🎯 Key Takeaways for quick navigation: 00:00 *🤓 Introduction to MTHFR gene, methylation cycle, and estrogen detoxification.* 01:09 *🧬 MTHFR gene provides code for enzyme that converts folate to methylfolate (active form).* 02:04 *�ill S-adenosylmethionine (SAM) is the major methyl donor, requiring methylfolate.* 03:28 *🔄 Simple diagram showing synthesis of hormones from cholesterol.* 05:40 *⚗️ Phase 1 and 2 liver detox pathways for estrogen metabolism involving COMT enzyme.* 07:59 *📦 COMT requires methyl groups from SAM, which needs methylfolate, B12, zinc.* 10:01 *🍽️ Xenoestrogens, obesity, poor liver function can cause estrogen buildup.* 12:55 *🔄 Vicious cycle of estrogen increasing histamine and histamine increasing estrogen. * 15:24 *🚺 Signs/symptoms of estrogen excess like heavy periods, PMS, migraines.* 16:18 *🥗 Diet/lifestyle tips: avoid xenoestrogens, increase fiber, folate, methylfolate supplements.* Made with HARPA AI
What does adequate meat consumption vs excessive meat consumption look like? A lot of articles I have read say avoid l-tyrosine which is basically all meat in existence. Is there a portion to body weight calculation we are missing?
Absolutely wonderful. Thank you so much for this video. COMT ++ for myself and son. Doing nearly all that you mentioned but was wonderful to have it explained.
@@JoanneKennedy I have a strategene report for my son and have the pathway planner. Trying to connect all the dots so wonderful seeing another Aussie working with strategene. Might have to organise an appointment to have a chat. It's a lot of homework. But explains so much.
If you're sensitive to it you may need to restrict doses to once or twice a week until your body catches up detoxifying itself. Also keeping the dose near 100% daily value. I'm struggling a bit too but positive changes are unfolding.
