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Introduction to Bioinformatics - Needleman Wunsch Algorithm 

Farhan Haq
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For Bioinformatics Services please contact farhan@jgiconsulting.pk
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Basics of sequence alignment
Topic : Global Alignment
Instructor: Dr. Hassaan Mehboob Awan
COMSATS University, Islamabad.
#Protein #DNA #Aligment #English #Urdu

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21 окт 2024

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Комментарии : 67   
@marianagonzales3201
@marianagonzales3201 2 года назад
This was excellent! Thank you very much for a very clear and detailed explanation!
@vicentcaselles4807
@vicentcaselles4807 11 месяцев назад
Very nice video, thank you Farhan Haq
@samarthtiku98
@samarthtiku98 Месяц назад
Beautiful explaination
@creativewrite2444
@creativewrite2444 10 месяцев назад
Thank you very much sir, tomorrow is my exam!! I will do it well❤
@FarhanHaqj
@FarhanHaqj 10 месяцев назад
Good luck
@haryank330
@haryank330 2 года назад
loved eur explanation sir from andhra pradesh,india
@FarhanHaqj
@FarhanHaqj 2 года назад
Pleasure
@Exploration_Avenue
@Exploration_Avenue 2 года назад
Very informative Dr Sab
@khan-fn7if
@khan-fn7if 2 года назад
Thank u sir , This video was very fruitful for me And gave me a clear concept about Needleman Wunsh algorithm.
@muhammadjawadhussain8441
@muhammadjawadhussain8441 3 года назад
from Lahore well explained great sir
@FarhanHaqj
@FarhanHaqj 3 года назад
Thank you dear
@jiilaanhani311
@jiilaanhani311 2 года назад
Thank you so much, you help me alot!!
@aasmaaslam8951
@aasmaaslam8951 2 года назад
Sir I have a question when we are finding T(i-1, j-1) why we put value of 4 and j=3
@m.scholl1001
@m.scholl1001 10 месяцев назад
Entry (3,1) is -3 not -5. The value to the left is -3 + 0 (gap panalty). The Entry (2,1) has no gap.
@mahashahid3748
@mahashahid3748 2 года назад
THANK YOU SIR ... IT WAS INFORMATIVE AND EASY...
@bitta1997
@bitta1997 11 месяцев назад
Thank you Sir
@adamharb9233
@adamharb9233 2 года назад
shoukran kteer hakeem
@phatimadesu9710
@phatimadesu9710 10 месяцев назад
W Alaikum AlSalam. Thank you
@sabaaltaf4567
@sabaaltaf4567 Год назад
Thank you very much sir. Best explanation i have got so far.
@alishbaejaz4964
@alishbaejaz4964 2 года назад
Thank you sir!
@anishav.s9049
@anishav.s9049 2 года назад
your explation was very useful and i got a clear idea about it thak you so much, but i have a doubt that how can i calculate the score in needleman and wunsch algorithm when i perform an alignment in that tool
@shrutikachaudhary672
@shrutikachaudhary672 3 года назад
Good explanation.... Thanks 👍
@lasthope3498
@lasthope3498 24 дня назад
Do you help in assignments?
@alaaaref3131
@alaaaref3131 2 года назад
thank you this was very helpful
@kishwersodozai4342
@kishwersodozai4342 2 года назад
Well explained JazkAllah
@wonderfulIndia1
@wonderfulIndia1 Год назад
Sir global needleman ek hi topic h or smith or local alignment ek hi topic h plzz reply sir I am very confuse now
@FarhanHaqj
@FarhanHaqj Год назад
Yes
@olaf466
@olaf466 2 года назад
thank you for the information it's much clearer now in my mind
@aroobazahid2892
@aroobazahid2892 3 года назад
For T(2,0) value is -4
@savagebunny3194
@savagebunny3194 2 года назад
-2 + (-2) is not 4
@syedsalehhaider415
@syedsalehhaider415 3 года назад
I have a question, If all the three values from (Upside, Left, and Diagonal) are the same then during traceback what do write in the table either (Up, Left or Diag)??
@FarhanHaqj
@FarhanHaqj 3 года назад
All three. After doing traceback you can draw all three possible alignment and select the best one if you want!
@nurulizzahmohammadnazir6285
I've been looking for confirmation in this thing for such a long time 😭 If all three are right, which one is considered the best one though?
