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Pharmacokinetics | Drug Metabolism

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Official Ninja Nerd Website: ninjanerd.org
You can find the NOTES and ILLUSTRATIONS for this lecture on our website at:
www.ninjanerd.org/lecture/pha...
Ninja Nerds!
In this lecture Professor Zach Murphy will be presenting on Pharmacokinetics, specifically discussing Drug Metabolism. We hope you enjoy this lecture and be sure to support us below!
Table of Contents:
0:00 Lab
0:07 Drug Metabolism Introduction
0:56 Mechanism of Drug Metabolism
2:55 Phase I Biotransformation
8:31 Factors Affecting Phase I Biotransformation
19:50 Phase II Biotransformation
24:18 Drug Metabolism Practice Problems
27:45 Comment, Like, SUBSCRIBE!
Pharmacology Source:
Whalen, Karen. Lippincott Illustrated Reviews: Pharmacology (Lippincott Illustrated Reviews Series). Wolters Kluwer Health.
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Опубликовано:

8 авг 2024

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Комментарии : 154

@wanahmadamsyarzafrie8080 2 года назад

Man I love the new quiz-types questions at the end of the video, they really test your memory, the videos/notes and illustrations are super great as well, thanks Ninja Nerds

@NinjaNerdOfficial 2 года назад

Glad you like them!

@naderahmed7938 6 месяцев назад

Please keep adding more quiz questions they really help solidify the lecture also thank you @@NinjaNerdOfficial

@marquisdesade6156 2 года назад

The thing that I absolutely love most about your phenomenal teaching is THE REPITITION, it does incomparable WONDERS for students MEMORY and so many teachers just pass through a term once and stroll on,, making it easy to forget

@khalilahd. 2 года назад

I don’t know how you do it but you make complex processes so much easier to understand! Definitely saving this for my watch list! 🙏🏽💜

@marianamelo9672 Год назад

these classes are GOLD! your teaching makes us excited about learning, thank you!

@onesmuskennedy3400 9 месяцев назад

Should pay my tuition fee here

@muhammadusama1347 Год назад

Am addicted to Ninja

@MichaelBrown-sf6py Год назад

Mr professor taught this today and had me completely lost and I didn't think I would ever understand this. But the way you break it down makes sooooooooo much sense so thank you.

@AbuhurairaJamil 8 месяцев назад

Never have I ever listened to pharmacology lecture for 40 minutes straight until now😂. Hats off man ❤

@coconut2262 Год назад

I was actually terrorised in med school when my teacher taught us this..couldn’t understand a bit and when asked about 1st pass metabolism in my test it moved me to tears to write what I had in my mind.. Thank you so much for this..🙏

@automntl Год назад

The fact that these got uploaded just in time for my pharm course is excellent. Im not religious, but I know Jesus loves you. I met him shortly after watching this.

@Ronaldo71543 3 месяца назад

Wtf 😒😅

@riogrl324 Год назад

These videos have opened my eyes! FINALLY someone explaining it without confusing the masses 😂

@lydiakaoudjt9369 Год назад

Thank you is never enough for your efforts dr ninja nerd. May Allah bless u and all your beloved ones u are making our life easier thanks a lot

@shaikabdulrafey4981 11 дней назад

Bless with the greatest blessing Aameen

@anulikaizuchukwu7198 Год назад

I have struggled for so long to understand this phase 1 and 2 reaction. This video made it so easy. Thanks alot!

@iyayii 9 месяцев назад

I have my pharm midterm exam in four hours and was confused on the topic. My notes and lecture slides didn’t help. Your video really helped break it down and make me understand the topic more. Will start watching your vids from now on!

@taliarabelo4034 Год назад

Hello! This class helped me a lot, I'm Brazilian and I was having a lot of difficulty understanding this subject, but with your incredible didactics it's impossible not to learn. Thank you very much!

@camillepage208 Год назад

Omg THANK YOU THANK YOU THANK YOU!!! I am studying to be a therapist & am struggling with my psychopharmacology class. You have helped me understand way way better than the book could. Thank you so much for breaking this down so it’s understandable to people who have 0 foundational knowledge like me!

@ssburrus 10 месяцев назад

grateful you are single-handedly teaching me my first few weeks of PA school :')

@manalemad1589 Год назад

clear and informative that's what a med student needs endless thanks for the ninja nerd staff we do appreciate your hard work ❣❣❣❣

@peaceomada9488 Год назад

I like the fact that you try to make everything simple and make everyone follow up

@noahelia1579 2 года назад

Allways a fan of these pharmacology videos! Such great content. I'd love to see one on pharmacogenetics and some in depth content on polymorphism of drug metabolizing enzymes.

