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PNH: When blood machinery goes wrong 

nature video
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In paroxysmal nocturnal haemoglobinuria (PNH), the immune system mistakes red blood cells for dangerous invaders and attacks them. This life-threatening disease is triggered by a fault in the body's blood-making machinery, and although therapies are available, researchers are still working on improving treatments.
This Nature Video is editorially independent. It is produced with third party financial support. Read more about Supported Content here: partnerships.nature.com/comme...
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25 фев 2020

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Комментарии : 170   
@DefinitelyNotaFurrySpy-zq2zs
@DefinitelyNotaFurrySpy-zq2zs 3 года назад
Blood cell: forgets to put on name tag Immune system: so you have chosen…death
@neymeravenir6126
@neymeravenir6126 3 года назад
No that only thatsunlucky
@filipthunell8631
@filipthunell8631 3 года назад
immune system: sees a cell without a name tag also immune system: ALARM ALARM ALARM
@treesimp6686
@treesimp6686 3 года назад
so immune cells to blood cells without tag is like a teacher in kindergarden if you dont wear your tag.
@sinkrada419
@sinkrada419 2 года назад
Blood cell: forgets to put on name tag Immune system: THERE IS A RED SPY IN THE BASE
@WasabiSniffer
@WasabiSniffer 3 месяца назад
@@sinkrada419 WE NEED TO PROTECT THE BRIEFCASE!
@Tempst
@Tempst 4 года назад
One of the best animations from nature video
@bluelightstudios6191
@bluelightstudios6191 3 года назад
Blood cells: don't have tags Immune system: slaughters thousands of blood cells The Fred flintstone vita gummies I ate when I was 5: "Alright, someone better be explaining to what the problem is!!!"
@OvertakeYou
@OvertakeYou 4 года назад
Marvellous animation, pretty accurrate.
@AphidOs
@AphidOs 3 года назад
As someone who was diagnosed with pnh last year. First off these comments are very funny. 2nd I had to do transplant, my transplant failed but I’m doing a 2nd transplant. I no longer have pnh but the pnh caused severe aplastic anemia which is hard to get rid of.
@Syxany
@Syxany Год назад
I wish you luck, I'll be praying for you.
@hadihasan4661
@hadihasan4661 3 месяца назад
You”ll be fine soon .
@uchennamaria9291
@uchennamaria9291 Месяц назад
This is one of the most beautiful animations/explanation ever. I appreciate you for this. Thank you.
@lilacspring2556
@lilacspring2556 4 года назад
This level of communication is so inspiring
@djpupsik98
@djpupsik98 2 года назад
what did you expect from cells that cannot see/hear/speak in common manner? only chemicals, only hardcore
@applea8253
@applea8253 4 года назад
I DONT EVEN NEED TO LISTEN THE ANIMATION SAYS IT ALL. THANK YOU
@enderman700
@enderman700 2 года назад
There is more structure in yourself but u are the main leader of your body.
@professionalnoob5474
@professionalnoob5474 2 года назад
2:28 Pov: friendly fire is on
@gurkiratsingh4157
@gurkiratsingh4157 Год назад
That part where complement system came in and MAC was formed was just awesome Cleared my concepts
@nerdicperson6235
@nerdicperson6235 2 года назад
Its always fascinating how well the immune system can function in a body, and how easily the immune system can turn against the body.
@pribarros1681
@pribarros1681 Год назад
Immune System when a minor issue happens in your body: "you know when a kid screams? yea that"
@MominHashir
@MominHashir 3 года назад
even a lay man can understand the science with this channel. Awesome
@ritikatrivedi7468
@ritikatrivedi7468 Месяц назад
Best animation to explain this .
@revan012
@revan012 2 года назад
Should have also added that Paroxysmal Nocturnal Hemoglobinuria can correct itself. I was diagnosed with 80% clone size now at 0.2% clone size. I am very lucky.
