Remyelination for Multiple Sclerosis [Clemastine]

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Start watching to learn about clemastine, the old anti-histamine drug which has the potential to remyelinate multiple sclerosis lesions.
Comment or ask questions below! I would be happy to answer!
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Make video requests in the comments section!
My book "Resilience in the Face of Multiple Sclerosis" on Amazon: www.amazon.com/dp/B07WP7H5LK
Selected Sources:
The legendary screening study for FDA approved drugs which promote remyelination (Dr. Jonah Chan):
www.ncbi.nlm.nih.gov/pubmed/2...
The ReBuild Trial: Clemastine fumarate as a remyelinating therapy for multiple sclerosis
www.ncbi.nlm.nih.gov/pubmed/2...
The ReCOVER trial:
www.nationalmssociety.org/Res...
2017 Remyelinating therapies for MS:
www.ncbi.nlm.nih.gov/pmc/arti...
M1 receptor mediates effect of clemastine: www.ncbi.nlm.nih.gov/pubmed/2...
Clemastine reduces behavioral changes in socially isolated mice and enhances myelination in the prefrontal cortex:
www.ncbi.nlm.nih.gov/pubmed/2...
Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.
Follow me on twitter: / brandon_beaber
Music: INNER GRACE - Copyright 2018 Wilton Vought
Source: Really Really Free Music
Link: • Video
The video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.

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14 апр 2020

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Комментарии : 346

@Lisa_P73 10 месяцев назад

Please do a follow up on this?

@HurricaneHeather 2 месяца назад

Had Optic Neuritis in 2008, was finally DX'ed in 2023 with MS after a major flare in my spine at C1-C2 gave me this intractable spasticity. Was given Clemastine (because I begged for it) in August 2023. Took 6 weeks worth and noticed a noticeable change in the center field of vision in the affected eye. Completed my 2nd year of discontinuous DMT with Mavenclad last month. Started up with Clemastine again at the beginning of this month. It's important to mention that I have had an eye exam after the first round and the correction in my left eye had to be reduced. If cog fog doesn't get me, I'll work to remember to come back here and tell you all what my anecdotal experience is/was.

@angelabutynski8543 4 года назад

That seems very promising. As someone who has damage from prior optic neuritis, this seems like a step in the right direction.

@DrBrandonBeaber 4 года назад

I definitely look forward to the results of the ReCOVER trial with Dr. Ari Green and his team at UCSF.

@carlosore2660 3 года назад

Me podría enviar información

@Gerbs601 3 года назад

@@DrBrandonBeaber ..my wife Mary (former Dr. Weiner patient) would be interested in Clemastine and the ReCOVER trial. You may recall she is 30yr+ diagnosed and now secondary progressive. Sounds promising ..we will schedule time. Thank you for your commitment and passion.

@setapart902 3 года назад

@@DrBrandonBeaber what about immunocal? Have you seen the trial done by NIH for this PROTEIN and Lou Gehrig's disease?

@ldjt6184 2 года назад

Have you started using it in the last two years since this video came out?

@davezay5933 3 года назад

This is a beautiful discovery and I hope it follows through and helps re-myelination and reversing damage caused by that whole multiple sclerosis process, hopefully big Pharma does this new gain in medicine and turn it into some other money game and we still suffer, this is where God will prevail just Gotta keep the faith!!

@EChomkoful 8 месяцев назад

Thank you so much for making these videos. They are supremely intelligent and helpful. What are your thoughts on whether there are alternative therapies that may help demyelination, such as NAD+ infusions, or oral or sublingual ND/NMN? I would be interested in a video on this. Thanks again Doc!

@SouadSouad-wc2zc 4 года назад

Thanks from Algeria Doctor.

@FaithFarmClips 4 года назад

Clemastine! Wow so exciting!

@Shasha8674 Год назад

LDN helps get rid of plaques in the brain. Vit B12 methylcobalamin shot with folate/progesterone/lecithin and more may help once gluten/dairy/soy/sugar/GMO are stopped. Vit D3/sunlight may help.

@jamieresqguy6813 4 года назад

Always appreciate hearing about potential MS treatments that treat the damage done by MS. I am hopeful to recover some of what I have lost to MS. Thank you for sharing.

@DrBrandonBeaber 4 года назад

This is indeed an exciting aspect of MS research. I will try to do more videos of this type in the future.

@setapart902 3 года назад

Try looking into immunocal

@arr2820 2 года назад

@@DrBrandonBeaber can you please explain if it is possible to have the OCT results improve?(as far as I know Optical coherence tomography) shows the neuronal volume and its loss, so it is more precise than MRI. Is it possible to get better results? Since I had done 2 OCTs which have different results of RNFL(retinal nerve fiber layer).

@DrBrandonBeaber 2 года назад

@@arr2820 I don't think improvement of retinal nerve fiber layer thinning is very common. Are you saying is it "possible" with remyelination therapies? It may be possible, but there is no evidence of this yet.

@arr2820 2 года назад

@@DrBrandonBeaber I have had two OCTs i which the second one had better results. I was really confused. It is more about neurogenesis I guess much more complex than remyelination.

