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Randomized, double blind, placebo controlled trial 

Dr. John Campbell
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A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19 (3rd June)
BACKGROUND
Whether hydroxychloroquine can prevent symptomatic infection after SARS-CoV-2 exposure is unknown.
METHODS
Randomized, double-blind, placebo-controlled trial
United States and Canada
Testing hydroxychloroquine as postexposure prophylaxis
High risk, less than 6 ft for more than 10 minutes while wearing neither a face mask nor an eye shield
Moderate risk, while wearing a face mask but no eye shield
n = 821 asymptomatic participants (719 of 821) reported a high-risk exposure
Randomly assigned, placebo or hydroxychloroquine groups within 4 days of exposure
Primary outcome, incidence positive test of clinical diagnosis
RESULTS
Incidence of new illness
Hydroxychloroquine group (49 of 414), 11.8%
Placebo group (58 of 407), 14.3%
P=0.35
Side effects in hydroxychloroquine group = 40.1%
Side effects in control group = 16.8%
No serious adverse reactions were reported.
(Nausea, upset stomach, dizziness, headache)
Hydroxychloroquine group
Taking zinc 15% developed new disease
Not taking zinc 10.8% developed new disease
Placebo group
Taking zinc 15.4% developed new disease
Not taking zinc 14% developed new disease
Relative risk with zinc use was 1.23
Hydroxychloroquine group
Taking Vit C 14.3% developed new disease
Not taking Vit C 10.6% developed new disease
Placebo group
Taking Vit C 20.8% developed new disease
Not taking Vit C 11.2% developed new disease
Relative risk with vitamin C use was 1.60
The Lancet (and NEJM)
Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis, (May 22nd)
Serious scientific questions about the validity of data
‘Expression of Concern’
www.thelancet....
Issued a correction regarding location of some patients
Conclusions were not changed.
WHO resumed its trial of hydroxychloroquine
Crisis of trust
Medical journals
WHO
Governments
Scientific / medical advisors

Опубликовано:

 

21 авг 2024

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Комментарии : 1,7 тыс.   
@isthisadagger9607
@isthisadagger9607 4 года назад
1. Lowest p value in this is 0,35 2. Only 13 PCR confirmed 3. Asymptomatic not registered 4. Only 75% adhered to the treatment plan 5. Biased sample with mainly healthcare workers (probability of higher inoculum load higher) 6. Stopped after 14 days, serious cases develop later 7. Only 2 out of 113 symptomatic in hospital which supports 6. 8. Oldest participant was 51 9. No zinc 10. Only 5 day treatment with hcq 11. Hcq + zinc supposedly reduces severeness not prevent infection. It is not a vaccine. If you ignore 1-10 you could say hcq does not prevent infection. Well another thing confirmed we already knew.
@jotatsu
@jotatsu 4 года назад
2 and 3 boggles my mind, specially this part ""Clinical Criteria for Reporting1 In outpatient or telehealth settings at least two of the following symptoms:fever (measured or subjective), chills, rigors, myalgia, headache, sore throat, new olfactory and/or taste disorder(s)ORat least one of the following symptoms:cough,shortness of breath, ordifficulty breathingORSevere respiratory illness with at least one of the following:Clinical or radiographic evidence of pneumonia, orAcute respiratory distress syndrome (ARDS)."" Basically their false postiive and negative diagnosis for covid-19 is all over the place. They can mis-categorize muscle pain and self-measured fever for covid.
@garyfumeaux9226
@garyfumeaux9226 4 года назад
Isthis I agree with you totally this is junk science and John is not prepared to call it out??? We should be shouting from the rooftops about this study for 2 reasons (1) Only 4 people were hospitalised and none died which highlights the non-lethal nature of this illness. (2) Secondly, only 13% of people who were put in a high-risk environment contracted the disease which means this disease spreads less rapidly than first thought. With this new data, we should all sleep easy and John needs to rethink all the data and percentages he has been feeding you. Other than the great news about it's a pretty useless study. John just because it's Double-Blind Placebo-Controlled doesn't make it a good study. Just a few things to consider. 1. This is not a high-risk age group so why do the study? 2. Many people are asymptomatic so without antibody testing, you have no idea as to how many people actually contacted the disease which makes the data quite useless. 3. Talking about Zn when it wasn’t part of the protocol highlights the poor science 4. All participants self-assessed which again is very poor science. To do a study like this with a product that is so politically charged is ridiculous. John you need to do a better analysis of junk science. Just like your analysis of the NIH study www.nejm.org/doi/pdf/10.1056/NEJMoa2012410 Instead of jumping from the rooftops because the study showed that patients on HCQ died 31% of the time compared to 65% of non HCQ patients. That alone makes this a miracle drug but instead, you preferred to praise the junk science. Come on you can do better. here is the analysis of this study if you want it Here are just 7 reasons why this study was designed to fail. (1) First, the study is funded by the NIH. This is a “Fauci study” who has a vested interest in it not working. (2) The Study is using a “multivariable Cox model” with inverse probability weighting according to the propensity score, which allows for massive data manipulation. (3) it took up to “48 hours for 85.9% of patients to be treated. Why would you delay treatment? The next point helps to explain why. (4) "Hydroxychloroquine-treated patients were more severely ill at baseline than those who did not receive hydroxychloroquine" Yes this is written in the study. (5) No Zn was given with the HCQ. It is well established by many Drs treating patients that the HCQ allows for the movement of Zn into the cell which then stops the viral replication. (6) Death or Intubation endpoints are considered the same outcome, so even if they recovered after intubation they were still considered a negative outcome. (7) All patients in the HCQ group had more older, male and comorbidity patients. Note In-fact if you look at the most important result hidden in the appendix Table S1 you would see that of all patients put on a ventilator only 32% of the HCQ and 65% of non HCQ died. Therefore HCQ halved the death rate of ventilated patients. This is an incredible result and yet it is not mentioned because the study is manipulated to fail Table S1 HCQ / No HCQ Primary Outcome 262 / 84 Death 157 / 75 Intubated 154/ 26 Intubated then Death 49 / 17 Death after Intubation%. 31/ 65 
This study is a joke and doctor who references it should have their medical licence revoked. How was this allowed to be published?
@peterturner9941
@peterturner9941 4 года назад
BREAKING NEWS.... THE LANCET HAVE PUBLISHED A RETRACTION OF THE ARTICLE
@buzzpedrotti5401
@buzzpedrotti5401 4 года назад
Do the staff of WHO have the ability for their assignments?
@Theggman83
@Theggman83 4 года назад
Funny how much shit the 'never-trumpers' were talking about Hydroxychloroquine with no scientific basis to back it up.... They aren't talking now.
@LondonSteveLee
@LondonSteveLee 4 года назад
Whilst attempting to RETROSPECTIVELY peer-review the article, it turns out Surgisphere have "lost" the data to support the article. The Lancet - a great journal like this have been caught publishing non-peer-reviewed junk designed to discredit Trump.
@Curling12341
@Curling12341 4 года назад
Will Dr. John give a retraction????? Well John?????
@buzzpedrotti5401
@buzzpedrotti5401 4 года назад
@@Curling12341 Um. An unfair troll. Out of bounds. Unacceptable misrepresentation. This helpful man is summarizing novel work for you. To help you. He doesn't do the work. He curates it (..look it up..) so you don't have to. He is hard-working,scrupulous and transparent and generous. Your comment is an undeserved slur. If the rouge country who birthed this mess were led by men of Dr. John's caliber, we wouldn't be in this mess. (I'm sure 10 million troubled souls in Hong Kong agree...)
@kenneyg100
@kenneyg100 4 года назад
Breaking: The Lancet have just retracted the paper that halted hydroxychlorochine trials. The Guardian.
@-astrangerontheinternet6687
@-astrangerontheinternet6687 4 года назад
I predict this one will also be retracted. Or called out for it’s utter uselessness.
@breakthroughschool1456
@breakthroughschool1456 4 года назад
He forgets to tell you only 2% got tested for covid.
@CivicPetunia
@CivicPetunia 4 года назад
The underlying data in this study seems to be available; it was not in the study published in the Lancet. That makes all the difference.
@georgerbuchanan
@georgerbuchanan 4 года назад
Michelle Glo if you’re such a great expert on experimental design, go run your own study?
@barbarahenninger6642
@barbarahenninger6642 4 года назад
@@CivicPetunia Could you please provide a link for the underlying data?
@iansmith2549
@iansmith2549 4 года назад
Yesterday, the authors proactively initiated an independent audit of the data used in the New England Journal of Medicine (NEJM) paper after discrepancies and concerns were raised about the reliability of the database. The third-party auditors will provide their findings directly to the editors of NEJM upon completion. Scientists are questioning the validity of two influential studies of COVID-19 patients as concerns grow about the provenance of the dataset underpinning them. Despite assurances from Surgisphere Corporation, an Illinois-based company that owns the data, hundreds of researchers have now signed open letters to The Lancet and the New England Journal of Medicine (NEJM), voicing their concerns. Today, NEJM and The Lancet issued expressions of concern about the reliability of the papers’ conclusions.
@GOLEMUK
@GOLEMUK 4 года назад
Surgisphere will either very rapidly produce rock solid proof that their data is both real and has been obtained and reproduced correctly, or they will find themselves at the business end of Legal action likely involving Law enforcement officials. Considering what has been revealed about the company so far, I think the latter is looking inevitable.
@pezo1919
@pezo1919 4 года назад
I am totally with you, but can you please give me a source on that: "hundreds of researchers have now signed open letters" - I'd like to show it to my community.
@GOLEMUK
@GOLEMUK 4 года назад
@Henrik Wallin I'll give you a small tip here. Any little known company or individual spraying buzzwords like "A.I"., "machine learning" and "Big Data" around their every action should be regarded with the same skepticism as BitCoin get rich quick schemes until rock solid evidence is forthcoming that they aren't full of s**t. Those terms have been overused so much they have ceased to have much meaning. They rank alongside "Blue Sky Thinking" and "Synergy" as 'tells' that someone may well be the type of individual that would start a website Indiegogo promoting a wearable “next generation human augmentation device that can help you achieve what you never thought was possible”. Exactly like the Surgisphere CEO did. The device, curiously, never materialised. We can only speculate on what it may have been, an invisible hat perhaps. Or a nifty shoulder bag containing magic beans.
@DrNancyLivingCoCreatively
@DrNancyLivingCoCreatively 4 года назад
Wow. Is your comment up to date. To me this is more implications of the war in research for profit. Truly sad. I miss the days when universities and governments funded instead of corporations. Very sad.
@theauxochrome
@theauxochrome 4 года назад
Cant be to reliable if these "Scientists" are saying Protests & Riots are ok. AFTER PREVIOUSLY Stating 50% of black & brown people DIE when they catch it???? Oh wait, that was last week!!! Small Business owners were sited, Fined & Arrested for wanting to go bk to work in N.Y.??? Alterior MOTIVES =YES COMMUNIST SYMPATHIZERS ARE OUR POLITICIANS
@kevinbyrne4538
@kevinbyrne4538 4 года назад
The prescribed regimen consists of Hydroxychloroquine, Zinc, and Azithromycin. Of these medications, zinc is the most important. Yet it was excluded from the trial.
@Greg_P611
@Greg_P611 4 года назад
Done purposely I'm afraid
@dobishs
@dobishs 4 года назад
@Steve Sheldon 16:30
@btango6929
@btango6929 4 года назад
Are we watching the same video? The one I watched said 20% of the patients used HCQ + Zinc.
@nicolebarker6438
@nicolebarker6438 4 года назад
I hope there is a double blind study of the effects of Vitamin D at some point.