@leilaali7896
@leilaali7896 2 года назад
Can you please share if you have followed any diet, medication. Also, were you following any treatment? What were your symptoms? Thank you
@revan012
@revan012 2 года назад
​@@leilaali7896 I was diagnosed with PNH back in 2004 with an 80% clone size when I was thirteen, back then the only treatment to "cure" PNH was a bone marrow transplant. However, the benefits did not outweigh the risks. the only medication I was put on was iron tablets, warfarin and folic acid. Before my diagnosis I was very active and fit, I played football, went running and trained in martial arts (Judo.) I had to stop after my diagnosis due to being put onto warfarin, contact sports were a risk. I did however, continue to run and started weight training (only light not extreme again due to warfarin.) My diet was manly white meat with the recommend daily intake of fruit/veg. I very rarely ate red meat. My symptoms considering I had 80% abnormality were mild. At times I could feel quite lethargic even with plenty of sleep, this was mostly after being unwell i.e common cold flu etc. Recovery from a cold/flu took longer than most people two three weeks. The main symptom that led to a PNH diagnosis was after a bout of very dark urine (deep brown.) caused by haemolysis. Even with the destruction of red blood cells I did not need to have blood transfusions. I was already being seen by a haematology specialist due to low red blood platelets however, I was about to be discharged from their care due to this returning to normal levels when the PNH symptom occurred. The main treatment for symptomatic PNH is eculizumab (Soliris) with also ravulizumab becoming available on the NHS. The cost on average for both is still exceedingly high so I do not know if it is covered by insurance. luckily I am in the UK so both are covered by the NHS.
@nayanc6533
@nayanc6533 8 месяцев назад
I also need this info 😭
@hadihasan4661
@hadihasan4661 3 месяца назад
How , can you tell please.
@silent0089
@silent0089 3 года назад
Good thing AE3803 wasn't one of those cells but a clumsy sickle red blood cell
@soulfulsinger7447
@soulfulsinger7447 Год назад
Such an amazingly done video. Bravo !
@elizamaria3008
@elizamaria3008 2 года назад
Brilliant work!!!
@paulborisiv519
@paulborisiv519 2 года назад
So the Immune System basically miss-identifies it as a Cancer Cell, interesting, at first, going by what i saw in the initial part of the video, i started assuming it was a problem during the T-Cell's Activation, that for some reason faulty T-Cells were not being killed and had "graduated" despite their bad-readings, way to prove me wrong, still kinda interesting to look into :) Thank you for sharing such vital information and educating others!
@65snehakothapalli98
@65snehakothapalli98 3 года назад
Very WONDERFUL and intriguing level of explanation and visuals combined, simply awesome..keep doing more
@orenkrimchansky
@orenkrimchansky 4 года назад
beautiful!
@hili4763
@hili4763 Год назад
Excellent illustration THX
@wiamalbouzidi7778
@wiamalbouzidi7778 Год назад
Thank you!
@ibrahimssen
@ibrahimssen 4 года назад
Nice video, thanks.
@alijasim8567
@alijasim8567 3 года назад
Great explanation, amazing job, thank you so much👌👌👌❤️❤️❤️
@artiomvas
@artiomvas 4 года назад
Awesome animation
@tysoncook5152
@tysoncook5152 2 года назад
Very well made!
@itsquran
@itsquran 3 года назад
thank you for this video its amizing
@gamerx112
@gamerx112 2 года назад
great. just yet another thing to be thinking about.
@exactscallion7
@exactscallion7 8 месяцев назад
Amazing visuals ❤ beautifully done
@aashishshah6695
@aashishshah6695 3 года назад
You guys should make more of these videos its does help us as a medical student
@Mahdi.alkawaz
@Mahdi.alkawaz 3 месяца назад
Really good work guys
@vivekanandabhat
@vivekanandabhat 3 года назад
Extremely good
@MrDESHAN93
@MrDESHAN93 3 года назад
Great job. 🤩
@studytime4231
@studytime4231 Год назад
Thank you
@comfynarwhal
@comfynarwhal 2 года назад
This reminds me of something else I was watching in yt shorts and how they made something so boring like science (at least too me) a lot more understandable and fun to learn with a cute animation like this that gives you an idea on how it works by using more understandable stuff like the certificate on the blood cells
@manel8843
@manel8843 2 года назад
Kurzgesagt is kinda like this way,i really recommend kurzgesagt channel!
@DaGreyCar5734
@DaGreyCar5734 3 года назад
Wow awesome animation.