@daphnephinopoulos7864 4 года назад

Thanks, very informative

@DrBrandonBeaber 4 года назад

@everhernandez915 2 года назад

Thank you for making this video I have Multiple Sclerosis so see that resurrection has been done with this issue is the best thing to finding out a cure against this Multiple Sclerosis sickness. ( like a piece to this puzzle that needs to be found )Thank you

@perrymurton7730 2 года назад

I will be asking my neurologist about this

@KindaNewHere 2 года назад

Hope! Thank you for sharing this information.

@DrBrandonBeaber 2 года назад

@mientay8255 4 месяца назад

⁠@@DrBrandonBeabercan you treat ALS my wife has ALS please please 😢😢😢😢

@vicbonilla9954 7 месяцев назад

This is very fascinating! What do you know about us who got HSCT and the ability to take this drug?

@mccorn75 4 года назад

I enjoyed this video and found the research intriguing! I participated in the CombiRx Phase Iii trial circa 2005-2012. Wo hi of you be able to review the results of this study please? I did receive both treatments in the study and feel that the course of my disease was dramatically slowed because of early and aggressive treatment. I understand that DMTs are very expensive and no insurance company probably would not cover two therapies. However, I wasn’t able to find the results of this study. Thank you!

@DrBrandonBeaber 4 года назад

The Combi-Rx study did not show any benefit of combining the two medications (copaxone and avonex). Copaxone was slightly superior in efficacy to avonex. I am actually going to do a video shortly looking at head-to-head trials which you may be interested in. This is the full publication of the combi Rx study if you would like to take a look: www.ncbi.nlm.nih.gov/pubmed/23424159

@brianthompson9241 4 года назад

Very interesting. Thank you.

@DrBrandonBeaber 4 года назад

You're welcome. I plan to do more videos on emerging agents for remyelination in the future.

@brianthompson9241 4 года назад

Dr. Brandon Beaber please do!

@martinallenuk 3 года назад

Mind blown...

@agilityredux9486 3 года назад

Is there any work to be done with clamastine? Please let me know. Thanks for making these videos, I was feeling depressed earlier, but your video gavee hope to live! Thanks doctor Beaber!

@DrBrandonBeaber 3 года назад

I'm glad you found the video encouraging. The Assessment of Clemastine Fumarate as a Remyelinating Agent in Acute Optic Neuritis (ReCOVER) trial is still ongoing: www.clinicaltrials.gov/ct2/show/NCT02521311?term=clemastine&draw=2&rank=3

@esraabahaa8357 2 года назад

We are waiting for the updates doctor concerning the advances in this particular research.

@DrBrandonBeaber 2 года назад

I will make a video if there is a major update

@grzegorzporada 4 года назад

Good video

@DrBrandonBeaber 4 года назад

Thanks

@rickyoceans2943 3 года назад

Excellent video. I knew of this study a while ago, brought it up to dr. Who was familiar. Too soon to recommend using it! Also in the study on humans, they were receiving above recommended dose? I live in San Jose, may look at the study you mentioned. Is that the phase 3 study i hope? Or something else?

@DrBrandonBeaber 3 года назад

The phase III trial is the "Assessment of Clemastine Fumarate as a Remyelinating Agent in Acute Optic Neuritis (ReCOVER) study" which you can find here: clinicaltrials.gov/ct2/show/NCT02521311 The contact information is near the bottom. The dose they are using is 12mg (4mg 3x/day) clemastine for 7 days followed by 8mg clemastine (4mg 2x/day) until 3 months. This is a relatively dose which could be sedating for many people when taking during the day.

@rickyoceans2943 3 года назад

@@DrBrandonBeaber Thank you sir. Indeed i understand now. Very sedative effects.

@fantomblack 2 года назад

Can you make a video about how to talk to your neurologist about getting on these medications? I tried to get on the one for neurogenic bladder, and even mentioned it by name, but she prescribed me something else and I'm frustrated.

@mathematicssolved 4 года назад

Lithium does, just look up images of it between controls and Lithium. Lithium does all kinds of wonderful things below the toxic doses and really isn't even that bad. -Raises WBC -Jacks up the proliferation of stems cells in the brain and elsewhere -Acts as a powerful broad-spectrum antiviral -and of course regenerates myelin.

@StonerSquirrel Год назад

…and charges our batteries.

@insertname5421 2 года назад

One year after, where are we?

@roberture5903 4 года назад

Thankyou Dr Beaber for this information. You mentioned that it may help those with optic neuritis but would it help at all with mobility issues? Thanks again for your time.

@DrBrandonBeaber 4 года назад

It is possible that it could help with mobility in MS, but we don't have specific evidence of this yet.

@aditya50499 3 года назад

@@DrBrandonBeaber it seems that there are two parts of the phase 2 in which the trial was conducted...one is REBUILD trial which assesses remyelination in general and measures Visual Evoked Potential as primary outcome measure and measures Myelin Water Volume, Magnetization Transfer Ratios, tolerability and EDSS score as secondary outcome measures... The other part of the trial is ReCOVER which is for acute optic neuritis... Regards.

@DrBrandonBeaber 3 года назад

@@aditya50499 You are right. I also mention the ReCOVER trial at the end of the video

@aditya50499 3 года назад

@@DrBrandonBeaber sir, as you mentioned in one of your comments that it is unlikely to get an FDA approval for MS as it is an already approved drug, then how can we know if the drug Is really effective in humans and at what dose (so that we could start taking it off label)?