@garyfumeaux9226
@garyfumeaux9226 4 года назад
Nicole double-blind or not the study can be manipulated. We should be shouting from the rooftops about this study for 2 reasons (1) Only 4 people were hospitalised and none died which highlights the non-lethal nature of this illness. (2) Secondly, only 13% of people who were put in a high-risk environment contracted the disease which means this disease spreads less rapidly than first thought. With this new data, we should all sleep easy and John needs to rethink all the data and percentages he has been feeding you. Other than the great news about it's a pretty useless study. John just because it's Double-Blind Placebo-Controlled doesn't make it a good study. Just a few things to consider. 1. This is not a high-risk age group so why do the study? 2. Many people are asymptomatic so without antibody testing, you have no idea as to how many people actually contacted the disease which makes the data quite useless. 3. Talking about Zn when it wasn’t part of the protocol highlights the poor science 4. All participants self-assessed which again is very poor science. To do a study like this with a product that is so politically charged is ridiculous. John you need to do a better analysis of junk science. Just like your analysis of the NIH study www.nejm.org/doi/pdf/10.1056/NEJMoa2012410 Instead of jumping from the rooftops because the study showed that patients on HCQ died 31% of the time compared to 65% of non HCQ patients. That alone makes this a miracle drug but instead, you preferred to praise the junk science. Come on you can do better. here is the analysis of this study if you want it Here are just 7 reasons why this study was designed to fail. (1) First, the study is funded by the NIH. This is a “Fauci study” who has a vested interest in it not working. (2) The Study is using a “multivariable Cox model” with inverse probability weighting according to the propensity score, which allows for massive data manipulation. (3) it took up to “48 hours for 85.9% of patients to be treated. Why would you delay treatment? The next point helps to explain why. (4) "Hydroxychloroquine-treated patients were more severely ill at baseline than those who did not receive hydroxychloroquine" Yes this is written in the study. (5) No Zn was given with the HCQ. It is well established by many Drs treating patients that the HCQ allows for the movement of Zn into the cell which then stops the viral replication. (6) Death or Intubation endpoints are considered the same outcome, so even if they recovered after intubation they were still considered a negative outcome. (7) All patients in the HCQ group had more older, male and comorbidity patients. Note In-fact if you look at the most important result hidden in the appendix Table S1 you would see that of all patients put on a ventilator only 32% of the HCQ and 65% of non HCQ died. Therefore HCQ halved the death rate of ventilated patients. This is an incredible result and yet it is not mentioned because the study is manipulated to fail Table S1 HCQ / No HCQ Primary Outcome 262 / 84 Death 157 / 75 Intubated 154/ 26 Intubated then Death 49 / 17 Death after Intubation%. 31/ 65 
This study is a joke and doctor who references it should have their medical licence revoked. How was this allowed to be published?
@esecallum
@esecallum 4 года назад
Surrey scientists have said vitamin D could cause death.
@Pronoob88990
@Pronoob88990 4 года назад
Ese Callum yeah, potentially everything could casue death
@brendanh8193
@brendanh8193 4 года назад
@@garyfumeaux9226 To be fair, John has already, and rather cap in hand, withdrawn his support for the Lancet study in a previous video. Thanks for the points that you made though. I'll add that p=0.35 simply answers this question: do we have enough data to be certain of the difference? No, we need more data.
@aprilapril2
@aprilapril2 4 года назад
Ese Callum what Surrey scientists?
@mary4318
@mary4318 4 года назад
Trust is lost. The big question is this. Will hydroxychloroquine/zinc prevent or reduce SEVERE COVID 19 disease. Will it prevent hospitalization, intubation, death.
@esecallum
@esecallum 4 года назад
its a question of money....
@mary4318
@mary4318 4 года назад
Hopefully the researchers have continued the study more important questions.
@draganap3241
@draganap3241 4 года назад
ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-WZq-K1wpur8.html
@mary4318
@mary4318 4 года назад
Dragana P Thank you.
@GOLEMUK
@GOLEMUK 4 года назад
The WHO trial has restarted and other studies may be forthcoming with severity of illness as an endpoint. This study is still valuable in ruling out one possible use for HCQ. while Vitamin D still has excellent evidence in preventing respiratory tract infections. For other prophylactics MedCram 59 is superb. ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-NM2A2xNLWR4.html
@briteness
@briteness 4 года назад
"Science is a self-correcting process." This is what makes science and the scientific method one of the most important tools human beings have. Just like any other group of people, the scientific community is filled with those who are corrupt in small and sometimes large ways. Everybody is looking to increase the flow of money and prestige coming to themselves, so it is unsurprising that the pursuit of truth is sometimes not the foremost thing in scientists' minds. However, over time the truth will tend to emerge. Science does not run on rails, and the "truth" is often more elusive than people might think, but, broadly speaking, the scientific impulse is one of the most ennobling aspects of mankind.
@briank10101
@briank10101 4 года назад
It's taking over half a century to get a definitive conclusion on climate change and still waiting. Hope that's not the case with HCQ and Zinc. Remember, it's the reduction of severity of symptoms and reduction of death rate that should be evaluated not whether HCQ prevents you getting a positive diagnosis.
@nmarbletoe8210
@nmarbletoe8210 4 года назад
@@briank10101 The biosphere is perhaps the most difficult to model of all earth's systems, as it includes everything else on earth as subsets. A single virus in a single bat in a single cave in a remote canyon in China can impact climate change... and it is!
@UteChewb
@UteChewb 4 года назад
@@briank10101, the conclusion on climate change was known since the 1980s. But it did take decades because the data gathering and climate science were still being pioneered. HCQ and zinc will be resolved very quickly.
@inquaanate2393
@inquaanate2393 4 года назад
Brian K it is difficult to do experiments on the whole atmosphere to test a model. We have to make models first and see if what humans do pumping various gases into the air outside of the study conforms to the model. It is no where near as easy as just testing a drug.
@georgegale6084
@georgegale6084 4 года назад
Hear you. But in my mind, science us effected by money and pride, , , ,, so we get crap science from time to time. Soviets and Fascists loved science....that served their purposes.
@emacro65
@emacro65 4 года назад
OK, now we have a trial showing no prophylactic effect. How about a trial on post symptom early use of hydroxychloroquine to alleviate or reduce severity of symptoms.
@jwr77777
@jwr77777 4 года назад
That is why this video is garbage
@cwolf8841
@cwolf8841 4 года назад
It was Postexposure Prophylaxis
@inquaanate2393
@inquaanate2393 4 года назад
emacro65 because we have no reason to believe it will do anything, just think, why are these studies even happening? It’s all based on an anecdote from a french doctor and trump’s escalation. Giant waste of money, we can do a couple more of your suggestions but don’t get shitty about them not all getting done. Not every chemical gets this special treatment you know.
@deidrecoday1269
@deidrecoday1269 4 года назад
@@inquaanate2393 stop making everything about Trump.
@benmm8244
@benmm8244 4 года назад
Its a shame they didn't record severity and duration of symptoms while they were at it. Surely that's the main point? I wonder if this one makes the headlines.
@lohphat
@lohphat 4 года назад
I thought the antiviral we're after is ZINC with the h.c.q. acting as the ionophore to get it into the cell to do its work. If zinc isn't part of the trial, what's going on?
@123danks
@123danks 4 года назад
Are you surprised that the establishment will not push a vitamin? I mean come on really.
@shardlake
@shardlake 4 года назад
I think why he was careful as the paper only deals with people already infected, if it works prior to infection, still no studies.
@jerzykowalskiShosa
@jerzykowalskiShosa 4 года назад
This shows we do not understand well enough the mechanisms involved Neither those of the immune system, nor those of the virus We (the scientists among us) have a working hypothesis of the mechanisms This changed time after time, not sure we are at the end of our journey of knowledge If history is an indication, we know not much Imagine a caveman with a cone of ice and a running computer By accident the caveman fumbles the ice cone and shorts the computer Now the caveman knows that, at least once, an ice cone switched the computer off. Not knowing that there is an on-off switch or even a command, screen button that does almost the same (just not damaging the computer)
@RGBEAT
@RGBEAT 4 года назад
There was zinc in the study. Watch the last half of the video
@Hunter_Bidens_Crackpipe_
@Hunter_Bidens_Crackpipe_ 4 года назад
There is a trial that compares HCQ vs HCQ+zinc and the zinc group fared better. This study says the opposite...
@tangent2658
@tangent2658 4 года назад
I'm not seeing anything regarding the severity of the infection, maybe I missed it. The argument for prophylactic use was not that people would not develop infection but rather it would mitigate effects of infection, leading to less damage and fewer deaths. There is not enough here to dispel HCQ as a treatment especially with other sources showing very conflicting data from medical professionals. The real story is that we should have had this data months ago and the fact that we didn't is very suspect. Trust issues indeed.
@mikemclaurin2889
@mikemclaurin2889 4 года назад
Exactly right. The point to using HCQ was that it allowed Zinc to get into the infected cell and disrupt the virus replication process. I don't recall anyone saying that if you take HCQ you won't get the disease. So, this study dispels something that was never at issue as far as I'm aware. What we're hoping for is that HCQ or HCQ + Zinc (if you are deficient) and/or + Z pack will be effective at disrupting virial replication. If it does that, you'll have an easier, perhaps shorter course of the disease.
@debpratt52
@debpratt52 4 года назад
@@mikemclaurin2889 Right - no mention of zinc.
@tangent2658
@tangent2658 4 года назад
@@mikemclaurin2889 It's not a complex argument, is it? Every debunk of HCQ I have seen does not contain relevant data and it's always outside of the capabilities suggested of the drug. They give it as a hail mary to people in late-stage and/or on ventilators as though that may magically heal the full system damage. Here, they focus on base infection statistics as though anyone with half an interest in this is saying it can 100% prevent infection. How long did it take them to admit masks work? Why did it take months to listen to virologists explain the concept of viral load at and beyond the point of infection? Damn right I have trust issues, that's for sure.
@jimh.8138
@jimh.8138 4 года назад
Tangent Don’t confuse us with the facts mate! In the words of my future President...”We chose truth over facts” (Joe Biden). We just keep moving the goalposts to make sure that expensive hospitalization is the only acceptable therapy, not a cheap and widely available pill. Get with the program.
@garyfumeaux9226
@garyfumeaux9226 4 года назад
We should be shouting from the rooftops about this study for 2 reasons (1) Only 4 people were hospitalised and none died which highlights the non-lethal nature of this illness. (2) Secondly, only 13% of people who were put in a high-risk environment contracted the disease which means this disease spreads less rapidly than first thought. With this new data, we should all sleep easy and John needs to rethink all the data and percentages he has been feeding you. Other than the great news about it's a pretty useless study. John just because it's Double-Blind Placebo-Controlled doesn't make it a good study. Just a few things to consider. 1. This is not a high-risk age group so why do the study? 2. Many people are asymptomatic so without antibody testing, you have no idea as to how many people actually contacted the disease which makes the data quite useless. 3. Talking about Zn when it wasn’t part of the protocol highlights the poor science 4. All participants self-assessed which again is very poor science. To do a study like this with a product that is so politically charged is ridiculous. John you need to do a better analysis of junk science. Just like your analysis of the NIH study www.nejm.org/doi/pdf/10.1056/NEJMoa2012410 Instead of jumping from the rooftops because the study showed that patients on HCQ died 31% of the time compared to 65% of non HCQ patients. That alone makes this a miracle drug but instead, you preferred to praise the junk science. Come on you can do better. here is the analysis of this study if you want it Here are just 7 reasons why this study was designed to fail. (1) First, the study is funded by the NIH. This is a “Fauci study” who has a vested interest in it not working. (2) The Study is using a “multivariable Cox model” with inverse probability weighting according to the propensity score, which allows for massive data manipulation. (3) it took up to “48 hours for 85.9% of patients to be treated. Why would you delay treatment? The next point helps to explain why. (4) "Hydroxychloroquine-treated patients were more severely ill at baseline than those who did not receive hydroxychloroquine" Yes this is written in the study. (5) No Zn was given with the HCQ. It is well established by many Drs treating patients that the HCQ allows for the movement of Zn into the cell which then stops the viral replication. (6) Death or Intubation endpoints are considered the same outcome, so even if they recovered after intubation they were still considered a negative outcome. (7) All patients in the HCQ group had more older, male and comorbidity patients. Note In-fact if you look at the most important result hidden in the appendix Table S1 you would see that of all patients put on a ventilator only 32% of the HCQ and 65% of non HCQ died. Therefore HCQ halved the death rate of ventilated patients. This is an incredible result and yet it is not mentioned because the study is manipulated to fail Table S1 HCQ / No HCQ Primary Outcome 262 / 84 Death 157 / 75 Intubated 154/ 26 Intubated then Death 49 / 17 Death after Intubation%. 31/ 65 
This study is a joke and doctor who references it should have their medical licence revoked. How was this allowed to be published?
