Psilocybin Induces Long Lasting Modifications to Brain Connections 

Research has shown psilocybin to have potential to treat a range of psychiatric and behavioral disorders.

I have been depressed for a long time, but after taking shrooms few months ago, l feel much happier and highly motivated and my ADHD gone , lost a ton of anxiousness and had a few epiphanies about how I should live my life. I decided to buy an ounce for backup, but haven’t yet felt the need to take any more since then.

I tried micro-dosing yesterday for the first time, and I had wonderful experience. I'm someone who suffers from chronic depression, and I was simply happy, not overly ecstatic, but genuinely happy and active with my friends and family. I was even excited to get out of bed this morning.

One of the uses of psychedelics is administering psilocybin to cancer patients, it allowed them to confron their mortality, remove fear and anxiety and to die with peace and equanimity. What a gift this is.

This is the power of psychedelics. I used DMT hoping to get rid of some chronic pain associated with a mowment disorder. I got so much more. My brain learned to stop creating pain and then find abstract ways to turn those sensations into useable signals. Not even a year later im not even the same person and dont think a neurologist could even see abything wrong at all. I had previously been told physical therapy wasnt even worth trying.

Anybody who has undergone intend psilocybin therapy will understand that trying to get life changing therapeutic benefits of psychedelics without the trip is laughable.that’s what rattles you out of depression.

I have been finding microdosing psilocybin very useful for fatigue and ADHD. The fatigue which is psychosomatic seems to be eradicated by psilocybin. It's literally incredible. For the first time in years I can work physically all day and still have enough energy to do sport after. I can also focus on tasks, work systematically, and be very focused. I also stack with Lions Main, Reishi and Siberian ginseng.

I was more than a year in the pain clinic for back pain. extremely painful attacks in my back. Had many injections in my back, several treatments nothing helped. Most of time a was in extreme pain and couldn't do anything. After one session psilocybin my pain was gone. In that session a owl took me to walk through my spine and I saw that it was clean en healthy and strong. Somehow my brain had made this information to reality.

My last trip kicked my ass. The shrooms had enough of me abusing them. They sat me down and had scolded me like never before. I saw all my flaws, all the wrongs I’ve done. My body felt old, frail, damaged. My nerves were damaged. I was alone, felt alone. They showed me that staying in isolation away from friends and family will not lead to happiness. I have been pushing life away for too long and it was time to pay consequences. Normally I have fun, light, wild trips. Like a vacation from life. This time, no vacation, no fun. It was time to sort myself out. It was very difficult. Now a few days later I feel like I am glad it happened. First couple days were not easy. I felt broken and alone. Now I have begun talking to my family again and am starting to feel like myself. Shrooms can have a great impact, but I would not say it’s easy !!! Have a plan !!! Trip alone is okay but have a safety plan or someone to call. Good luck friends 👍

Mushrooms helped me get of opiates. Truly magical. They helped me connect with the past, present, and future. I was able to build new and rebuild old bridges. These connections allowed me to remap my mind and life. It gave me the inspiration to break through a massive barrier that was controlling my life. 1.5 years later now, my life has changed in wonderful ways.

I have server ptsd spent 3 years in and out of a hospital for self check out reasons. I friend gave me an oz and said eat this. I didn’t know anything so I ate it all. Hard night but I have never wanted to self check out since then and it’s been 13 years. I owe a lot to mushrooms and teaching me about how beautiful the world could be again.

Me and a friend had our Psilocybe Cubensis up for the first time in 1978. What I noticed early on was how the mushroom built its threads and created a network in the jar, which was completely snow white. It glistened from the small drops of moisture that the medium created. It was a powerful experience and the network really resembled what is in the brain. I was struck by the beauty of the image and you could clearly feel a great intelligence present within this network. A biological internet of the highest kind. We knew it early on, and now the facts are finally on the table! It has been with me for over thirty years, opening unimagined doors to paying attention to the great world, beyond the horizon of the five senses. Thanks for passing on this important knowledge!

