Psoriasis and beyond: targeting the IL-17 pathway 

I was diagnosed with PSA 16 years ago and have tried just about every biologic drug out there. They usually start working but then after a while become less and less effective. I have been on Cosentyx which is an IL-17a blocker for a few years now. I noticed that it worked well but never quite lasted the full 4 weeks between injections. My rheumatologist put me on a 2 injections a month regimen but said I could take one every 2 weeks and that seems to be what works best for me. So far so good. It is pretty interesting to see how the stuff actually works. I assume the inflammation causes the same problems in the joints that they do in the skin. When I was between jobs and thus between insurances I couldn’t take anything but ibuprofen because the costs were ridiculously high. My joints got so swollen and sore and my TMJ froze up as well as my neck. It was horrendous. I’m very thankful that my employer has amazing insurance coverage but unfortunately not everyone does. It really sucks that here in the US you have to chose to get meds that help you move and function or pay rent and buy food for your family. No joke… each shot is at least $1k. I appreciate the research and development but there needs to be better accessibility to people that have crappy insurance.

If I had animations like this in high school I could have been a doctor!

Everything is better with animation

This is a fantastic video but it has so much information I'll have to watch it multiple times.

Thanks for the muzac. Always such a pleasure.

Great video, thank you for producing it and putting it out. I am a sufferer and have it on my face, it has sure knocked the shit out of my confidence and encroached itself on my life.

This video, sponsored by Eli Lilly Co., is primarily to advertise the target of the Lilly drug Taltz. I have been on Taltz now for more than 28 months and have experienced full remission of both plaque psoriasis and psoriatic arthritis. I was put on Taltz by my US dermatologist after failed treatment with Methotrexate (which I started on via the French healthcare system) which had helped somewhat but had failed to fully control the skin plaques. Taltz is very expensive, at many thousands of dollars a dose, but luckily I have good insurance that covers it. Getting control of my psoriasis has done wonders for managing my pain and discomfort, as well as the growing depression and self image issues that apparently are common to psoriasis.

Amazing video and content! Thank you so much for this.

The best part is at the end where the patches fades away. Thanks for this video

Great video, lots of useful information that helped me better understand my treatment. Thank you.

Sadly i am one of those "2-3 %" :(

Phenomenal animation!

This was Brilliant so informative Big thank you . Yvonne mullion Cornwall England

This animation is so professional that dotctors can also study.

Psoriasis is defined as a long-lasting autoimmune disease which is characterized by patches of abnormal skin that are usually red, dry, itchy, and scaly. It is a common skin condition that speeds up the life cycle of skin cells. It affects men and women equally and can begin at any age, but it is most common between the age of 15-35 years and again between 50-60 years. Psoriasis is commonly associated with several other conditions, including- type 2 diabetes, inflammatory bowel syndrome, heart diseases, psoriatic arthritis, etc.

I love these videos! Well done, keep em coming! Moar!!

Elbows and knuckles with me I’ve had it 6 years the desire to scratch the scales especially after a stressful day is remarkable. And the relief given can leave me red in the face literally it’s that intense. Then comes the stinging when moisturiser is applied

great video! today, i have finally been diagnosed with Psoriasis and GOD it s a pain in the ass to figure how to cure it... I had been dealing with it since i was 15 and had been scratching it on my ears and scalp for 8 years straight, i had been to dermatology before and doctors on there havent figured... :/ but i went to dermatology this last month, again and finally got diagnosed with it... i had been better than usual when i was using the cream called triamcinolone acetonide, and god i am slowly improving, rn tho i wanted to learn it as much so i can understand it a bit more -w-

Animated video is amazing and the informations given..is too good.