@DrBrandonBeaber 3 года назад

@@aditya50499 We would have to wait for the results of the ReCOVER trial to see if it is actually effective in humans.

@dudejoyce 3 месяца назад

I need this asap

@mikaelaslak8808 2 месяца назад

Great video and thanks. I'd really like to be able to walk normally (after a few blocks) again and run because after about 100 meters my legs just lose coordination and I can't lift them. I can't run because of drop foot. Do you know of any way to cure this? I'm trying a lot of different things but have to wait and see if they have any effect. Thanks a lot. 😎✌

@adrianaluciacespedes9252 2 года назад

Interesting.. Can you do a video about mirtazapine and JC Virus? Maybe is something with Histamine receptors going on..

@hardcorgamer007 4 года назад

I've tried metformin and it helped me a lot. Im on tecfidera and i was in a very bad place. My MS is mainly characterized by severe anxiety (partially treatment resistance), heavy fatigue, and imbalance. After the metformin, everything improved. Im still suffering and will switch soon from tecfidera to ocrevus........I take 1 pill of metformin 750 MG Extended release, somedays i take 2. No hypoglycemia thankfully. Peace to all

@DrBrandonBeaber 4 года назад

Thank you for sharing. There is some preliminary evidence in rats that metformin may have an effect on remyelination as well: multiplesclerosisnewstoday.com/news-posts/2019/10/11/diabetes-drug-metformin-promotes-myelin-repair-in-rats/

@hardcorgamer007 4 года назад

yes doctor beaber, there is a good body of evidence for its anti neuroinflammation/regenerative effects.......I was in a bad place anxiety/leg weakness and fatigue wise. Now, my head is above the water. Overall improvements, i'd say everything got better by 30-35%. Been on it for 5 months and I'm excited for the ocrevus switch. I think ocrevus + metformin will help keep the illness at bay. My case is moderate though. Compared to others patients I've seen, i'd say my MS is level is about 6/10, but the nastiness comes from it's comorbidity with an anxiety disorder also do intermittent fasting 16/8, take fish oil and flaxseed oil (which lower some inflammatory markers especially flaxseed oil) Peace :D

@7760087800 3 года назад

Ayushprana best for ms

@demoskunk 3 года назад

Are you RRMS or PPMS? Also....PLASMA! (huge Earthworm Jim fan, here :)

@rachelmoseley8065 2 года назад

Hi, I know this post is old. My MS is also very severe treatment resistant anxiety and some other things. How are you doing these days?

@jacekchwedenczak5894 3 года назад

@Dr. Brandon Beaber - Could you please comment or make a video on Clemastine vs. Metformin vs. Alpha-Lipoic Acid? And thank you for all these great videos!

@DrBrandonBeaber 3 года назад

Is there a specific study doing this comparison?

@jacekchwedenczak5894 3 года назад

@@DrBrandonBeaber When I saw your list of the most effective MS drugs, I thought something similar could be done for the remyelination. I've found only this, but I don't feel qualified enough to comment on that - www.researchgate.net/publication/346858325_Systematic_approach_to_selecting_licensed_drugs_for_repurposing_in_the_treatment_of_progressive_multiple_sclerosis

@DrBrandonBeaber 3 года назад

@@jacekchwedenczak5894 Right now, there would be no way to create an evidence-based list of potential remyelinating therapies.

@jacekchwedenczak5894 3 года назад

@@DrBrandonBeaber Thank you for your reply! I hope the research will progress over time.

@DrBrandonBeaber 3 года назад

@@jacekchwedenczak5894 It certainly will, but I can't predict the exact pace and direction.

@allkeyspro6606 9 месяцев назад

Hi Dr Brandon. I suffer from a disease called AMN. It is a rare genetic nerve disorder. At present, there are 0 treatment options, and breakdowns of myelin are the big issue. Do you think this treatment might be a possibility for this disease?

@carlosore2660 3 года назад

Plis mayor información. Gracias

@gabbyfranks78 4 года назад

Excited to hear this. Now what's the cost? Is my ins gonna approve this. Can I even take this is this an injection or a pill.

@DrBrandonBeaber 4 года назад

It's a very inexpensive pill. The availability may be limited because it's not generally used in modern times, but I can't speak for insurance companies.

@mientay8255 4 месяца назад

@@DrBrandonBeabercan you treat for ALS please please help 😢😢😢😢

@consciensnesttv3775 3 года назад

100,000 IU PLUS VITAMIN K2... Lots of exercise... Stay away from all processed food.. laugh laugh.. family family.. stay active.. do not let your drop foot or your fatigue discourage you from keeping your body from moving. IT'S EITHER YOU WIN OR MS

@adamgerman2017 3 года назад

Thanks for the amazing information! The only problem is I am from Europe and Clemastine itself doesn't seem to be so readily accessible (also, I wonder that if it is proven to be effective, it will be taken off the market and then re-sold as an expensive MS drugh). Towards the end you mention that what's key is the muscaranate antagonist function. I wonder if I can fnd a list of available muscaranate antagonist drugs marketed in Europe...