Its changed my life. Its given me feelings i havent had in years back Its also made my brain quiet

I have never used psilocybin for depression, but I have used LSD for spine pain management when my pain is so severe, nothing touches it. It works! Another friend who has similar spine pain from a deformation in the spine tried it and it worked for her as well. We definitely need to explore unconventional treatments like these more and change our thinking about pharmacological treatment options.

I was searching for a non vulgarizing video about psilocybin effects on the brain, finally found it! Thank you mate, it was very interesting.

I stopped taking anxiety medication, had 2 mushroom trips 1 week apart, and I have to say I feel so much better. Happier, more confident, more engaged, I am certain that the mushrooms helped. I also believe that they may have played a role in human brain evolution.

During a singular occasion, I decided to embark on a profound journey by consuming what is commonly known as a heroic dose of mushrooms. Little did I know that this extraordinary experience would transport me to a realm of surreal enchantment. As the effects of the mushrooms began to take hold, I found myself standing atop a verdant hill, surrounded by an ethereal landscape that seemed to pulsate with vibrant life. It was there, in that magical place, that I encountered a majestic being-a gryphon of immense stature and elegance, known by the name of "The Hornigan." The Hornigan's regal presence was accentuated by an intricate golden helm that adorned its noble head. With wings outstretched and a commanding gaze, it exuded an aura of wisdom and transcendence. Engulfed in a mix of awe and wonder, I engaged in a captivating conversation with The Hornigan. Its words resonated deep within me as it expounded upon the wonders and majesty of conscious existence. The Hornigan spoke of the interconnectedness of all living beings, the intricate tapestry of the universe, and the boundless potential that lies within each of us. That is the reasons governments the world over try to criminalise its use because it is very useful and directly contradicts that which the governments the world over would have us believe.

They provide the only “great reset” of any true value! ❤

this is amazing the promotion of these connections is literally the science of consciousness

When I was 14 years old I was diagnosed with traumatic scoliosis resulting from a car accident. For years my orthopedist would tell me it's irreversible and surgery was my only option. The pain and nausea were so unbearable I was willing to try anything but refused surgery time and time again. And by pure happenstance, I took about 5 grams of mushrooms ONE time with some friends and I was CURED the next morning. Went to get xrays done a week later and the look of perplexity on my doctor's face when he saw the results, I'll never forget it. And needless to say I've been taking them ever since. Now mushrooms aren't for everybody, but I encourage anyone to try it at least once in their life. Especially those suffering with chronic back pain. But I'm also not a doctor so do your own due diligence.

I suffer from Bipolar 2, and Borderline Personality disorder. I spent many years in counselling, and still see my psychiatrist on a regular basis. I take my meds regularly for many years now and have found the combination that works best for me. I have done both CBT and DBT therapy a number of times. A couple of years ago I started experimenting with micro dosing and have gone through a number of off/on cycles now. I tried short lengths of time taking it, I tried longer times and different breaks in between etc. I can say beyond a reasonable doubt that it makes a very noticeable difference for me. My depression and anxiety are pretty much non existent and I am far more motivated and interested in things. I cant praise them enough for the changes they have helped me make in every aspect of my life.

40 yrs of the regular toxic meds i really need to try this. blessings on everyone in here and their journey to health

Brings new meaning to the old saying "Grow a spine!"

I micro dosed for a different reason than my spinal issues I had. I kept noticing my micro dosing regimens was helping my back pain. I did a longer than normal micro session for around a month, normally did 2 weeks stents. My back feel so good right now. I broke my L5 and T12 and has disc damage afterwards on 3 different occasions. I feel really good and it somewhat surprising. I really think my micro dosing did something to help repair my muscle tissue in my attached muscles and it helped with nerve pain a lot.

Very interesting, thank you so much for explaining things, I would love to check out more of the publications you suggest. But , despite my best efforts at teaching myself as much physiology and anatomy as I can I am always amazed at the fact I don't really understand anything. As soon as I think I have a grasp on things I realize there are so many more, deeper levels to it, that I just can't keep up. It would take lifetimes to understand wtf is going on inside me every second.