the strategy is simple, if you really want to cure psoriasis then do this: 1. Don't eat processed foods, like cake, candy,chocolate, pasta and bread 2. Don't eat gluten, I already said it but I just want to be clear for you because I really want you to be better because I had it too 3. Don't eat eggs and dairy, you can slowly incorporating the eggs after you healed your psoriasis, but make sure that the chicken has a natural diet and is outside (chickens naturally eat little insects, they don't eat wheat). The same is for dairy, the cow(goats are best but cow is ok) needs to be grass fed and the dairy has to be raw 4. SUGAR, almost forgot it, this is the worst with the processed food, sugar is highly inflammatory and you will see this on your skin 5. Eat grass fed beef(no pork bc it's toxic), the best thing to do is go to a local farmer who sells grass-fed meat, such as lamb and beef. 6. Don't eat too much fruit, almost all the fruit is gmo, the fruit from today is not the same as our ancestors ate, sure it has vitamins and minerals and it's good to eat them but it should me like a snack. just eat them when you're hungry but do not want to cook something 7. Eat veggies, however also almost all the veggies are gmo, the do not have a lot of sugar like fruit. 8. Go to the doc and ask for the best vitamine d and zinc, I do not know where you live and how much it costs for you, but I was fortunate enough that I live in the Netherlands and it was free for me, but it's not really really necessary, it just speeds up the healing 9. Food combining: My psoriasis didn't heal because of this in the beginning. I just ate whenever I wanted, but this is very important. When you wake up, wait 2 hours before you consume anything ( you can drink water if you really need something). After the 2 hours eat some fruit/nuts/veggies (you can do them together if you want). Then wait 2 hours again before you consume anything. At dinner don't combine meat/fish with fruit, you can do some veggies with it if you want. After dinner again wait 2 hours till you consume anything again. Search on the internet on foodcombining and it will be clearer for you 10. Don't consume cafeine, you can drink tea with herbs in it, but look good because in almost all the tea there is sugar. 11. Fatty fish is very good against psoriasis, but it's only good if you eat wild caught. Wild caught salmon is very good, also sardines are good. But almost all the big fishes like tuna and swordfish are very bad for psoriasis, because of the high mercury in it. On the internet you can find a lot of fish with low mercury If you are going to follow this, I know it will be very hard. I was 14 when I was diagnosed wit psoriasis but on my 16th I didn't want to take those drugs and did some research, I'm now 17 and i completely healed my psoriasis. Sometimes you will crave for processed foods, I even still do that but just hold on and eat some fruit or nuts if you really can't anymore, now I'm going to stop writing (hahaha) because this took me a serious 30 minutes. I hope this will work for you !, if you want to chat or something, my instagram is: ibi.b_ (i have no profile pic). Good luck on your journey!

I heard recent news that IL-17 pathway is involved in obesity too. Apparently in mice obesity was cured by using a treatment that affected the IL-17 pathway. If this is true could biologicals be developed to treat obesity? I have obesity and psoriasis and they both started in the same year in early adulthood. I wonder if they are linked.

Many major universities have an Integrative Medicine Department. Maybe they can help your psoriasis with an AIP Diet (or some other diet) ? The foods that you crave the most may be triggering your problem.

I believe it is a gut biome issue. I noticed when I went on a keto diet and had apple cider vinegar every day I never scratched at all. All of my broken skin healed up. I was so impressed I started telling everyone but I know. Most people like to take a pill to solve their issues, they don't want to do the hard work. Since not being strict with my diet it is back to normal. My ONLY problem is, is whether I can give up the carbs that I like, ie red wine, lollies, chocolate, and cigarettes that I weigh up as more of an effort than putting up with the itching and the sores.

Hi🙏, what is role of neutrophils in psoriasis. Is it the marker for severity of PSORIASIS?

This animation is amazing

Fantastic ... 👍🏻

Fascinating !!!For me Lilly Eli's TALZ (Biologics) proved nothing short of miracle!!!! For decades I had extensive psoriasis and tried every possible suggested treatment and diet..with absolutely no felt or visible result...TALZ got rid of it all in days!!!!

Why does Psoriasis affect just certain areas.....such as PalmaPlantar Pustulosis....Most ppl that I know that has PPP all say it starts on the left arch/sole and the right thumb base and then spreads from there. What causes it to be confined in the same areas for most people? Curious to know!