@DrBrandonBeaber 3 года назад

You may be right about the marketing strategy, but clemastine is generic, so there should be multiple formulations available. Often, a pharmaceutical company will market a specific unusual dose or extended release formulation and then pretend the drug is brand new. You can look at the wikipedia article for muscarinic antagonists, but taking a drug just because it is in the same class as a drug which isn't even proven in humans with MS is somewhat dubious: en.wikipedia.org/wiki/Muscarinic_antagonist#:~:text=A%20muscarinic%20receptor%20antagonist%20(MRA,of%20the%20muscarinic%20acetylcholine%20receptor.&text=Besides%20responding%20to%20their%20primary,a%20variety%20of%20other%20molecules.

@javafiendx9428 3 года назад

Didn’t they stop selling this over the counter awhile back?

@kaligulajovanovic 2 года назад

It is possible to buy it in Spain, Lithuania and Turkey.

@DMhockey33 4 года назад

Has anyone researched clearing the debris from the demyelination? Or researhed the effects of that debris on OPCs ability to mature?

@milindjagtap1897 3 года назад

Sir will it be helpful for corticospinal axonal degeneration in dorsal spinal cord

@karmennash7479 21 день назад

My hubby always says, “how many hotel rooms can you rent for the price of that property?” He’s right - we can travel farther that way and won’t own a place used by others that we have to fix and maintain vs enjoy,

@DrBrandonBeaber 21 день назад

why this comment on a video about remyelination?

@ldjt6184 3 года назад

Does this mean that all drugs that block the M1 muscarinic receptor would work in the same way in regards to remyelination, at least in theory?

@vyk7579 4 года назад

Hi, Is it possible to know how the current experiment is going on in humans, as well as a possible date for the end of the experiment? Also, regarding the experiment, in case it has positive results, would the treatment be valid for all types of Multiple Sclerosis or only those that suffer from Acute Optic Neuritis? Thank you very much, it was a very interesting video. Kind regards.

@DrBrandonBeaber 4 года назад

I don't know how the ReCOVER trial is going. Generally speaking, the results are not released until it is completed or for a planned interim analysis. In theory, the beneficial effects would be in general for multiple sclerosis and not just for acute optic neuritis. They chose to study optic neuritis because there are a lot of good paraclinical markers of optic nerve function (visual evoked potentials, ocular computed tomography). You can take a look at the ReCOVER trial on the USCF website here: greenlab.ucsf.edu/recover-trial You could also try contacting the coordinator Tracy Tran by email (listed on the website)

@premamarnani5161 3 года назад

When will it be FDA approved? Have it gone through clinical trials?

@ernietollar407 9 месяцев назад

Wow! How does this video's topic possibly relate to BDNF and IGF-1 proteins which I understand are instrumental in remyelinization?

@joanneesch4277 3 года назад

Very interesting that anticholinergic drugs can have this effect, yet they also have been linked with cognitive decline, at least in the elderly. Have the studies of clemastine evaluated for changes in cognitive function as well? Is clemastine and anticholinergic? Would love to hear your thoughts on this! Thanks Dr.!

@DrBrandonBeaber 3 года назад

Clemastine is anticholinergic, but it can actually be shown that it is the antimuscarinic effects which drive remyelination. Cognitive side effects are a consideration with clemastine.

@ajpello2003 2 года назад

@@DrBrandonBeaber I thought that had to do with the “D” option that was removed from the market?

@emilye709 2 года назад

As far as I know, cause and effect has never been proven for anticholinergic drugs and cognitive decline. There are correlations. It is just as likely that people who have symptoms of cognitive decline, happen to use benadryl often. People with early dementia have insomnia so it makes sense that they would use things like benadryl to sleep.

@TotalRookie_LV 11 месяцев назад

I've taken no special drugs, but MRI late last year showed hints of remyelination - older lesions are less pronounced or gone. However, my condition is getting worse. Seems like contradiction, right? My doctor expressed saspirinos, that the damage by 2019 flare-up was so extensive, some isolated nerves in my spinal cord are still dying off, thus connection is getting worse.

@matildaGin777 Месяц назад

It would be nice to see some interviews with patients with MS who microdose with magic mushrooms. It is incredible how many go into remission.

@notapplicable3143 2 года назад

They have tested people with MS and gotten remyelinaton. The myelin has grown back thinner that it orginally was. Would this be because of scar tissue on the nerve being a issue?

@marcussmart3275 3 года назад

There should be more collaboration and study's done with ms. It seems like there are many people willing to sign waivers for experimental treatments and other countrys that have proven treatments which are like a fairy tail in other places. I've heard many of these remil stories from accredited people in the medical field about the same subject of remilination. This is where the trail runs dry. It goes into clinical trials purgatory.

@pattischmitz2680 Год назад

What treatment do other countries have?

@marcussmart3275 Год назад

@@pattischmitz2680 there's a few I've heard about when the covid vaccine was being experimented with. Then of course stem cells but that's a serious procedure and price that may take several times to work and no one knows if any lasting effects come from it. There are others I forget, TBI.

@angelaaccetta7843 2 года назад

what can help with remyelination to the point of moving a body, such as wheelchair bound and moving arms and legs?

