Myelofibrosis Treatments in 2024: Treating this RARE, BLOOD Cancer | The Patient Story

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Ruth Fein has been living with an MPN for nearly 30 years. She was first diagnosed with essential thrombocythemia (ET) then polycythemia vera (PV) and was later diagnosed with myelofibrosis. In this discussion, she's joined by top MPN specialist, Dr. Naveen Pemmaraju with MD Anderson.
They give a comprehensive overview of the four FDA-approved JAK inhibitors used to treat myelofibrosis - ruxolitinib, fedratinib, pacritinib, and momelotinib.
They also share exciting developments in clinical trials, including combinations with selinexor, navitoclax, luspatercept, pelabresib, and others. Plus, the role of stem cell transplants, manging anemia and potential treatment side effects.
Full article here ⇢ tinyurl.com/4khaks5a
#cancerstories #thepatientstory #myelofibrosis #rarecancer #MPN #cancerresearch #bloodcancer #cancertreatment #myeloproliferativeneoplasms #myeloproliferativeneoplasm #raredisease #bloodcancer #hematology #diagnosis #treatment
Myelofibrosis:
Myelofibrosis is an uncommon type of bone marrow cancer that disrupts your body's normal production of blood cells. It can cause severe scarring in your bone marrow, leading to severe anemia that can cause weakness and fatigue. Myelofibrosis often causes an enlarged spleen.
Myelofibrosis is considered to be a chronic leukemia - a cancer that affects the blood-forming tissues in the body. Myelofibrosis belongs to a group of diseases called myeloproliferative disorders.
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Video Chapters:
00:00 Introduction
01:58 Overview of JAK inhibitors
09:25 Considerations for switching JAK inhibitors
11:30 Combination therapies with JAK inhibitors
13:50 Combination therapy with BCL inhibitors
15:23 Combination therapy with Luspatercept
19:09 Other approaches beyond JAK inhibitors
23:59 Improvements in treating anemia
26:00 Role of stem cell transplant
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The interview has only been edited for clarity.
* Thank you to GSK and AbbVie for their support of our patient education program!
The Patient Story retains full editorial control over all content.
RARE Blood Cancer Treatments in 2024 | Myelofibrosis | The Patient Story
• Myelofibrosis Treatmen...

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31 май 2024

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Комментарии : 3

@joytotheworldrandomperson4098 20 дней назад

Mom mom had PV that has progressed to advanced myelofibrosis. Her spleen is enormous causing pain and discomfort. She can’t eat much because her spleen takes up so much room. She just started on Ruxolitinib. I hope this brings her relief. My mom is a warrior and doing well considering her battle. I’m grateful for this. This video - although there was much scientific discussion and I’m just a blue collar woman - was helpful for me to know where we can go forward if the RUX doesn’t do the trick. Thank you.

@stirlingrae2465 18 дней назад

can anybody tell me what reactive marrow means? I got a pet ct scan because I've been constantly sick with infection after infection for two years. 4x covid, double pneumonia, flu, uti's, eye infection, toe infections, bronchitis, kidney infection with a total of 5 rounds, b symptoms itchy, sweats, reoccurring fever almost every day, weight gain 50 pounds in 12 weeks 3 years ago from 48 kilo to 75 kg to sudden weight loss a year ago now 30 pounds down 15kg, two blood clots with elevated thrombocytes but on the high end of normal, high lymphocytes 3 times in 2 years, cough, breathing and swallowing problems, pain in teeth and face, flank pain, lower back pain to the point I can't walk on some days, headaches, 3 paralytic attacks that look like hypokpp, I've had a swollen spleen and swollen liver at one point, passing blood on and off, hemolysis anemia, they found a 16mm lesion on liver that they assumed was a fnh, after hysterectomy two cysts found on ovaries, metaplasia cellular change in stomach from chronic heart burn for 15 years, went through puberty at 7 and was done by 12 years old, high cholesterol with no known cause all across the board, bone pain in legs, arms, chest, itchy under arms and anywhere where there's lymph nodes, were swollen but none that stay, helicobacter pylori, 8 weeks straight vomiting, nausea, alcohol intolerance since 2015,and skin manifestations between 2011-2024. Had a pet scan and this is what was said Normal aspect of pharynx, high activity in epiglottis. Narrow No increased activity in neck lymph nodes A-specific activity near Bauhin's valve No active foci in the skeleton. Increased bone marrow activity, reactive. Now I'm being told I'm fine, but I'm not fine and have this gut wrenching feeling it's not good. I've been on a 2 year sick leave and lost two jobs. I have extreme days of fatigue and can sleep up to 16 hours a day. I live in Europe and going to a hospital that has the worst rep for ignoring information that have led to many unnecessary deaths because they ignore things. Reactive bone marrow is never a good sign or any hotspots found on my scan. can someone help explain if i should be getting a second opinion and what it means? please and thank you ❤