Is ME/CFS Curable? Ronald W. Davis' Lecture at the 2023 Fatigatio Symposium 

I pray to God that Ron Davis has a long healthy life, so he can see his son Whitney cured of this terrible disease. Thank you to all the people working on this and all the sponsors and donors. God bless you all!

Ron is a living legend and it’s shameful that the NIH hasn’t invested more in his crucial work on ME/CFS.

I had severe ME/CFS and was cured by trying hard not to do anything which crashed me (to do this I had to rely on others for a lot of help), slowly though I got better. It probably took me 4 to 5 years (maybe 6) until I was in full remission and during that fully cured time I was out running marathons, I did a 100km trail blazer marathon and lasted 90km before I had to stop due to a groin injury and hypothermia. I did that without a ME/CFS crash so was in full remission from this illness. I was cured until I caught what was a common cold going around after 3 years of complete wellness and that to my shock crashed me back into ME/CFS so now I'm have to rely on others for hep again and use support workers to push my wheelchair and help me with so much else. Im in Sth Australia and sadly now have had ME/CFS almost half of my life.

Thank you so much for trying to help us!!! It means the world ❤

Thanks Ron - and all involved at OMF and its research partners - for all you're doing, I really hope this line of research bears fruit!

If avoiding crashes is all there is to getting cured, the solution is simple for chronic fatigue and something the entire world around us never wants to allow - - that all important REST, not working beyond your limits, *listening to your body's cues*. We aren't allowed these freedoms. We must always produce, you know? "Keep going. Everybody is tired." That's what you hear when you try to communicate that you just can't keep up the pace demanded of us all. You literally work until you collapse, day after day after day. It honestly, makes for a truly miserable life. I'm thrilled medicine is finally getting to the bottom of this. You can't tell people that the cells in your body just don't make energy. They don't get it. We should all just be able to will ourselves over that physiological hurdle because 'mind over matter'. If you can't see you, you won't believe it mentality. Magical thinkers are everywhere in your little world of hard physical limits.

Dear Ron and OMF Team, thank you for everything you are doing, tirelessly... we all really appreciate your hard work 🙏. God bless you and strength to persevere to all, especially courageous patients. Let's keep going and stay strong in spirit🦋

Thank you for giving me hope! I’ve been sick for nearly 30 years. I was functioning but disabled when I got COVID and spent 6 months bedridden. Then I woke up one day and my brain was clear. That was six weeks ago and I’ve been regaining my functioning since. So I have experienced both the ongoing illness and the spontaneous recovery(just from the COVID part). I’m working to get back to my previous disabled level. I’ve noticed that people who get sick and have people to take care of them seem to get all better in two years. Your theory makes so much sense! ❤

I have Severe ME/CFS & was just able to read a book for the first time in over ten years in book form ...it was the puzzler solver... God Bless the Entire Dafoe/ Davis Family ❤❤❤ ... Wait'in on Superman 🎶🎵

this is incredibly encouraging... thank you so much Dr Davis for all your wonderful work...

Pr. Ron Davis - you are my hero! God bless you and your family. I have so much hope now!

Thank you for your dedication in researching M.E/CFS Your research findings are comforting. I live in hope for a cure 🙏🏻

The more I learn the more I realise we also need to be looking at Mast Cell Activation. This seems to be so important but so missed.

Thanks to the OMF-team, keep up the good work. Updates like these are greatly appreciated.

Mis oraciones para todos los enfermos e investigadores. Especialmente para el doctor Davis y su esposa e hijo. Dios los bendiga abundantemente. Desde Argentina 😚😚😚😚

Thank you for all you do for our population…..hope is so important when you’re not believed

I definitely think you are onto something, it would help millions of people all around the world. Super exciting!

Thanks Ron + OMF team. Let's solve this!

Thank you Ron and all involved in this research. Your hard work is greatly appreciated.

Thank you so much. I've been so excited by the itaconate shunt hypothesis. But the previous videos on it didn't mention the potential reactivation of the innate immune system through crashes which is what I've been waiting to hear. It coincides very much with my experience of the disease which is why I try to avoid crashes at all costs - this has worked very well for me and I've seen great results by doing this. I also knew that if I fell into Very Severe ME, the crashes would be impossible to avoid and would perpetuate the disease keeping me trapped in it ( I was very close to it at one point). So, hearing this so clearly explained is wonderful. The best news. It gives me great hope. Thank you, thank you, thank you xx

JAK-STAT path is tightly connected to the insulin pathway (PI3K/AKT). which means that insulin-resistance/hyperinsulinaemia will activate JAK-STAT and VICE VERSA! targetting insulin resistance (fasting / ketogenic diet) is the way to go!

