Pilot study of prophylactic anakinra to mitigate CAR-T-related neurotoxicity in R/R LBCL 

Neurotoxicity is a key side effect of the CAR-T therapy axicabtagene ciloleucel (axi-cel). Preclinical data has suggested that the IL-1-targeting anakinra can help prevent neurotoxicity. Paolo Strati, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, discusses primary analysis results from a pilot study (NCT04432506) of prophylactic anakinra, aiming to mitigate CAR-T associated neurotoxicity in patients with relapsed or refractory large B-cell lymphoma (R/R LBCL). Dr Strati explains the study design of this trial and reports that the use of anakinra reduced neurotoxicity by approximately 50%. This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.
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