New Obesity Drugs May Impact Mental Health 

It could be genuinely anything because as much as I'd like to say it's just that they're happier because they're losing weight, my mother's hot flashes have stopped since she started mounjaro, which implicates the hormonal involvement, and a couple patients at my pharmacy specifically say that they feel "crazy" when they can't get their medication. This lady asked me "do you know what it's like to eat a single slice of pizza and then stop thinking about it?" Like okay ma'am yes, that's just the usual for most people! But they describe the drugs as killing their obsessive thoughts, which is very cool and neat and fun and I can't wait to see what it does for alcoholics

Its crazy to me that obsessive behaviors and hunger might have a physical connection in the human body, but at the same time it makes perfect sense.

Right? I’d like to see a study that compares to a control group not taking the medication but also loose weight

Seriously. Overweight people are going to be happier when they lose weight... Are researchers really this nearsighted to not see this?

Like a duck.

There are studies ongoing right now looking into this. Anecdotally it's done that for me. I've went from drinking 8-10 drinks a week to 1-2. Just doesn't do anything for me anymore. The taste is fine but I just don't want alcohol. It's weird and cool. (I'm in a clinical trial for a new GLP-1 called retatrutide)

I believe this is true of Wellbutrin also

I drink way less now after being on it. Just don't want it nearly so much. I love it

Naive question, do you think your dose is "too high" now that you lost so much weight?, because dose per kilo is usually how you standardize dose

How long have you been on Ozempic?

@@marcelosilveira7079 nearly 2 years now!

If that is the case then the drug still causes reduced depression, but it does it via weight loss and then it only works in an obese population, you could do a trial in lean depresses people and see if the effect also holds there

@@JanCRefsgaard Since the drug leads to weight loss, I don't expect they'd want to (and it might not be ethical/safe to) give it to people who didn't want or "need" to, but I get what you're going for - control for the variable.

It wouldn't be terribly difficult to parse statistically, if they had enough data. You'd need subgroups of people who'd lost similar percentages of body weight using this drug and other methods. From there, the analysis is the same as for controlling any other variable.

@@SpeakShibboleth this is much harder than you think, you could loose similar amount of weight because you are very sick, it's very hard to find the correct counterfactual comparator. Also some of the glp1 weight loss could come from galaxy brain things like you losing weight makes you eligible for a gastric bypass surgery so you loose even more weight, causal inference is very hard!

Existing treatments for? Obesity? Because in general the treatments against anxiety are really helpful. Even hydroxyzine has majorly improved my generic anxiety riddled (ADHD) life. The digestion tract is lined with brain cells (like a computer GPU compared to a CPU), it makes sense that what affects the digestive tract also affects your mood. We just have to double blind test these medications thoroughly on people who have zero obesity.

That’s an excellent point. The existing treatments they compared against probably included phentermine, which I have heard can really mess with your head

I think being overweight in this society causes anxiety all on its own.

Fatness is from you living in a society where over half the food supply available to you is actively poison. But that's too profitable to change so instead we get drugs that mess with your brain chemistry so you eat less.

Most of these pills work by making your body bypass nutrients. It doesn't matter if it's genetic or "natural" or psychological... it's gonna work for ya.

There's an important difference between being a bit overweight and being full on obese, especially morbid obesity. Especially for women, having a lot of extra fat in your thighs and butt is normal and health advantageous. Having a lot of fat on your gut is really bad no matter if you're male or female, and being morbidly obese (ignore BMI, pay attention to muscle amounts and fat distribution) is bad for everyone. Someone super muscular who still has a huge beer gut lives a dangerous life even if their limbs are lean, someone super muscular with an even spread of a bit extra subdermal fat all over isn't living anywhere as dangerously as the lean-ish beergut person, even if they have the same other base-statistics about their bodies. If you're a bit overweight, especially in the lower body, that's not the same thing at all as someone who has a terrifying amount of upper body fat (especially the hard gut fat, viceral fat) and way less in the legs and butt.

That wouldn't explain the difference in results between semaglutide and other weight loss treatments, though.

People who are subjected to fatphobia in society are more prone to mental health struggles.

​@@victoriafrombhbh8659Being mean to fat people was how the food industry got the rabble to blame each other for the poisoned food supply instead of the people selling the poison.

@@IceMetalPunk Semaglutide helps with symptoms of depression and other weight loss treatments don't

@@HeliosPlayGames So... causation.

The way you worded it, makes it sound like you're saying it's a binary choice between the weight loss drug and lifestyle changes. But it's not, you can do both. In fact there are probably synergies that make taking both options superior to either one alone.

​@@quadratichorizon you work for big pharma in some way, don't you. 😂

It's not lifestyle. It's an actively and perniciously poisoned food supply. Which isn't going to be changed because capitalism.

There are a lot of issues that people used to claim were just lifestyle issues, that turned out to not be. For instance stomach ulcers were claimed to be a stress/spicy foods only thing, it turned out that the majority of the cases were h.pylori cases. People used to claim being lefthanded was an evil choice, literally evil as in caused by the devil. There are many things that ignorant people used to claim are purely lifestyle issues that turned out to not be, including depression. Depression is a complex issue involving *both* lifestyle and medical issues. In a few cases it's even only lifestyle or only medical. Difference is that lifestyle changes don't fix the ones that aren't just lifestyle issues, see the athletic people who get plenty of sunlight and don't have environmental reasons to feel depressed, yet they can still be acutely suicidal. Rich people can effortlessly buy these pills as a "lazy" way to lose a few kg so they don't have to learn nor hire personal trainers and a personal chef. Poorer people who already have tried hard to address it via lifestyle changes have something more wrong with them than just the usual issues, they need extra help. I have a little sister who eats healthier than me and yet she has so many more health issues than me including obesity (I've mainly got autoimmune issues). She even has PCOS, while my periods have always been like a clock. She's getting medicated for so many different things, because she needs it. Her issues are not lifestyle created. Yet twenty or even 40 years ago people did claim issues like hers were lifestyle created. Most people probably still do out of sheer ignorance, the same way they probably argued I could just magically produce a normal high amount of saliva if I just stopped keeping my mouth open in my sleep or something (which I never have done, I've always been a nose breather) or even stopped taking my medication that has a chance of side effects that leads to reduced saliva production, conveniently ignoring that I wasn't diagnosed and medicated with those until near my 30s and I still had all those issues growing up and that my medication didn't worsen my condition. Don't assume things are only ever lifestyle caused just because in you they would absolutely be lifestyle caused.

For real. Doctors have been absolutely brainwashed by big pharma. Pills are a quick fix for everything. Sad really, especially for the trusting patient.

You can't outrun or outlift a poisoned food supply.

That literally does not work for some people, that's why these drugs are used. Educate yourself.

Tell that to a messed up thyroid.

When I was working a physically demanding job I was still fat - exercise doesn't make one skinny. If it were that easy there would be few fat people.