vitamin b12 is used in the DNA replication of baby blood cells (progenitors). A lack of B12 causes faulty manufacturing of cells, the odd shape of these cells normally gets them killed by the immune system. this leads to a reduced blood cell count meaning there are less cells to transport oxygen.
This is from impaired DNA synthesis that inhibits nuclear division. Cytoplasmic maturation, mainly dependent on RNA and protein synthesis, is less affected; this leads to an asynchronous maturation between the nucleus and cytoplasm of erythroblasts, hence the large size of the megaloblasts. The process affects hematopoiesis and rapidly dividing tissues like gastrointestinal cells. Green R, Datta Mitra A. Megaloblastic Anemias: Nutritional and Other Causes. Med. Clin. North Am. 2017 Mar;101(2):297-317. [PubMed]
😂woou how many things I loyrn hear about my blood I fell so wik sleep taiert my brain dose not faxiont I can remember things before years some doctors give me ingexio vitamin B12 and I feel stronger now I don't have doctor too Kerry's any more I can find out what to do thank you for the information you gave to me
Excellent explanation. I have no intrinsic factor. I would like to know the difference in treatments with cyanocobalamin, methyl cobalamin or hydrocobalomin?? It seems all are not equal. Why would a physician only prescribe the synthetic one?
so clear and great illustrations help tremendously such dry subtopics! thank you for this. how to test for these antibodies, and for parietal cells - do you have one addressing that specifically? thx :D