@mrnerd73
@mrnerd73 3 года назад
Excellent presentation.... And animations are soo cool❤️❤️❤️❤️
@Polaris97
@Polaris97 3 года назад
Wow! This animation is very amazing. You get entertained while learning at the same time
@Santy_4799
@Santy_4799 2 года назад
Beautifully animated holy shit
@nitinnarwade4075
@nitinnarwade4075 3 года назад
Mind blowing. The perfect scientific illustration for the people with non-biological background.👌👌😊😊
@hennabyrg9053
@hennabyrg9053 4 года назад
Amazing video 😍
@dncmi1436
@dncmi1436 3 года назад
1:52 look at the bad boi behind.....the expression kills me 😂😂😂
@drilldoggoboi5618
@drilldoggoboi5618 3 года назад
That's cells
@sucsotheautdam1311
@sucsotheautdam1311 3 года назад
@@drilldoggoboi5618 That's bacterial
@sucsotheautdam1311
@sucsotheautdam1311 3 года назад
A green boi
@Noavailableusernamesadly
@Noavailableusernamesadly Год назад
This video taught me more than my biology teacher for 2 years
@nnjz679
@nnjz679 4 года назад
nice video!!
@JiveDadson
@JiveDadson 4 года назад
Can you do one on polycythemia vera?
@stol9r520
@stol9r520 2 года назад
Хорошее! Познавательное Видео.
@canavirichurakarenanahi9670
beautiful
@muna-cv3wo
@muna-cv3wo 4 года назад
Correct, 👍
@leanntuck807
@leanntuck807 3 года назад
Keep doing this
@user-km4we4xm1l
@user-km4we4xm1l 6 месяцев назад
The most interesting video I have ever seen 🎉❤
@fauxvier8519
@fauxvier8519 4 года назад
Curious!
@maxjpz
@maxjpz 2 года назад
Interesting to have this recommended, but very informative so I don't mind it.
@Snaomib
@Snaomib 7 месяцев назад
the sound effects went crazy in this video lol
@jayvoncampana7231
@jayvoncampana7231 4 года назад
Nice and beautiful...
@bonvg6037
@bonvg6037 2 года назад
Please make educational video more like this
@stevesabba2379
@stevesabba2379 2 года назад
Doing my ULTRAKILL homework dont mind me
@godzuky2743
@godzuky2743 3 года назад
RU-vid: "COVID-19 Get the latest information from the CDC about COVID-19." Literally anyone with eyes and ears watching this: "Yes thank you for telling me something completely irrelevant to the video I am watching explaining a blood disorder."
@heathenspider
@heathenspider 3 года назад
better than a science teacher
@zelmaria6363
@zelmaria6363 3 года назад
Very nice I like it
@davieugenio6495
@davieugenio6495 2 года назад
i hate how such a amazing video is getting constantly memed by people without sense of humor nor intention to understand
@hammoodraad2011
@hammoodraad2011 3 года назад
omg i love you soo much thank you
@106tricey
@106tricey Год назад
2:21 rip cell
@haiaarshid3781
@haiaarshid3781 2 года назад
wow love it
@fantasyromance7560
@fantasyromance7560 3 года назад
Scary.
@mariusphilippebulawan4671
@mariusphilippebulawan4671 3 года назад
Blood : i got forget my tag name Complement system: u haven't a tag you chose die Blood : owww Complement system : release light Dead blood : nooooo... X _ X
@TheAlextv100
@TheAlextv100 5 месяцев назад
For anyone who is more curious about this disease and the current leading theory behind the pathology: While we sleep, our breathing slows down, meaning that there is a decrease in oxygen in our blood. Importantly, due to metabolism, the production of CO2 will continue as we sleep. Due to CO2 having acidic effects, we will find a decrease in blood pH. This decrease in pH is what activates the Complement system as we sleep (which is an entirely normal process). In normal patients, our Red Blood Cells carry a few proteins that prevent the Complement System from attaching and attacking. These proteins are called CD55 and CD59. In patients with PNH, they lack the ability to SECURE these proteins to their cell surface. This is because the PIGA gene cannot produce the appropriate anchor proteins. In other words, patient's with PNH fail to create the anchor protein needed to hold the CD55 and CD59 proteins in place on their cell surface. Therefore, without CD55 and CD59, the red blood cell is defenseless against Complement when it is activated in our sleep. When Complement binds to a cell, it will literally punch holes into that cell and cause the cell to "bleed out." Almost like getting hit with a 12 gauge slug to the chest hundreds of times. Hemoglobin is very toxic to our cells, so when it leaks out of the red blood cell, our liver will quickly dispose of it by sending it to our kidneys to be urinated out. This is why patients of PNH wake up with dark red urine when they wake up! Hope this helped further explain the disease.
