Restrictive Lung Diseases - Interstitial Pulmonary Fibrosis. Pathology, Clinical, Tests, Treatment

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This video presents the introduction to restrictive lung diseases. We will discuss:
Definition
Types
Extrapulmonary restrictive lung diseases
* Obesity
* Scoliosis
Pulmonary parenchymal restrictive lung diseases
* Idiopathic
* Autoimmune
* Granulomatous (Wagner's granulomatosis, Sarcoidosis)
* Occupational (pneumoconiosis, silicosis, asbestosis, coal, etc.)
* Other irritants
* Chronic infections (Tuberculosis)
Neuromuscular restrictive lung diseases
* Myasthenia gravis
* Diaphragm issues
* Polio
Cellular events/pathogenesis
* Damaged Type I Pneumocytes
* Hypertrophy of Type II Pneumocytes
* Irritated epithelium
* Irritated macrophages
* Apoptosis of epithelium
* Tissue damage leading to local inflammation and lung destruction/scaring.
* Neutrophils releasing cytokines, proteases, tumor growth factors (TGF)
* Macrophages releasing transforming growth factor beta, tumor necrosis factor (TNF), platelet activation factor.
* Fibroblasts overactivity resulting in more extracellular matrix and hardening.
* Epithelial-mesenchymal transformation.
* Smooth muscle proliferation.
* Respiratory interface thickening. Disrupted gaseous exchange.
Clinical:
Dry hacking cough
* Dyspnea
* Hypoxia
* Respiratory alkalosis
* Late inspiratory crackles
Abnormal chest X-Ray
* Reduced volume in chest X-Ray
* Lower lobes show more involvement and the reason why.
* Right heart failure/cor pulmonale
Lung Function Changes
* FEV1/FVC ratio increases above 80% (normal or above normal)
Treatment
* Anti-inflammatory (may not be very effective)
* TGF Beta-blockers
* Oxygen
* Lung transplant ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

Опубликовано:

2 дек 2017

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Комментарии : 94

@kishwarbanotelar3282 6 лет назад

I have never saw the teacher like you .. You are so great..if these type of teachers teach in my college I will definitely become a doctor one day..thank you so much mobeen sir..

@DrBeenMedicalLectures 6 лет назад

I am glad that lectures are valuable. Check out tons of more lectures on drbeen.com.

@irinarakovicprivatepractice 6 лет назад

Well done! It's so much fun to listen to you! Thank you!

@grntara78 5 лет назад

Wow....you are the only one....who can make restrictive lung diseases understandable...thanks a lot for the lecture.

@thivz6630 5 лет назад

This was an amazing lecture! Thank you sir 😊

@ayudiahmayasari1182 6 лет назад

Finally i can understand..bravo.good explaining

@claudeanurudha7907 3 года назад

Great lecture.Very educational and clear.Thank you.

@muskandeshwal9299 3 года назад

Such an amazing lecture......very conceptual ......thank you so much❤️❤️

@helean1344 4 года назад

This is so great ,thank you so much

@tenderprecious 3 года назад

Thank you for your work 💓

@cmikewilson 6 лет назад

This was helpful. Thanks.

@vinitasolanki3218 3 года назад

Thanks a lot sir... Keep it up... Your videos are very helpful

@thandimtshali3465 3 года назад

Thank you for this 🙏

@paulwang7765 5 лет назад

you're a god ! appreciate this so much :)

@mairakhan8586 6 лет назад

great lectr,thanku sir.

@khamikos1 6 лет назад

excellent.you are a great teacher. keep it up. thanks fromGreece

@DrBeenMedicalLectures 6 лет назад

My pleasure. We got tons of content on drbeen.com. Check it out.

@blessedcharles2279 3 года назад

Good lecture God bless you

@maleeshajayasundara6318 3 года назад

Thank you very much.

@dr.faizanali4770 4 года назад

Sir .. as co2 cant go outside during exchange , how it cause alkalosis ? There must be acidosis

@ayudiahmayasari1182 6 лет назад

Nice ..thanks

@motocephalic 3 года назад

very good presentation, reminds me of respiratory school.

@sanjusingh8124 3 года назад

Thank you so much sir 🙏

@dr.md.atiqurrahman4802 4 года назад

Excellent

@mohammedumarfarooqui6373 4 года назад

You are awesome sir

@m-HamzaQayyum 4 года назад

Sir, I think decrease CO2 from blood to cause build up CO2 in blood and hence Respiratory acidosis will develop not alkalosis. Plz correct me if I'm wrong

@paulvijith2732 6 лет назад

Thank you sir

@jindijulie105 5 лет назад

THANK YOU SO MUCH !

@DrBeenMedicalLectures 5 лет назад

You are very welcome.

@kushaltarafder6425 3 года назад

Thank you sir😊

@fatimaemad7402 4 года назад

Sir , you said the irritant will cause apoptosis of epithelium then you said that pneumocyte type ii will be hypertrophied and thus making more pneumocytes type i so where the apotopsis exactly occurs?

@gins8781 4 года назад

A comprehensive explanation.

@DrBeenMedicalLectures 4 года назад

Thank you!

@anildutta2750 5 лет назад

thnx a lot sir😊😊😊😊

@MuntazerAyyed 3 года назад

Great ❤️

@muzaffarshah9319 6 лет назад

Top class

@srirambhardwaj2343 3 года назад

Thank.you.so.much.sir.

@PrabhatKumar-mu1nr 6 лет назад

Nice Lecture, Thank You Sir.!

@DrBeenMedicalLectures 6 лет назад

My pleasure.

@jamalsayed8828 4 года назад

Sir I need your all lecture where to get those ?

