Ketogenesis 

no worries :-)

Yes thats correct. However, it is also a survival mechanism that the metabolism draws upon during times of need when carbohydrate supply is extremely limited. So for example during times when food is not available (e.g., prolonged fasting and starvation). The ketones produced act as an alternative fuel source (to glucose) for tissues such as the brain improving survival time.

thanks Simone :-)

Glad it helped!

Thanks Aaisha :-)

Glad it was helpful!

Guarav, strictly speaking the TCA cycle also known as the citric acid cycle is never switched off during ketogenesis. Attempt to think of ketogenesis as a metabolic overspill mechanism converting excess levels of acetyl coA produced from beta-oxidation of fatty acids into ketones. While this is occurring the remaining levels of acetyl coA can be used by the TCA cycle to generate ATP for liver hepatocytes. In short, the TCA cycle still operates during ketogenesis producing ATP for hepatocytes. In addition, as you have correctly pointed out, gluconeogenesis provides hepatocytes with glucose. What is interesting is that hepatocytes cannot use ketones as a fuel source. This spares ketones for extrahepatic tissues during fasting. I would encourage you to discuss this with your lecturer or do some more reading around the subject area as you have shown a clear interest in the topic. Below is a link to an article that you might find useful :-) www.ncbi.nlm.nih.gov/pmc/articles/PMC4050641/

Yes, thas correct :-)

Thanks Hamza

Gracias mi amigo :-)

Correct. In glycolysis, pyruvate turns into AcetylCoA However through gluconeogenesis, pyruvate turns into oxaloacetate to make more glucose