Psoriasis - Pathophysiology 

Thank you so much for your blessings 😊

You are most welcome. I am glad you liked this video. There are many more on the channel, and many more to come in the future. 😊😊

I am happy this video was fruitful for you. Thank you for watching. I try to make complex mechanisms simple to grasp. Check out other videos, especially on Pathomechanisms of various dermatoses. 😊😊

I am planning to start clinical dermatology too. Would surely teach pathophysiology of other disorders.

Thank you for your valuable blessings!!! 😊😊 These are good suggestions. I will make videos on vitamin d and its role in dermatology, as it plays an important and varied role in skin physiology. I will be discussing retinoids while discussing acne. 😊😊 Till then, please continue to watch these videos and provide suggestions 🙂🙂

Sure I will. These videos take time to prepare and shoot. And I work alone in these video lectures. Please bear with me. Eventually we will cover all topics in dermatology, venereology, and leprology. Keep watching and sharing these videos. 😊😊

Most welcome!

That's a good question. Steroid suppresses immunity and inflammatory cytokines. We keep them suppressed till the inflammatory activity quiets down. When the immunity is suppressed, it increases the inflammation as a counter response. Since the suppression by steroids is strong, the moment they are removed, there is a rebound in activity. Hope this helps. Let me know if there are any queries 😊

Thank you sir for reply But what I was trying to ask is that there is a risk of flare in Psoriasis but not in Pemphigus or Pemphigoid even though all are autoimmune diseases.@@sabhderma

Thank you so much for your appreciation. I will be making more videos on varied topics. The idea is to discuss academic topics in detail at the post-graduate level. Just keep watching these videos and share with other students. 😊😊

@@sabhderma yes sir please take pigmentary disorders and malignant tumours including appendageal tumours if possible

@@sabhderma sir happy Diwali 😊

That's a good question. Neutrophils are one of the inflammatory cells implicated in the pathogenesis of psoriasis. They act as an important source of crucial inflammatory cytokines required for the disease. Whether their numbers are correlated with disease activity, that could be there since more the inflammatory cytokines more the neutrophils. However, if this has a clinical impact, I will have to get a concrete reference which I will share with you.

Thanks for the reply Sir 🙏🙂, We mostly read about (neutrophils/lymphocytes ratio)...to check the severity of the disease.. As this increased in severe( asthma/psoriasis & even sepsis) Please guide 🙏🙂

Thank you for asking this good question. Psoriasis is a very difficult disease to manage and patients require help and assistance by a trained dermatologist who can examine them and provide them with the best of options to keep the disease under control. With proper guidance, it can be easily managed so that daily life is not affected. Cure essentially means that the disease will never return, and frankly, that cannot be said for any disorder of any organ. It is very important to consult a trained dermatologist for proper treatment for psoriasis, and with a well designed treatment the disease can easily be controlled.