Reproductive System | Fertilization 

I'm watching this 6 years after production and it is amazing how far Ninja Nerds have come❤

I'm in my 6th year of medical school now. I am watching this to refresh my memory and I just can't help it but smile at how much I used to watch your videos back in the day. Thank you bro ❤

I don't usually comment on videos, not even on those I like. But you deserve some thumbs up man. Thank you so much!!

didn't attend embryology class this semester, now im getting more knowledge of the course than i would have from my professor, your are truly a hero. Big thanks from Morocco.

I've watched dozens of fertilization discussion. This is by far the most thorough. It helped me digest all the other information. Thank you, thank you.

I love how you add a lot of details and still make everything really understandable, thanks :)

9:24 Changes in sperm for fertilization 1) *Capacitation* -Cleans head -Increases motility 2) *Acrosomal reaction* 3) *Fast block to polyspermy* 4) *Slow block to polyspermy*

Outstanding. One of the best medical videos here in the web!

I have to pay 1.800 dollars for attending the med school per semester, and here i just got lectures for free... Thanks a lot zach and team, i love you guys, god bless you all👍

Sir, you are the best ever, sir please don't stop uploading videos, we all Nigerian medical students are impressed to have you, you are a blessing to all medical students of the world, please keep uploading much of embryology videos, like, respiratory, urogenital,cardiovascular, nervous integumentary ,and musculoskeletal system development, embryology of ear, eye, head and neck embryology, and finally birth defects and signaling pathways and molecules, like wnt, hedgehog, fgfs etc

God I hope my professors explained like this in their lectures. Your videos save my ass once again 😂

you made medicine so much easy on me. You're vids are my best friends while studying

You just have a way of making these topics easier and more understandable. Thank you so much sir. You're helping a lot of people☺

Hi guys, I noticed there is no videos that summarize the physiologic changes that occur during pregnancy? Anyways I hope you Prof Zach can make a video on that. Thank you

These videos are a lifesaver with distance learning. Thank you big time.

Love you sir,,salute your hardworking,,you are amazing teacher of the globe,,I just pay fee to university not absorb a single words from university,,I am copying your every lecture and remember,,you are my ideal teacher,,God blessing you,,more than 100 students I spread your lectures and daily consouling,,abundle of thanks

this is the best embryology lecture I have ever seen. Sir, the lecture was too good with all the details of enzymes and differernt secretions.My concepts are crystal clear after watching your video. Thanks!

Best medical channel ever!! Sir, you really helps medstud like me ☺️🙏

What a way of teaching ..you make me understand each and everything just simply without wasting time.. best way of teaching👍

THE WAY HE DELIVERS THE POINTS! you cant be bored at all!

Summary- Changes in the sperm- 1. Capacitation- alteration in glycoprotein and seminal proteins that coat the spermatozoal head. Occurs in the uterus Increases motility 2. Acrosomal reaction- The sperm has specific protein that bind to the zona pellucida receptors ,ZP3. Upon binding, acrosomal head opens releasing acrosin and proteases. This creates a hole in zona pellucida. 3. Fast block to polysperny- As the sperm touches the cell membrane, Na+ influx occurs . 4. Slow block to polyspermy- Smooth ER releases Ca2+ ions which activates lysosome to fuse with the cell membrane of occytes. Hydrolytic enzymes are secreted causing degradation of Zp3 proteins and hardeining of cell membrane.

As a nursing student, i read wide and versatile like am a doctor (though is my wish).... You make it easier and gracious to learn more.... Thank you. 🎉

I'm watching your videos alongside my lecture notes and it's ten Times more fun

I have not even completed my schooling but when I see those videos I feel like I am learning true Biology and you are 👍👍👍

this is the only channel that i actually waant to remind me to hit the like button at the end of the video

I just understood this concept in less than 30 mins. Take your flowers🌹🌺. I use to hear of Ninja Nerd before I became a medical student. I'm glad to learn from you sir.

Helping me get through Anatomy classes one video at a time

Wow! One would think it's world war in these bodies of ours. The number of events happening at the same time is insane. Thank you, this is well understood.

I lack to express my joy, you explanation is excellent you're the best ever

This guy does wonders! He is so good at teaching and it's fun to watch! Got a really good grade bc of him.

Hi Mr Ninja Nerd Sir, you really teach all of these concepts with so much passion. I am going to pass Anatomy & Physiology because of you.

@15:47 I laughed out loud!

Can't thank you enough, thank you for making it available, you are a superhero a real med ninja 🤗🤗

حرامات انتهى الفيديو و الله الواحد ميحس بالفيديو من كثر المتعة اليقدمها زاك thank you zach 😍! it was unbelievable explanation

You are my lifesaver. I couldnt understand anything from my professor. Love u from Thai Medical student ❤.

so far the best vedio explaining fertilisation on a medical level i myself as a post-graduate appreciate your effort thanks alot

I haven't seen such a cool teacher!! It really help to understand quick and kind of grap most of the things.. Yo!! Sir!! Big salute... outstanding lecture.. ever boring topics seem interesting.. when you explain..

These lectures are really a huge box of gold to me !!!!! Really awesome thanku so much for such a beautiful , amazing explanation !!!!!!!

you deserve the 1k likes but you dont deserve the 7 dislikes, great job man i really appreciate the effort you put into the videos keep making these kinds of videos.