CAC Twak tailam is very effective for the skin as it deeply nourishes the tissues and improves the skin luster. The tailam is composed of yashtimadhu (Glycyrrhiza glabra), manjistha (Rubia cordifolia), etc. The tailam supports skin health, helps in reducing uneven pigments, improves complexion, and helps in deep detoxification and blood purification without any side effects.

Dr Osoria is great, He has been very attentive to my health issues. I have had complicated health problems and he has addressed them all. He is very kind and patient. I am very grateful for him.

Very interesting I hope that this issue will be cured. I take medication and the psoriasis stops. Then after a months it returns.😔

very nice

jeez im even more confused about my psor than ever after video lol...great vid though so thank you:)

I only have psoriasis on my scalp, and it only happens when I get stressed. yesterday, I got extremely stressed and anxious, and within about four hours of this happening, I had so many huge plaques growing on my scalp, it looked like there were half a pound of broken eggshells all over my scalp (they were in big, solid, white pieces like eggshells, too), and it was so itchy. I had to go to the bathroom and scratch it all out. after I got it all out and calmed down, it was absolutely fine and not itchy at all, and with no more plaques. then, I got a bit stressed this morning, though not nearly as much, and I just had a minor "attack" of psoriasis. I just scratched out the last of it a minute ago though, and I'm fine now, especially since I calmed down.. what I think is that, when I'm stressed, my body is preparing for a fight, so it starts producing more skin cells to heal me from any injuries I might get. I've heard of this happening to the blood of some people as well, where an excess of platelets are formed to make the blood more likely to coagulate to heal wounds. IDK why this only happens on my scalp though, although I also experience minor effects in my facial hair.. it's so bizarre, but it almost never bothers me too much, except for yesterday when my stress levels were incredibly high..

They have identified IL32 related to Lichen Planus/Prurigo Nodularis

Who was this video made for? RA doctors? Biology majors? Dermatology majors?

what role might cauterization or site specific drug application via tattoo injection be in treatment for skin related conditions?

I loved it becoz i just asked how psoriasis form but u knows me aboout total immune system also.... Thanks...

ya hay casos de personas que se han curado de psoriasis severa, en Veracruz hay un caso muy sonado en México....

thank yoou!!

Nice animation

My psoriasis is getting worse. I had COVID 19 back in December 2020.. Since then I have diabetes 2 , my right eye has blurred vision . I'll be 69 in February and if I don't get some help I'll have a difficult time to reach 70. I haven't worked since December 2020. And my motivation is absent

Dear sir I am suffering from Psoriasis. It happened after 2-3 months of corona vaccine. Is it related with vaccine or normally it happened? My age-49M, psoriasis in knee for the last 3 months. Please send me updates of treatment.

Keto Diet. This put mine into remission

Could this type of research provides any clues about how to handle other types of allergies such as respiratory or dietary ?

Hi, I would like to ask for permission to use the clip for my Thai Medicine class project, who should I contact?

try watching these videos while listening too joy Davison and bauhaus , its fun .

I just wanna ask ...in psorisis which layer is affected stratum basale or Spinosum ?

Bhaut acha

Holy fuck, what an amazing video!

HYPERINSULINEMIA (or insulin resistance) is at the root cause of most inflamatory diseases wich is all problems, really.

IL-12 makes a naive T cd4 cell to a TH1 cell The TH1 cell makes IL -2 ( to maturate other t cells ) and IFN gamma ( to maturate macrophages)

Since it starts on the cellular level it has to be stopped on the cellular level. Question remains- how?? 👍👍👍

Could you do i hidradinitus supparativa video

have you tryed freezing it ?? I did this with a product used to remove warts and it does wonders, so you need to take like 3 showers before you start, then apply the procedure, it takes a long time to advance as you are freesing the layer that has the problem... it may be wise to do it in sections... with this process you will get rid of the problem for at least 2 years

Good for science to get into such details and beautifully show it in color. But I'm mainly interested for finding solutions. I know how complex the workings of the human systems and processes are and that we are walking walking miracles originated from stardust through Creation. Sister, the problem I face is how to cure my Psoriasis. I miss my long showers and bath tub pleasure that were suspended by my Doc.