A true hero.

It's encouraging to hear many get to a better place in their lives. Thank you for everything you and your team are doing. Prayers going out for your son.

Those of us who are severe and bedbound are so desperate for a cure. Today, I can barely find the energy to breathe and cannot listen to this video 😢 Can someone please sum up?

Thank you so much for your efforts! On sunday I have been ill in this sickness for 10 years and that is most of my childrens childhood. This give me hope for the future! Thank you🙏🏼💙

Thank you very much for your dedication. Things are beginning to show promise thanks to you and your colleagues. The thought of a real cure is exhilarating.

Is that why we feel improvement when supplementing with sugars like D-ribose? My question would be if in our disease it is easier to obtain ATP from sugars or carbohydrates than from fatty acids and I would also like to ask if a cpt2 or vlcadd style diet low in fat and rich in sugars could help us? Thank you so much for help us 🙏🌹

Thank you Doctor. More avenues to explore in a hope of being cured 😊

Thank God we have you and your team trying to figure this out

Thank you for all your work. I was diagnosed in 2016 after years of drs not believing my symptoms.

Thank you so much for this excellent information. Blessings for you and your family and your beloved, precious son.

But, can we get better and be mild when we pushed too much and ended up severe? I didnt know thats cfs and everybody was saying you have to push through 🤷🏼‍♀️

Thank you again for all the work that you and many more are doing!! 🙏🙏🙏🙏

Great work! Thanks for the info. Praying for your research team. These videos give me hope. 🙏🏼🤍

Good morning Ron. I started Abilify today, wish me luck.

Thank you I find your updates the best in the research forums and have hope when reading 😊❤

Covid triggered it for me

I notice that I have more energy when I don’t eat. Obviously, this is not sustainable because I’m a thin person. But it does make me wonder what the hell they’ve done to the food with all the factory farming and whatnot. Glutathione IVs have also been helpful for me, particularly with the migraines.

🙏🙏🙏🙏 thank you for all your efforts. When I saw this video I was so excited and it didn't disappoint. I wish you luck with exploring this further and praying it unlocks this mystery

This give me hope that recovery is still possible, even after nearly a decade of this.

Thank you, thank you, thank you, Dr. Davis, for ALL you do to help those with this disease. ❤ Our loved ones are in a better place and actually have some hope knowing that you’re focused on this.

Hi Ron I recovered from many years of severe CFS. I could hardly walk around the house. Now I can do intense exercises and mountain hikes no issues.

Thank you for all you are doing to research CFS treatment!

Someone actually taking ME/CFS seriously and not trying to sell the backwards idea that we're just lazy or depressed or attention seeking; it's a legit illness with real triggers and an illness can be at least treated if not cured. The possibility of a cure though is amazing. But first we require more people in the medical community to understand it's a real and legitimate illness. Bless this gentleman and others working on figuring out what this illness is and what to do about it.

There was an article from 2010 that reported suppression of both adaptive and innate immune responses following spinal cord injury, Held et al., "Impaired immune responses following spinal cord injury lead to reduced ability to control viral infection". I was wondering if the immunosuppression leads to opportunistic viral infection, which then causes ME/CFS in some. Also wondering if people who have recent spinal cord injury should be advised that they could be at increased risk from infections, especially considering current circumstances.

Long Covid since 2019 the fatigue is just the worst xxx

I’ve had covid twice and for some strange reason my ME/CFS symptoms improve at the beginning of the covid infection.

Thank you very much for your participation and your valuable lecture, Ronald Davis. It was a pleasure to have you as part of the symposium. Best regards, Fatigatio e.V. - Bundesverband ME/CFS

Hello Ron, please take a look at the mechanisms bat viruses use for viral reactivation! Short: During flight the mitochondrial stress is so high, innate immunity shuts down to avoid inflammation/NLRP3 and Autoimmunity e.g. Cardiolipin, leading to massive viral reproduction . After a few hours after restoring metabolism the virus reproduction is stopped. In humans, this process leads to crashes

I've been suffering and getting worse for 27 years. I got shingles at 9yrs old then hit with unexplainable pain suddenly at 10yrs old. They first thought it was JRA, then leukemia, Lyme, mixed connective tissue disorder, lupus, MS, and finall back to the unknown. Doctors have all, but given up. I have all the symptoms for ME/CFS. Where can I go or who can I contact to be tested?? It's ruined my work life and getting harder to rebound from. I'm only 38 and feel 90 daily.

Really working on not crashing since spring of 2023... not much of an improvement yet. Perhaps by next spring things will get better?