I definitely feel like my nervous system gets a reboot. I have a lot of neurological damage so its nice to know shrooms are actually good for you in moderation. Its as if the mushroom wants you to know how beautiful it thinks the universe is. You instantly feel cosmic connection and realize life is a presentation for you to give and receive and simply make the universe a warmer place. I say if everyone could try it, we could find forgiveness without God because we would find it in ourselves to make every day count. If I feel sad I just remember what I learned. Sadly it also requires a place to feel safe and secure or you feel the opposite.

Psylocybin micro dosing cured my anxiety. Got me over opioids and gave me my life back. I am now a very social person. It really cured my nervousness when it comes to public speaking too. This stuff should be legal everywhere.

First time on your channel. Well done. Thank you.

Please keep going on in study of depression treatment, i need your help! Thank you for work!

From first hand experience I will say that after "experimenting" with psylocibe cubensis mushrooms I noticed my own capacity for learning and adapting to situations grew, I'm not exactly sure how to explain what it was like before it's as if that was me but I didn't know that I had such a deficiency in my own intellect or abilities but after I can't learn enough I have a thirst for knowledge that I wish I had when I was in school. I was in my mid twenties and was a bit of a cold I enjoyed drinking and good times with friends. As it would happen the friends had told me about mushrooms and the good time it was, had some and I tried it. Not scientific in any way and I wanted more because I really enjoyed the intoxication they provided I procured them a few times from various sources and decided that I'd make my own to be sure if what I was getting and quickly found my self reading and seeking out more info on almost every subject that I came across. I never microdosed I was going after profound experiences, and found them eventually it seemed to slowly lack in the psychedelic experience and I would have to wait longer and longer between trips to even get a experience at all first 3 days then 5,7,10,15 days till I could get the psychedelic effect, as it got to be too much of a stretch and larger amounts to achieve the results I lost the desire to continue and gave it up. I still find and consume cubies but I still don't get the mind bending introspective moments I remember but I enjoy what I do get which is only a watered down version of the experience. The change in my personality is positive and I feel like my mind plasticity is that of a toddler. I adapt to horrible situations so quick it seems like there is nothing I can't handle. I have seen the new micro dosing trend and I'm intrigued. I'm curious if there would be benefits to persons with brain injuries the ability to regain or gain in general better cognitive reasoning and motor skills. Increases eye hand coordination (I learned to juggle when I was 12 after my mushroom experimenting I learned to do it with one hand, in a day) theres going to be a lot of new ground covered with psychedelics in the near future, I hope the others out there like myself can contribute to the good that will come.

Fascinating and uplifting. Thanks.

Mushrooms saved my life, overnight. I went from several suicidal thoughts every day, down to zero. That was 18 months ago, and I'm still alright.

I use just over threshold ammounts before doing something im not necessarily good at. I find that my progress at learning tasks is improved when i do this and the growth in that skill is measurable.

Mushrooms cured my depression and led me into my autism diagnosis. I'm glad they exist.

Good to see clean science about this

Thanks for the info!

I appreciate your presentation style & articulate content. Very 👍🏾. Immediate subscriber. I check your videos list I didn’t not see anything on MDMA/MDA & brain 🧠 from your neuro pharma perspective. Would very much like to see that.

Your careful way of speaking, makes your words so clear, and easy to understand. Thank you. Your pronunciations are very helpful. I’m so glad you take time. Thank you for the useful synopsis!

What a great work. Your accent is very interesting, and your pace and pronunciation is excellent. A pleasure to listen to. Subscribed.

You are so right Dr Sage. Thank you for being open and caring. Very spportive in getting people to realise that they are entitled to have there real thoughts and feelings. 👍👍👍🤞🤞

What a class, good quality content, explain very well the points, news dendrites can increase the neurotransmitters connections.

