Phenomenal video!!! Thank you for drawing the connection between linkage disequilibrium and haplotypes. The absence of this connection increases confusion when texts explain LD blocks (haplotypes) that ARE associated with diseased alleles. It’s easy to question “just because two alleles are linked doesn’t mean a diseased allele is nearby, right?”, but the fact that linkage disequilibrium creates haplotypes/LD Blocks makes this much more reasonable to understand how these haplotypes can indicate diseased states. Having this said, without actually genotyping the intervening exons and introns… how can we say for certainty the haplotype is pure to the reference and isn’t experiencing an alternative mutation?
This was amazing!! I'll have a genetics exam soon and this will be part of the material! You explained it really well, I enjoyed listening to it and I think I actually understood this subject quite well :))
