sadmanchowdhury9823 3 года назад
Incredible well explained. God bless you!!
@abijeyarajan2173
@abijeyarajan2173 3 года назад
Very clear explanation on imprinting. Thank you 😊
@riflemusket
@riflemusket 4 года назад
OK. For proper cytogenetic nomenclature, 15q11 is read as "Fifteen-Q-One-One", not "Fifteen-Q-Eleven". Same with 15q13 -> Fifteen-Q-One-Three.
@saadsohail9379
@saadsohail9379 4 года назад
cant thanks enough........ May Allah blessed u
@nesrinech3967
@nesrinech3967 3 года назад
you made it so easy to understand , thanks a lot.
@pallaviguha9354
@pallaviguha9354 3 года назад
Thank you so much! I was having such a hard time understanding uniparental disomy😭!
@Salopovpaz
@Salopovpaz 4 года назад
Thank you very much. God bless you 🙏
@markmegaly1626
@markmegaly1626 4 года назад
Awesome Content! Keep it up. Thank you
@opoppo6413
@opoppo6413 9 месяцев назад
the best I found on RU-vid I think
@arzofaqiri-aksoy6857
@arzofaqiri-aksoy6857 4 года назад
thanks a lot, best explanation ever
@namrtasharma335
@namrtasharma335 3 года назад
best video, appreciate ur work
@faizanshahzad8598
@faizanshahzad8598 3 года назад
Awesome vid with a clear explanation, Kudos 2 u :)))
@umerkhan7545
@umerkhan7545 4 года назад
Very nicely done
@saul3965
@saul3965 4 года назад
Spectacular, Im reading over this for my medical genetics and the book did not make it easier.
@studiesaura
@studiesaura Год назад
This is lit 🔥 Thank you so much.
@revanthsurapaneni6258
@revanthsurapaneni6258 Год назад
Thank you man!
@crichighlights2612
@crichighlights2612 3 года назад
Nice explanation bro! Couldn’t understand the concept in other channel videos.✌️
@ivangrishin8547
@ivangrishin8547 3 года назад
Perfect explanation
@juliaaysemcconaughey
@juliaaysemcconaughey 3 года назад
Thank you so much 😊
@Sparrow6_
@Sparrow6_ 2 года назад
That’s a very good explanation 🤝🤝
@workation6663
@workation6663 Год назад
thank you so much)))) u helped a lot
@divyeshkhatri2538
@divyeshkhatri2538 4 года назад
Excellent explanation 😋😋😋😋
@lotfiadj5896
@lotfiadj5896 3 года назад
much love from algeria
@cubba20
@cubba20 2 года назад
amazing video
@jared394
@jared394 Год назад
Killed it!
@femidaelettil1002
@femidaelettil1002 4 года назад
Thanks a lot
@ibraheemalma
@ibraheemalma 4 года назад
beautiful thank you sir
@mandyads
@mandyads 3 года назад
5:47 for heterodisomy vs. isodisomy
@maryamhani7725
@maryamhani7725 Год назад
Nice presentation
@burns1606
@burns1606 3 года назад
great video!
@GermanHeul
@GermanHeul 4 года назад
Amazing thx 💗
@Robertson284
@Robertson284 2 года назад
awesome. thanks a lot
@DazeOpYT
@DazeOpYT 4 года назад
In your question about Prader Willi Syndrome, it's also likely that the father underwent a mutation in the imprinting gene which causes the methylation of the paternal PWS-gene and thus the wrong imprinting pattern. Just a side note, your video explains it very well :D
@chocolatecharley99
@chocolatecharley99 4 года назад
Is everyone's paternal gene silenced because of imprinting in that section of chromosome 15 that causes angelman syndrome? (I'm asking if every typical person has this imprinting for angelman syndrome and vice versa maternally for PWS) I'm getting confused while writing a report
@DazeOpYT
@DazeOpYT 4 года назад
@@chocolatecharley99 Not necessarely, there can also be a misstep in the meiotic splicing of the cell which causes the child having to maternal copies.
@chocolatecharley99
@chocolatecharley99 4 года назад
@@DazeOpYT But the reason these maternal copies don't do anything and causes Prader-willie syndrome is because it is imprinted (silenced) and there is no gene expression, right?
@chocolatecharley99
@chocolatecharley99 4 года назад
@@DazeOpYT I'm wondering if you and I both have our maternal genes imprinted on PWS on chromosome 15
@salehFayoumi
@salehFayoumi 4 года назад
thanks a ton , many many thanks
@physeo-USMLE
@physeo-USMLE 4 года назад
@cakuh8900
@cakuh8900 Год назад
in Germany we dont say "good video" we say: "geiles Video Bruder, du bist ein geisteskranker Ehrenmann", and i think thats beautiful.
@jenniferjdaidani1397
@jenniferjdaidani1397 3 года назад
THANK YOU
@ishanisingh862
@ishanisingh862 3 года назад
Thank you 😊
@manuelgoncalves9753
@manuelgoncalves9753 4 года назад
great video
@iw16n17
@iw16n17 3 года назад
thank you so much
@rawanaimat2367
@rawanaimat2367 3 года назад
thanks a lot
@drswekcharanjan7481
@drswekcharanjan7481 3 года назад
Really good
@muntehakhatun7783
@muntehakhatun7783 9 месяцев назад
Thanks👍
@azadbharath7444
@azadbharath7444 3 года назад
In a RFLP related question -boy has symptoms of praderw ,means paternal deletion,means at the time of fertilitzn incompatible trisomy caused by incoming spem,so incoming paternal gene chr deleted,is that so is only possible by maternal disomy by nondisjunction M-1#opt-a???&M-2,means is aspermatogenes view na ,so paternal disomy -un compatible trisomy by incoming maternal ova.
@mellowdoctor9029
@mellowdoctor9029 3 года назад
Boss of the bosses
@Alexandra-sd4yy
@Alexandra-sd4yy 4 года назад
so is it a problem if it is heterodisomy? the cromosomes are different, one from grandpa and one from grandma, right???
@oviyagnanasekaran2756
@oviyagnanasekaran2756 9 месяцев назад
How exactly does the cell loose a chromosome during fertilisation?
@phantasmalphasmidzoo8280
@phantasmalphasmidzoo8280 10 месяцев назад
So if an embryo has a deletion of the pws gene of the male side, can you avoid Prader Willi by demethylating the pws gene on the female side??
@benjaminazumah9833
@benjaminazumah9833 4 месяца назад
No because unlike histone methylation, DNA (cystine) methylation is almost always irreversible.
@arnebshaikh9879
@arnebshaikh9879 3 года назад
😍😍👍🏻👍🏻
@DoctorKlenk
@DoctorKlenk 4 года назад
4:35 B is just as likely
@jrh1677
@jrh1677 4 года назад
Wow
@mellowdoctor9029
@mellowdoctor9029 4 года назад
❤️
@jesiraj2448
@jesiraj2448 3 года назад
It is a clear explanation, but please do not say q eleven instead it is q one- one ...
@zainab_abd3776
@zainab_abd3776 4 года назад
مرحبا ممكن أعرف اذا كنت بدرس دروس خصوصية لمواد المجموعة الطبية ؟؟؟
@ahlamal-bloshi9656
@ahlamal-bloshi9656 3 года назад
THANK YOU
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