Interesting video, kiitos! I wonder if there's any studies / data on possible treatment some ASD symptoms and eating disorders with psilocybins.

Fascinating mushroom health benefits information. Sending love and warm greetings from Missouri.

Utterly fascinating.

Erittäin mielenkiintoinen ja valaiseva video.

Since it’s believed the mechanism that produces psychotropic effects for ketamine and psilocybin is from binding to NMDA and 5HT2A receptors, respectively. Does this suggest a single common receptor for binding that stimulates dendritic growth or is it through binding to their respective receptors (mentioned above) that initiates or stimulates additional cascade pathways that drives growth? Or did the authors speculate?

Great video, great channel! Subbed!

I love how he sats dendritic spines!

I've see improvements in me. I bartend and I have noticed that I consolidate my time effortlessly especially multitasking behind the bar. I had long covid and my brain was fried from it. I honestly feel like a different person. But like everything use with extreme caution I can see experiences going down hill in every way.

I experienced the anxiety and depression relief that mushrooms bring. It was a good and bad experience as I had a bad trip too. I have to say exercising such as walking also had a tremendous effect on my anxiety and depression. I was on pills for a few months so I know a little bit about this topic. I quit the pills due to the lowered sex drive and the panic it would cause when I was out of pills. Never again.

That's awesome because I've had to do it the old fashioned way.

Yep. Made it much easier bro. Thanks!

Ah, so that's why it felt like I became more intelligent while under the influence of shrooms. I love it when science catches up to intuition/common sense.

Here I was, hoping magic mushrooms would make me taller.

Im not surprised. Psilocybin is here to help

Great explanation, tank you.

I have no idea what a " dendritic spine " is , but I have eaten so much psilocybin in the last 35 years that I should have them growing out of my head !

Try the fadiman protocol around 100 mg and you'll see positive changes. Increased empathy, more clarity in your thinking, calmer thinking, sudden light bulb moments and insights you weren't aware of before (on all kinds of things), and stronger memories of your childhood as if it was yesterday and all positive that give you happiness and joy being thankful for all the wonderful things that made you into who you are today.

Wow, thank you.

Thank you!

I like to see real data like this.

It works.

I healed my spine by microdosing a strain of cubensa with lionsmane. I had a compressed disc due to dehydration and moved incorrectly so I torn my spinal column. Worst pain ever in my life. It took months to heal my spinal chord injury with microdosing, What I learned during the process is to eat alot of clarified oils with the microdosing: Ghee, omega 3&6 oils. This speeds up the process.

iboga is one i suggest researching thoroughly in regards to this sort of benefit and more

I took it a few times last year and I had 4 months of intense visual snow and tinnitus. The effect is almost gone, but I can still feel it sometimes. I hope the someone tries to study the side effects as well. Remodelling is not always good.

The Psilocybin mushroom might taste awful, but it actually made my depression better.

I definitely believe it. I've eaten this stuff now and then since I was like 15 years old. I can definitely say without sounding super egoic that my brain developed beautifully. Doing shrooms now and then and smoking weed definitely helped me evolve mentally. Its abusing the hard stuff that becomes an issue ( Mostly because hard drugs compromise the immune system, making You susceptible to chronic disease infection ) . I believe the body is fully capable of repairing damage done by drugs and replacing dead cells with healthy ones, but when the body becomes infected with chronic disease, it's no longer able to do so efficiently, so its very important to be careful when doing drugs. For instance, say You are doing cocaine or sniffing some sort of chemical, You dont want to put a finger in Your nose and touch any potential scar tissue, because it could get infected with whatever bacteria You might have on Your finger. Then of course theres the more obvious ways to contract infection like STD's. Dont believe people who say smoking weed makes You dumb. I knew a guy who smoked all day everyday, but he also studied all day and He was beating out all the other kids in his college with a grade of like 99.8% and I think second to Him was like 99.3% . I believe diet plays a huge factor as well as overall mood and of course, habitual daily lifestyle choices.