@prashantj50 6 лет назад

Nice job sir , specially fev1 ,about restrictive lung disease have more elastic

@Vd.Krishna 5 лет назад

Tq so much

@harikrishna70 5 лет назад

thanks sir we want more lecturere s from you plzzzzzzzzzzzzzz

@zareenakhan1536 4 года назад

Sir whyy respiratory alkalosis occurs if co2 cant go out there should be respiratory acidosis????

@sindook6085 4 года назад

Amazing teacher. Masterhood at display. Great teachers are are always Purposeful.

@DrBeenMedicalLectures 4 года назад

Thank you dear!

@user-jj1nm4sx6w 6 лет назад

wouldn't the increasing of co2 pressure in the blood cause acidosis not alkalosis ? . thank you for the lecture

@cristinavanloon8028 6 лет назад

yes it would cause respiratory acidosis! the lecture is great though.

@gunabharathi3152 6 лет назад

Sir... Would u take respiratory failure lectures???

@ishwaryapatil3429 5 лет назад

Awesome ur

@yasirhasnat9795 4 года назад

Thank you so much sir

@DrBeenMedicalLectures 4 года назад

Very welcome!

@dharmrajmaurya605 4 года назад

thank you so much

@DrBeenMedicalLectures 4 года назад

Your are very welcome.

@drshivamtomar511 3 года назад

At 15:58 you said elevated co2 in blood cause respiratory alkalosis... I think its cause respiratory acidosis..

@raghavsoni717 5 лет назад

Bestttt

@AsadUllah-wp8hn 4 года назад

Increase CO2 pressure suppose to cause Respiratory Acidosis rather than Alkalosis BTW nice explanation Sir

@usmleislife3396 6 лет назад

grt lecture sir.... sir plz make vedio on general pharmacology which is highly tested in usmle..

@shamimakhanam261 5 лет назад

Amazing

@ramnathyaduwanshi9579 3 года назад

Sir please upload complete lecture on COPD 🙏🙏🙏🙏

@shery123love 6 лет назад

great lecture sir !

@deepankarkaushik6384 5 лет назад

Can you tell what to do in ild last stage

@triargotube 4 года назад

Grupo de HP no facebook facebook.com/groups/683424751844146/

@shrutikshirsagar4537 6 лет назад

1st you said transforming growth facter then after some time tumour growth factor.....

@dutarnab 4 года назад

Sir, why do we usually have tremors of rib casge for patients with Idiopathy interstitial fibrosis or lung disease.

@iambikash6596 4 года назад

Thank you sir ....i wish if only i would get a lecturer like you

@drabhishekparihar 4 года назад

Sir Is this resp alkalosis Or resp acidosis?

@muskandeshwal9299 3 года назад

Sir please make a video on wbc disorders.....🥺🥺

@champion8912 4 года назад

why cracles

@mustaquenadaf18 4 года назад

@15:52 it should be respiratory acidosis not alkalosis

@freedomuk9418 4 года назад

Hi pls give some advice they told me I've got ristrictive lung I dont smoke am so stressted as dont know what's happening to me pls help any advice

@triargotube 4 года назад

Grupo de HP no facebook facebook.com/groups/683424751844146/

@arjunharikumar9040 4 года назад

If sarcoidosis is a restrictive lung disease then why does it show a different kind of pathology

@abhisek241288 6 лет назад

around 16 minutes mark I guess that should be respiratory acidosis.

@geraldhoskins1506 6 лет назад

I agree with DrAbhisek Nanda - the increased interstitium thickness initially results in a localized acidosis due to the inability for CO2 to diffuse and leave the blood vessel. It isn't until there is a response from the patient (in which they would be breathing more deeply or more rapidly) that there is the potential for hyperventilation... However, hypercapnia is the primary driver for breathing - once that is resolved, the hypoxemia may not be sufficient enough to justify breathing as deeply/rapidly. Instead, the patient will feel tired, but generally more comfortable than symptoms associated with hypercarbia, so I posit to you that there will continue to be a compensated respiratory acidosis until late-stage processes in the disease occur.

@9032290952 5 лет назад

yes even great teachers make mistakes

@dr.priyankaganglani895 5 лет назад

it would b acidosis!!

@rogodanelena2721 5 лет назад

i think it's correct alkalosis because co2+h20=h2co3 which is a normal compensatory mechanism of the body. So if co2 increases, also h2co3 increases so it gives alkalosis

@rogodanelena2721 5 лет назад

this happens over time. initially the body develops acidosis, but as time goes by, the kidneys start to produce more bicarbonate to compensate the acidosis, so finally we have alkalosis.

@clintchimbangu2476 5 лет назад

Good lecturer , but I thought increase in carbon dioxide pressure would cause metabolic acidosis, ..

@fatimaemad7402 4 года назад

Respiratory acidosis

@drhumzaashrafsial6500 4 года назад

Exactly

@debbieautry-skubik6594 4 года назад

I'm not a teacher or student but I do have Restrictive Airway Disease at 32% and Chronic Obstructive Pulmonary Disease at 52% pluse Asthma which were caused by a Ventilator I was on while in my long Coma. I NEVER smoked one day in my Life. I am 62 years old and very ANGRY cause I was healthy all my LIFE until 3 years ago! How does this happen?

@doctorashraf7731 5 лет назад

Jesus bless you

@DrBeenMedicalLectures 5 лет назад

Thank you

@jayantclasses3089 4 года назад

Sir, my father is suffering from "cronic I L D", and he is near about 70. Doctor has told that 60% of the lungs has been ruptured. I want to ask that, is it curable or not ? This very disease caused due to infection.