Ketone Body Synthesis | Ketogenesis | Formation Pathway and Regulation 

Bro just made me understand in less than five minutes rather than studying a slide of fourty pages four three hours 😂😂😂 and get nothing

This is flat out, the best explanation of this topic on RU-vid. Great job.

AMAZING! My professor spend an entire class explaining this and I could not get it! You made it perfectly simple! Nice work

This video is life saving for biochemistry lectures. THANK YOU.

Wooow actually last 3 days lm reading about the ketone bodies but didn't got it l saw this video and completely understood even my professor also didn't explain this much thank you sooo much waiting more video if possible with CC

I’m a personal trainer and as of late I’ve been trying to broaden my nutritional knowledge. These vids are amazing! Keep it up 👍🏼

Seen once. Shall be seen again. Great vid.

Good clear explanation and good slides as well.

Great video! Thank you so much!

Really Helped with my BioChem II Class! Thanks

I understood...thank you so much

At 0:34, you said that decreased pyruvate dehydrogenase (PDH) activity leads to high levels of acetyl CoA, but I think is PDH responsible for converting pyruvate into acetyl CoA, so isn't it the *increase in PDH activity* that leads to the higher level of acetyl CoA?

Very nice explanation! Ty!

Thank you. This was really helpful

Thank you for the great video

Excellent lesson!!!!!

Amazing!! Thank you so much

thanks so much for the help!

"Mitochondrial synthase or synthetase". Idk what you meant there, but they are not the same thing. Its name is HMG CoA Synthase. Synthetase means that uses ATP, which this enzyme doesn't use.

Great education video, thank you for sharing. ⚛️

thank you very much for this

Great videos. I do want to make one comment and the is to say that ketones are far from being a simple energy source. Ketones are signaling molecules of which bind to receptors and therefore cause down stream effects. Ketones mediate immune responses, they act as HDAC inhibitors and provide a very efficient and less reactive energy source. There are dozens of good peer reviewed papers explaining the various ways in which ketones alter physiology advantageously. If you are interested I suggest you search the following. 1. Epilepsy and ketones 2. Ketone signaling 3. Inflammasome (NLRP3) ketones 4. Hdac ketones and aging 5 metabolism and ketones

more biochem videos! med students are in need :) thank you!!!

Very interesting, thanks!

Thank you for saving my life

This is just so amazing

Wouldn’t decreased pdh activity lead to more pyruvate and less acetyl-CoA since it is the enzyme responsible for the conversion? @0:40

This vedio is very helpful thank you👍❤️❤️

Why does decreased pyruvate dehydrogenase activity cause more acetyl CoA? Isnt that enzyme the one that converts pyruvate into acetyl CoA?

Thank you

It was really easy to understand with my notes.. thank you

can you tell me how much ATP is generated from glucose and how much energy (ATP) from ketones? I cant figure this out, maybe asking you might help. Thank you very much!

Thank you very much 🥰

Thank you !!

absolute legend

Love this explanation. One cinfusion on @0:55 wouldnt decreased levels of pyruvate dehydrogenase lead to decreased levels of acetyl coa since less pyruvate is being converted into aceytl coa?

Amazing!👌🏾👌🏾💙💚

From Egypt 🇪🇬 Saying “ thank you ☺️ “

why high levels in acetyl coa is due to decrease level of pyruvate dehydrogenase when the pyruvate dehydrogenase complex helps in conversion of pyruavte to acetyl coa??

I love your channel 🙂💝💝💝💝

Awesome video,thank you so much! I have a doubt: why could the decreased activity of Pyruvate DeHydrogenase result in high levels of acetyl CoA? Since pyruvate dehydrogenase synthesizes acetyl-CoA, aren't the acetyl CoA levels supposed to be lower during reduced PDH activity?

Thank you sooooo much

Thank you for such a great video. But I have a question; I don't understand how high levels of acetyl coA can be a consequence of decreased pyruvate dehydrogenase activity??

Excellent 😊

Thank you ❤❤❤

Thanks 🥰

Thanks.

Thans a lot!

Thanks lot

seen the trails from the 50 I think it was when they dropped the bloodglucose levels in a few patients so low that they would have entered coma but didnt since they had fasted for such a long time that the brain more or less was not dependent on blood-glucose at all?

