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Metabolism | Regulation of Gluconeogenesis

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Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
In this lecture Professor Zach Murphy will be continuing our discussion on gluconeogenesis, where we go into more detail on the regulation of gluconeogenesis as well as the enzymes involved in this process. We hope you enjoy this lecture and be sure to support us below!
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Опубликовано:

5 сен 2024

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Комментарии : 268

@renivp3208 Год назад

This man is single-handedly saving the grades of students taking biochem

@shayamorre2882 5 лет назад

Who are you!? And why are you just so amazing? Please continue. I’m shouting you out at graduation!! Thank you for being a magical deliverer of the teachings of this once evil subject which is actually fun now.

@piyushsumera9076 6 лет назад

No matter ho much technology advances,The best way to study is by Classroom method and anyday the Erase board explanation will have edge over those fancy presentations..Because teacher can never get involved with the teaching by that premade presentations and You prove that again and again. You dont have an idea How many videos and sites I have browsed to go through this Tandem enzyme regulation..And You explained it ridiculously easily. Thanks a ton man !!!

@lailashoukat714 2 года назад

the best way is teaching on board and then showing gross pics through slides.

@signalrod2213 2 года назад

but also only because of advanced technology this method works for many, the key difference is that you have the ability to pause or rewind, which you can't do irl in class

@praisehart7737 Год назад

@@signalrod2213 if more professors allowed students to take them back without making them feel bad that'll be the case in real life too

@signalrod2213 Год назад

@@praisehart7737 it's not exactly like that: putting myself in professors skin, how is it professors fault that I zoned out for 15 mins, and I don't feel like studying rn, I rather do it in 40 mins. You can't just listening to a lecture when you are tired of it and don't feel like you are accepting all the information, you can't just stop and look up some other topic, which you missed, and spend like 30 mins learning that first and then coming back to this one

@signalrod2213 Год назад

@@praisehart7737 it's subjective, but personally for me studying in class is 15 times less productive than on my own in front of a screen

@monarch3507 Год назад

People don't realise how important public speaking skills are for a teacher... I have tried to watch the same topic elsewhere but fell asleep in the middle of the video... You just are amazing Prof...

@SilentEagle2029 4 года назад

Biochem exam is in 36 hours, you have saved my life! Thank you!

@mehmetalitaspinar9938 4 года назад

Mines too

@studybiology9673 2 года назад

How was it?

@SilentEagle2029 2 года назад

@@studybiology9673 This was 2 years ago, I am graduated now and passed Biochem with an A, but from what I remember, that exam went terribly lmao. But it would've been even worse without this video, so my original point still stands, this man is a life saver!

@studybiology9673 2 года назад

@@SilentEagle2029 👍👍👍

@zzoldd Год назад

@@SilentEagle2029 ooo congrats

@frajwggg1568 6 лет назад

Man those videos should have a millions views

@NinjaNerdOfficial 6 лет назад

+Frajw Ggg Hopefully someday soon! Thank you so much!

@Outono937 6 лет назад

I strongly agree with you!!

@nero91 6 лет назад

"one mor thing, to finish off" - Half the video left. JK'ing my friend, love your videos. Biochem exam in 2 days and you give me confidence.

@miriamwilliams9603 4 года назад

Dude, what's your day job? are you a doctor? professor? The One? Thank you for everything!!!

@pzahtisham5944 3 года назад

He's a super hero 😁

@thewarrior9508 3 года назад

He is Engg

@nomanmunawar2158 3 года назад

He is ninja

@melodykalita6445 Месяц назад

Imma developing a huge crush on this dude due to my admiration towards this teaching skills 😭 u literally save me each and every time T~T

@Uds_Baduge 5 лет назад

You have no idea how much I love biochemistry now thanks to you!!! I used to HATE it with a passion before I found your videos!!!!! Thank you so much!!!!!!!!!!

@karinsedlakova6316 5 лет назад

same here :D

@Antoniooo1206 4 года назад

@@karinsedlakova6316 Same here. Started to love it because of him. It's fascinating how our body deals with everything, really asthonishing.

@solomonyokim6762 2 года назад

Same too.

@osielcecenas7669 4 года назад

restudying gluconeogenesis for my MCAT & I can say this is probably the best source I have had for information. Better than khan academy and Kaplan MCAT test prep

@nourhaedar1618 3 года назад

You've saved my education! Thank you from the bottom of my heart. -from a pharmacy student in Syria.

