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As for Metoclopramide, it is also said to block 5HT3 receptors to some degree (antagonist). Interestingly, the mentioned increased gastrointestinal motility is initiated through the stimulation of 5HT4 receptors (agonist), which lead to a release of acetylcholine. Very good video, thank you!
The cause of motion sickness is not limited solely to the inner ear. It's because the different organs which we use to determine our position in space (inner ear, eye and cerebellum) sometimes send incompatible information to higher centers, resulting in nausea. That's why sitting in the front of the vehicle helps with motion sickness - because then we see the road moving in front of us, which is more in line what our vestibule and cerebellum pick up on.
Hi Armando; amazing video thank you. I am an advanced practice paramedic in the UK currently doing a prescribing course and this was really helpful. Maybe a little more info on the pharmacokinetics e.g. absorption, elimination and half life etc would have been extra amazing too...although I get that this is not where you were pitching this. Thanks and keep them coming.
Would love a updated video that includes Neurokinin-1 Receptor antagonists (Substance P antagonists) like aprepitant, fosaprepitant, netupitant, etc. Great video!
in the vomiting center, there are other several receptors like serotonin receptor cause if the vagus nerve transiting the serotonin signals it makes sense that it is only can attach to serotonin receptors but overall this was an amazing video thanks so much for your hard work
Fascinating. Our own bodies produce an effective anti-emetic, from one of those glands in the neck area. You can test it out by taking little sips of something that really "doesn't agree with you". When your body tells you either to stop or to throw up, ignore it and carry on. You'll feel something flow into the back of your throat which will quell your need to vomit. It has quite a distinctive taste, which I can't really describe, but pleasant. I understand it's a very functional thing for other species, though it rarely comes into play for us. Have a bucket handy if you try this experiment.
You probably should've mentioned this small detail regarding the medulla oblangata since it's pretty high yield: not only does it contain the vomiting center, it is also the reason why alligators are ornery (despite what mama says).
*Chlorpromazine 😊 Thank you for making concepts easier, making me understand things I couldn't quite understand from my books ❤️ right when finals are around the corner 😂
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Thank you so much for this video. We were just taught this topic in class, I forgot to bring along my book to review, so I was super happy to see this uploaded, helped alot.
I've experienced hyperemesis with all my pregnancies, currently my 3rd pregnancy and this was surprisingly the 1st time antiemetic medication helped at all.
Thanks Armando for a great video! One question; in the part about the vomiting reflex you say that one of the symptoms of the reflex is a tachycardia. Should't that be a bradycardia because of the vagal response when the vomitingcenter is triggered? Thanks again! Greetings, Jaap (the Netherlands)
you are a guru mehn...i can kiss u a billion times...u just made my day! make more videos on any health conditions and pharmacological approach...thanks a lot!
Excellent lecture! Never saw anyone make barfing look so fascinating and artistic! I'm serious. If you can do that for this topic, you can do it for anything,. Fantastic job 🙂.
Thank you for the video as it was very helpful to understand. You mentioned that Ondansetron is not recommended for 1st trimester, why? What could be the side effect to the fetus?
video is really nice. but please give the mechanism of action of prokinetic drugs like metoclopramide , dompirodone. u gave details about CNS effect hw it acts on g.i. please elaborate.
Thank you so much sir....plz make videos o chemo bcz it is very difficult to understand and remember..... I hav tried a lot of ways but no use......so plz plz plz
Can I ask you where dexamethason, canabinoids, benzodiazepines and NK1 receptor antagonists act? My professor told us they are anti emethics too but he didn’t say where their action was...Anyways thanks a lot, the video is clarifying!