@fredo1070
@fredo1070 4 года назад
Wasn't the lancet study debunked the other day? They've had to retract it.
@ancienbelge
@ancienbelge 4 года назад
Different study, different research question, but yes. spinstrangenesscharm.wordpress.com/2020/06/03/covid19-update-june-3-2020-serological-study-in-israel-surgisphere-data-scandal/
@OzzieOzzieOzzieOyOyOy
@OzzieOzzieOzzieOyOyOy 4 года назад
Yeah, but wasn’t that a different trial? This trial was only published yesterday.
@nikodimus86
@nikodimus86 4 года назад
Yes. Right now I don't trust anything that comes from the US badmouthing hydroxychloroquine.
@simonallen2199
@simonallen2199 4 года назад
Probably funded by WHO Which can't even do there job they were set up to do ! To busy jet setting it and living it up in 5 star hotels, and.....
@mary4318
@mary4318 4 года назад
It was a retrospective survey of clinicians.
@candybeads
@candybeads 4 года назад
I watch your videos every day. I *really* appreciate the time you spend doing these.
@carlbrowning8409
@carlbrowning8409 4 года назад
Thanks Dr John. SOME of us come here to see what your latest take on this mess is and appreciate what you're doing with what you have to share. I can't speak for the ones coming back time and again that clearly DON'T appreciate it. Cheers!
@ppumpkin3282
@ppumpkin3282 4 года назад
The Wall Street Journal had an article today about about an HCL study in the Lancet. In summary the Lancet HCL was based on questionable data. the Lancet had also published anti-Trump editorials questioning the bias in their research reporting. Also reported anti American bias. Frankly Dr. Cambell, I am disappointed in your reporting on HCL, and refusal to report on where HCL works with ZInc. Yes, there are many situations where HCL doesn't work, but why waste our time with those, unless you are biased, why not report on where it IS USEFUL? I'm really disappointed in you doc, and I stopped watching your videos after I saw how biased they are, but just came back to report that the Lancet politically motivated fraud is out of the bag now.
@lindman399
@lindman399 4 года назад
I like it when he says, "What we conclude from this" and he pauses, I think he is going to say "What a load of bullshit"
@dancolombo6050
@dancolombo6050 4 года назад
I felt the same
@particleconfig.8935
@particleconfig.8935 4 года назад
Campbell turning Walter White lol
@matttheratt
@matttheratt 4 года назад
I find it funny that this study concludes that Hydroxychloroquine is deemed ineffective in preventing the infection when the study itself says that the people in the study take up to 4 days to start the treatment (either with Hydroxychloroquine or placebo) and the accepted infection time could be as low as 2 days. That right there says that people could be infected BEFORE starting the treatment which completely blows this study's results to shreds. Also, these are all self reported results, very few were actually verified by testing.
@harryroger1739
@harryroger1739 4 года назад
My God! why no zinc? This is so bias. All the time.
@RGBEAT
@RGBEAT 4 года назад
Harry Roger Dr Campbell talk about zinc in the video. Why are you so biased all the time?
@douginorlando6260
@douginorlando6260 4 года назад
No zinc in the original set up proves it is biased from the start.
@Robubbabub
@Robubbabub 4 года назад
No zinc. Therefore, not the methodology the biochemists were arguing for since January.
@briank10101
@briank10101 4 года назад
You have to ask why there isn't a clinical study of severity of symptoms and death rate being conducted when HCQ and zinc are used prophylactically. Every widely reported study so far is architected to make HCQ predestined to fail. No prophylaxis, no zinc, administration too late, administration to those intubated, etc. This is incredibly suspect. Waiting on official results of Dr.Zelenko's study being prepared by top German researchers.
@pandora770
@pandora770 4 года назад
I do feel that hydroxychloroquine may have efficacy against covid19, but only when combined with zinc, as an ionophore. The ionophore makes the cell membrane porous to the Zinc ion ZN+2. The RNA of the virus needs to be converted into proteins for the virus to replicate. The Zinc is the hero of the story as it inhibits this process. The viral RNA is inhibited from creating a new copy of the viral body. The virus data is transcribed in multiple runs over the viral rna. I am praying the authors of the study/clinical trial, OR someone else, will offer this combined protocol as a treatment , to stop unnecessary deaths and infections. Also to look at quercetin as a zinc ionophore instead of hydroxychloroquine, or combined with lower doses of hcq.
@ghollisjr
@ghollisjr 4 года назад
@@Mulinaster What's the medical or "scientific" (translate: "theory-based") reason for including placebos? There isn't one. Placebos are included because it is known that belief affects perception. How is this known? Not from any scientific theory, but from experimental observation. This is why when a claim is made, e.g. "Chemical X + Chemical Y improves symptoms", you can't test this claim by saying "Well, my theory says that Chemical Y is irrelevant, so I'll just test Chemical X and when it fails I'll conclude that your treatment is bunkum". Experimental science relies on experimentation, not just theory. Otherwise we're back to making up stories to explain the world without ever confirming them.
@planesandbikes7353
@planesandbikes7353 4 года назад
They did look at many of the subjects taking zinc with the HCQ/placebo. again, the zinc alone offers no protection, and the zinc with HCQ offers no protection either. Pay attention.
@satyanarayanatiruveedhi5215
@satyanarayanatiruveedhi5215 4 года назад
@@planesandbikes7353 It means those doctors that are recommending HCQ with Zinc, so passionately, have some ulterior motive. But the testimonials from their patients look very convincing. Something is amiss.
@robinhood4640
@robinhood4640 4 года назад
The French professor said it treats the disease when given early. First study shows it is no good when given late. Second study shows it doesn't stop you getting the disease, but doesn't even mention the outcome of the patients. When is there going to be a study to see if what the professor said is the truth, instead of studies showing how crappy it is at doing things he never said it does?
@bluecrown4451
@bluecrown4451 4 года назад
Words! You are 100% right.
@CharlesvanDijk-ir6bl
@CharlesvanDijk-ir6bl 4 года назад
They tested his drug and it is found wanting.
@chuckschumer7783
@chuckschumer7783 4 года назад
@@CharlesvanDijk-ir6bl - no the study doesn't show anything
@KennyTew2
@KennyTew2 4 года назад
There was a massive scale observational study that showed outcomes, it was something like 12-25% more likely to die if taking it. If I can find it I’ll post it here. Not that it will matter, Donnie Doofus fans have never cared about facts and aren’t going to start now.
@hizzlemobizzle
@hizzlemobizzle 4 года назад
That is why published and peer reviewed papers exist. There are wacked out doctors because there are wacked out people. If you take the word of one wacko over the entire community something is wrong with you.
@JosephFrancisBurton
@JosephFrancisBurton 4 года назад
Dr. Campbell, thank you very much for these more scientific presentations.
@fasteddiejs
@fasteddiejs 4 года назад
Dr John Campbell is working for Big Pharma. The ‘protests’ seem to have cured the disease. Oh wait, neo Marxist politics was the disease. The covid scam deconstructed: edwardjblack.com/2020/04/24/the-invisible-war/
@AaronJCourtney
@AaronJCourtney 4 года назад
@@fasteddiejs get profession help 🤦
@fransimms3803
@fransimms3803 4 года назад
@@fasteddiejs stupid BOT. Ignore.
@fasteddiejs
@fasteddiejs 4 года назад
@Fran Simms A classic case of projection. That’s all you people have: mocking and attacking those who expose the emperor’s nakedness.
@garyfumeaux9226
@garyfumeaux9226 4 года назад
Please at least question the science... We should be shouting from the rooftops about this study for 2 reasons (1) Only 4 people were hospitalised and none died which highlights the non-lethal nature of this illness. (2) Secondly, only 13% of people who were put in a high-risk environment contracted the disease which means this disease spreads less rapidly than first thought. With this new data, we should all sleep easy and John needs to rethink all the data and percentages he has been feeding you. Other than the great news about it's a pretty useless study. John just because it's Double-Blind Placebo-Controlled doesn't make it a good study. Just a few things to consider. 1. This is not a high-risk age group so why do the study? 2. Many people are asymptomatic so without antibody testing, you have no idea as to how many people actually contacted the disease which makes the data quite useless. 3. Talking about Zn when it wasn’t part of the protocol highlights the poor science 4. All participants self-assessed which again is very poor science. To do a study like this with a product that is so politically charged is ridiculous. John you need to do a better analysis of junk science. Just like your analysis of the NIH study www.nejm.org/doi/pdf/10.1056/NEJMoa2012410 Instead of jumping from the rooftops because the study showed that patients on HCQ died 31% of the time compared to 65% of non HCQ patients. That alone makes this a miracle drug but instead, you preferred to praise the junk science. Come on you can do better. here is the analysis of this study if you want it Here are just 7 reasons why this study was designed to fail. (1) First, the study is funded by the NIH. This is a “Fauci study” who has a vested interest in it not working. (2) The Study is using a “multivariable Cox model” with inverse probability weighting according to the propensity score, which allows for massive data manipulation. (3) it took up to “48 hours for 85.9% of patients to be treated. Why would you delay treatment? The next point helps to explain why. (4) "Hydroxychloroquine-treated patients were more severely ill at baseline than those who did not receive hydroxychloroquine" Yes this is written in the study. (5) No Zn was given with the HCQ. It is well established by many Drs treating patients that the HCQ allows for the movement of Zn into the cell which then stops the viral replication. (6) Death or Intubation endpoints are considered the same outcome, so even if they recovered after intubation they were still considered a negative outcome. (7) All patients in the HCQ group had more older, male and comorbidity patients. Note In-fact if you look at the most important result hidden in the appendix Table S1 you would see that of all patients put on a ventilator only 32% of the HCQ and 65% of non HCQ died. Therefore HCQ halved the death rate of ventilated patients. This is an incredible result and yet it is not mentioned because the study is manipulated to fail Table S1 HCQ / No HCQ Primary Outcome 262 / 84 Death 157 / 75 Intubated 154/ 26 Intubated then Death 49 / 17 Death after Intubation%. 31/ 65 
This study is a joke and doctor who references it should have their medical licence revoked. How was this allowed to be published?
@margarettt7675
@margarettt7675 4 года назад
Thank you for reviewing this research. You certainly get a lot of highly emotional responses to a review!
@klondike444
@klondike444 4 года назад
Because he's no good at reviewing trials. He should stick to what he knows.
@dMoniker
@dMoniker 4 года назад
@@klondike444 Please share with us how one should present the results of a trial
@MFranklinstein-vw2tn
@MFranklinstein-vw2tn 4 года назад
Peak Prosperity, watch him and learn.
@klondike444
@klondike444 4 года назад
@@dMoniker First you learn how to read and understand a trial. John has shown that he can't do that well enough to report on one.
@klondike444
@klondike444 4 года назад
@Seine O'More No need to be a professor to you know you're hearing bad science. Pity you're not even at that level.
@Winstonsmom
@Winstonsmom 4 года назад
I find it interesting that this study does not look at severity of disease or disease outcome. Is there any data on that? My understanding is that hydroxychloroquine is a treatment that when given early in the course, slows viral replication; not necessarily preventing disease, but resulting in a milder infection...