As a future biochemist who's on a ketogenic diet, this is key

@JJ Medicine Thank you for the helpful and to-the-point videos. I have 2 questions on this one please. 1) if fats can't cross BBB then how does the brain use ketones for energy? and 2) can you explain how certain amino acids can feed into the ketogenesis pathway please (lysine and leucine?) Thanks!

High levels of Acetyl CoA from "decreased" pyruvate dehydrogenase activity?

Any transcripts available?

Is it true that during dry fasting you can enter in ketosis much faster? If so can you explain why?

great

Great explanation! Thanks alot sir❤️

Acetoacetate is formed first so is called primary ketone body.

Thank u so much.

Why the beta Hodrxybutayrate is abundantly produce

question, which part of it is responsible for losing weight rapidly? is it because the fat is burning non-stop?

decreased PDH activity?

Really helpful, but where are the sources :/

My own experience suggests that the keto diet is over-hyped. A good diet shoould be easy to stick with and be healthy. Agoge diet is a good option, I lost a lot of persistent belly fat.

I really tried sticking with the keto, but I just felt awful and it is also really tough to adhere to. I then tried the Agoge diet and it was life changing, I highly recommend it to everybody.

God I hate metabolism.. why did choose this major what have I done ..:’’’’)

Ничего непонятно. А то что понятно и так давно было известно. Жаль нет наглядности. Где-то находил 3D анимация химических реакций. Вот там намного лучше

Blah blah blah

No one has seen any of this under a microscope. Because we are talking about what takes place inside a body, de novo, naturally, organically. There is not one study done on the ketogenic diet that was done by a biochemist, nor any books on the keto diet that were penned by a biochemist. Even the original ketogenics had zero to do with foods - and certainly not bacon not butter. It was about no foods at all. It was about deprivation of foods. And those folks in medical science at the time these original studies were done, came to zero conclusions except that seizures had to do with certain proteins in the brain. Somehow, someway, modern man, non science folk, adopted this diet to mean we can eat steak and eggs all day and slather everything with copious amounts of butter. Love of fried foods is what gave the "keto Diet" it legs, it wings (pun intended). There is zero science knowledge exhibited by anyone who now writes or speaks about the keto diet and ketones etc. None of them realize that ketones are made by sugar. They also don't realize that sugar is NEVER EVER leaving the body - unless one is dead. And, none of them realize that when they speak to fat as fueling, ATP the endgame, final stage in energy (production/transfer) is sugar based. Yes, ATP is a sugar based molecule. So sugar wins the day always. Not fat, not at all fat. And they also don't realize that the fat we have on our body and in our body (with the exclusion of the stomach and digestive tracks), is made by us, via dietary carbohydrates. Yes, humans make their own fats, triglycerides. As for dietary fats, the list is long how they can harm us. You can google any of this stuff to see for yourself - but here are just a few things; Oxidized and rancid fats and oils can cause malnutrition, anemia, diarrhea, hair loss, dermatitis, swelling of the lips and eyes, kidney and liver bleeding, gastric papilloma (growths in the stomach), reproductive failure and loss of offspring, cancer, and death; Toxic oil syndrome (TOS) - fever, rash, muscle pain, and problems with blood vessels and white blood cells; respiratory failure (lungs stop working) is main cause of death;In continuing - muscle pain, muscle wasting, fluid retention, high triglycerides, pulmonary hypertension (high blood pressure in the lungs), liver disease, and sicca syndrome (aka Sjogren syndrome, an autoimmune disorder that stops tear and saliva production and is often accompanied by rheumatoid arthritis); main causes of death were thromboembolism (a blood clot that moves to an area of the body like the heart, brain, or lungs) and pulmonary hypertension. Corn Oil: contains very large amounts of biologically active fats called Omega-6 polyunsaturated fatty acids, which are harmful in excess and are associated with an increased risk of various diseases, like heart disease, cancer, diabetes and obesity. Corn oil may also impair immune function. Omega 3 oils have never ever been proven to be effective in a human. And by proven i mean absolute proof of molecular efficacy. There is not one study wherein they tagged a fat molecule, O3 and tracked it from place of original, through the extraction process, through processing (purification, handling etc.), through digestion - and on to where all of these crap doctors on TV (Larry king show) say it will go and do what it will do. We are just now, in this century/decade, fine tuning various tech that gives us the ability to see what molecules are actually doing inside a cell, in real time, de novo. So anything prior to having this tech is speculative and assumptions - many which turned out to be wrong. And none of these food companies nor supplement companies have and use this tech

Thank you

Thank you