@henrymorgan1130 3 года назад

Thank you Mr. Brandon for the amazing explanation! I will start. to use "Betaferon" on next weeks and do you think that it's gonna be a trouble to use both "Betaferon" and "Tavegly" together? Also, there's an only "1mg tablet" is available for sale in my country but in text, you mentioned appx. 5mg a day.. Do you have any recommendation about dosing? Best Regards and thanks again!

@DidemYufkayurek 3 года назад

Eren Bey selamlar, siz basladiniz mi tavegyl kullanmaya

@henrymorgan1130 3 года назад

Hayir oyle kafama gore baslamak cok yanlis bu klinik calismalarin hepsinin dozu, kullanim araligi gibi detaylar var. İlaclarinizi duzgun kullanin, pozitif dusunun ve mutlaka doktorunuza da danisarak fonksiyonel tip ile ilgilenin, paleo diyeti yapiyorum ben tum problemler geride kaldi :) sevgiler

@haseozenithmaru1186 2 года назад

Thanks for that information

@DrBrandonBeaber 2 года назад

You're very welcome

@juliemae8307 Год назад

Can you do a video of Lemtra VS HSCT comparing treatment and long-term risks? I have been curious about which is better but haven't found much information comparing the two.

@DrBrandonBeaber Год назад

You may appreciate these videos: 1) ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-0rvT_DuAJ3Y.html 2) ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-jNgoxJTgQJc.html

@juliemae8307 Год назад

@@DrBrandonBeaber thank you, I will check them out right now :)

@mary-vy3mo 7 месяцев назад

see "lemtrada vs hsct ms news today" no contest...get hsct save your life.

@emilye709 2 года назад

Thank you so much for your videos. Can you please make an update video. I noticed in a comment that you have prescribed clemastine before. I would like to talk to my neurologist about replacing my sleep aid with it. How much should I use?

@DrBrandonBeaber 2 года назад

I can't give you personal advice, but these are doses which have been used previously. The dose used in the RECOVER trial was very high and would likely be sedating (12mg (4mg 3x/day) clemastine for 7 days followed by 8mg clemastine (4mg 2x/day)). For the ReBUILD trial, the dose is 5·36 mg orally twice daily. I think a practical approach is to take a lower dose only at night until there is real evidence.

@emilye709 2 года назад

@@DrBrandonBeaber Thank you for the reply. I know you can't give personal advice. I was just curious how you prescribed it. How many mg at bedtime do you think it's a good dose? Do you have a video on Metformin? I read that it actually showed improvement on MRI. I wonder if it will be safe for those with normal blood sugars to use for MS in the future.

@stevenordberg 3 года назад

My wife was diagnosed with MS around 1998. She has only had two attacks of which one caused optic neuritis, which she recovered from. Her main issues involve poor mobility (walking and balance). Recent MRIs from 2017 and 2020 show no changes. Most demyelination is in her spine. She has never taken any of the traditional MS drugs. In 2017 she began seeing a doc at Mayo here in AZ. She only recently saw him again in 2020, hence the new MRIs. She has mostly been cared for by natural paths. No one has ever discussed the potential of re-myelination or Clementine with her. Any advice from you Doctor? My wife is 56 and a successful business executive who walks with my assistance and uses a cane. She has no pain but does have occasional spasticity.

@DrBrandonBeaber 3 года назад

Unfortunately, I can't give you medical advice here. Clemastine is currently unproven in actual humans with MS, but some people with MS do take it.

@stevenordberg 3 года назад

@@DrBrandonBeaber yes I understand your position, however if you had MS and mobility issues and have the knowledge you have; would you try Clemestine?

@DrBrandonBeaber 3 года назад

@@stevenordberg maybe

@gabikynigou2523 Год назад

I know exactly what you are saying… i have MS from 1998 and nobody said anything about, maybe because I have RRMS but the sickness is there!!!😢

@gaelle4328 Год назад

Not a dr in anyway nor a medical professional. I’m taking Clemastine for my allergies. I’m personally satisfied.

@Skevanston 10 месяцев назад

Would this be similarly helpful for NMOSD and MOG?

@baldipkaur7475 3 года назад

Hello doctor I recently heard that intake of alpha-lipolic acid (300-600mg daily) can reconstruct the damaged nerve. Do you have any information regarding this? What about the side effects associated?

@DrBrandonBeaber 3 года назад

ALA is sometimes used for neuropathic pain (there is some evidence in diabetic neuropathy), but I am not aware of any good evidence in regrowing nerve tissue.

@baldipkaur7475 3 года назад

@@DrBrandonBeaber ok.. thanks a lot for the reply 😊

@harirsabz7253 4 года назад

Thanks a lot for this hopeful video.How long do you think it takes to it becomes a treatment?

@DrBrandonBeaber 4 года назад

I'm not sure it would ever be an FDA approved treatment as this is an old drug, so there is not a lot of financial incentive. However, if the ReCOVER trial is successful, it might become more popular.

@klinexXEst1997 2 года назад

Hey doc what's your opinion about nvg-291 and MD biotin 003 what do u think ll would live to see this kind of treatment In this lifetime

@DrBrandonBeaber 2 года назад

I have a specific video on biotin: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-CS6CWPBHKGM.html I don't think there is any clinical data on NVG-291. It is still in phase 1 trials, so it is years away, but certainly we would see it in our lifetime (easily within 5-10 years) if it is effective.