@shivamchandok7826
@shivamchandok7826 4 года назад
Yes, one of the latest Medcram video talks about it, as the disease gets more severe, HCQ is less effective in saving lives. Given early in the course, it decreases viral shedding.
@Mrs.TJTaylor
@Mrs.TJTaylor 4 года назад
Rosemary Spurll Why is that interesting? The study had a narrow focus, as it should have. Other studies will answer other questions concerning hydroxychloraquine.
@Winstonsmom
@Winstonsmom 4 года назад
Diane Taylor maybe what I should have said is “we should keep this in mind, and not dismiss its value based on this one study”.
@Mrs.TJTaylor
@Mrs.TJTaylor 4 года назад
Rosemary Spurll Yes, the data is not complete. It’s one narrow study.
@-astrangerontheinternet6687
@-astrangerontheinternet6687 4 года назад
I find it interesting who funded the study.
@vincentgardner853
@vincentgardner853 4 года назад
P=10 when science is corrupted by politics and money it stays corrupted!! RESPECT GONE, TRUST GONE, HONESTY IS A FRAGILE COMMODITY
@akanecortich8197
@akanecortich8197 4 года назад
This study from Uni of Minnesota. FROM a former employee of there ..Quote ""Corruption, cronyism abound."
@johnd2058
@johnd2058 4 года назад
Links or it didn't happen.
@hizzlemobizzle
@hizzlemobizzle 4 года назад
@Big Deeper hahah well said
@klondike444
@klondike444 4 года назад
May be true, but it needs evidence. If you have a quote, you should have a link.
@-astrangerontheinternet6687
@-astrangerontheinternet6687 4 года назад
If you search Minnesota university and corruption, you’ll have your pick of scandals. From basketball to research. Unfortunately, could do that for too many universities.
@trustdivinemercy
@trustdivinemercy 4 года назад
I'm fed up with cronyism. It's ubiquitous.
@billbaldwin9544
@billbaldwin9544 4 года назад
I'm disappointed to see some seriously poor analysis of the data re Zinc and Vitamin C. They were not part of the double-blind trial, but some people, on their own initiative, were taking Zinc and/or Vit C. The most likely thing is that the people taking these for protection, were people who believed themselves to be at greater risk. Therefore this data is completely worthless, there is absolutely no reason to believe that they do not work, or even increase the risk. I'm basing these comments on the analysis in this video, I haven't looked at the trial writeup.
@lynnmckenna9934
@lynnmckenna9934 4 года назад
I study with you everyday- one of my favorite professors of all time💙
@markumbers5362
@markumbers5362 4 года назад
Thanks Dr Campbell. After I retired I did a unit of introductory statistics at uni and therefore found your explanation of the study terrific. As can be seen by the comments below personal bias has a very strong influence on people so double blind studies are the only ones worth taking time to look at. After a good study like this is completed there are ALWAYS more questions to be asked. "Ok we know this so what about that". That is what science is all about building on properly conducted, repeatable experiments. I particularly liked your explanation of P values. Thank you.
@JB-qc1kj
@JB-qc1kj 4 года назад
Pretty worthless study... :-( The trial did not demonstrate a significant benefit of hydroxychloroquine as postexposure prophylaxis for Covid-19 BECAUSE THE SUBJECTS DID NOT GET A TEST TO CONFIRM WHETHER OR NOT THEY HAD THE VIRUS!!! A quote from the study, "We acknowledge that this trial has limitations. Because of the lack of availability of diagnostic testing in the United States, the vast majority of the participants, including health care workers, were unable to access testing."
@pappy37
@pappy37 4 года назад
It's all about the money.
@deidrecoday1269
@deidrecoday1269 4 года назад
And population reduction.
@shanerobins1428
@shanerobins1428 4 года назад
Mortality rate ? The most important question not answered. Remdesivir has no impact on mortality rate. HCQ mortality impact ? Still unanswered with and without Zinc.
@garyfumeaux9226
@garyfumeaux9226 4 года назад
There is great news about the mortality rate We should be shouting from the rooftops about this study for 2 reasons (1) Only 4 people were hospitalised and none died which highlights the non-lethal nature of this illness. (2) Secondly, only 13% of people who were put in a high-risk environment contracted the disease which means this disease spreads less rapidly than first thought. With this new data, we should all sleep easy and John needs to rethink all the data and percentages he has been feeding you. Other than the great news about it's a pretty useless study. John just because it's Double-Blind Placebo-Controlled doesn't make it a good study. Just a few things to consider. 1. This is not a high-risk age group so why do the study? 2. Many people are asymptomatic so without antibody testing, you have no idea as to how many people actually contacted the disease which makes the data quite useless. 3. Talking about Zn when it wasn’t part of the protocol highlights the poor science 4. All participants self-assessed which again is very poor science. To do a study like this with a product that is so politically charged is ridiculous. John you need to do a better analysis of junk science. Just like your analysis of the NIH study www.nejm.org/doi/pdf/10.1056/NEJMoa2012410 Instead of jumping from the rooftops because the study showed that patients on HCQ died 31% of the time compared to 65% of non HCQ patients. That alone makes this a miracle drug but instead, you preferred to praise the junk science. Come on you can do better. here is the analysis of this study if you want it Here are just 7 reasons why this study was designed to fail. (1) First, the study is funded by the NIH. This is a “Fauci study” who has a vested interest in it not working. (2) The Study is using a “multivariable Cox model” with inverse probability weighting according to the propensity score, which allows for massive data manipulation. (3) it took up to “48 hours for 85.9% of patients to be treated. Why would you delay treatment? The next point helps to explain why. (4) "Hydroxychloroquine-treated patients were more severely ill at baseline than those who did not receive hydroxychloroquine" Yes this is written in the study. (5) No Zn was given with the HCQ. It is well established by many Drs treating patients that the HCQ allows for the movement of Zn into the cell which then stops the viral replication. (6) Death or Intubation endpoints are considered the same outcome, so even if they recovered after intubation they were still considered a negative outcome. (7) All patients in the HCQ group had more older, male and comorbidity patients. Note In-fact if you look at the most important result hidden in the appendix Table S1 you would see that of all patients put on a ventilator only 32% of the HCQ and 65% of non HCQ died. Therefore HCQ halved the death rate of ventilated patients. This is an incredible result and yet it is not mentioned because the study is manipulated to fail Table S1 HCQ / No HCQ Primary Outcome 262 / 84 Death 157 / 75 Intubated 154/ 26 Intubated then Death 49 / 17 Death after Intubation%. 31/ 65 
This study is a joke and doctor who references it should have their medical licence revoked. How was this allowed to be published?
@alexanderleuchte5132
@alexanderleuchte5132 4 года назад
The most important question is how well Diethylcarbamazine combined with copper works. Nobody is looking into that, there must be some sort of agenda behind it
@-astrangerontheinternet6687
@-astrangerontheinternet6687 4 года назад
They followed only for 14 days. One hospitalization in each group. No deaths. Most deaths and hospitalizations would happen after 14 days of exposure, though. The study wasn’t designed to look at those things.
@-astrangerontheinternet6687
@-astrangerontheinternet6687 4 года назад
Gary Fumeaux thank you for your comment.
@shanerobins1428
@shanerobins1428 4 года назад
Jack M. Can you provide a link to this clinical data so that I can update my opinion based on scientific fact. Statements without a link to the a peer reviewed publication is the reason we are here. So please send it on. The data I have seen to date for Remdesivir shows no impact on mortality only 4 days less hospital stay.
@SilvanaDil
@SilvanaDil 4 года назад
*BUT* did the study show whether or not the people given hydroxychloroquine were less likely to develop severe disease and/or die?
@hizzlemobizzle
@hizzlemobizzle 4 года назад
It showed no difference with or without it. Granted it would be nice to learn if those who took it also suffered from the drugs side effects. It has some serious side effects.
@shivamchandok7826
@shivamchandok7826 4 года назад
Exactly, HCQ is not meant to prevent the disease but to reduce severity and viral shedding which has not been talked about in this study.
@shivamchandok7826
@shivamchandok7826 4 года назад
@@hizzlemobizzle Certainly it would be good to know the number of people getting side effects to get the fear of it out of your head. HCQ has side effects because it has been researched upon extensively, remdesevir is a new drug and vaccine which hasn't been even developed might be more dangerous which we probably might come to know about in future.
@-k--2965
@-k--2965 4 года назад
@@hizzlemobizzle It can take up to a year, but most will show cytotoxic effects to other biologic systems within six months of administration. Some don't have the initial adverse reaction, but will suffer later effects. They need to follow them to see. Most times it is ignored and attributed to auto immune disease rather than the quinolone exposure because of the late onset.
@davidmcmillan4183
@davidmcmillan4183 4 года назад
@@hizzlemobizzle They did, if you read the study. The study said no one experience serious side effects but the treatment group did experience side effects at a higher rate than the placebo group.
@LucyBlue0823
@LucyBlue0823 4 года назад
Good morning from Alpine, Texas!
@MeasAgun
@MeasAgun 4 года назад
Morning from France
@dixiedoos3512
@dixiedoos3512 4 года назад
Hiya regards from ne england
@babygroot2078
@babygroot2078 4 года назад
Science paper on antibodies of mild COVID19 infection www.medrxiv.org/content/10.1101/2020.05.19.20101832v2
@MJ-zo5gb
@MJ-zo5gb 4 года назад
Poor reasoning when he says that you wouldn’t get on a plane with only a 65% chance of surviving. A better analogy would be you’re already on a plane flying with engine problems and you can do something to increase your chance of landing safely a little and it has a 65% of working, but it may be do nothing and has minimal side effects you would do it. 🤔
@bonitagails
@bonitagails 4 года назад
I thought the whole point of taking the HCQ, zinc and an antibiotic was to reduce the severity of the systems. NOT to prevent the disease. If we can prevent hospitalization then the goal is achieved.
@trisha4797
@trisha4797 4 года назад
Thank you for reading through the studies for all of us. And, for sharing it in an intelligent, informative way.
@chuckschumer7783
@chuckschumer7783 4 года назад
Except the way he explains is incredibly deceptive.
@irenamangone
@irenamangone 4 года назад
Chuck Schumer are you qualified to say that or do you have an agenda. Just asking
@hulderifjellet656
@hulderifjellet656 4 года назад
@@chuckschumer7783 You are, of course , a doctor?
@klondike444
@klondike444 4 года назад
@@chuckschumer7783 Not deceptive, just wrong.
@elainemagson213
@elainemagson213 4 года назад
I love the way you stick to data that is generally trusted. All the same, I am not happy with this study because so many respected medicos say that taken BEFORE infection takes hold and with ZINC the results are more than interesting. Lets hope there is more data soon on which you can report. I am getting a bit sceptical these days with the mainstream science pronouncements!
@allangibson8494
@allangibson8494 4 года назад
The human body has thrown spanners in the works before.
@RGBEAT
@RGBEAT 4 года назад
There is zinc in the study- he talks about it about 3/4 way in
@esecallum
@esecallum 4 года назад
no money in it. Why is everyone obsessed with hcq? Its not over the counter. First you need to carted to hospital then you need qualified staff to give it plus 2 other drugs. You people are very stupid. Just take 10000 to 20000 d3 plus cofactors and be immune. ...
@williethomas2628
@williethomas2628 4 года назад
Thanks from Florida. I am a Biologist and enjoy you so much. U are like a interesting professor.
@kilroy987
@kilroy987 4 года назад
Seems odd that the paper didn't study the severity of symptoms, just whether or not you get them. Medicine is mostly about improving something, not preventing it.
@hizzlemobizzle
@hizzlemobizzle 4 года назад
well, I wouldn't say that, but I get your point.
@jasonwomack4064
@jasonwomack4064 4 года назад
It didn't prominently show the numbers for severity and deaths. Which makes me suspect it doesn't match the narrative and people actually lived.
