CD4+ T cells become Helper T cells because CD8+ co-receptor is down regulated (1:55). Those with CD8+ co-receptor are found on cytotoxic T cells or natural killer T cells.
Thank you, Video helped me in clearing confusion, it means that CD25 which is Receptor of IL2, so this CD25 is present over both Treg and CD4 T cell, and so Treg CD25 competes with CD25 of CD4 cell so that IL2 doesn't act on CD4, so CD4 doesn't get activated, Is my thought process right?
bro if its ok...can i get ur ppt file or pdf file...i need this for my thesis...and ofcourse i will credit you and also label your name under reference...
Thank you for excellent lecture. I have one question The question appears on test in Korea. What is the biomarker of Treg cell and is related to IL-2 receptor? 1.CD4 2.CD19 3.CD25 4.FoxP3 5.GATA3 I think there are two answers(both 3&4) Can you choose one?
Foxp3 is a good marker of Tregs especially if panels of markers were used for their identification. T REG Cells will be CD4(+)CD25(high) Foxp3(+) . CD25 alone is not a very specific marker.
Very interesting! Do you know if there are ways/research to increase Treg cells? Would be great if you could try to boost these to reduce inflammation / improve autoimmune response.
@@animatedbiologywitharpan amazing thank you for the link and your reply! :) Definitely a fascinating topic - personally was diagnosed with MS 3 weeks ago and am looking for ways to biohack my body a little / stop it attacking itself besides the treatment I will likely start soon
Sir, what happens when Tregs supress APC Or Macrophages inflammatory response? Does the Macrophage become unable to signal Th2 cells and that way allergies stop happening?
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