❤ Thank you for the updates. They give me hope.

This could be the cure for ME/CFS. ATP is also a major problem in Long COVID. Please keep up the great work Doctor Davis and your Amazing Team

How are people healing from mind-body work? I’d like to know Dr. Davis’ opinión on that and how it relates to his research.

Thank you!!!!

Thank you 🙏 ❤

I have ME/CFS and I'm in so much pain all the time. Also type 2 diabetes, and chronic acute sleep apnea. Not terribly overweight. But the ME/CFS started first in this whole mess. With all treatments for co existing other condition I still have chronic awful pain. I wish there was something to stop this.

Thank you to OMF for the molecular biochemistry updates applied to making sense of post-viral chronic health and wellbeing challenges. Real time considerations, and post-viral experience: For the adult patient, everything - social expectations, anticipated challenges - is the same; however the patient's ability to address and meet those realities half-way is altered. Awareness, lacking alertness - a diffuse versus discrete neurocognitive state. Evolutionary time considerations, and post-viral experience: Evolution may have incidentally generated this immune mediated altered state... Afflicted early humans may have self-quarantined away from the group, partly because of a reduced ability to meet everyday realities half-way. The larger group's genetic character would have moved into the future - thanks to this self-quarantine behavior, provoked by multisystem immune reactions - long before germ theory. Beyond that, a diffuse character of mind allows a kind of sensory and information overload. Some of the self quarantined early humans may have survived; because they had enough processing power to make positive sense of the cognitive overload. These, (self-quarantined), individuals, able to cope and survive, would have become a part of human genetic evolution as well.

Can we help with the studies some how? We who are sick. I would gladly be used to get information about CFS

This might explain why some smaller studies in the past saw improvements (no cures!) with interventions that help cell metabolism. Enzymes, co-enzymes, amino acids, high-dose vitamins, that stuff. It might "just" help the body to provide more ATP. At first glance, it doesn't really seem to explain stuff like orthostatic intolerance or sympathetic overactivity, so maybe there are different subsets of people (that is to say that "CFS" might refer to a few different yet-unknown diseases). However, strictly avoiding crashes and helping your body as much as possible (good* nutrition, sleep and mental health) definitely helps to at least establish a baseline. * relative fof everyone

Thanks for all your work kind sir. I think it’s important to note that it’s also highly correlated with connective tissues disorders and POTS and can arise in anyone without any identifiable trigger too. Correct me if I’m wrong but any disease process that makes the body reach aerobic threshold too quickly is likely to cause an ME CFS like condition. I think the disease may be more cardiovascularly related than we think. Also likely most if not all patients have a completely different root cause which would explain some being cure and some not as well certain medications working for some but not others

Hi Ron. I'm not sure if you'll get a chance to read this or not. I was diagnosed with M.E in 2010, and I've had multiple kidney operations since that time. I noticed that my symptoms are always better for a few days after receiving Saline ( ringers solution) drip. I'm not sure if there's anything to it, but thought I'd pass on the info anyway. Maybe it's something you can test with your son? Keep up the good work. We're all routing for you! I'm currently testing Cetirizine to see if it has anything to do with the NF-kB pathway.

Do we know what the function of the Itaconate pathway is in healthy people?

Theres been some other research coming out this year e.g. Prusty and WASF3 protein, would be interested to know what Dr Davis thinks about those things. I got surprising improvements after being stung by a wasp a couple months ago, prior to that I was in a tough situation, with onset of multiple chemical sensitivity and reactions to many foods, also a big increase in mold hypersensitivity. I think I have issues with stomach toxins particularly H2S but I don't know the root cause, for years I had CFS but none of these issues and no periods of extreme stomach bloating reminiscent of SIBO.

Thank you so much Dr. Davis for not giving up!!! My son who is also has a severe ME/CFS for over 6 years, he bedridden and uses feeding tube for nutrition and fluids. We are trying everything under the sun for his cure. I was just wondering if maltase enzyme could help to process the glucose? I was trying to buy it but can't find it anywhere.

And with covid more retriggering so many peoples ME, what are people supposed to do? Is so contagious. It’s scary. No one send to care about preventing infection and what will happen to people with ME? If we invested in this research early on, we likely wouldn’t have had to deal with long covid as a phenomenon. Thanks for doing this work. Can you provide a timeline for song updates? I have a vaccine injury that caused what seems to be ME and I’m afraid if catching ANY infection at this point. I do not want to be bedbound again. I feel like I’m just waiting for the day when it triggers again after some infection or traumatic event and the clock will be reset on any incremental progress. Laying in bed so fatigued as we speak. This gave me some hope but I worry I won’t hear about any updates😢 I’ve only been dealing with this for a few years but I’ve seen some people trapped with ME for decades. It’s really one of the most debilitating things I can imagine honestly. Didn’t know childbirth can trigger it too. New fear unlocked lol

Thank you so very much! Does this include fibromyalgia?