@johnkosi6798
@johnkosi6798 4 года назад
It would also be nice to know how many patients in the trial went on to develop serious symptoms. Even though that would likely be statistically insignificant as well. Thanks doc
@hizzlemobizzle
@hizzlemobizzle 4 года назад
They already have studies to show the side effects of the drug. Nasty side effects. No idea how many in the trial had side effects, but we know they exist.
@glynnec2008
@glynnec2008 4 года назад
Exactly. Was the mortality reported in this study? That's what everyone really wants to know.
@tweeked267
@tweeked267 4 года назад
hizzle mobizzle your ignorance and repetition of things you don’t understand is not helping.
@glynnec2008
@glynnec2008 4 года назад
@@hizzlemobizzle I wouldn't call a headache or a tummy ache a "nasty" side effect. This drug has been around for decades and doctors already know who shouldn't be taking it.
@hizzlemobizzle
@hizzlemobizzle 4 года назад
@@glynnec2008 Hydroxychloroquine side effects. Serious side effects Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following: blurred vision or other vision changes, which may be permanent in some cases heart disease, including heart failure and issues with your heart rhythm; some cases have been fatal ringing in your ears or hearing loss angioedema (rapid swelling of your skin) hives mild or severe bronchospasm sore throat severe hypoglycemia unusual bleeding or bruising blue-black skin color muscle weakness hair loss or changes in hair color abnormal mood changes mental health effects, including suicidal thoughts
@richardgab7591
@richardgab7591 4 года назад
What I get from this is that the trial was done to determine ONLY the effect of the drug in PREVENTING disease after exposure to the virus. But it does not deal with its use in treatment once the disease is contracted. It also does not state what amounts of zinc and vitamin C were being taken during the trial, and whether these amounts were consitstent from patient to patient.
@andrewelstein3596
@andrewelstein3596 4 года назад
Hi John, Thanks for your videos as always. Your dedication is admirable. One note I couldn't help make as an aerospace engineer: your explanation of a p value as the % chance that an effect occurred by chance is not accurate. A p value is the probability of obtaining an effect at least as extreme as the one in your sample data, assuming the truth of the null hypothesis (which in this case is that the drug does not work). The difference is subtle but very important. A p value of 0.35 indicates that 35% of random experiments of this size that included 2 identical control groups like this would result in a difference between control and "experimental" (2nd control) groups that is as large or more than was reported in this study. Please consider correcting this in a future video and editing the description to reflect this as the p value is a commonly misunderstood concept. Source: blog.minitab.com/blog/adventures-in-statistics-2/how-to-correctly-interpret-p-values
@alisonmorris7686
@alisonmorris7686 4 года назад
Very interestingly, today on my COVID symptom Study from Kings College London, they asked me for the first time how long I had been taking vitamins and Vitamin D, C and zinc were mentioned. Does this mean at last they are listening to you Dr J? I really hope so.
@elainemagson213
@elainemagson213 4 года назад
Let's hope so - and Medcram, and Chris Martenson and their ilk. They've all been saying this now for months. It's only the experts who are lagging behind.
@endintiers
@endintiers 4 года назад
@@elainemagson213 This latest study indicates that taking Vitamin C is very dangerous!
@esecallum
@esecallum 4 года назад
@@endintiers let's ban it.
@esecallum
@esecallum 4 года назад
@Stephen Morris ban all vitamins. they can cause death if taken wrongly.
@susanstricker5416
@susanstricker5416 4 года назад
endintiers and where is the proof, do you have a link?
@PainfulSin2811170
@PainfulSin2811170 4 года назад
If the 'study' did not include zinc, it was already flawed from the beginning. Zinc acts as an ionophore. three drugs are needed here(HCQ, Z-Pack, Zinc) they create a synergistic effect. Also, Dr. Raoult in France has been taking the approach of using this treatment EARLY before more serious symptoms set in.
@EvinFox
@EvinFox 4 года назад
The Lancet retracted the study that concluded that hydroxychloroquine was dangerous for COVID 19 patients, today.
@EvinFox
@EvinFox 4 года назад
Oh, I see these are two different studies.
@bogipepper
@bogipepper 4 года назад
How much zinc and when? How much C and when? Was their vitamin D levels monitored? Your conclusions are made from data or beliefs?
@solidfuel0
@solidfuel0 4 года назад
Data, I went and checked the study. People just stop talking about zinc working with HCQ
@hilarymcclure4138
@hilarymcclure4138 4 года назад
I downloaded and checked the appendix. They asked participants whether they were taking zinc or vitamin C. But it was just yes or no. They didn't ask specifics about the formulation, or the dosage or duration for either supplement, and therefore stated that the results were not conclusive. This is certainly NOT a test of the Zelenko Protocol.
@loopbraider
@loopbraider 4 года назад
@@hilarymcclure4138 Where in the appendix did you find the mention of zinc and vitamin C? Under Appendix all I can see is list of the authors' names and a bibliographical list of references. Would really like to see the zinc and vit c references myself! Can't find it anywhere it either the online or downloaded version... I pored through the whole study too. Could you give me a page number???
@loopbraider
@loopbraider 4 года назад
@@hilarymcclure4138 Oops never mind! I found it - it's in the "supplemental appendix", page 14.
@jillseigworth6734
@jillseigworth6734 4 года назад
Thanks again for educating us so wonderfully ♥️
@fasteddiejs
@fasteddiejs 4 года назад
He’s working for big pharma. The ‘protests’ seem to have cured the virus. Oh wait, neo Marxist politics WAS the virus. The covid scam deconstructed: edwardjblack.com/2020/04/24/the-invisible-war/
@klondike444
@klondike444 4 года назад
I'm afraid by helping to spread these "studies" John is unintentionally spreading disinformation. He is STILL NAIVE.
@RM-oz6xq
@RM-oz6xq 4 года назад
“We have to believe the evidence”. In these times it is really truly hard to believe anything including “the evidence”
@RM-oz6xq
@RM-oz6xq 4 года назад
Seine O'More what evidence? what’s the evidence?
@philipandrew1626
@philipandrew1626 4 года назад
The "good" HydroxyChloroquine study has some limitations. The drug was given several days after symptoms show (after the virus already taken off in the body) or some eight day after first infection. The participants were not in a high risk group. The participants were selected based on 'self-reported' symptoms but only 3% were later confirmed to have the virus based on the PCR antigen test. This test is notoriously unreliable but the "infected" were not later checked with blood serology to check for the presence of anti-bodies and confirm that they were infected with corona-virus. Also 3% of a 800 sample size is not a very large group. Further the group that were taking Zinc was only 15%, so that infected group shrinks further. Split that group into two (experimental vs placebo) and its a tiny sample. Worse, the placebo group were on vitamin D which is known to improve your immune defence.
@joeydefarco7707
@joeydefarco7707 4 года назад
They have fudged every study, i wonder if its done on purpose. Here in iran as soon as you show symptoms you are prescribed hydroxochloroquine and antibiotics and our death rates have severly decreased since the first initial weeks of the outbreak. I have many students and friends who are doctors nurses etc. So i am well informed on the daily statistics here for my area. There needs to be a decent study on covid19 patients who start on this regiment within the first 48 hours of symptoms.
@SherriSLC
@SherriSLC 4 года назад
You're an excellent educator. Thank you for teaching us all about epidemiology and how to interpret clinical research. That said, I'm fascinated by the comments here that reflexively defend hydroxychloroquine...and sometimes I wonder if it's politically motivated for some, because their political leader recommended the drug. Hmm.
@garyfumeaux9226
@garyfumeaux9226 4 года назад
This has all become political but not for the reasons you think. Don't accept this junk science and do more of your own analytical thinking. This is not a good study. We should be shouting from the rooftops about this study for 2 reasons (1) Only 4 people were hospitalised and none died which highlights the non-lethal nature of this illness. (2) Secondly, only 13% of people who were put in a high-risk environment contracted the disease which means this disease spreads less rapidly than first thought. With this new data, we should all sleep easy and John needs to rethink all the data and percentages he has been feeding you. Other than the great news about it's a pretty useless study. John just because it's Double-Blind Placebo-Controlled doesn't make it a good study. Just a few things to consider. 1. This is not a high-risk age group so why do the study? 2. Many people are asymptomatic so without antibody testing, you have no idea as to how many people actually contacted the disease which makes the data quite useless. 3. Talking about Zn when it wasn’t part of the protocol highlights the poor science 4. All participants self-assessed which again is very poor science. To do a study like this with a product that is so politically charged is ridiculous. John you need to do a better analysis of junk science. Just like your analysis of the NIH study www.nejm.org/doi/pdf/10.1056/NEJMoa2012410 Instead of jumping from the rooftops because the study showed that patients on HCQ died 31% of the time compared to 65% of non HCQ patients. That alone makes this a miracle drug but instead, you preferred to praise the junk science. Come on you can do better. here is the analysis of this study if you want it Here are just 7 reasons why this study was designed to fail. (1) First, the study is funded by the NIH. This is a “Fauci study” who has a vested interest in it not working. (2) The Study is using a “multivariable Cox model” with inverse probability weighting according to the propensity score, which allows for massive data manipulation. (3) it took up to “48 hours for 85.9% of patients to be treated. Why would you delay treatment? The next point helps to explain why. (4) "Hydroxychloroquine-treated patients were more severely ill at baseline than those who did not receive hydroxychloroquine" Yes this is written in the study. (5) No Zn was given with the HCQ. It is well established by many Drs treating patients that the HCQ allows for the movement of Zn into the cell which then stops the viral replication. (6) Death or Intubation endpoints are considered the same outcome, so even if they recovered after intubation they were still considered a negative outcome. (7) All patients in the HCQ group had more older, male and comorbidity patients. Note In-fact if you look at the most important result hidden in the appendix Table S1 you would see that of all patients put on a ventilator only 32% of the HCQ and 65% of non HCQ died. Therefore HCQ halved the death rate of ventilated patients. This is an incredible result and yet it is not mentioned because the study is manipulated to fail Table S1 HCQ / No HCQ Primary Outcome 262 / 84 Death 157 / 75 Intubated 154/ 26 Intubated then Death 49 / 17 Death after Intubation%. 31/ 65 
This study is a joke and doctor who references it should have their medical licence revoked. How was this allowed to be published?
@klondike444
@klondike444 4 года назад
SherriSLC Political leader? Trump is garbage, like this study.
@gabrieloneill968
@gabrieloneill968 4 года назад
He didn't just reccomend the drug he is taking it himself. This guy on here is just a paid liar for Bill Gates. Will Gates be taking one of his Vaccines. Of course not, and how come his three kids don't get vaccinated either.
@ivermec-tin666
@ivermec-tin666 4 года назад
No. I didn't vote for that man. Contain your TDS. This study is statistically meaningless, and the hypothesis is irrelevant in any case. Might as well test to see if HCQ cures acne. Who cares?
@freek8609
@freek8609 4 года назад
J Anders Your wrong! Its HCQ with Zinc! A life can be saved! Or do you want to wait for the vaccin?
@rv6amark
@rv6amark 4 года назад
Ok, I searched the entire report for "zinc" and "Zinc", but NOTHING was found. Dr. Campbell, where did your zinc data come from? Did you get this report, and the one from the Lancet mixed up? Should we add YOU to the list of untrusted medical sources? What page or section was your zinc data taken from?
@singledad1313
@singledad1313 4 года назад
It's in the complete report, not in the article. There is a link to the data at the end. www.nejm.org/doi/suppl/10.1056/NEJMoa2016638/suppl_file/nejmoa2016638_appendix.pdf
@wmsatic
@wmsatic 4 года назад
What was the severity? This study is almost worthless if it didn't report on the severity of the cases. I don't expect a prophylaxis treatment to prevent a highly contagious illness: but I do hope it will reduce the severity.
@Bhatmann
@Bhatmann 4 года назад
The Lancet retracting a study is not a ‘bombshell’. What is an absolute bombshell is The Lancet publishing GARBAGE in the first place. And they absolutely deserve what consequences they get and more. I would burn them to the ground.
