New BREAST CANCER Vaccine For Her2 Positive Patients || Dr Liz O'Riordan

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Breaking News!
A DNA vaccine has been developed that could be a game changer for HER2 positive breast cancer patients.
A phase 1 Trial published in the JAMA oncology tested the vaccine on 66 women with metastatic disease.jamanetwork.com/journals/jama...
Chapters
00:00 Introduction
00:25 Take home message (if you want to skip the rest of the video)
00:44 What was the study about
00:56 What is the HER2 receptor?
01:27 Why was the vaccine invented?
02:07 Who did they test the vaccine on?
03:01 What were the trial results?
03:58 What happens next?
The vaccine encourages the body to mount an immune response to breast cancer cells that over-express the HER2 receptor.
The study showed that the vaccine was safe - with only minor side effects similar to the Covid vaccine. But it also showed that over ten years, 80% of the women were still alive (only 50% were expected to live that long).
A phase II trial is now going ahead to test the vaccine on a larger group of patients, and in the years to come, there could be a possible treatment and even cure for HER2+ breast cancer patients. Similar trials are also being done with vaccines for TNBC patients.
Let me know if you've got any further questions
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12 июн 2024

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Комментарии : 70

@Kristybonet 9 месяцев назад

Hi im in the Flamingo trial for the vaccine here in Tucson AZ. I hope to get the drug but if not I am happy to be able to help another woman in the future. My mom had the same cancer as me, triple positive, and she was in the clinical trial for Herceptin. Its so important that we do these trials to move the science forward. Thanks so much for sharing this info.

@DrLizORiordan 9 месяцев назад

I really hope the trial works for you

@laurasarah2663 8 месяцев назад

I hope it works, too.

@SweetUncleG 4 месяца назад

Is this vaccine already avaliable in the market...? Is it expenssive...? 🤔🤔🤔

@Kristybonet 4 месяца назад

It's in phase 3 trial right now

@stefanymarangoni6897 3 месяца назад

Hi, i would like to be in the trial , how can I contact You?

@libworld44 Год назад

Thanks for posting..We hear about so many of these trials and never hear of them again, hopefully this time it does happen. I was talking about it with a doctor who researches in harvard.. I’ve had the exact same treatments that my family members had over 20+ years ago.. 🙏🏼

@DrLizORiordan Год назад

The treatments for ER* cancers haven’t changed for years sadly

@rebeccakarlsson1395 Год назад

Same.

@jgreen5820 10 месяцев назад

I was Her2 positive, have had double mastectomy. If I have understood this, this has so far only been tested in metastatic her2, much like Herceptin was in the beginning. If this does prove to be effective this is huge and hopefully will not meet the resistance from scientists and NICE that Herceptin did in the beginning. I wonder if the aim with this vaccine is to eventually replace treatments such as Herceptin and Perjeta in stage 1 onwards.

@DrLizORiordan 10 месяцев назад

I think it could be. It's really exciting to see what will happen in the future

@raquelapresentacao9569 Месяц назад

If the study is successful... How long will it take to be available? Thank you Dr Liz 🧬

@karenmcgroarty4187 Год назад

Thank you for the information you share with us. I really appreciate it. It help me to feel calm and not stress about things

@DrLizORiordan Год назад

Oh that has made me day. It’s lovely to know that my videos are helping people x

@rebeccakarlsson1395 Год назад

Thanks for this encouraging news!

@DrLizORiordan Год назад

Isn’t it?

@rebeccakarlsson1395 Год назад

Yes. I could say that it doesn’t apply to me personally, but one never knows does she? I am thrilled for ALL advances being made in cancer treatments/prevention, regardless of the type, but get especially excited when they are for BC. Understandably.

@raquelapresentacao9569 Месяц назад

That's what I'm most looking forward to 🥺 I'm an oncology patient metastatic to the bones, triple+ (100% strong estrogen, 20% weak progesterone and Her2++ Positive)

@sandragilmer4943 Год назад

I had Her2+ plus Er+ breast cancer Stage 1, age 71. I am in Canada. Where are these trials taking place? How soon do you think a vaccine will be available? Could all women get the vaccine prior to any cancer diagnosis? Thank you for this encouraging news. I really enjoy and appreciate all your posts.

@DrLizORiordan Год назад

newsroom.uw.edu/news/breast-cancer-vaccine-safely-generates-anti-tumor-immunity info here

@devanandvyas2559 4 месяца назад

I pray that every women who has done no wrong and got this cancer gets treated even my mom is diagnosed with her2 + metastatic breast cancer which has spread to bone and brain I pray that my mom gets this vaccine 🙌🏻

@nazlavdan9424 5 месяцев назад

Thanks for these informative sharings Linda. I have HER2 positive cancer with metastasis on the lymph nodes. I have just completed my planned chemotherapy and soon will have the surgery. I’m wondering if I am eligible to be recruited for the test of the vaccine and who should I contact to discuss this. I also have a request if possible. Can you please share your knowledge about eating sugar and red meat during cancer treatment. I’ve read conflicting opinions about this. 🙏

@simonehelene8691 4 месяца назад

Hello, and thank you for this video. My sister is interested in getting into trials as she has metastatic her2 positive breast cancer, stage 4. We live in Canada, which is notoriously slow on the uptake to have Health Canada approved new medication so we are concerned about the wait time for trials and approval and so she is really trying to get into a trial for this type of vaccine. Do you have any advice for people who are looking to get into trials?