Has anyone looked at the possibility that the mitochondria gene might be compromised? They talk about mitochondria disease but has there been any link to CFS being activated?

Q: Regarding Long Covid, wouldn't viral persistance make blocking interferon alpha production futile?... I certainly hope not...

What a legend.

Does this mean if we take ATP supplements it could help?

Dear Ron and Team, thank you much, you're all wonderful human beings! Could an underlying Fatty Acid Oxidation Disease be the cause for this? I had metabolic tests done 10 years ago and again last month and it shows that I am unable to digest and utilise fatty acids properly, the profile being the same, just much worse now. I had some genetic tests and it shows that I have mutations on the gene that codes for short-chain CoA dehydrogenase deficiency. I am going to have more done soon for other genes, but it makes sense since I have severe ME/CFS now from Covid, but have clearly had milder versions every time any additional energy requirements have been put on my body - oftentimes being given strong medications, infections, fasting periods, viruses and even pre-menstrually. I assume that I am relying on just pyruvate and a tiny bit of amino acid with any fatty acids having to go through one of the non-Acyl CoA routes to be useful, but this is very very slow. I can also see now that any starches and fats, that need to be broken down in the colon aren't going to be very successful because there is a double-edged sword of them needing certain bacteria to break them down, but that process (for most bacteria) requires ATP too. So I have high levels of phospholipids and no short-chains in my stool and a number of metabolites in my urine that reflects this too such as high adipic acid, etc. I was wondering whether you have looked into FAODs as a potential cause since the symptoms of this (exercise intolerance, muscle weakness, neurological impacts, neuropathy, etc) and relying on alternative routes to derive ATP from fatty acids seems almost identical... I'd be very interested to hear about your understanding of any links and where I might be able to find more information to read. Thank you so much for everything you're doing!

So what is the treatment

🙏♥️🙏

I was poisoned by highly toxic chemicals that crossed the placenta when i was a fetus & i was born with MECFS & FM...& a genetic disease...i did get polio from the sugar cube vax & was in an iron lung for 6 weeks which may have added insult to injury...ME isn't all bug related! Consider more environmental reasons & causes!! 🙏 So i'm guessing i will never know what it's like to be pain & symptom free 😖 Thanx for trying to help ❣️

We are unwell because our environment is unwell. We are living in a toxic soup and at some point it needs to be addressed. There are way too many toxins in the environment. They may not be the root cause in all cases but it’s certainly a factor to consider. The lab report for most municipal water facilities is downright horrific.

So what's the strategy for those of us who have no treatment other than symptomatic treatment? I manage mine with Ambien and Tramadol; it gives me 3-4 hours of functional time per day that I use to exercise and keep up the house. I do Jiu Jitsu and supplement with barbell work, so I'm fit, but still very fatigue sick. Should we be asking our healthcare providers to try specific treatments with us, or do we wait while this is explored further? Keep up the good work, Ron! BEARHUGS!!!

❤

So are you scrapping the Metabolic trap hypothesis?

what does CAD stand for?

I kinda hoped that JAK stat inhibitors are the way to go.😢 But apparently, they are not effective.

Im not sure how blocking interferon helps?? Although not cures, substances like immunovir and I believe but could be wrong, ampligen, increase natural killer cell function by increasing natural interferon production. Also several Russian products such as cycloferon which are classed as interferon inducers and they also increase nk function and can help with chronic infections and have improved symptoms in cfsme patients. So, im intrigued at how blocking interferon alpha will help🤔

Hi Ron. I've manufactured pneumatic exercise equipment that provides a consistent resistance through the exercise repetitions. A clents with Lupus, who's severe condition was triggered by a hysterectomy 16 years ago started doing exercise 14 months ago. Doing 20 min at manageable weights twice a week. After 3 months she chose to stop her chronic meds. Subsequent blood tests showed improved organ function. She has not had a flare-up while continuing her routine for the past 12 months. Where she now does 350 reps at very respectable weights in 25 min. Would you speculate that her body has decided to cooperate during exertion, rather than remain in a defensive mode. Would you consider the myokine released from skeletal muscles being partly responsible for signalling her immune system to move towards normal levels, and improved mitochondrial health? As she now feels energized after 20 min of exercise.

So what is the plan from here?