@LondonSteveLee
@LondonSteveLee 4 года назад
@Andrew Ongais The Lancet are supposed to publish material from recognised sources - not a science fiction writer and an adult model who wrote the paper this video is based on.
@yancymuu4977
@yancymuu4977 4 года назад
In my opinion you are far to negative on HCQ and risk doing much harm if research turns out that there is a benefit.
@user-qy7ny4de6h
@user-qy7ny4de6h 4 года назад
The hcq treatment was given for 4 days only, given the incubation period and the immune response, it should have been given for 10-14 days
@Jamesbruceblakley
@Jamesbruceblakley 4 года назад
Brilliant presentation. Thanks so much. I hope you are teaching in a medical school, as you have a fantastic, clear, engaging and authentic way of presentation.
@nitrostudy9049
@nitrostudy9049 4 года назад
There is not only crisis of trust, there is a crisis of repeatability of results, and a crisis of scientific spin doctoring. Science is being increasingly politicised as universities became increasingly political.
@mistymac9345
@mistymac9345 4 года назад
Indeed. Follow the money
@mw3516405
@mw3516405 4 года назад
Very strange it's a anti inflammatory ! California at Sinai Hospital using it with zinc and oxgen therapy ! They are having good results ! Best keep testing? Thank you ! Research test research ..
@bobcharlotte8724
@bobcharlotte8724 4 года назад
Yes. As soon as possible. 4 days is too long.
@theresaswan20
@theresaswan20 4 года назад
I understood that Hydroxychloroquine with Zinc and Oxygen therapy, reduces the severity of the symptoms, which sounds like a God send. I know it wont stop people getting the virus but reducing the severity is fantastic as that can save lives.
@crusindc5282
@crusindc5282 4 года назад
MW: Lots of medical teams have started using it and then rapidly abandoned doing so because of alarming side effects from Covid-19.
@mballer
@mballer 4 года назад
@@crusindc5282 Really? Where?
@GrubbyPaddler
@GrubbyPaddler 4 года назад
Branch 4 how gas been used for decades with many millions of doses given, it was studied and promoted by the who with absolute minimums of side effects, it’s only since covid hit the US and big pharma sees $$$ that these ‘studies’ came out Chris Martin son from peak prosperity gives a great run down of this
@cantankeroushousewife2942
@cantankeroushousewife2942 4 года назад
Thank you for your work
@dMoniker
@dMoniker 4 года назад
Thank you as always John
@Jamesvandaele
@Jamesvandaele 4 года назад
Saying that it doesn't work when the severity of the disease isn't talked about and the fact that the death rate isn't talked about seems like jumping the gun. Also I would like to see the average time from infection for the hydroxychloroquine group versus the time from infection on the placebo group since that obviously has the most bearing when you're dealing with something which has an average viral replication phase of 5 days
@connieinga9638
@connieinga9638 4 года назад
My friends that took it where in the hospital and the Drs admitted it cut the virus short. 7 days vs 14 days of fever and severe respiratory problems. I have not heard that it has been used here at Emory prophylactic at all. So the study is good but not the way Emory is using it.
@garyfumeaux9226
@garyfumeaux9226 4 года назад
Connie the study is not good We should be shouting from the rooftops about this study for 2 reasons (1) Only 4 people were hospitalised and none died which highlights the non-lethal nature of this illness. (2) Secondly, only 13% of people who were put in a high-risk environment contracted the disease which means this disease spreads less rapidly than first thought. With this new data, we should all sleep easy and John needs to rethink all the data and percentages he has been feeding you. Other than the great news about it's a pretty useless study. John just because it's Double-Blind Placebo-Controlled doesn't make it a good study. Just a few things to consider. 1. This is not a high-risk age group so why do the study? 2. Many people are asymptomatic so without antibody testing, you have no idea as to how many people actually contacted the disease which makes the data quite useless. 3. Talking about Zn when it wasn’t part of the protocol highlights the poor science 4. All participants self-assessed which again is very poor science. To do a study like this with a product that is so politically charged is ridiculous. John you need to do a better analysis of junk science. Just like your analysis of the NIH study www.nejm.org/doi/pdf/10.1056/NEJMoa2012410 Instead of jumping from the rooftops because the study showed that patients on HCQ died 31% of the time compared to 65% of non HCQ patients. That alone makes this a miracle drug but instead, you preferred to praise the junk science. Come on you can do better. here is the analysis of this study if you want it Here are just 7 reasons why this study was designed to fail. (1) First, the study is funded by the NIH. This is a “Fauci study” who has a vested interest in it not working. (2) The Study is using a “multivariable Cox model” with inverse probability weighting according to the propensity score, which allows for massive data manipulation. (3) it took up to “48 hours for 85.9% of patients to be treated. Why would you delay treatment? The next point helps to explain why. (4) "Hydroxychloroquine-treated patients were more severely ill at baseline than those who did not receive hydroxychloroquine" Yes this is written in the study. (5) No Zn was given with the HCQ. It is well established by many Drs treating patients that the HCQ allows for the movement of Zn into the cell which then stops the viral replication. (6) Death or Intubation endpoints are considered the same outcome, so even if they recovered after intubation they were still considered a negative outcome. (7) All patients in the HCQ group had more older, male and comorbidity patients. Note In-fact if you look at the most important result hidden in the appendix Table S1 you would see that of all patients put on a ventilator only 32% of the HCQ and 65% of non HCQ died. Therefore HCQ halved the death rate of ventilated patients. This is an incredible result and yet it is not mentioned because the study is manipulated to fail Table S1 HCQ / No HCQ Primary Outcome 262 / 84 Death 157 / 75 Intubated 154/ 26 Intubated then Death 49 / 17 Death after Intubation%. 31/ 65 
This study is a joke and doctor who references it should have their medical licence revoked. How was this allowed to be published?
@Zirckonium
@Zirckonium 4 года назад
@@garyfumeaux9226 Speaking of data manipulation, you left out part of the table. The difference between Death after Intubation between HCQ and non-HCQ group is due to patients still being intubated and hospitalized in the HCQ group (89) without death outcome or discharge yet. This is much less in the non-HCQ group (only 6 still intubated after experiment) tl;dr: your conclusions are entirely invalid
@lauriemccormack6645
@lauriemccormack6645 4 года назад
Nobody not even a doctor know’s the length of time somebody is going to have a fever for.
@JR-zw2vb
@JR-zw2vb 4 года назад
​@@garyfumeaux9226 These are research hacks to promote the use of ICU and ventilators because they create more income to the hospital. Our medical system in the U.S. is in itself a pre-existing condition to us all. I've posted a separate reply to Dr. Campbell's video from a research done early on and published on Nature journal on cell research section. And another article at BBC, reviewing case in Turkey which has significantly managed Covid-19 by administering HCQ at early stage. Here they are: Research done and published on Nature journal (Feb, 4, 2020): www.nature.com/articles/s41422-020-0282-0 "Our findings reveal that remdesivir and chloroquine are highly effective in the control of 2019-nCoV infection in vitro. Since these compounds have been used in human patients with a safety track record and shown to be effective against various ailments, we suggest that they should be assessed in human patients suffering from the novel coronavirus disease. " "Coronavirus: How Turkey took control of Covid-19 emergency" www.bbc.com/news/world-europe-52831017 "Chief doctor Nurettin Yiyit ... says it's key to use hydroxychloroquine early. "Other countries are using this drug too late," he says, "especially the United States. We only use it at the beginning. We have no hesitation about this drug. We believe it's effective because we get the results." " To look at the economy: It is less than 50 cents in the U.S. per pill for Hydroxychloroquine, but they can charge as much as up to $100,000 per day if you lay in the ICU with ventilators. No wonder.
@michellependergrass8479
@michellependergrass8479 4 года назад
What a weird paper! I thought they were supposed to be studying whether people who were taking it when exposed, died from or needed a hospital/icu stay from their symptoms?
@allangibson8494
@allangibson8494 4 года назад
This was discussing Hydroxychloroqine as a prophylactic. It doesn't appear to work and gives side effects in around 20% of users.
@mballer
@mballer 4 года назад
@@allangibson8494 it was not discussing a prophylactic, they were giving it up to 4 days after exposure
@hizzlemobizzle
@hizzlemobizzle 4 года назад
The claim is that it will prevent the disease. Already know it will not help when you have the disease.
@vihuelamig
@vihuelamig 4 года назад
@@hizzlemobizzle They are changing it now. It has to be given with Zinc and Strawberry jam. Without the strawberry jam it won't work. Obvious.
@georgerbuchanan
@georgerbuchanan 4 года назад
M Ball you clearly don’t understand the difference between exposure and infection
@thedemonq6618
@thedemonq6618 4 года назад
Very interesting and unfortunate results. Are the patients from the study that developed CoViD19 continuing the HCQ or placebo? It would be interesting to follow those same infected patients to determine if the disease is lessened or made more severe by taking HCQ and zinc prior to exposure!
@seeibe
@seeibe 4 года назад
"Randomized, double blind, placebo controlled trial" of vitamin D? B12? Zinc?! No, Hydroxychloroquine. :(
@mballer
@mballer 4 года назад
The placebo in this study was folate.
@doriangray_1999
@doriangray_1999 4 года назад
@@mballer Folate...? It's a B-vitamin (B9) mostly needed to help pregnant women to protect their child! It's not an inert drug!!
@GOLEMUK
@GOLEMUK 4 года назад
Not yet, but this is definitely interesting. A cohort study to evaluate the effect of combination Vitamin D, Magnesium and Vitamin B12 (DMB) on progression to severe outcome in older COVID-19 patients. www.medrxiv.org/content/10.1101/2020.06.01.20112334v1 It's not without problems, not least the small size and not enough attention paid to keeping the control and trial groups equivalent in comorbities and age, but, more RCTs and studies are coming it seems.
@kaustubhpatil201
@kaustubhpatil201 4 года назад
Thanks for the video! Excellent example of how to conduct experiments and a lesson in critical thinking and problem solving methodology.
@fasteddiejs
@fasteddiejs 4 года назад
“Critical thinking”. Please. The CDC says this has a death rate of 0.26% of those infected: www.cdc.gov/coronavirus/2019-ncov/hcp/planning-scenarios.html?fbclid=IwAR0qTy4FlcgV3xarcw-2tyY2jHchaaOBNJEB1VNMMXWj1PtkVOhDLwRH7Es When you remember that half of all deaths are in care homes, that means the death rate is under 0.1% of non care home infections. That’s why the ‘protests’ have cured the disease. The disease was the neo Marxist politics all along, destabilising and designed to destroy the economy, and Dr John Campbell’s role is to be a shill for Big Pharma and the politics of “the new normal”. The covid scam laid bare: edwardjblack.com/2020/04/24/the-invisible-war/
@kaustubhpatil201
@kaustubhpatil201 4 года назад
fasteddie ok boomer
@Ruzhki
@Ruzhki 4 года назад
Just a thought, the ppl taking zinc and vitamin c, are mayb higher risk group? If your "high risk" its more likely that u take the supplements?
@mary4318
@mary4318 4 года назад
Ruzhki That could be true.
@lubricustheslippery5028
@lubricustheslippery5028 4 года назад
I think the same. But in the end it wasn't significant data so it could also just be by chance. After a quick read of this paper I was thinking about getting some zinc supplement www.ncbi.nlm.nih.gov/pmc/articles/PMC3724376/
@wolumandreas1130
@wolumandreas1130 4 года назад
Thank you Dr. Campbell. This type of review [by yourself] , interpretation for the audience is most valuable for your viewers. Please continue with such as these analyses will not be offered by media or governments; unfortunately.
@klondike444
@klondike444 4 года назад
No. He's very bad at this. He should stick to what he knows.
@Muzakman37
@Muzakman37 4 года назад
@@klondike444 You should stick to what you want to hear, elsewhere.
@johannaquinones7473
@johannaquinones7473 4 года назад
Thank you!!! If I would have had a professor like you in HS or college I may just have considered going into medicine. You were born to teach!💖💖💖
@earthangel2524
@earthangel2524 4 года назад
What effect does HDC+zinc have on severity of symptoms?