@tinkerfae1977 6 месяцев назад

Zachary your amazing I have turned my uni colleagues onto your channel and they are all so grateful , I have even been given all clear to use your website in my references xx ❤

@rashmijagadeesh5753 6 месяцев назад

You made such a complicated topic into simpler job that I never forget the concepts which you taught . I admire your efforts and thank you so much 👍

@calvinklein6903 Год назад

This dude right here is the GOAT!

@anouckvanes 7 месяцев назад

You are really the best teacher I never had! Please keep up the good work

@rebekahparris2425 2 года назад

Thanks once again, you make learning so exciting and this isn't even necessary for my studies, just out of curiosity I wanted to know about this. I also love the Q&A at the end. ✌🏽🇹🇹

@sabaiqbal8873 Год назад

Super great videos. I understand every bit of your lesson. Thanks are not enough for your efforts. Superhero, an ideal teacher.

@user-fw3yb8ix4x 9 месяцев назад

By far, you are my best prof. in med school!

@22.Satty. Год назад

Sir you are my favorite teacher for rest of my life thanks a lot 🙏

@dominicbarandica6717 Год назад

Add more questions going forward that was super helpful for a check of understanding. Keep up the great work. 😊

@saffaayub4570 Год назад

Grateful that I found them right before exam!!

@minutemovienight9094 Месяц назад

Thankyou so much Ninja Nerd! Your are doing great work. I will repay you one day

@Jay-lq8ly 10 месяцев назад

Best explanations!! You simplify all topics❤

@sharminbala Год назад

Very nice! Clearing concepts

@linaaa2535 Год назад

Please make more pharm videos! These are amazing, thank you so much!

@mamalyfarahmand592 Год назад

thanks to you and the team that is supporting you

@doc_matox 9 месяцев назад

Just though of commenting on the wonderful videos i have watched recently. Thank you so much for making my Pharmacology journey going smooth❤❤

@mhammedsuiman6493 2 года назад

Thank you so much 💓 💗 I have an exam in pharma next week ..... i can't answer the cases questions but you help me...... thank you again ❤ Great explanation 👌

@user-oc4si3ef6i 7 месяцев назад

Thank You ❤

@brazuca14 11 месяцев назад

I’m Acing CRNA school thanks to you!!! Thank youuuuuuuu.

@samhasanpour1628 Год назад

Love love loved it! Much appreciated🎉

@nnajilight8008 Год назад

Ninja nerd you don't know how popular you are among Nigerian university students...bless you brother

@crespomwakapande6299 8 месяцев назад

Thanks very much u make concepts easier

@sr689 Год назад

Very well explained. Thanks

@juanmartinvillamea378 3 месяца назад

the explanation is on point, as always

@Lusungumsimuko5816 Год назад

Thank you very much This very helpful and unforgettable 😊

@Jaycar1997 Год назад

@ninjanerd First off I wanted to say that I love your videos. They've been keeping me afloat through med school. I usually don't comment at all but at 11:50 in the video you talk about codeine in slow metabolizers and in those cases I think it would actually be more beneficial for the children with low metabolism because codeine is a prodrug with the active metabolite causing respiratory depression. So it would actually be ultrametabolizers who are at risk for respiratory depression since they're turnover rate into the active metabolite is increased.

@user-ix6pf9iw5z 2 года назад

Great explanation 👏🏻👏🏻👏🏻❤️

@fearlessgamershubandroidga9305 6 месяцев назад

Hats off man. You're the best

@tahaalameri4832 Год назад

I think that the codiene become toxic when you metabolize it more, because codien metabolite is morphine, 11:50

@JJadx Год назад

apparently some people think doctors shouldn't google stuff. i'm so glad my doctor does haha. ain't no human remembering every drug interaction. great bg asmr for drawing once again b.t.w. mr ninjaman.

@AboobiadaAlmohager Год назад

I love your science prof. Zach ❤❤

@niyadeo7970 10 месяцев назад

Amazing!!

@alexmukisa Год назад

I appreciate you so much doctor 👍

@biybimaryamjoldasbaeva506 10 месяцев назад

THANK YOU SO MUCH

@hamlilasma5434 8 месяцев назад

thank you infinitely

@AMDALReviews Год назад

Thank you so so so so much sir 🌷

@darlingrunnerpt3342 11 месяцев назад

This makes sense as to why I have so many side effects with medications. Must be a very slow metabolizer. Had horrible side effects on 3 different DOACs. Hematologist had no idea why.

@bobj9923 2 года назад

Dr zach, what's your specialty? Cause you make videos about everything medical and it's mind blowing!

@tabatakalhelo3993 10 месяцев назад

Thank you doctor

@gabrielpetersen8528 11 месяцев назад

This is so interesting.

@carolinaruiz6227 Год назад

eternal gratefulness

@coconut2262 Год назад

😭😭😭😭😭😭 I can’t thank you enough sir..

@user-ut8hu8zs5w 2 года назад

Hi Bro, I am very thankful for your superunderstandable explanations and I may seem abrupt, but can you make a video about all fossa( infratemporal, temporal, pterygopalatine and so on). Please!

