Your breakdown of the NMJ to the AP to the C+ Release to the unlocking of Troponin and the whole process just gave me sooooo much clarity where so many pieces were missing. Thank you sooooo much for this!!!!
What a teacher!!!! Please add more video on physiology......explained very clearly and precisely....u cleared many confusion....thank you very much madam........waiting for more videos.......
Omg this video explains it all! It’s the first video I watched after being completely lost after my muscle physiol lecture. No need to look elsewhere :)
First seen the heading of this video am not happy, bz I searched these topics everywhere but I don't get helpful video .After watching this am heartfully thanks.. really thankuu mam
Hello! thanks for sharing this! I am starting as a physiology teacher, and I am studying to make my first classes, and your video is really helping me a lot by using it as a guideline to ensure that my students understand the concepts well, thank you so much! I am sure I'll be using your other videos as guidelines too, so thank you for all your hard work!
Hi there!!! Congratulations on your new teaching position! I am always happy to help new instructors and share my materials. Please feel free to email me: drsandholdt@gmail.com
Thank you so much!! I have been having a hard time grasping this whole concept..esp with learning remotely during covid. I've probably watched about 10 videos and your video made it all click and come together! This has been a great help!! Thanks again!
Hello ma'am, Is there any separate channel your anatomy lectures? Please leave a link over her that would be a great help ma'am. Thankyou ma'am for delivering excellent lectures.
Hi DNAunion - this is a bit of a definition issue. Technically for one contraction, the myosin head is prepared in the prior step by a fresh ATP hydrolysis- this 1 then is "used" during the cycle. A second ATP then must come in to reset the myosin head for the muscle to relax and reset. So its 1-2 depending on how you define it. Ask your instructor his/her preference.
Do you have a copy of your lecture notes available? I'm working on a physiology course this summer and unfortunately there is no lecture notes just a guide on what topics are most important. Would be helpful to have something to refer to. Thanks!
this is amazing😍 im having a physiology viva exam and this is the best class i've ever had. thank you so much DR. S. by the way whats the name of the physiology book you were using?
Hello Mahesh Yadav. I have two lectures on neurophysiology from this set, I will also have a new one on membrane potential next week! For now, try this one: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-k6xpar7F5Rs.html and this one: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-PhVU0Gr0ndw.html
I am happy to help, napster phantom Please send me an email with a list of what you need at drsandholdt@gmail.com and I will reply with the ppt's you request.
Hi Sunidhi, we used Sherwood Physiology: www.amazon.com/s/?ie=UTF8&keywords=sherwood+physiology&tag=googhydr-20&index=aps&hvadid=241647112769&hvpos=1t2&hvnetw=g&hvrand=18324943641765428103&hvpone=&hvptwo=&hvqmt=e&hvdev=c&hvdvcmdl=&hvlocint=&hvlocphy=9032443&hvtargid=kwd-302156976704&ref=pd_sl_5hz3q60f5j_e_p37
Does anyone know what Troponin is because I was a bit confused by her analogy. Troponin: Acts as a lock to the chastity belt (Tropomyosin) and binds to it but can also move the Tropomyosin away. Or do they just have the ability to move tropomyosin away
Hi :) I think she just writes the easiest way to summarize the definition. I think, what she means is that when the troponin is present it can lock the tropomyosin and hold it in place but when there's calcium to bind with troponin, it unlocks the troponin, leaving the tropomyosin free. In short, Troponin can lock the tropomyosin as well as "move it away" from the actin. I know this doesn't helped. hahaha I'm just a passerby.
Hi Ojala. Troponin and tropomyosin are proteins that regulate the myosin binding sites on actin. Tropomyosin normally blocks the binding sites. Troponin is bound to tropomyosin and responds to calcium. When calcium binds to troponin, a conformational change occurs that allows the tropomyosin to release from the myosin binding sites. This frees the binding sites. Once the binding sites are free, the actin can bind to myosin (crossbridge formation).
Here you go Fawad Ullah - Its Sherwood - Human Physiology www.amazon.com/Human-Physiology-Systems-Lauralee-Sherwood/dp/1285866932/ref=asc_df_1285866932/?tag=hyprod-20&linkCode=df0&hvadid=312168166316&hvpos=1o2&hvnetw=g&hvrand=12880813701685711805&hvpone=&hvptwo=&hvqmt=&hvdev=c&hvdvcmdl=&hvlocint=&hvlocphy=9032443&hvtargid=aud-829758849484:pla-487146046496&psc=1
You said it requires ATP in Powerstroke but other lecture videos say that ADP+P detach in Powerstroke and it's not until next step when myosin releases Aktin that it requires ATP, what is correct?
Hello Zahraa, great question. The ATP is required before the cycle begins to reset the myosin in a prepared state, then during the powerstroke, the ATP is hydrolyzed as you say to ADP + Pi. The release of the Pi is what gives energy for the myosin to move the actin. Once the powerstroke is completed, then a new ATP must come in to allow myosin to release from the actin binding sites and reset again for the next cycle. It is a constant cycle. Does this make sense?
something seems amiss with the anatomy of the muscle bit --> we have bundles of muscle fibres that make up the fascicle, and the muscle fibre itself is made up of the myofibrils
@@PhysiologyforStudents hello referring to slide at 5:49 where there are 3 pictures. shouldn't picture 1 be labelled as a fascicle instead of a muscle cell?
@@shawankumar5020 you are right! My goodness, that is a typo! The text descriptions are correct, but the label is wrong. I'm glad you caught that (wish I could fix it, but alas, its not possible for me to go back to edit this ...)
and also find a good job nursing is a good career it pays good money I been through a four year school so ill have two careers when I graduate and I dont want to be disappointed cause of the money difference u know what I mean teachers who are good teachers pass their students u have to really slow to fail with these teachers
Oh My god!!! When this lecture was taken by my professor everyone was sleeping 😅😅 And now I watch your video What a way of teaching ! Very easy to understand Thank you so much 😊
44:33 you say it correctly, but your slide is wrong. The slide says "Fibers *HYPER*trophy when not used" ... that should be "Fibers *A*trophy when not used". By the way, nice video, with a lot of very good information.
I'm currently taking physiology and was having trouble understanding my professor's lectures. After watching this video I've come to realize we need more professors like you. You are amazing, thank you!
all I need is to pass my hesi2 test go to nursing school and get that degree I can't wait to graduate and she teach in a timely manner in otherwise her teaching digest
Thanks a lot, Very informative and covered almost everything. It would have been better if you could have added the smooth and cardiac muscles physiology into this as well.