@pteppig
@pteppig 4 года назад
Based on the NYU study, it increases treatment effectiveness by 150% compared to HCQ alone. Full study in lnk posted above
@CarolRosiniCreations
@CarolRosiniCreations 4 года назад
A group out of the UK proved that previous study on HCQ was totally false. The information that has come out on the people that wrote it is very disturbing, I recently saw an interview with a doctor in Dallas the prescribes HCQ for positive people with symptoms and she has experienced 100% success. patients showed dramatic improvement in as little as 24 hours. I have an aunt who is 82 that takes it for RA and she has no side affects.
@JustJudy
@JustJudy 4 года назад
Carol Rosini exactly, my arthritis dr at a VERY large clinic, in Shreveport La said everyone of his partients who had lupus and rheumatoid are on It and the people who had covid had a VERY mild case, it didn’t prevent it. . I overheard my ENT doctor prescribing to a positive patient also with the antibiotic, no drug is perfect .. but if it will help prevent a serious case of getting in the lungs,, that’s what we want.
@garyfumeaux9226
@garyfumeaux9226 4 года назад
Carol you are absolutely right this is junk science We should be shouting from the rooftops about this study for 2 reasons (1) Only 4 people were hospitalised and none died which highlights the non-lethal nature of this illness. (2) Secondly, only 13% of people who were put in a high-risk environment contracted the disease which means this disease spreads less rapidly than first thought. With this new data, we should all sleep easy and John needs to rethink all the data and percentages he has been feeding you. Other than the great news about it's a pretty useless study. John just because it's Double-Blind Placebo-Controlled doesn't make it a good study. Just a few things to consider. 1. This is not a high-risk age group so why do the study? 2. Many people are asymptomatic so without antibody testing, you have no idea as to how many people actually contacted the disease which makes the data quite useless. 3. Talking about Zn when it wasn’t part of the protocol highlights the poor science 4. All participants self-assessed which again is very poor science. To do a study like this with a product that is so politically charged is ridiculous. John you need to do a better analysis of junk science. Just like your analysis of the NIH study www.nejm.org/doi/pdf/10.1056/NEJMoa2012410 Instead of jumping from the rooftops because the study showed that patients on HCQ died 31% of the time compared to 65% of non HCQ patients. That alone makes this a miracle drug but instead, you preferred to praise the junk science. Come on you can do better. here is the analysis of this study if you want it Here are just 7 reasons why this study was designed to fail. (1) First, the study is funded by the NIH. This is a “Fauci study” who has a vested interest in it not working. (2) The Study is using a “multivariable Cox model” with inverse probability weighting according to the propensity score, which allows for massive data manipulation. (3) it took up to “48 hours for 85.9% of patients to be treated. Why would you delay treatment? The next point helps to explain why. (4) "Hydroxychloroquine-treated patients were more severely ill at baseline than those who did not receive hydroxychloroquine" Yes this is written in the study. (5) No Zn was given with the HCQ. It is well established by many Drs treating patients that the HCQ allows for the movement of Zn into the cell which then stops the viral replication. (6) Death or Intubation endpoints are considered the same outcome, so even if they recovered after intubation they were still considered a negative outcome. (7) All patients in the HCQ group had more older, male and comorbidity patients. Note In-fact if you look at the most important result hidden in the appendix Table S1 you would see that of all patients put on a ventilator only 32% of the HCQ and 65% of non HCQ died. Therefore HCQ halved the death rate of ventilated patients. This is an incredible result and yet it is not mentioned because the study is manipulated to fail Table S1 HCQ / No HCQ Primary Outcome 262 / 84 Death 157 / 75 Intubated 154/ 26 Intubated then Death 49 / 17 Death after Intubation%. 31/ 65 
This study is a joke and doctor who references it should have their medical licence revoked. How was this allowed to be published?
@georgerbuchanan
@georgerbuchanan 4 года назад
Just Judy you clearly have no idea of medicine if you’re spouting this...what are your qualifications?
@JustJudy
@JustJudy 4 года назад
George Buchanan mine are none,, this is what my doctors said, .. I said this is what I was told,,, why did you say that to me.. when I was relaying what I was told by my doctors.. and others are clearly giving the same message, I never once said I had any qualifications to treat anyone. But truth is many doctors are treating patients in the USA with this.. i was told by 2 of my doctors.
@JustJudy
@JustJudy 4 года назад
I respect dr Campbell a LOT. I wanted to put out there what I was told in person by my medical doctors.
@canice123
@canice123 4 года назад
Gosh Dr. John, I hope you have time for a cup of tea and a biscuit or two. Your research is astounding. Thank you.
@joeande101
@joeande101 4 года назад
Dr Dr.Campbell, Why aren't you mentioning all the millions on the Maliara treatment for say Lupus, none of the patient's have been hospitalized for covid19?? Why is That?
@mostdreadedterror7084
@mostdreadedterror7084 4 года назад
Excellent analysis. Early on, you pointed out that people knew whether they were taking zinc and the possibility presents itself that those who were more worried or had just an inkling although technically pre-symptomatic, like they'd lost the sense of smell, which might not have been on the symptom checklist, were more likely to have been taking zinc or vitamin C. So the statement, "There is an intimation that zinc/vit C might cause an increase in developing symptoms is not true. Not only is it not statistically significant, but but the alternative explanation really ought to be mentioned. Meanwhile, they can have my quercetin pills when they pry them out of my cold stiff fingers. (o; Trust. Well I trust you, And you say there is a crisis, and I agree.
@therealrussellsmyth
@therealrussellsmyth 4 года назад
Once again... John needs to subscribe to Chris Martenson’s channel !!
@frederikhoffmann382
@frederikhoffmann382 4 года назад
I love this channel. Reliable info every single day baby 💪💪
@drjamesfroggatt7647
@drjamesfroggatt7647 4 года назад
Parker Pen. I've had mine for over 20 years, still working just fine.
@lizeggar2421
@lizeggar2421 4 года назад
Another test designed to fail. The participants were each taking vitamins and zinc, but the amounts were unknown.
@dallysinghson5569
@dallysinghson5569 4 года назад
Read the study
@bluemarlin2004
@bluemarlin2004 4 года назад
Did that study include the data when (what day) the stage of infection the HCQ was given?
@ucouco78
@ucouco78 4 года назад
Watch the video, he said 4 days, why are you commenting without watching?
@davidmcmillan4183
@davidmcmillan4183 4 года назад
It wasn't given during infection, it was given to people who had a high risk contact, within 4 days of their contact to see if HCQ could prevent infection, which it didn't.
@ivermec-tin666
@ivermec-tin666 4 года назад
Day 4. Too late for an anti-viral to be of benefit... predictably.
@ucouco78
@ucouco78 4 года назад
@@ivermec-tin666 so it's useless then, we need a critical care drug since most people go to the hospital already in bad shape.
@OlJackBurton
@OlJackBurton 4 года назад
@@ucouco78 So far the only thing that has been shown to be effective against people in bad shape is plasma with neutralizing antibodies. We also need something that helps against the cytokine storm as that is the biggest killer...
@CrypTales007
@CrypTales007 4 года назад
65% success rate of a drug might be good enough for a patient in desperate state...if I am not mistaken, cancer treatments provide much less hope, some say under 10% might help. Anyway, hope there will be a sufficiently good drug found rather soon. I am sorry the study did not prove much, but I appreciate the hard work of all people involved. I hope the subjects are doing well.Thank you doctor for taking the time to explain us
@garyfumeaux9226
@garyfumeaux9226 4 года назад
Alex this is more junk science. Look a little deeper yourself We should be shouting from the rooftops about this study for 2 reasons (1) Only 4 people were hospitalised and none died which highlights the non-lethal nature of this illness. (2) Secondly, only 13% of people who were put in a high-risk environment contracted the disease which means this disease spreads less rapidly than first thought. With this new data, we should all sleep easy and John needs to rethink all the data and percentages he has been feeding you. Other than the great news about it's a pretty useless study. John just because it's Double-Blind Placebo-Controlled doesn't make it a good study. Just a few things to consider. 1. This is not a high-risk age group so why do the study? 2. Many people are asymptomatic so without antibody testing, you have no idea as to how many people actually contacted the disease which makes the data quite useless. 3. Talking about Zn when it wasn’t part of the protocol highlights the poor science 4. All participants self-assessed which again is very poor science. To do a study like this with a product that is so politically charged is ridiculous. John you need to do a better analysis of junk science. Just like your analysis of the NIH study www.nejm.org/doi/pdf/10.1056/NEJMoa2012410 Instead of jumping from the rooftops because the study showed that patients on HCQ died 31% of the time compared to 65% of non HCQ patients. That alone makes this a miracle drug but instead, you preferred to praise the junk science. Come on you can do better. here is the analysis of this study if you want it Here are just 7 reasons why this study was designed to fail. (1) First, the study is funded by the NIH. This is a “Fauci study” who has a vested interest in it not working. (2) The Study is using a “multivariable Cox model” with inverse probability weighting according to the propensity score, which allows for massive data manipulation. (3) it took up to “48 hours for 85.9% of patients to be treated. Why would you delay treatment? The next point helps to explain why. (4) "Hydroxychloroquine-treated patients were more severely ill at baseline than those who did not receive hydroxychloroquine" Yes this is written in the study. (5) No Zn was given with the HCQ. It is well established by many Drs treating patients that the HCQ allows for the movement of Zn into the cell which then stops the viral replication. (6) Death or Intubation endpoints are considered the same outcome, so even if they recovered after intubation they were still considered a negative outcome. (7) All patients in the HCQ group had more older, male and comorbidity patients. Note In-fact if you look at the most important result hidden in the appendix Table S1 you would see that of all patients put on a ventilator only 32% of the HCQ and 65% of non HCQ died. Therefore HCQ halved the death rate of ventilated patients. This is an incredible result and yet it is not mentioned because the study is manipulated to fail Table S1 HCQ / No HCQ Primary Outcome 262 / 84 Death 157 / 75 Intubated 154/ 26 Intubated then Death 49 / 17 Death after Intubation%. 31/ 65 
This study is a joke and doctor who references it should have their medical licence revoked. How was this allowed to be published?
@freebirdh604
@freebirdh604 4 года назад
Thank you again for all the information you gather for us online Campbell Covid students ❤️🌈
@ja687
@ja687 4 года назад
So 25% of the patients became symptomatic. How many of them experienced severe symptoms? No deaths? Sounds like a great result to me.
@markrancatore9525
@markrancatore9525 4 года назад
I’m not convinced! What’s the p value of the flu vaccine or Remdesovir?
@itbinktransferblade6057
@itbinktransferblade6057 4 года назад
Dr. Campbell, maybe you should wait a bit before presenting these papers on you channel. You had problems with the recent Lancet paper and now this one today has its own problems. Apparently it was well done under the circumstances of the early situation but those limitations used in the study have put some doubt in the results. Apparently, none of the people in the study actually were tested positive for covid19. All the people in the study were quite healthy. No one died in either group. The placebo was not a totally inactive chemical. The study also probably was not suitable to study the use as a prophylaxis but more as an after exposure situation. The medications were self administered by those in the study. No one checked compliance. You have good intentions but you really should not trust studies so quickly.
@nannyoggsally
@nannyoggsally 4 года назад
The results are quite wild. I'm very astonished. Especially about the zinc and vitamin c.