Low dose psilocybin mushroom therapy may greatly help these patients as well. 🙏 Praying for all those affected. ❤️

This is about cell health and mitochondria health. What about the blood flow issues we see in Long Covid? Especially the hypoxia due to blood flow issues which doesn't allow for enough oxygenated blood to the muscles? Can that also be caused by this? Or are the blood flow issues need to be sought with another cause?

Sorry as part of my ME, I have brain fog, what is the cure? Did I miss it?

As an energy healer with 45 yrs. exp., I have had 100% success in getting rid of chronic fatigue with my clients, and also with my daughter who had it for 8 years before I learned about cellular memory and how to tap into it. Then, I found the cause and was able to cure it in 2 days.

It took months for him to tell us the same thing we need a cure now !

How come taking a whole stack of ATP supplements does absolutely nothing?

What does it mean that CAD gets "imported" into the mitochondria. How? 😅

First update in 9 months,and I still feel like your a long shot of curing the disease!! It's the same old update, people thank ya and say this sounds like good news, but nothing ever comes of it and just sit around and wait year after year!! It's getting ridiculous,how long this is taking!!

How does this theory tie in with some CFSers improve after having c0vid vax?

A cure? Too much to hope for after all this time. We need a cure.

pfizer did it to me

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The problem is this. Using two terms is really stupid. For cfs does not exist. So if you get on the bus make sure its not a ship. Secondly M.E defines itself. Thirdly yes it is curable. In the sane way that any other auto immune illness is solveable. Ive got more than ten years on the matter Im not a proffesor but I am able to convey the problem in a more understandable manner. The truth is that there are indeed a lot of variations on a theme (causes)because they are not recognised , they are not recognised because no one looks appropriately. Thus its made complex by duff information in the first place. Im listening as I type. The crash is a result of a delay in the automimmune process. Thus if you push yourself at all you embed the illness. The delay in the immune response means sufferers are unable to identify the cause. The cause is always the same exaserbating the oxidative stress and thus the transfer of oxygen glucose and mito chondria. Thus making things worse. People who have the illness should be confined to bed . Because its severity gets worse with medical and individual neglect for lack of sane advice. Overvtime the immune sytem gets worse as it gets more and more exhausted. Medcine should not be given to rectify specifuc issues for you akready have misinformation from the hyperthalamus trying to make sense of its homeostasis , which it is unable yo do. The wrong exhaust gasses in the auto immune reaction replacing carbon dioxide with nitrogen means foggy thinking ...rarher like a diver ..with the bends. My solution was very simple . 12years very very ill. Bed bound ...unable to talk or think coherently from timevto time , black outs from the inflammatory pain . No help or assistance in any way .....I did get further damaged when I was unfortunate enough to land in hospital....never a want ...knowing full well the definitions were all moronic. I was ill from 1999 until well thats hard to decipher. I embarked on a cure in 2012. That failed for one reason and one reason only . By 2015. I had worked out what that was as slow improvements to my health enabled more coherent thinking. For me that was working out how to create interferons that would be able to jump the brain barrier to get at the source of infection. Thats what I did. Inside six weeks I started to get sleep. Normal sleep. Before that it was not skeep it was passing out thru exhaustion .....the coming around. More tired ..as folk will know, than when they thought they fell asleep. The auto immune orocess carries on 24/7. So really why should it not be so. Folk are in deep oxidative stresss. And if you ask any severre sufferere to hold yheir breath you will eill find either they cannot ot they can fir perhaps a second or so. Unless you suffer with this illness proper there is no way to convey its severity however eloquent you are. For the record I chased back uk m.e which goes back to the 1950s. Thats recorded. Its origin proper , shortly prior to that. And the same origin for the usa. They both report historical examples which are red herrings . That goes back to the twenties. Both countries do the same . For the dame reason...you should have consulted Dr Byron Hyde. He was there when they created the horse shit term cfs. Having I cured myself from my own intelligent enquiry . It took 7 years to get normal homeistasis. Thats how damaging this bugger is. The immulogical responses to the body are the sane as any other auto immune issue. The thing that confuses is the dysfunctioning of homeostasis which can be different for each sufferer. This alone ought to be easily recogniseable . So several standards then a mish mash of symptoms. Which incidentky because its not exp lained confuses them further...which again is really really stupid. You would have thought some silly bugger would have worked this out 50years ago. Its only the subderfuge of stupidity that has created this chaos. That and who ......pile of dogs doings.

Why stop the video mid sentence????

Have you determined toxins (endo, actinomycetes, or mycotoxins) as a root cause for some?

Back surgery & bad divorce, ME since around 1996 to now 2024 & fibromyalgia.