@sarapamintuan1879 2 года назад

i have been seeing many of your videos and i just want to say thank you! you´re so so so good at explaining!!!

@okodioscar7518 2 года назад

This man is very good in teaching because he made work simple by adding jokes that makes fun in lectures. Is so amazing and I look for his channel first before others

@eggs8352 5 лет назад

If I discovered your channel during my biochem class maybe I understood the subject better. I'm just here because I felt the need to review these pathways because this is heavily related to the subjects I have trouble understanding with :( Thank you sir for making such efforts to help students understand these complex subjects. Keep the passion burning. Salute to your team!

@888167 5 лет назад

At 7.48 you probably meant "in the muscle" not "in the liver". Otherwise it would be Glucokinase not Hexokinase Great video as always mate you guys are a blessing

@erwinbla1401 4 года назад

Gucokinase is just one specific isoform of Hexokinases -> Glucokinase = Hexokinase4

@seren1104 3 года назад

yeah, it should be glucokinase cause we're in muscle

@laluna5548 5 лет назад

If you ever go out of your mind and decide to visit a shitty town of Belgrade, Serbia-you have a place to stay free of charge. I am not even kidding. You are my hero! Thank you so much. I am bad at memorizing, but understand logic-and that is what you use. Simply amazing :)

@NastroArzurro 5 лет назад

You simply make the best biochemistry-videos!!! Thanks so much man!

@montaserhattab6152 6 лет назад

19:50 absolutely nooothing lamo

@gretathunberg6197 3 года назад

Wait i dont get that reference lol

@mazinesam7183 6 лет назад

thank you for making this difficult topics easier to us You are even better than khan academy 💀for real.thank you❤

@IWAC2013 4 года назад

way better, its not even close tbh

@andreiasousa9688 6 лет назад

Thanks again for all the videos! Just a random question/suggestion: would it be possible for you to put a final picture of the board in the end? Sometimes it would be really helpful to check a little detail instead of watching the whole video again! But anyways, I'd really like to thank you for all the content. Y'all are just amazing

@NinjaNerdOfficial 6 лет назад

This is something we have recently started to do in all of our videos. Thanks for the suggestion!

@andreiasousa9688 6 лет назад

Ninja Nerd Science wow thanks! That's just great. Can you please check my previous comment on the gluconeogenesis video? :)

@farisabbas7897 6 лет назад

Andreia Filipa Lopes Sousa +1

@JohnSnow-vg4tz 2 года назад

This was so intense, but it was worth watching. I watched it twice and understood the concept. Thank you, Zack!!!

@32-gokilavanis95 4 года назад

Really amazing lecture.... Now I am interested to study biochemistry.. Thanks a lot for giving me hope ❤❤❤

@alih6953 3 года назад

Your videos are amazing. They deserve a million. Some silly youtubers buy a t-shirt and get 1 million that I don't agree with You deserve everything

@mujtabaalizafar5680 4 года назад

the last two minutes of this video >>>> literally everything

@user-hw9bh9ro3t 5 лет назад

teacher who I never have like him , thanks from all my heart

@Luna-xl7dv Год назад

It was absolutely fun and enjoyable, thanks for being there, you're a miracle that happened in my life ❤❤

@paulinaleon6029 4 года назад

What a beautiful way to explain biochemistry, I entIrely love your channel!

@saraa.h3787 4 года назад

this channel deserves 1 million subscribers and moooreee

@shambhavigupta4263 4 года назад

shoutout to this man for making me pass biochem

@minaltariq1191 4 года назад

Thank u so much .... 👌✨ It's awesome .... MashAllah .... May ALLAH ♥️ bless u with endless blessings ✨😊

@J3ug 2 года назад

Also Glucagon phosphorylates Pyruvate Kinase and therefore inhibits conversion of PEP back into Pyruvate. This has the effect of diverting PEP to the synthesis of glucose!

@abbasnasir8832 3 года назад

Biochem exam is in 15 hrs and he's gonna save me❣️

@ughsirius 3 года назад

I have a question: why does a higher ADP/ATP ratio (as in a low energy state within the cell) inhibit Pyruvate Carboxylase and Fructose 1,6 Bisphosphatase? Don't we need more energy in a low energy state? And so shouldn't gluconeogenesis increase when the cell has low energy, so more glucose is made and can be broken down for energy?