@ajpello2003 2 года назад

Hi Doc do you see this being effective for myelin repair across all nerves or more just vision? I have vertical nystagmus from MS hoping this will prove to be an effective treatment post clinical trials.

@DrBrandonBeaber 2 года назад

I hope it could be effective throughout the nervous system, but who knows.

@ajpello2003 2 года назад

@@DrBrandonBeaber Do you have any updates on the Clemastine metformin trials?

@DrBrandonBeaber 2 года назад

@@ajpello2003 Unfortunately, I do not

@ericchamberlin4744 4 года назад

Interesting. Dr. are you aware of any MS Neurologists, who have or are currently, prescribing Clemastine as an off label use to treat MS? I ask because this theory has been around for a few years although the studies had not been done to support it until now.

@DrBrandonBeaber 4 года назад

Yes. I have prescribed it myself, though I can't say I actually advocate clemastine at this time. I would like to see better evidence.

@msenit4lifepattylong76 4 года назад

Would this be prescribed in addition to your DMT? It’s exciting to hear and I’ve heard this about a few of the newer DMTs. Personally, I wouldn’t want to drop one for the other. Thanks for your great videos! 🤗❤️❤️

@luisfernandoparedes9840 3 года назад

Great Presentation Dr. Could Clemastine work with Guillen Barré Syndrome ? Tks

@DrBrandonBeaber 3 года назад

Possibly. the peripheral nervous system is myelinated by schwann cells rather than oligodendrocytes, so this research doesn't really apply, but the underlying muscarinic receptor target may be the same. In general, the peripheral nervous system has greater potential for remyelination.

@luisfernandoparedes9840 3 года назад

@@DrBrandonBeaber Thank your very much..

@randholtham8493 3 года назад

What about aspirin? I think I heard it has remyelination possibilities. I have found while taking aspirin to combat headache from nystagmus that I walk significantly better...still bad but much better from adding aspirin to everything else I take (not relating to demyelination of course) . I’d be interested in you doing a similar aspirin use in MS!

@DrBrandonBeaber 3 года назад

Off the top of my head, I haven't seen any articles on aspirin having remyelinating potential.

@randholtham8493 3 года назад

Dr. Brandon Beaber Tsau et al. Bcm medicine (2015) 13:153 but doesn’t directly address my walking improvement. Could be that as a pain inhibitors that opens up some amount of neural plasticity? Thoughts? Additionally I exhibit noticeable walking improvement immediately after Ocrevus treatment, my suspicion is the solumedrol? It doesn’t last. Could low grade inflammation be a component to my daily walking difficulty that is lowered with various anti inflammatory agents ? This strays from the remyelination but I’m equally interested in both because intimately I just want to walk straight again or at least keep walking! Love your work on RU-vid you are help the suffering searchers!

@dudejoyce 3 месяца назад

I'm having neuropathy like feelings in my feet and in the last couple months its moved up my legs and in my hands and arms ...it could be ms? Im losimg my mind dealing with this what can i do ?

@ramazan9857 2 года назад

How long will this continue? we want remeissation treatment

@amarcelous 3 года назад

Is it only for optic neuritis?

@charlespatton7402 3 года назад

Doctor Beaber, I have been digging into the histamine and MS connection a little deeper. Seems like the data is mixed and lacking at this point. Many of the drugs shown to promote Remyelination appear to be antagonist against Muscarinic Receptors. So an anti-histamine such as clemastine seems highly probable to be effective. Do you know if they studied diphenhydramine as a possible remyelinating agent? It is non-specific to the M receptors and has known access to the CNS. Also it is widely available over the counter and very cheap.

@DrBrandonBeaber 3 года назад

I am having trouble finding a list of medications they screened, but they used a 1,000-compound library screen, so I'm sure some antihistamine agents were screened. I'm not sure if diphenhydramine was included.

@charlespatton7402 3 года назад

@@DrBrandonBeaber That was my thoughts as well, I will try to dig and find the entire list, even if it means scraping through the entire publication haha. Thanks for your response, I watch every video, and love your content. The MS world is so incredibly thankful for you!

@DrBrandonBeaber 3 года назад

@@charlespatton7402 Thanks Charles. That really means a lot to me. Let me know if you have any video suggestions. I would like to do more videos like this in the future, and I am going to interview Professor Dwight Bergles about his work with OPC soon

@carrikartes1403 Год назад

Ursolic acid will remylienate nerves. Exciting research

@cboy5oc Год назад

Is there any studies that connect Central Pontine Myelinosis with protocols being used/researched fir MS? My son got this in 2014 in connection with treatment from a hospital for very low sodium by raising it too fast. Is there a chance that this protocol could be helpful?

@DrBrandonBeaber Год назад

I am not aware of any specific research on clemastine for central pontine myelinolysis.

@ph7346 3 года назад

The "Old Mouse" that couldn't walk miraculously walks again drug. I've heard this for over 10 years now. HSCT for real results

@DrBrandonBeaber 3 года назад

That's a fair point. We will have to wait and see if it pans out in humans with MS.