I confirm that mushrooms are affecting spine cord condition from my own experience,, but would like to mention that it's not only related to psylocibin mushrooms, Medicinal strains like Lion's Maine, Reishi, Chaga etc. will make your cord dance like that cobra )))

Took a dose of shrooms soon after a near death experience. Said fuck it. After the psychedelic experience I felt a lot better about it. It helped me process how I feel about myself and my life in that time. I still feel awful about nearly dying but the improvement was noticeable.

Thanks for posting, any bit of accurate, breakthrough scientific data helps me understand my anecdotal knowledge better.

I'm growing my dendritic spines all day today!

I am not being hyperbolic when I say it saved my life when nothing else worked

Here we go again, the materialists will not talk about psilocybin's benefit to spiritual growth, if you took psilocybin you would realize that indeed there is a spiritual component to the human and to the world .

Lions mane mushroom has similar effects too.

Great stuff.

Does it grow presynaptic nmj

So this with Lion's Mane Mushroom combined could reduce and or reverse dementia???

In the mid 70s when I was 15 years old, I picked a bread bag full of psilocybin shrooms and ate most of them and survived. Since then, in '74 and '77, I had powerful and very real telepathic encounters and countless metaphysical "miracles" happen but not sure if there's a correlation, as I'm hyper-spiritual anyway and live an amazing flowing life.

For me I've always felt it "Lubricates" the brain for a few months. And first time experiences can allow to you to see the world different, more positive way for life. I'm an artist I certainly feel it helps me in some aspects of creativity. Always in moderation, do your research. Setting is paramount.

My mother has nerve damage along her neck legs and hips and doctors cannot figure out what is wrong. She had what seemed to be “mini strokes” last year and has foggy memory along with the body nerve symptoms. They’ve told her they just want to put her on “pain management”. Do you think that microdosing could help with her body nerves as well? She has numbness and sharp pain occasionally.

I doubt it

I had the same effects doing the Gateway Tapes.

been microdosing golden teacher shrooms for just over 2 months. i started after MS diagnosis. my gait , cognition, focus. balance are all slowly improving.. improvement comes, kind of in the same timeline as these ablities were eaten away... about a month ago i added lions mane to my microdose schedule. kind of feel like i'm running my own personal research project!! feel much more alert and physically energetic, which is sooo great. this has better risk:benefit ratio than DMT's , and it's working i think! btw, i worked critical care for almost 25 years

Every time I’ve taken psilocybin I’ve felt that I have much better posture and I feel taller. I wonder if this has anything to do with that

Can anyone recommend a safe source for psylosybin capsules in the UK?

Ate so much psilocybin and mushrooms when I was younger maybe that's why I'm awesome

One really cool thing to look at when You're high on mushrooms is holographic collector cards. Look at Your old pokemon or Yugioh cards when Your high. The colors are so vibrant from the shiny holographic images. Its gorgeous. I remember being high and watching a tarot reading once and this girl had this set of cards called Alice the Wonderland Holographic Deck . One of the prettiest things I've ever seen when lit.

I first used psychedelics when I was 15 years old. I did them a lot. And I think it actually damaged my brain. Initially it enhanced my brain. The first two or 3 times, I gained the ability to draw spontaneously and became extremely organized and my grades in school increased. I don't know if it was the shrooms, alcohol, or marijuana, but eventually I lost all of these gains and have been confused ever since with memory and recollection issues. I would say kids should not do drugs or alcohol. Perhaps once your brain is developed try it a few times.

4:29 It can last 34 days... Could this explain why some people experience a month-long lasting psychosis if we interpret psychosis as a long lasting increase in Glutamate activity? What about people who "trigger their schyzophrenia" with drugs by (maybe) permanently unbalancing their GABA/Glutamate balance? And now, maybe a stupid and uninformed question but could the lasting anti-anxiety/depression effect from psilocybin be the result of the brain "remapping itself" during a glutamate storm, thus learning to manage such an overload of stress? I have so many questions and I have no idea on how to do my own research.