Hey, I love your videos. They have helped me so much throughout my studies. You are honestly a god send

Your videos are very helpful! I was trying to count how many times you say "actually" but I lost track at about 100. lol

Hey, I'm from Brazil. Your classes help me a lot, I'm in Nurse school.

Can you please consider making anatomy videos like these please?? You're the best at explaining

U r like blessing for medical student like me u made all content very easy to understand ... It's my request plzz never stop making video ..... Loads of respect...

Dear, you have a good way to elaborate the complex process of fertilization

This helps me so much with my medical carrer, thank you so much, totally understand every topic i have watched on here 💗

Hey Zack! it would be so awesome if you could possible make a series on obstetrics/gynae as well as neonatology!

Thank you so much! You cleared so much stuff for me! My professor let us go over this part on our own and the book was so confusing! 😁

Nursing student from Kenya am enjoying the lessons.keep it up

Thanks for the lecture. It is helping me a lot. The number of sperm that get to the fertilization site is actually about 200, but one usually fertilizes the oocyte.

perfect... I am an Arabic medical student..and your videos are very simple and useful..thank

It is Allah great design❤❤

This is the first time I am commenting here. Zach, more power to your elbow. And I read that there's no fast-block to polyspermy in mammals. To the contrary it is found in marine invertebrates like sea urchins to ensure that sperms from other species in the water do not fertilize the wrong egg. But hey, I trust you and hope you will respond. I will be over excited to get your response.

GOAT prolly the best teacher ive ever seen

your lectures are very very helpful to me😊. Thanks for making embryology easier 🌼

I've read, and my lecturers also told this, that in humans practically the whole sperm cell enters the oocyte. Plasma membrane gets left behind but everything else goes in. I think paternal mitochondria get destroyed so only maternal ones are left, and the centrioles of the sperm cell are inherited by the zygote. There are so many misconceptions and alternative explanations going on about what parts of the sperm cell actually enter the oocyte, and right now I'm too busy panic-studying for my exams to really look into this. Just thought I'd give y'all something to think about and maybe do your own research if you're interested. I'm gonna go with the explanation my professors gave, and hopefully pass my exams :'D

Bestest ever!!!! Why i didnt find you in my first year of med school!!!! 😍😍😍😍😍😍

YOU ARE LITERALLY THE BEST. It all made sense and the whole explanation was very entertaining and fun to watch. Thank you so much

Thank you so much for these videos sir. You are literally the best!!

You are the best person on this planet

Your videos are all I watch ....I actually got a B from this lecture in my today exam thanks 🙏 ✅

WOW!! Thank you! You have a lot of videos. Which one informs me when human beings begin to exist, i.e., at conception/fertilization or...?

You my friend, have a natural gift/ talent. Keep up the great work.

Big thanks to you. From Afghanistan

I freaking die laughing with those comment, you put in sometimes: "normal males ejaculate 200 - 500 million sperm cells, unless you're some type of freak" HAHAHAH... this is entertainment and educational! 😂👏🏼

Happy teachers day 💗💗💗

You save all our degrees thankyouuuuu

You are th smartest person in the world at all, love you dude, thank you for your affords

Daamn bro wen the embryology lec taught this i never really thought fertilization was this mental damn mahn ... U r awesome

Respect & love from Indonesiaaa

thank you so much the best teacher ever

One of the best teachers out there! Kudos

Your lectures are very very very helpful Thank you sir❤ Love from Bangladesh

Hi Nerd We appreciate u here in Zambia, continue with the great work ✊✊✊

It helps it helps alot Thankyou sincerely a PT student

brother, you are special. please dont stop

Hi ninja nerd , your vedeos are very useful for my studies.I hope you Will upload vedoes entire medical syllabus 😇 Second year medical student, Srilanka

Thank you so much. You make everything as simple as it can be. Keep going god bless you 👏🏻

Wow !!! Such a beautiful explanation Alot thanks✨💓 to figure out such concept easily 👍👍

Amazing! I really appreciate this hope you don't stop......I need you to complete my medicine course

THANK YOU SO MUCH, I HAVE QUIZ TOMMOROW AND UR A SAVIOR

Thank you so much 🙏🇮🇳 love from india 🌹🙏🇮🇳

sir, i'd be delighted if you made videos on histology

Excellent explanation. Best to be in the pre-nuptial councilling for couples before wedding. And good for pre-medical students before the seminar on reproductiive system of man and woman.

this vid is really helps me understand more than my own teacher:)

Don't stop ur lecture sir we need ur classes 🙏🙏🙏Namaste 🙏 🙏 🙏

Can't thank you enough, but just know we are grateful

Please have a video on pregnancy please

Thank you very much, i was confused,but you gave me the all points 😍😍

Ur a god gift for medicos

2023 and still does wonders❤❤❤

thanks for saving our report!!! :)

so helpful, you are the best ever, thanks a lot Ninja Nerd!

thanks a lot. very helpful

What is the purpose of the cholesterol and glycoproteins before they were cleaned off during capacitation?

YOU ARE THE TRUE HERO ✨✨✨✨

Love ur teaching way and the diagram😇😇

Wow, now I just know, what a miracle, thank you.

Aslamualikum sir i really appreciate ur lactures more more thanks alottttt i understand better an better sir dont stop uploading lactures plzzzzz

Thanks team @NinjaNerd