@gattac900 6 лет назад

Best bio-chem vids in the RU-vid.

@sandraschmelzer9961 2 года назад

I am eternally grateful for your videos. I've watched a few of them several times and I have your diagrams in my head which help me remember what is going on during all these metabolism pathways and cycles :-)

@hanamostafa5268 2 года назад

Thanks so much!! You man is a true legend, and your videos is so valuable, you make a very complicated and long topic that I hated in Uni into a story with smiley enzymes and simple metabolism :) Thanks for being there and always trying to make your best and for the tonnes of efforts that is placed in these videos, Looking forward for more videos Ninja Nerd!!

@mehrzikamel7123 3 года назад

You are amazing man my appreciation to you, biochimistry is so cool with your explanation and encourage student to love the whole medicine big thks dude)

@janbazkhan4222 6 лет назад

hii sir ur lectures are really fruitfull the way u explain the things is very esay to understand ..i mostly follow ur lectures for my MACs exam preparations.bravo and praiseworthy...

@sarrahkhanrahim2917 9 месяцев назад

You are seriously a life saver!Ive read few comments and totally can relate with them you truly are very good at your work.I see you erasing your mistakes with your fingers pls use a finger cap or something as those ink molecules can be harmful or even carcinogenic.Your safety is very important to your students and your family! one of your students from India❤️

@factsinshortslm Год назад

From now on, I should pay the tuition for you. Btw, you're videos are not boring at all, I enjoy watching them . Biochemistry is fun with YOU and ONLY YOU.

@moondust7027 4 года назад

sir, if you put a long ads at the end of the video, I gladly watch it to support you and your team

@waqarsarfraz4205 4 года назад

Actually there are ads now, I don't if they're new, but yes I always watch them. Least I can do now. Will definitely donate to this channel after becoming a doctor.

@attacktitan703 3 года назад

@@waqarsarfraz4205 Same, watching ads is the only way I can support them financially. NEED MONEY ASAP.

@AshwaniKumar-gk9ng 5 лет назад

Love from India Thank you so much sir

@zaharramaearucan6479 2 года назад

Thank you so much! Im a huge fan here from the Philippines. I am currently taking my 3rd year in college.

@MuhammadTanveer-vt4xu 3 месяца назад

Amazing explanation.Thanks Sir

@rizwanilyas4289 2 года назад

No one can compete such a great legend 🙂

@dr.varsharajan3153 2 года назад

Seriously dude ...such a wonderful explanation .. thankyou for making me understand this concept

@rajhellskitchen3658 3 года назад

We are grateful for ppl like you. Thank you bro

@umerbinshabir6561 5 лет назад

How beautiful it was.....thank you sir❤️

@dondamishitha468 4 года назад

Your like osm sir Really your videos boosting me confidence in biochemistry Our teachers just read ppt, rather they explain nothing, u r saving me in building up my subject in biochemistry Thank u very much😊

@virtuesbernadettecadile6869 3 года назад

Thank you so much!!

@sahibwahab4867 Год назад

Thanks sir today I clear my biochemistry only because of you

@nalnalhee_seoul 4 года назад

I like your singing “absolutely nothing~~” :-D

@user-qq7ww4ub6k 6 месяцев назад

Thankuu so much...your teaching method outstanding

@sonykaviarasan4152 9 месяцев назад

Super u are clearly understand

@BRAVE_AGAINST_MYSELF 4 года назад

Thank you so much

@jdegiov 2 года назад

Another source of lactate comes from red blood cells which can only carry out anaerobic respiration. Keep up the good work.

@annafiroozi8682 6 лет назад

FYI Your education method rocks !

@NinjaNerdOfficial 6 лет назад

+Anna Firoozi thank you so much for your kind words I'm so happy that we were able to help!

@HealthifyU 3 года назад

Thank you so much ❤❤

@manulanimsara 3 года назад

You are the best thing that i found on youtube brother❤️😍

@potatowithlimbs1335 3 года назад

u the best dude .... seriously u saved my life !!

@marbeliscopello7153 Год назад

Muchas gracias, muy bonito la interrelación entre el músculo, hígado y sangre en la gluconeogenesis.

@sandemichael7242 Год назад

I love your lecturers sir just keep it up 🙏🙏

@muhammadhuzefa3568 3 года назад

You are KING ❤️

@pierpaolotofani3929 6 лет назад

Great video. You are very talented !

