Renin Angiotensin Aldosterone System (RAAS), Plasma Renin Activity (PRA) Assay…What is renin? Why is renin elevated? Primary Hyperaldosteronism, Secondary Hyperaldosteronism. Renin is released by the juxtaglomerular cells (JGC) of the kidney. Renin converts angiotensionogen to angiotensin I (AT I). Angiotensin I is converted to angiotensin II (AT II) by angiotensin converting enzyme (ACE). AT II orders the zona glomerulosa of the adrenal cortex to release aldosterone. Aldosterone promotes renal absorption of sodium and water while enhancing the secretion of potassium and hydrogen ions.
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