@esecallum
@esecallum 4 года назад
vitamindwiki.com/99+percent+of+the+380+Indonesians+who+died+of+COVID-19+had+low+vitamin+D+-+May+2020
@garyfumeaux9226
@garyfumeaux9226 4 года назад
Don't be sucked into this junk science We should be shouting from the rooftops about this study for 2 reasons (1) Only 4 people were hospitalised and none died which highlights the non-lethal nature of this illness. (2) Secondly, only 13% of people who were put in a high-risk environment contracted the disease which means this disease spreads less rapidly than first thought. With this new data, we should all sleep easy and John needs to rethink all the data and percentages he has been feeding you. Other than the great news about it's a pretty useless study. John just because it's Double-Blind Placebo-Controlled doesn't make it a good study. Just a few things to consider. 1. This is not a high-risk age group so why do the study? 2. Many people are asymptomatic so without antibody testing, you have no idea as to how many people actually contacted the disease which makes the data quite useless. 3. Talking about Zn when it wasn’t part of the protocol highlights the poor science 4. All participants self-assessed which again is very poor science. To do a study like this with a product that is so politically charged is ridiculous. John you need to do a better analysis of junk science. Just like your analysis of the NIH study www.nejm.org/doi/pdf/10.1056/NEJMoa2012410 Instead of jumping from the rooftops because the study showed that patients on HCQ died 31% of the time compared to 65% of non HCQ patients. That alone makes this a miracle drug but instead, you preferred to praise the junk science. Come on you can do better. here is the analysis of this study if you want it Here are just 7 reasons why this study was designed to fail. (1) First, the study is funded by the NIH. This is a “Fauci study” who has a vested interest in it not working. (2) The Study is using a “multivariable Cox model” with inverse probability weighting according to the propensity score, which allows for massive data manipulation. (3) it took up to “48 hours for 85.9% of patients to be treated. Why would you delay treatment? The next point helps to explain why. (4) "Hydroxychloroquine-treated patients were more severely ill at baseline than those who did not receive hydroxychloroquine" Yes this is written in the study. (5) No Zn was given with the HCQ. It is well established by many Drs treating patients that the HCQ allows for the movement of Zn into the cell which then stops the viral replication. (6) Death or Intubation endpoints are considered the same outcome, so even if they recovered after intubation they were still considered a negative outcome. (7) All patients in the HCQ group had more older, male and comorbidity patients. Note In-fact if you look at the most important result hidden in the appendix Table S1 you would see that of all patients put on a ventilator only 32% of the HCQ and 65% of non HCQ died. Therefore HCQ halved the death rate of ventilated patients. This is an incredible result and yet it is not mentioned because the study is manipulated to fail Table S1 HCQ / No HCQ Primary Outcome 262 / 84 Death 157 / 75 Intubated 154/ 26 Intubated then Death 49 / 17 Death after Intubation%. 31/ 65 
This study is a joke and doctor who references it should have their medical licence revoked. How was this allowed to be published?
@GOLEMUK
@GOLEMUK 4 года назад
This RCT has indeed shown that HQC no real efficacy as a prophylactic to prevent developing COVID19. Disappointing, but that is what it shows. The WHO are continuing their HCQ arm of the solidarity trial. It's results are still to come. There may be other studies / RCTs hopefully coming with the efficacy of HCQ in mitigating severity of illness as a primary endpoint. Zinc too needs more study.
@chuckschumer7783
@chuckschumer7783 4 года назад
The study doesn't show anything because the results aren't statistically significant
@GOLEMUK
@GOLEMUK 4 года назад
@@chuckschumer7783 For you, clearly. The rest of us will continue to monitor the science and simply not care about political agendas. If an RCT of a similar size shows HCQ has efficacy in preventing onset of severe COVID19 I will be delighted. If it doesn't I will still regard the data as valuable. Same with Zinc or any other treatment.
@dirkdegraaf567
@dirkdegraaf567 4 года назад
John quit telling what your told by Dommic Cummlye. Please?
@Bareego
@Bareego 4 года назад
The interesting part is not preventative outcomes, in how many patients end up getting infected or show symptoms, but what the eventual outcome is. I really hope that the researchers keep tabs on the patients going forward and publish another paper once the results are known. As Dr. John said, the later numbers regarding Zinc and Vit C were not significantly different in statistical terms. Also there is surely a selection bias between people who take supplements, and people who do not. At this stage it seems probable that HCQ does not prevent the onset if administered post exposure, or help in late stages of the illness, with or without Zinc. Notable is also that when used as a preventative measure against Malaria, you are taking HCQ 1 week before the first possible exposure and ongoing through possible exposure and several weeks after. To me this indicates that to be effective as a preventative measure, it might require to be administered before someone is exposed to the virus. Giving it within 4 days after exposure means you administer it up to 11 days later than it is used traditionally against Malaria when used as a preventive measure. The Lancet paper has since been withdrawn by the 3 authors that were not involved in the company providing the data.
@michaelbradley7704
@michaelbradley7704 4 года назад
As I get older and having had lots treatments I am trusting conventional doctors less and "herbal" doctors not at all. Now I have to conduct my own extensive research and have to comprehend each issue down to the most infinite level just to make sure that these so called health professionals don't damage my health further or cause other issues. Really I have learned through practical experience that the "specialisation" of medical fields has ended up with ignorant doctors who know nothing about cross field interaction. A good example of this is cancer, A surgeon wants to cut it out, an oncologist want to poison it off, a nutritionist want to improve your immune system to fight it - a surgeon I met called the oncologist "the poisoner", an oncologist called the surgeon "the butcher" and both the surgeon and oncologist called the nutritionist "the hippy" and I already new the rubbish they serve in hospitals can not be called food. So I went with the "Hippy" alone and fought off a terminal cancer without the other two idiots. I have seen so many people destroyed by these professionals because they trusted them. I now run a brain tumour charity to help those people pick up the pieces of their lives after they all get dumped back into society when the "treatments" fail. A 15% chance of a 5 year remission is as good as it gets is the stat they are told, I am here ten years later because I figured it out down to the ROS and RAS pathway level. From what I have seen Hydroxychloroquine and ZINC is effective only as a preventative not as a post infected treatment. So everything else is just BS. The clue is that silly term "New Disease" what the hell is that supposed to mean.
@billymule961
@billymule961 4 года назад
I believe Tedros' term is over with the WHO. I believe the new head is from India. Hence the HCQ re-trial.
@Muzakman37
@Muzakman37 4 года назад
@Stephen Morris I suspect you 2 are liars as well.
@ichbinueber18
@ichbinueber18 4 года назад
I hope there will be a study like this with early treatment and the severity of COVID. personally I didn't expect an antiviral given after exposure to protect. It may help with the severity hopefully. Then we can reduce the risk. If finally there have been studies for this with HCW, and they show no change, we finally can put a lid on it. Personally I hope they find it to be effective, because nothing else seems to be.
@particleconfig.8935
@particleconfig.8935 4 года назад
PLUS ZZZZZIIINK Zink is an essential for HCQ's workings as an anti-viral treatment. And they didn't study it. Absurd. These are our brains !?
@JB-qc1kj
@JB-qc1kj 4 года назад
Pretty worthless study... :-( The trial did not demonstrate a significant benefit of hydroxychloroquine as postexposure prophylaxis for Covid-19 BECAUSE THE SUBJECTS DID NOT GET A TEST TO CONFIRM WHETHER OR NOT THEY HAD THE VIRUS!!! A quote from the study, "We acknowledge that this trial has limitations. Because of the lack of availability of diagnostic testing in the United States, the vast majority of the participants, including health care workers, were unable to access testing." Read it for yourself here: www.nejm.org/doi/full/10.1056/NEJMoa2016638?mod=article_inline
@rainy2090
@rainy2090 4 года назад
@@particleconfig.8935 About a third of patients in the study took either zinc or vitamin c along with HCQ and they didn't find any statistical difference.
@frankpierco8826
@frankpierco8826 4 года назад
The concerns of the Lancet about the validity of data is almost funny, if it wasn't for human lives depending on it. Doctor, it is worth a couple of hours of your life to look into this. Apparently, the WHO got their data on the occupancy of hospitals worldwide from an obscure company with 11 employees. None of them having any experience in collecting medical data. Actually, the spokeswoman for the company is a pornstar, the ceo is an ex- doctor that is no longer allowed to execute his profession, another senior employee a science fiction writer. In other words: swindlers. Bottom line : WHO's health advise for the entire world seems to have been largely based on the unreliable early declarations from China and made-up statistics. Possibly even made up medical studies! Wonder how much of the above is actually true, but it did make the press over here in Belgium. As they say, when there's smoke....
@georgerbuchanan
@georgerbuchanan 4 года назад
Frank, the lancet study that you’re worried about has no connection with the WHO. Only the dodgy organisation that supposedly gathered the data claims a WHO link...the WHO themselves deny it. Those guys clearly weren’t honest about Australian data...why trust them on the WHO?
@colinfryett8174
@colinfryett8174 4 года назад
Cheers John and thx for all the work you are doing making these videos for us.
@imgayasheck595
@imgayasheck595 4 года назад
Prepare, don't panic. Eat a whole food plant based diet, get enough sleep, exercise and reduce stress. Take care of yourself and each other. We can't rely on corporations and governments.
@lisaway9141
@lisaway9141 4 года назад
Absolutely!! I try to eat a well balanced meal i exercise 30 min a day and limit my stress by not watching media all day and i have a hobby that occupies my mind and I also take vit D3 and i get my sun daily and i take a melatonin at evening to make sure i get a full nights sleep and im well rested the next day. That's what im doing to build up my immunity. Goodluck to all..remember facts over fears ppl!! Wear mask in public keep your distance and wash your hands often!! Go out and enjoy your life and dont get caught up in the media!! Go live life
@KlanHoffman
@KlanHoffman 4 года назад
With this lack of trust, we need more than one serious study.
@chuckschumer7783
@chuckschumer7783 4 года назад
This wasn't a serious study
@hizzlemobizzle
@hizzlemobizzle 4 года назад
This is not the first or last study. They have determined it was not effective earlier, but so much heat is generated by Trump's claim it does they have to do more studies to prove what they already know. A malaria drug will not stop this.
@hizzlemobizzle
@hizzlemobizzle 4 года назад
@@chuckschumer7783 because it does not tell you what you want to hear?
@KlanHoffman
@KlanHoffman 4 года назад
This may have been first attempt to a serious study. All previous studies have been seriously flawed.
@DefendYourBase
@DefendYourBase 4 года назад
Elderberry is known to fight off coronaviruses. Elderberry also contains quercetin which is a zinc Ionophore. So... why are people taking Hydroxychloroquine + Zinc instead of Elderberry + Zinc?
@wandamaria6140
@wandamaria6140 4 года назад
The article reads (the final paragraph) "Whether preexposure prophylaxis would be effective in high-risk populations is a separate question, with trials ongoing. 1. The whole point of giving HCQ is about profilaxing high risk patients. 2. No mention of the dosage of Zink
@renaissancenovice7202
@renaissancenovice7202 4 года назад
As always. How embarrassing.
@pakde8002
@pakde8002 4 года назад
You're kicking the hornet's nest again LoL. These people are convinced and no amount of facts or data is going to change their mind. But good for you for trying.
@santinorider7536
@santinorider7536 4 года назад
Yes, it's like a political debate. Data and facts mean nothing. Hope and guesswork, everything...
@mballer
@mballer 4 года назад
When carpenters hit their thumb with a hammer, the carpenters say the pain is from the hammer hitting the thumb, doctors aren't sure yet, and are waiting for the results from a double blind placebo controlled study.
@VagoniusThicket
@VagoniusThicket 4 года назад
M Ball 🤪🤫🤐🤦🏻‍♂️
@esecallum
@esecallum 4 года назад
correlation is not proof of causation -- big pharma.
@adrienneconroy4208
@adrienneconroy4208 4 года назад
Really ??? Something not right about that study . !
@2piecesofwood1pieceofrope
@2piecesofwood1pieceofrope 4 года назад
Dr. Campbell I'm a big fan of yours and your clear explanations regarding updates on covid 19. I have strong reservations on any study claiming Vitamin C correlates with increased disease. There is an entire field of medicine (orthomolecular) which will vehemently refute this. Dr. Richard Cheng has gathered much evidence of decreased symptoms of covid 19 using vitamin C treatment.
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