Counteracts: * PTSD ("shell shock" - constant nerve firing caught in an endless feedback loop) * Nerve Entrapment (again, constant firing) It does this by: *Increasing connections of nerves. *Increased connections to allow communication bypassing compromised neurons And / Or *Allows compromised neurons to brake the feedback loop. - Both causes over a prolonged period will rewire the brain - A rewired brain will produce body chemistry chemicals (estrogen, testosterone, seretonin, etc.) - If you treat chemical shortages without fixing the "overloaded feedback loop", its not a fix, just a "band aid" - When fixed, the chemical balance will be off again and need revaluate to rebalance with correct medication. (1) This will not resolve PTSD - Survivors Guilt (2) Selling you a band aid is more profitable for pharmaceutical companies than the fix (3) Finding a good doctor that is more concerned with your total health and not just a quick $$$ will be the hardest part in today's age

Cured my PTSD

Het i started smoking weed, wax, and tobacco products at age 13, and only quit about 7 months ago, (18 now) ive been reading studies on how much cannabis use in adolescence fucks with your brain, learning, memory, and development, and behavior overall. It's made me super scared and neurotic over my memory, I'm working on my emotions and psychology interally, but is there any way I can treat my brain? Supplements that would reverse the detrimental effects of my stunted development? Restore memories? Gain a better learning capability?

A large number of people I talk to about this believe microdosing with LSD will have the same time effects despite it being derived from ergot . Are there any study's to support this or is it just a public misconception that's becoming widely believed?

Golden teacher 🍄 👍

I’ve been battling with alcoholism for over 15 years. I grew my own mushrooms and with microdosing and 2 medium trips I got 75 days. During that time I got into hiking. One of my hikes was the best day of my life, absolutely amazing. I stopped taking mushrooms because of the stigma from others and started drinking again. Later I was diagnosed with ADHD and prescribed Ritalin. I was honest with my psychologist about my history of drug abuse and alcoholism and he still gave it to me, and now I am totally f’d. Like everything it started of Ok, but enough is never enough for me. I’m trying my best to get the strength to grow them again. I can say first hand that mushrooms worked for me. But do your own research and make sure it is right for you and know what you’re getting into. I think mushrooms could be beneficial for most but it’s not for everyone, if you have a slippery grasp on everyday reality just do your homework first. I wish us all the best 🙏🍄🌅

Noticed the Finnishness immediately

Hope it helps you all

The thing is that there is still a difference between shrooms with ripped hymen/veil and ones picked prior to it opening. Ofc if you have alrdy done the ripped ones tones of times you might not notice. I also prefer very very small/low doses from very very big shrooms. And not more than 0.1g at once, but might take 3-5 times from it in a day. Also add lemon (juice) and dark chocolate, it prevents almost all bad experiences. Ofc from time to time like 2 times a year, some years 5 times. I take like 1-5g and when I eat them fresh (which is 90% more mass) i sometimes consume like 100g over the period of a whole day. But that exp needs to be prepared for, alone in my room on my bed, laying down, relaxing, having a playlist, making plans and thinking about stuff. But low doses of lsd is also awesome, some derivatives are legal in some places. Just saying "less is more" because when you are still in control, you gain more control instead of seeing your skin fall off or having gigantic trash piles with insects n stuff, is "being in control", which means "getting what you want", the problem is "when I tell you my secrets and you copy me, you might get what I want and thus I don't get it", which is why there is a lot of wrong information out there, other people telling you bs, so you mess it up and do "a science of a thing where you don't realize the bottleneck of a problem and have completly warped views on variables" - that's all I'm saying.

I had a gram of mushrooms two days in a row… I didn’t take any for the next 5. I noticed that my brain seemed to be permanently different. The baseline of my mood has shifted.

Given the results of this study and the existing body of work done on Psilocybin, would you personally ingest it if you were suffering from depression? Just curious 🙂