@ballzvlogz4601 4 года назад

What are the side effects of this medication? And how is it administered? I imagining it’s a little pill that makes your tired and prevents allergies like Benadryl. If so that sounds worth a try to take before bed every night. Unless their are further side effects or precautions on long term use?

@DrBrandonBeaber 4 года назад

This is a pill, and most people take it at night because it can be sedating. It is an old antihistamine just like Benadryl, so it has similar side effects. It has been reported that long term use of benadryl for insomnia may actually be linked to dementia, but I don't think Tavist is generally speaking likely to cause serious side effects.

@ballzvlogz4601 4 года назад

Thank you for the response. Has this become a readily accepted treatment by most doctors or is still pretty unknown and controversial to prescribe?

@gaelle4328 Год назад

@@ballzvlogz4601 Personally I’m taking it for my allergies.

@dudejoyce 3 месяца назад

I need help like yesterday.

@baldipkaur7475 4 года назад

Hello doctor. Spinal cord lesions located centrally at C1 and T9 of size 10mm and 6mm respectively. How serious demyelination it is?

@DrBrandonBeaber 4 года назад

Sorry. I can't give you any direct medical advice here. I would suggest you review the films with your own provider.

@baldipkaur7475 4 года назад

@@DrBrandonBeaber ok doctor... thanks a lot for the reply :)

@cnt2495 3 года назад

It seems like this is very promising! I want to know what your opinion is on how close we can find a cure to MS. I'm not expecting it to be soon by any chance. Promising data like Clemastine didn't just occur overnight. As always, I'm very thankful for your videos as an MS patient myself.

@DrBrandonBeaber 3 года назад

I may do a video speculating on the possibility of a cure for multiple sclerosis. It is a little bit of a complicated topic because it depends exactly what is meant by "cure."

@marthabck7003 Год назад

They have been working on this for almost 30 yrs! But lately scientists guided to assist humanity with autoimmune condition… between 5 to 10 yrs… I just can’t!

@laureynamontanez3262 2 года назад

Are the trials still going on ? I live in northern cal

@DrBrandonBeaber 2 года назад

Yes. They are still ongoing

@imadmuhammedali5239 4 года назад

Hello! Greetings from Iraq! I only have one question. Generally speaking, would Zeposia help a patient who is 57, female, with psoriasis and JC Virus? And please, if you don't know the answer to that, could you please connect me with someone who can? Thanks in advance 😊

@DrBrandonBeaber 4 года назад

Sorry. I can't give direct medical advice here. PML would be a [very low probability] risk with ozanimod given our experience with Gilenya

@imadmuhammedali5239 4 года назад

@@DrBrandonBeaber ok, could you please provide me with your email address so I can send you her medical history, please?

@LittleDogLV Месяц назад

So if we grow Mylan over the lesions, which are scar tissue how can that even work? Doesn’t the damage have to be cleared up before you can Re-Mylanate?

@dylanabelson9551 Год назад

Can you cover Sobetirome? Why is it not FDA approved yet after positive animal and human trials for remyelination?

@DrBrandonBeaber Год назад

I am familiar with the animal studies, but I don't believe I have seen trials in humans with MS. Do you have a citation?

@marthabck7003 Год назад

The pharma will give hell but we humanity must stand up for their right for better medicine medicine…

@Grooovyspace 3 года назад

Greetings from India 🇮🇳, My brother is diagnosed with MS, Can we provide him with Tavegyl tablet, It's available in India. Please advice, I am glad to share his medical reports for your opinion. Thanks in advance.

@DrBrandonBeaber 3 года назад

Sorry, I can't give your brother personalized medical advice. Clemastine is currently unproven, but some people do take it. It can be sedating and cause other side effects sometimes.

@Grooovyspace 3 года назад

@@DrBrandonBeaber Thanks Doctor, Appreciate your swift response.

@anmo1973 Год назад

Give him some Lion's mane supplements from US. Preferably RealMushrooms brand.

@dominicp134 3 года назад

Clemastine, me with Optic disabilities also thinks its the very first step in the right direction of mutliple sklerosis research, all other drugs have the function to prove that they dont work.

@setapart902 3 года назад

Look into immunocal

@maryanngames9353 4 года назад

Where do you practice Dr. Beaber? I am in the San Francisco Bay Area and am with Kaiser.

@DrBrandonBeaber 4 года назад

In Los Angeles.

@maryanngames9353 4 года назад

Dr. Brandon Beaber thank you for replying. I thought maybe you are at UCSF.

@vishalbhardwaj 2 года назад

do you think that this can be applied to spinal cord injury pathologies ?

@DrBrandonBeaber 2 года назад

I suspect this would only be potentially helpful for demyelinating diseases.

@Raj-ul9my 3 года назад

I hope to god we find a cure soon I think we will it’s all about demyelination

@dawnkos4691 10 месяцев назад

This is probably why it hasn’t been available otc for years

@mattgold2118 9 месяцев назад

My thoughts exactly! I’m trying to find it - OTC unavailable EVERYWHERE - and even the animal versions at the online pet stores have them as “unavailable” - not even out of stock. Something smells fishy! Makes me more determined to get it…

@LighteningBugSong 4 месяца назад

My neuroimmunologist and MS specialist at UCI filled me in that clemastine is a bit of a dirty substance, has toxic effects and really only showed a reduction in latency for the VEP test in the studies. I decided to pass on it until they clean it up. He has published recent research on N-acetylglucosamine for remylination, fair warning, it will make you gassy! I volunteered to try it at 12 grams a day and have since been advised to sip that throughout the day instead of 3 big doses of 4 grams each. It doesn't affect A1c either. "NAG" not regular glucosamine.

