Metabolic Endotoxemia | Kiran Krishnan | Microbiome Labs 

I've had all my doctors watch this specific presentation This talk is incredibly persuasive and life changing

Fascinating!! But really poor sound recording. My volume up full blast, but still way too low,

Although I only just started Megasporebiotics and don't expect much, I'm still grateful for the work that you and scientists/doctors like you do. Thank you.

Kiran, the studies done on Postprandial Endotoxiema were performed on males. Can you so comparable studies with women included in the study populations? This may show a slightly different outcome, yet for that reason, should be performed. Women who are still menstruating are generating new blood cells monthly, changing markers on the cells, and the reactions those cells are creating within the whole body dynamics. Thank you for your valuable research and innovation. #WomenInMedicine #WomenForYang #AndrewYang2020 #YangGang

🎯 Key points for quick navigation: 00:00:00 *🧬 Overview of Metabolic Endotoxemia* - Introduction to Kiran Krishnan and the focus on chronic diseases related to metabolic endotoxemia. - Development of a probiotic product aimed at addressing chronic conditions like obesity and diabetes. - Importance of keystone strains in probiotics for gut health. 00:02:18 *🥗 Metabolic Endotoxemia Explained* - Explanation of metabolic endotoxemia and its association with low-grade inflammation. - High levels of LPS (lipopolysaccharides) in the circulatory system post-meal and its impact on health. - Connection between LPS levels and chronic diseases such as diabetes and cardiovascular issues. 00:04:34 *🔬 Role of LPS in Health* - Description of LPS as a component of gram-negative bacteria and its normal role in the microbiota. - Impact of saturated fats versus omega-6 fatty acids on the toxicity of LPS. - Mechanisms of LPS translocation from the gut to the circulatory system and its effects. 00:08:31 *🧪 Immune Activation by LPS* - Process of immune activation triggered by LPS in the circulatory system. - Interaction of LPS with LBP (LPS binding protein) and immune cells leading to inflammation. - Comparison to septicemia and its implications for chronic diseases. 00:10:25 *📊 Research and Implications* - Studies on LPS endotoxemia's role in type 2 diabetes and other chronic conditions. - Significance of CD14 activation in immune responses and its link to various diseases. - Potential clinical markers such as soluble CD14 to assess inflammation. 22:30 *🧬 Impact of LPS on Metabolic and Autoimmune Conditions* - LPS affects various health conditions through systemic inflammation and disruption of metabolic functions. - Decreased triglycerides were observed with probiotic use due to reduced LPS levels. - LPS can contribute to autoimmune diseases, mood disorders, and cognitive decline by influencing inflammation and neurotransmitter activity. 25:05 *🧠 LPS Effects on Mental Health and Neurological Conditions* - LPS impacts brain function and mood, potentially leading to conditions such as depression, anxiety, and cognitive decline. - Mechanisms include disruption of dopamine and serotonin levels, and inflammation in brain regions like the hippocampus. - LPS is linked to severe conditions like anorexia and Parkinson's disease through its effects on the brain's neurochemistry and immune response. 28:28 *🛡️ Addressing LPS Endotoxemia and Gut Health* - LPS endotoxemia is a major driver of chronic diseases and can hinder treatment success. - Key to managing LPS is addressing dysbiosis and dysfunctional gut mucosa through specific probiotic strains. - Animal studies show that certain probiotics can improve gut epithelial integrity and reduce LPS-related issues, indicating potential benefits for human health. 43:12 *🦠 Probiotic Strains and Metabolic Response Modifiers* - Probiotic strains can have different effects, including those from dead bacteria which might provide metabolic responses. - Lactobacillus rhamnosus GG (heat-killed) might offer benefits comparable to live probiotics. - True probiotics are live microorganisms, while dead bacteria can be metabolic response modifiers. - Research is being conducted on environmental bacteria and their potential probiotic benefits. 44:06 *📊 Studies on Probiotic Effects* - Current studies on specific probiotic strains focus on various health conditions and their impact on the microbiome. - A specific probiotic mix (Megaspore) shows promise in increasing microbiome diversity and improving gut health. - The probiotic strains studied have been used as prescription drugs in other parts of the world for decades. - Multiple ongoing studies are exploring impacts on conditions like pre-diabetes, elevated triglycerides, rheumatoid arthritis, and more. 47:12 *🧬 Research on Probiotic Impact in Health Conditions* - The effectiveness of probiotic strains in treating various health issues is being evaluated through multiple studies. - Studies include effects on liver failure, acne, weight loss, gum disease, low testosterone, and C. difficile infection. - Probiotics are being tested for their ability to affect conditions like hepatic encephalopathy and inflammatory skin conditions. - Research also explores the potential of probiotics in managing metabolic pathways and autoimmune responses. 50:09 *🔬 Future and Ongoing Research* - Ongoing and upcoming studies aim to explore the broader impacts and potential applications of probiotics. - Research includes glyphosate effects on the microbiome, the use of probiotics in combination with medications, and the potential for spore-based vaccine delivery systems. - Collaboration with various institutions is underway to study the interaction of probiotics with human microbiomes and environmental factors. - Probiotic strains are being investigated for their ability to improve glucose response and aid in treating specific conditions. Made with HARPA AI

Amazing !!!!!!!

Wow!

thanks. use your products for my clients

Wow this is very informative and the implications of this are tremendous

This may save my life

I went threw 1 bottle of the megaspore, it helped me with my digestion. I am going to try all 3 of the products , steps..

I love you kirran

Great presentation. What happened to the study on Hashimoto’s disease?

Doc, how would you compare the sporebiotics to a poop transplant? As the poop transplant was the only thing known to heal C Diff!

the website doesnt work anymore , and they make no more videos?

Thank you for your video, I have Hashimotos and a bad digestion, its even worse around my monthly time. I purchased the megaspore and Restorflora, how to I add the Restorflora to the protocol, thank you for your help.

So a "high fat" diet causes LPA to increase, but... He clearly states that hydrogenated vegetable oils are most likely what their diet consisted of... OK, then let's hear about a healthy, high fat diet instead... This is as misleading as any politician wanting to sell a product...

Megaspore probiotic can it be dangerous in some people? From my understanding it doesn’t leave the body and can,t be killed with antibiotic ?

Why go eat a meal at McDonalds, what if the person has generally good diet ? Usually people who dig deep into their health don’t eat McDonalds anymore

Hi Kiran, could I have access to your notes please?

So I can't just but the probiotic?

How to order from the Labs

Does Kiran Krishnan take Megaspore himself ? I would like to see a video on that

Why is this not measured in doctors office ?

You say that once you get a Auto immune disease you can’t fix it. Your trying to save people before? With this Maintain somebody’s condition prevent worsening or they’re gone these are not your exact words but you know

Kiran Krishnan, can endotoxemia be explanation for fybromyalgia type symptoms ?

Sjorgen better with saturated fat….

Fasting and Ketogenic diet and exercise will feed the good bacteria and diminish the bad bacteria... No need for probiotics, just eat high fat, moderate protein and very low carbs... And go long periods of time without eating!