@Kham_Gualnam
@Kham_Gualnam 2 года назад
I had to go to the hospital before and I got a lot of “needle” shots
@hernanhernandez6771
@hernanhernandez6771 2 года назад
I have this and I’m so nervous I’m afraid of a bad outcome
@ezgi8684
@ezgi8684 8 месяцев назад
harika bi video
@shahirajgill
@shahirajgill Год назад
Wow! One of the Research wore Turban.
@zev1342
@zev1342 4 года назад
Epic
@OMA407
@OMA407 7 месяцев назад
A guy in turban was a researcher... I liked 🎉😂that
@KaYA_Over
@KaYA_Over Год назад
Maybe some day, specialized blood robots will be able to detect whether a blood cell doesn’t have an authentication stamp and block the inspectors from destroying it.
@meenu7282
@meenu7282 2 года назад
Wow👌🏻👌🏻👌🏻
@carocardozo1507
@carocardozo1507 3 года назад
Genetic engineering is going to save and change so many life
@mariusphilippebulawan4671
@mariusphilippebulawan4671 3 года назад
Blood : nope hurt Antibody : touch hand Complement : what is your problem Antibody : ???
@ironphilly2366
@ironphilly2366 3 года назад
how about something that detects it a faulty cell
@havingicecream
@havingicecream 4 года назад
Very cool, thank you! Is this due to a spontaneous mutation or is it inherited?
@revan012
@revan012 2 года назад
You cannot inherit PNH. It is an acquired genetic disorder.
@havingicecream
@havingicecream 2 года назад
@@revan012 thanks!
@trashyCorn.12
@trashyCorn.12 2 года назад
2:23 if only the incpetor cells could see also I probably spelled insceptor wrong
@frater380
@frater380 Год назад
This is an ultra rare disease. I was diagnosed with PNH three years ago.
@ibrahimserdaralemdar8414
@ibrahimserdaralemdar8414 10 месяцев назад
I was diagnosed two months ago. Which treatment do you follow? How is your general situation? Thanks
@nayanc6533
@nayanc6533 8 месяцев назад
My father was diagnosed with this in 2014 he is still doing good with some homeopathic medications but needs blood transfusion once a year
@JP11155
@JP11155 Год назад
Am I the only one who thought the thumbnail looked like Kirby/Kirbies inhaling something?
@gregorymalchuk272
@gregorymalchuk272 4 года назад
Can they genetically modify the defective hematopoietic stem cells to the correct state, then reinject them as an autograft? Also, what is the typical penetration of this mutation? Does every cell in a victims body have it? If not, the genetic engineering part might not be necessary. Just separate and culture the healthy stem cell lines, nuke their bone marrow, and infuse it back in.
@Slapper9000
@Slapper9000 Год назад
RIP Blood cell
@mrhoho
@mrhoho 3 года назад
Good day. mate.
@AverageViet
@AverageViet Год назад
Tell the brain for not fixing the machines
@alybec1
@alybec1 3 года назад
Very sweet عسسسسسسل
@uncredited_user2602
@uncredited_user2602 2 года назад
0:17 iPhone alarm 😳😤😤😳😳😩
@TheZlegende
@TheZlegende 3 года назад
jey, swiss is in it XD
@rohaizaismail2037
@rohaizaismail2037 Год назад
😢 TX
@user-xy6om5hn1u
@user-xy6om5hn1u Год назад
Bit the red bone marrow is most responsible for blood .
@NPC1173
@NPC1173 5 месяцев назад
No CD55 CD59 complement attacks rbc
@skshahnawaz686
@skshahnawaz686 3 года назад
Plz sir help me pnh treatment easy tip
@RandomGuy-gw1cu
@RandomGuy-gw1cu Год назад
watching this for no reason lol🧿
@glinda9243
@glinda9243 3 года назад
Our daughter has this. She recently lost her pregnancy. "Kaitlynn's S Struggle With PNH" onn GoFundMe.
@jasonchen9916
@jasonchen9916 3 года назад
jokes on you i eat 10 vitamin gummys each day
@sueannabenson4267
@sueannabenson4267 2 года назад
0:13 starts the mutation
@jamesizaacjaafar
@jamesizaacjaafar 11 месяцев назад
Paroxysmal Nocturnal haemogloblnuria or pnh 0:11 0:11 0:11
@Beamattack862
@Beamattack862 2 года назад
NO NOT THE CELL! NOT THE CELL!!!
@adrianalonzo2868
@adrianalonzo2868 3 года назад
tommy??
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