@DrBrandonBeaber 4 месяца назад

I assume you are talking about Dr. Demetriou or Dr. Sy and their research. No doubt the clinical evidence for clemastine is limited.

@ramazan9857 2 года назад

When will myelin repair treatment be released?would you answer please

@DrBrandonBeaber 2 года назад

I honestly don't know.

@ramazan9857 2 года назад

@@DrBrandonBeaber Will it take 10 years?We don't want to be disabled

@DrBrandonBeaber 2 года назад

@@ramazan9857 I unfortunately could only speculate about this. hopefully not 10 years.

@ramazan9857 2 года назад

@@DrBrandonBeaber there is no hope😓

@franceszapata951 2 года назад

Clemastine is not available in Puerto Rico :(

@ajpello2003 2 года назад

Hey Doc is Tavist (clemastine) the same as clemastine fumurate?

@DrBrandonBeaber 2 года назад

Yes. They are the same as far as I know

@demoskunk 4 года назад

I've been looking forward to something that can regenerate myelin. Does Clemastine work for PPMS?

@DrBrandonBeaber 4 года назад

At this point, we simply don't know.

@Plasmamarino 3 года назад

@@DrBrandonBeaber i read on another video a person was taking this anthistamine along with Keltican forte Kapseln, and he said he's been feeling excellent

@ajpello2003 2 года назад

@@Plasmamarino did they have MS?

@kovacsmagdolnajulia Год назад

A d vitamin kúra segített már valakinek polineuropatiaban ? Nekem fluorokinolon okozta polineuropatiam van.

@mybachhertzbaud3074 11 месяцев назад

Considering my track record with pharmaceutical solutions, I think I will wait for a Google fiber upgrade.😜

@desiredecove5815 3 года назад

#SharingisCaring #WeHaveMS. When do you think this will get realized and acceptable for adding to our meds?

@isabellecathrinem.4566 14 дней назад

🙏🏼🙏🏼🙏🏼I pray to God for this to happen! In Jesus Christ's Name! Amen!🙏🏼🙏🏼🙏🏼

@mayurshinde5472 3 года назад

Can I use this medicine for Tranverse myelitis? Same problem demyelination.

@DrBrandonBeaber 3 года назад

I theory clemastine could be beneficial in any demyelinating disease, but there isn't any specific evidence in transverse myelitis.

@Yaya-oe2qs 3 года назад

CALL UC in San Diego in California, in transplant department. Im going on Monday.

@bigi-world 4 года назад

"A dual effect of ursolic acid to the treatment of multiple sclerosis through both immunomodulation and direct remyelination" it is stronger and two in one relieves inflammation and activates opc. even potentially for secondarily progressive.

@DrBrandonBeaber 4 года назад

Presumably, this type of treatment could be used in conjunction with disease modifying therapy.

@jillianking2952 4 года назад

@@DrBrandonBeaber that's very exciting!

@lthaus 7 месяцев назад

Wonder if this could help with diabetic Amyotrophy ?

@DrBrandonBeaber 7 месяцев назад

Possibly but there is no specific evidence to my knowledge.

@addyshimov 3 года назад

And what about covid19 vaccine and MS?

@niaanate4l983 3 года назад

Boohoo crying I pray this works .. I want to feel normal

@codysilvey7776 3 года назад

So, would this treatment help MOG, or nmo?

@DrBrandonBeaber 3 года назад

There is no specific data on this. In theory, NMO is more of an astrocytopathy than a demyelinating illness, so it may not be effective. It's hard to say.

@CHRISRepAZ 3 года назад

I did take for a year plus but I didn't take the high dosages like in the studies

@DrBrandonBeaber 3 года назад

Did you experience and benefits or side effects Christine?

@CHRISRepAZ 3 года назад

@@DrBrandonBeaber I would always take before bed. 2.68 mg tab. The side effect was drowsiness. I wish they looked at other area of nervous system besides the optic nerve. However the eye surgeon did tell me that he was really surprised that my right optic nerve looked amazingly good for someone who had had retro bulbar optic neuritis 3 times. (I had to get r eye Cataract removed over a year back from iv solumedrol)

@andrewkaldas3337 3 года назад

*What do I ask for at the Pharmacy in order to begin taking Clemastine?* Is it, or an equivalent, available over the counter? Is Tavegyl even available? How much to take?

@DrBrandonBeaber 3 года назад

Please do not take this as medical advice, but the dose used in the rebuild study was 5·36 mg orally twice daily (it comes in 2.68mg tablets). As far as I know, it is available as prescription only. Many people would find 5.6mg to be quite sedating, and again, this is not a proven treatment.

@Plasmamarino 3 года назад

Tavegil Tabletten Antihistaminikum, 20 pcs. Tablets look it up www.apohealth.de/en/products/tavegil-tabletten-antihistaminikum-20-st-tabletten