@ummkulthumabdussalam6726 10 месяцев назад

Hi, Omeprazole is an inducer not an inhibitor, thanks for the amazing class ❤️

@Taemna7 Год назад

I have no word to cheer up this angle😇😇😇😇😇

@mohammedabdulrehan6643 2 года назад

Thanks a lot sir

@urmilakumari6328 2 года назад

Amazing lacture!! Make lacture on pharmacodynamics plzzz

@PeaceOffmate Год назад

May Allah bless you and the entire team with immense success

@shahzadaliraza8345 2 года назад

Good explanation 👍 Just to notice, for CYP 450 inducers you mentioned the exls of CYP inhibitors and for cyp450 inhibitors the exls of CYP inducers are mentioned in haste. It is overlooked!

@prashanth-py9jc 2 года назад

Superbb sir always awesome

@doctortobe7345 Год назад

Thnk u 🙌🙌🙌🙌 u're the best ever

@MatimbaHope 16 часов назад

Yhooo this guy is something else❤️‍🔥❤️‍🔥❤️‍🔥

@kenshafirstyputrifariko854 2 года назад

Thank you so much

@tilwedie23 2 года назад

Do one on umbilical hernias or all the different type of hernias that can happen in the abdominal region. 👍

@Miah-jd1si 7 месяцев назад

fantastic

@PerfusionPrime 2 года назад

Thank you ninja nerd

@bawanomer1244 Год назад

Thanks.

@zainabfarooq5263 11 месяцев назад

Thanks

@lavinfatih8398 2 года назад

Thank you

@fatimah-2 8 месяцев назад

I followed you since 3y from iraq , keep going i respect you so much

@Ronaldo71543 3 месяца назад

May Allah heal the Iraqis whom suffered of cruel bush

@fatimah-2 3 месяца назад

@@Ronaldo71543 Amen

@90mehrunnisa32 6 месяцев назад

Oh! how much I love this man and his expressions🤌🏻😉

@fatimayusuf2802 2 года назад

Thanks alot Sir with your interesting concept,bt Sir don't know if you can also give concept on how to get a loading dose and maintenance dose,thanks Sir

@shryf742 Месяц назад

Thanks alot Professor Zac Murphy😊

@joyasia2752 2 дня назад

Good job

@karmagaming7112 Год назад

Love u 3000 ❤️ We are Ninja Nerds 🥷

@himalaydebsourav Год назад

you are simple awesome!!

@rakeshshah1074 2 года назад

U r amazing sir

@akinwonmioluwaseun6925 20 дней назад

I doff my cap Prof!!!

@ednulis Год назад

Fantastic videos! I can't find PK-Distribution :( Thanks a lot

@AhmedSalah-gw4wv 11 месяцев назад

Drug distribution isn't in the playlist of pharmacology!

@husseinsaied6061 Год назад

U R amazing ❤

@BaoTran-ls7oy 4 месяца назад

Thank you for great explanation and visually appealing board content! In phase II biotransformation, there are additional two substrate which are Glycine and Ribonucleoside/nucleotide synthesis. Can someone clarify this? 😕. Thank you

@shimaabdallah8719 2 года назад

So great 😍😍😍😍😍😍😍

@zizojaezekeom3565 Месяц назад

Amazing video ❤ i have a question please : in case of activation of drug, it passes through the two phases too or it doesn't?

@118_mirunaliniprem8 Год назад

Nee nalla irupa ya manusha ❤ love from Tamil Nadu India ❤❤

@mirror9lifer Год назад

I have a question regarding 18:48 - when turning a pro-drug into an active drug the effect is vice-versa. So an inhibitor such as Omeprazole would become an inducer, no? But then at 24:24 in case of a pro-drug activating we still have Omeprazole being an inhibitor. Not getting my hopes up that someone will see this comment and help out :)

@ranaarar1776 7 месяцев назад

These videos are awesome, and I really appreciate the time and effort you put into them.. I'm just confused about one thing, though.. you say that Amination isn't part of phase 2 conjugation reactions .. but in the curriculum I'm studying, it says it is and some Google articles also state so .. would u be kind to explain

@franciscosalgadoseixas1356 2 года назад

isn't codeine a prodrug for morphine? isn't it the opposite racionale? Thanks!

@tejrajpoot95 Год назад

Hey Ninja Nerd, BIg respect for you guys. I have been following you since last few months, and trust me no one has ever made me that focused to learn something as you did. i Dont know if you have time to respond on my confusion but still dropping one question here, So, as you said about codeine, with Poor metabolizer it increases toxicity in blood because it doesn't metabolize. but Codeine is prodrug of morphine so according to that with poor metabolisation it will not change into active drug and will not show the efficacy or therapeutic effect right? it means there are no chances of toxicity. please kindly reply and resolve this confusion. once again thank you so much for all the videos. it really helps. it does.