@technooooooooooful 6 лет назад

you are simply great, students from Serbia support you!!

@Immulate 8 месяцев назад

One more error, around 20:37. Although Glucagon, Epi, and NE activate PKA and can stimulate glycogen breakdown, which is a GNG favoring process, Epi and NE inhibit the enzyme F-2,6 BPASE which is a GNG enzyme. From this we can deduce that Epi/NE are glycolysis favoring as they're promoting glucose mobilization for immediate use as opposed to relieving stored glucose (glycogen) for the purpose of maintaining homeostatic energy demands.

@Sadaf0711 3 года назад

Thanks a lot for clearing the whole concept

@lina_dader 7 месяцев назад

amazing man! god bless you! thank you so much !

@olimpiagherghisan8746 3 месяца назад

God bless this man

@kataroxluvz2rok 2 года назад

what is this fructose-2, 6-bisphosphate reall y good for, beside AaaaaaBsoluTely nUuuuthin. you absolute madlad. thank u for existing and for making this chanel.

@AIZIKOVICHLARA 4 года назад

Great explanations! Thanks a lot ! (:

@minatonamikaze3193 5 лет назад

Great video, Thank you

@user-zq4fe4mq8c 3 года назад

*Reading Biochem for hours* Me: Finally a break... Now let's watch what I have been studding for hours in a 20 min video to relax Thank you SO much!!! A lot of love from a wanna be Pharmacist in Greece

@maohadad6893 3 года назад

Man those videos should have a millions views

@whatev3857 3 года назад

Zach, thank you so much, I finally understood it thanks to you💓💓💓

@IRENESAKAYA Год назад

It's awesome , u deserve the very best Mr😇💯

@mariaeduardasousa7603 Год назад

You make med school possible 😂😂 Seriously, I'm just loving biochemistry Wizard of metabolism 🧚🏻‍♀️

@saimsiddiqui9893 Год назад

Man you make it so easy, thanks alot

@up-si4tu 2 года назад

This is just some devil level teaching, thanku

@AishaGama-sl7ll 8 месяцев назад

This is an amazing explanation

@zns2871 7 месяцев назад

Thank you for this great inspiration

@shreeshchakraborty3121 4 года назад

Sir, You are amazing ❤️

@AhmedDahik Месяц назад

استمر في نفع البشرية يا زكريا ❤

@Hareem20 3 месяца назад

ik im too late to ask but pls tell ive heard that cortisol stores fat... then how it helps breaking these molecules

@ughsirius 3 года назад

THANK YOU SOOOO MUCH!! YOU'RE A LIFE SAVER ❤

@popitandrelax 4 года назад

explained AMAZİNG!!! !!رائع الشرح Açıklama şahane!!!

@user-sq3ls6sj7i Год назад

dude. THANK YOU

@udarachandrathilaka5200 2 года назад

Thank you very much.😍🤗

@SpizyPopstar Год назад

I'm just imagining who you learnt from because the person is a legend who produced another legend mightier than him

@emmanueljusticeoseitwumasi8241 Год назад

nice video. but you made mention of the enzyme in the liver as hexokinase but i think u wanted to say the enzyme hexokinase is found in the muscle. i stand to be corrected . realised it on the 7th minutes

@HIBAFADUL 2 года назад

You are amazing 🖤🖤🖤🖤🖤🖤🖤🖤🖤🖤🖤🖤🖤🖤🖤🖤🖤🖤🖤🖤🖤🖤🖤🖤🖤🖤✨.

@Immulate 8 месяцев назад

I think there's an error around 14:50 when talking about ADP & acetyl CoA's influence towards pyruvate carboxylase activity. High levels of acetyl CoA would indicate we are in a fed state, there's a surplus of energy. If that's the case then high acetyl CoA would inhibit pyruvate carboxylase activity. Additionally, if ADP is high, we are in a low energy state; therefore, we would want to increase pyruvate carboxylase activity to produce more OAA and eventually more glucose via GNG.

@modrribaz1691 8 месяцев назад

There is an over abundance of acetyl-CoA from fatty acid beta oxidation, which won't be that high except in fasting state. It's also the process behind ketogenesis.

@sabelomanqobatembe9760 6 лет назад

videos are cool make it easy for many people to understand and i would to see more videos such as malonyl coA pathway ,fatty acid biosynthesis and many more other than that you the best.