Metabolic Hindrances: Dietary Shifts, Drugs, and Low Fiber Intake 

The conversation between Paniz Jasbi, PhD and Micah Lowe discusses the metabolic factors that hinder our health today compared to 100 years ago. The main factors identified are dietary shifts, including increased calorie surplus and processed foods, as well as changes in macronutrient intake and low fiber intake. Sedentary lifestyles, urbanization, and environmental factors also contribute to metabolic hindrances. The conversation also explores the concept of calorie in, calorie out and the role of micronutrients in weight loss. The importance of spermidine, a metabolite involved in cellular longevity and various bodily functions, is highlighted.