@lianeisme 2 месяца назад

Thank you for this are you able to tell me when this would be available about. I have stage 4 her2 positive breast cancer

@lyndawilding4794 Год назад

Fantastic news,,i have her2 +cancer now,,now on quimo first!!😮

@DrLizORiordan Год назад

Hope it does it’s job x

@lupinedew 2 дня назад

Why does my Oncologist say that the Letrozole won't give me more benefit after 5 years. She submitted the cancer info to some sort of indicator... and it came back no further benefit? Also.... why is there no screening for breast area if there is no reconstruction after a mastectomy?

@lesleystyles9916 Год назад

I had HER2 + had chemo ,surgery ,radiotherapy, and immune therapy .How do you get the trial ?is it only in the US?

@DrLizORiordan Год назад

It’s only in the US

@donnabradley4577 Год назад

I've been reading about research into HER 2 Low breast cancer. I wonder if this new vaccine might eventually be used for that as well?

@DrLizORiordan Год назад

Hopefully

@user-gs2oe1bz9w 4 месяца назад

I was treated for HER2+/ER+ 5 years ago, I didn't have a full pathological response and too far out of tx to qualify for Kadcyla. Are the clinical trials available in the UK? Not sure I have 5 more years to wait for this to become available.

@DrLizORiordan 4 месяца назад

Try looking at cancer research Uk trial database

@marybrock2708 Месяц назад

I am getting ready to go on herceptin . How fo you see if you can get this vaccine.

@annatrowbridge2460 4 месяца назад

Hello Dr O'Riordan, is there a publication out yet on this research? Asking for a friend with HER2 stage IV.

@DrLizORiordan 4 месяца назад

Not yet

@HL-qv3yd Год назад

Dear doctor Liz, er positive breast cancer big group of patients, they don't have much progress this types, makes me sad 😢 Same time happy for her+patients.

@DrLizORiordan Год назад

I’ve done a video talking about all the new treatments for ER+ breast cancer - have a look at my video on the CDK inhibitors and at the end I talk about 5 new treatment options

@HL-qv3yd 7 дней назад

@@DrLizORiordan I will thank you so much ❤❤❤

@LifewithAnindita 2 месяца назад

When vaccine will come for Her2 ngtv er+ cancer patient?

@alypat3443 9 месяцев назад

Hi there, if I was treated 6yrs ago had Her2 positive breast cancer. Mastectomy chemo radiation and herceptin.ive been clear for the last 6yrs. Would I still be offered the vaccine as a preventative eventually when the trisls are finished? Thank-you

@DrLizORiordan 9 месяцев назад

I honestly don't know. It's still early days

@sychan1212 9 месяцев назад

Thx doc so in approximately how many treats this vaccine would be formally launched in the market and available to public hospital patients ? Would it be super expensive u guess?

@DrLizORiordan 9 месяцев назад

I honestly don't know

@vivekanandabharali415 Месяц назад

Hello mam my sister who is 36 year old having breast cancer of HER2 positive how about taking taking kadcyla TDM 1

@cindyscharr457 9 месяцев назад

When this vaccine becomes available to the public will it only be available in the UK? Will it move quickly to the world like the Covid vaccine? What will the cost be? If it is approved will insurance companies cover it and control the price? Her2 positive patients want to do more than thrive but be survivors. Thanks so much for sharing this information. I hope that it will be networked around the world.

@DrLizORiordan 9 месяцев назад

I hope so

@pashabakli 6 месяцев назад

Where we can get the vaccine

@tiagov.mendes4422 Год назад

Hi Liz, could you do a video on tumor resection in case of de novo MBC (prticularly in oligometastatic disease) on top of systemic treatment since you are a surgeon? There is lots of recent results from trials and studies that are quite interesting. I think this is not a subject that is sufficiently covered, as the standard position is that the cells have already "left the barn" but studies have shown that there may be an improvement depending on the type.

@DrLizORiordan Год назад

I’ll add it to the list x

@stewartsantiago8939 16 дней назад

Any new treatments on TNBC?

@DrLizORiordan 15 дней назад

Yes / if you check out my video on TNBC there are 5 new treatments I think x

@jennifersimmons964 Год назад

but for the most common type? My son is a Science buff, we are watching for cure not more bandaids.. we keep getting scared about my bc tumor markers that have stayed up.. well only somewhat.. which my doc says is due to the NAFLD, whatever, i still want the bloody markers down, and i dont eat too badly, so who knows.. thanks for sharing anyway and we love you..

@DrLizORiordan Год назад

Thanks for watching x x

@jp5419 Месяц назад

Is this RNA vaccine or traditional one? After the cv vaccine nightmare, I wouldn’t dare get one of these new ones.

@banker_dunia 9 месяцев назад

My mother has stage 4 tnbc . What can i do for increase her servival rate . How can increase her life . Plese guide

@DrLizORiordan 9 месяцев назад

I'm sorry but I can't give personal medical advice

@banker_dunia 9 месяцев назад

@@DrLizORiordan any doctor you have to suggest ..

@bhanumathikalyanasundaram.4930 4 месяца назад

Have you tried at Tata ,Mumbai?

@renukashivanandappa9711 11 месяцев назад

Is it vaccine available in Bharat. How is treatment ,what are the Results.Most of women may Benefit in Bharat,if available.now Breast cancer is rampant. Please Helpus

@DrLizORiordan 10 месяцев назад

I don’t know I’m afraid