My husband when he turned 18, psoriasis began. The scalp, eyebrows, elbows, and some random areas. The sun, vitamin D slowed it down as well as Selsun Yellow shampoo.

What is the best cure treatment in world for this ? I'm suffering from 23 years . I can't take it more . Getting more depression everyday .

Twin studies are needed here .

What about miner psoriasis or one spot area, if there is an ointment for it.. Thanks

OMG, I need to watch this video with portuguese subtitles. Someone can translate that to me??? I think I will understand a lot better my sickness!

😍wow 👏

Stopped gluten once I found out all auto immune diseases are caused by leaky gut due to gluten allergies. After 3 months my psoriasis was gone. Over a year later I’m still gluten and psoriasis free.

Turning off the inflammatory response via 17, would this be appropriate in treating Covid patients? It seems that one of the problems is a possible over active respiratory response with them. Just a thought.

Save nature 🌿 save Jungle 🌳

Pregunta seria a alguien que se puso inyecciones humira le causó infección recurrentes de orina espero que alguien contesté por favor saludos

And sometimes these medicines trigger the body to create Non- Hodgkins Lymphoma. Then, once the chemo leaved your system, the autoimmune disorders return full blast.

Questions to sufferers - does an extremely controlled diet help at all?

Tolong bikin vidio tentang sporiasis dlm bhasa indonesia dong..saya ingin tau penjelasn tentang sporiasis cos bpk saya trkena pnyakit itu udh lumyan lma hampir 7taun lebih 😢😢😢

This was published in 2015, its 2020 now, have they found out a cure. This video shows so much of knowledge about the disease.

Why not just tell people to get off sugar and every thing that you put in your pie hole that terns into sugar or is that too hard for people gasp.?

*My hubby has been having issues in his scalp since he was Fifteen. I`m glad I`ve discovered this chemical-free and safe psoriasis treatment method . I recommend it very highly. Right after using this treatment method, I`ve spotted great improvements on my disorder*.

The video says the psoriasis trigger is unknown, right? How on earth can you you treat a condition if you don't even know what is its trigger???

10/10

The music was terribly distracting.

The immune system is not stupid, there are infections or toxins present in the body.

PAPA DUVALIER WAP By Haitien Occupation ?

my self and my lovely husband was able to eliminate our deadly virus hiv with the help of Dr Osoria may God continue to protect you Dr Osoria #drosoria

Oh....😲😢😭

Watching this made me realize i have trypophobia

como lo puedo conseguir en español

try a de wormer for iternal parasites also a possible cause of this horrible aflctiion

To anyone who could understand everything the lady was saying, I envy your intelligence.

very informative video sir.. i was so so worried about my condition i never know what to do.. i was really depressed.. then i tried using planet ayurveda medications and now my condition is 50% better.

The thumbnail is killing me

This decease ruining my life. I don't know how long I can survive

It's Ok.

It’s too dangerous 😦

Anyone that knows what can help? I've been with this for two months.

Why ia so cold

I hate psoriasis so much i been dealing it since i was 7 and somehow now it got on my eyebags and people bullied me for those i felt like killing myself and i wanted to eat more healthy but i am a supertaster and very picky with foods i knew its a gut problen also i am very emotional so stress would be 100% why theres so much psoriasis on my body

What is photo therapy?

I had psiorasis on the sides of my head and managed to cure it by using lotions that carried salycrilic(spelling)acid.

I cleared Psoriasis by following a strict diet which I created. Suffered with it for 20 years and tried everything. Finally found the answer through diet and some natural supplements. Neve4 been happier.

The skin is called "the third kidney". Psoriasis is often triggered by sick or malfunctioning kidneys hence the inflammation resulting on the skin. What triggers psoriasis is a malfunctioning digestive system. Look after your kidneys and guts, then your state of skin, immune system and life in general will improve. Dietary changes are to remove: dairy products, processed food, red meat, yeast and all food stuff containing chemicals such as colorant and preservatives (E111 etc)

Anyone here know about treatment? Please help me

What are these new drugs ?

background music is very disturbing

Please koi urdu m btay ga es Bary ma

So these cells are just living in my body and not even paying rent...the audacity.