Nucleotide excision repair 

This is nucleotide excision repair in prokaryotes it is slightly different in eukaryotes. Just thought I would mention that incase people didn't realize and thought it was for in humans. Great video, all your videos are very helpful and effective.

There's some correction: 1-UVR aba. Dimer scanning the DNA for injury. 2-when finds, a portions release and b remains in the site of thiamine thiamine dimer, i. e injury. 3- UVRc come and combine with b to make 2 cuts few nucleotides away from the site of injury. 4- UVR d is a helicase Enzyme removes the cut portion. 5-DNA POL3 complete a correct strand. 6-ligase fixes it. Thats all. 😀

i think it is UvrA that makes a complex with UvrB and scans and binds to the lesion site. though thanks for the explanation

I like the way,how he suddenly remembered & explained the difference between 'nick' & 'gap' !!Have to show your videos to those undedicated professors to their job.Huge respect & hats off!!

i wish you could explain Double Strand Break Repair

Uvr A dimer formation is not shown which is crucial. I disagree with video data. refer Friedburg book DNA Repair and Mutagenisis

I have already check your previous videos and all of them are too much helpful to me. I always get a clear concept after watching your videos. So it's my request please don't stop making videos about biology. Thanks a lot .

I'm a microbiology master degree student and this man is my savior during finals

You are always so helpful, and with no need of great effects or tecnologies. Simplicity is key and you know how to teach.

in first step, either Uvr AB complex is formed or UvrBC??? according to my info it is Uvr AB complex formation..Regardless, i like ur videos overall. .. sir ur videos really help me in my studies... i am a microbiology student 😊☺thanks

thank you so much..you help me a lot in understanding molecular biology topic. i can say that you like my youtube lecturer.,

Wrong! UvrA forms dimer with UvrB dimer by ATP at the first step🤔

Sir, you are a life saviour!day after tomorrow I have my molecular biology final and I'm depending on your videos.The way you delivery your lectures, it really helps me!thank you!!

I really enjoy your videos. Just 2 points. This is Global Genome NER in prokaryotes, not eukaryotes. Also, UvrA first recognizes the damage then UvrB verifies the damage. Everything else is spot on!

I can not find a word to tell you thank you. You are a very talent man. Please continue your efforts to teach me and other people all around the world. Thank you again. God help you in your path. There is a very nice explanation about Nucleotide Excision Repair with nice clarification about the role of DNA Polymerase and Ligase in this process.

dont we need uvrA here because i studied somewhere that the detection process is done by uvrA

At the beginning it's uvrA and uvrB .

Thank you Sir... Excellent lecture Sir 🙂🙂👍👌🤗💞💕

you are genius men. i can't believe i got this helpful video for free!!!!

Thank you so much sir... it's always less no matter how much I thank you..! But you always save me..! thank you so much sir.🤗

Hey 2uvrA and 2uvrB is responsible for scanning d dna lession.actually uvr A does d scanning part and it leaves thn uvrc comes and forms a complex with uvrB cz c is responsible for cleaving.

the lessons are very clear and easy to understand.thank you sir

You understood the central dogma better than the ones identified it

يكسبك دنيا واخره يا رب ❤️🌹

Again here sir 🙋‍♀️ And again Crystal clear understanding !

your knowledge and your explanations both are best just keep it up and make more videos releated to genetics plz

you are so helpful !! THANK YOU

And you said that the UvrB and UvrC dimer scans the distortions due to leision . But once i read that UvrA and UvrB scans the DNA for leisions . Then which actually does the scan??

you are a magnificent help to this world please please keep of this awesome work. karma

Superb explanation. Thanks a million. All the way from Republic of Ireland Filipino

All the way from Republic of Ireland Filipino

Is UvrB a endonuclease too?? Once i read that UvrB cuts at the 3' end of the leison and UvrC at the 5' end .

He explains everything that related to my subjects..Iam Medicine student

UVrB enzymes is exonuclease or endonuclease?

Thank you so much sir ❤️

Sir, I just want to about photoreactivation process

Thanks Shomu ❤️🥺

Sir can u plz tell why UvrB is used here bcz the separation to the lesion region is made only the Uvrc ... Why we don't only used Uvrc for the process instead of the UvrB/c complex??

uvaA is not mentioned here, it is wrong

Thanks a lot sir your videos help me for preparing for exam

Why DNA polymerase can not ligate the DNA nicks by phospodiester bond but can make phosphodiester bond between daughter nucleotides?

Sir uvrB first bind to uvrA right ?

Is there any video where you described the RecBCD model in Prokaryotes ; very much needed ; pls help

Uvr A and uvr B form a tetramer may be

thank you sir...your almost all videos are very helpful.😊

U r so good...thank u for clearing the topic .. Nd please make video on recombination repair 🙏

You describe the process in very good manner but how does this effect overall body and but kind of mutation it caused. Please give some brief idea about it. Example xeroderma pigmanotosum is caused due which failed repair mechanism.

Thank You , Sir

U teach very well..

Tq so much sir 🙏

sir there is an UVrAB complext instead of UVrBC trimer complex as i read it from book......can u tell me whatactually that is?

Very useful video

Sir, how does an abnormal base determines it needs mismatch or an excision repair?

absolute help

why not dna polymerase 3 filles the gap...y always dna polymerase1...?

You are a life saver 😭😭

Thanks a lot shomus je.. my topic cleard

UvrA is the dna binding protein that exists as a heterodimer uvrA2B2

thanku sir👏

nice and awesome video... keep it up

Thank you!!

I jst love all ur video's sir. U make things easy to understand BT jst for nt getting other people confused its the AB complex formed fist which scan the DNA and binds to it then after UvrC is loaded

I need a teacher like u💙

Thanks sir ❤

Outstanding

شرح ممتاز ❤❤❤

Sir please explain the double strand base repair. Its a humble request to you.please sir

Thank you so much sir i really want to thank you because i attempted this question in my msc exams successfully just because of you your way of giving concept to yout viewers is simply owsum 👍👍👍

Brilliant Explaination😊finaallly 😌i got it🤟

Thank you

You save me sirrrr❤ thankyouuu💞

Waoooo

Sir I have confusion in this lecture.. bcz my teacher talk about UvrA protein also but you didn't

Great

Dhanyavad

Thank you sir It was amazing

cyclobutane pyrimidine dimer process is same?? please tell

i think in this video u should talk about exinuclease isnt it ?

Where is uvr A

Not sure why I watched this but you are smart.

❤️❤️❤️

resume 10:34

Lot of thank... Your diagrammatic representation easy for understand and also clear the basic things....well done good job.. keep it up

Awesome videos you have, Shomu! Thanks a million

thank u very much sir

You are genius 👍🏻

you've been great help! thank you very much

clear explanation .thank you

Thank you sir

Ur awesome....ur vdo's r really helping me...

Oh God!You are soooo goood..🥰

Explained very well

Tnx sir

you are awesome!!!!! best way to learn genetics :)

wrong discussion

u r the great 👏👏

You are amazing dude!

excellent

very helpfull ☆