@dillid-8894
@dillid-8894 7 месяцев назад
@@nurulizzahmohammadnazir6285 could you find the answer
@moetasembellakhalifa3452
@moetasembellakhalifa3452 2 года назад
When finding the Levensthein Distanz do we need to use the same scoring shema in the matrix? or can we use a different scoring shema after we have found the best alighnment?
@rajputanjalisingh1538
@rajputanjalisingh1538 2 года назад
Can any one explain the value of T(4,2)... What's the answer?pls ...
@aryakrishnanls6745
@aryakrishnanls6745 Год назад
-4
@mehwishrehman9787
@mehwishrehman9787 3 года назад
hello sir, I have a question.. how to solve the trace back step if we get 2 highest common values i.e. one in the first box of top right column and second value in the second box of the right column lets suppose I have 2 as my highest value.. and it's present in both the1st and 2nd box of extreme right column then how to trace back?
@FarhanHaqj
@FarhanHaqj 3 года назад
If you are solving needleman then getting the maximum value in the top right column is wrong, since first row of the matrix contains only GAP values. Gap values are always in negative. Secondly, if the alignment is correct, then regardless of the maximum value, traceback of needleman starts from the bottom right cell.
@WillWiz-l1l
@WillWiz-l1l Год назад
T(5,2) arrow from T (4,2) only coz it's a mismatch
@WillWiz-l1l
@WillWiz-l1l Год назад
You didn't calculate the optimal alignment
@MA-ny2gc
@MA-ny2gc 3 года назад
please say something on gap penalty determining
@nirjhar9725
@nirjhar9725 3 года назад
Very good
@zahramasood6846
@zahramasood6846 3 года назад
Is it complementary to put arrows?
@FarhanHaqj
@FarhanHaqj 3 года назад
Helps to traceback and build alignment
@FarhanHaqj
@FarhanHaqj 3 года назад
Ok
@pristineeducation6815
@pristineeducation6815 3 года назад
An excellent explanation
@azizbaloch7897
@azizbaloch7897 3 года назад
Plz help me in my assignment vu bif 401 spring 2021 I want to understand then do myself there are lots of solutions but I want to understand very well then do myself plz help me sir
@jawaheralhuthali
@jawaheralhuthali 3 года назад
thank u
@WillWiz-l1l
@WillWiz-l1l Год назад
T(1,4) again arrow comes from T( 1,3) coz it's a mismatch
@Bint924
@Bint924 2 года назад
Mashallah well explained
@sautrikbhattacharya
@sautrikbhattacharya 3 года назад
If the both sequences are not of equal length then how to place them in the matrix?
@FarhanHaqj
@FarhanHaqj 3 года назад
Two sequences donot need to be of same length. Row and column can be of variable lengths.
@sautrikbhattacharya
@sautrikbhattacharya 3 года назад
@@FarhanHaqj ok but both both the sequences will always start from i1 and j1 respectively, right? Or can there be rows and columns left blanks at the start?
@FarhanHaqj
@FarhanHaqj 3 года назад
There must be always one row and one column blank in the beginning of the matrix
@gabrielsamora9351
@gabrielsamora9351 2 года назад
This video is saving my ass from failing my Bioinformatics exam Thank you so much
@A2S_ArtsToScience
@A2S_ArtsToScience Год назад
Why j=3?
@azizbaloch7897
@azizbaloch7897 3 года назад
Salam sir plz explain formula which is s1(I), s2(j)
@ayush9462
@ayush9462 2 года назад
Bro it's similarity function. Duh
@innocentgirl5923
@innocentgirl5923 2 года назад
Penalty?
@ruthboniface6911
@ruthboniface6911 2 года назад
be blessed
@rajputanjalisingh1538
@rajputanjalisingh1538 2 года назад
Rest of the not match with the answers
@maheshpatil6653
@maheshpatil6653 2 года назад
Work on your speaking.....
@Jayesh-w-005
@Jayesh-w-005 2 месяца назад
Jay shree ram🚩🧡
@anaranyabose
@anaranyabose 2 года назад
Bad explanation since you just showed us the process but not the reason behind this.
@lamaayoub8420
@lamaayoub8420 Год назад
bhebak bas hek
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