RHR: Low Dose Naltrexone (LDN) as a Treatment for Autoimmune Disease 

I started taking LDN 3 months ago after being nagged by my sister to take it. Her friend a physician told her to take it. His wife had MS, couldn't walk and had trouble talking and after taking LDN she can now walk and talk. His son has Crones and he gave him LDN and now he no longer has crones. My sister took it for Fibromyalgia and now sleeps thru the night and it has eased her pain. My nephew has Psoriatic Arthritis and Fibromyalgia and swears by LDN. I decided to take it when I Amitriptyline was no longer helping me with my sleep problems. I stopped the Amitriptyline and I started taking 1.5mg. LDN The first night I felt relaxed after I took it. I woke up in the middle of the night, but was able to fall back to sleep, something I could not do in the past. IN the morning I realized that pain I have in my right shoulder from a very damaged tendon (damaged from Levoquine) that interfered with my sleep ever since it occurred was not there. For the 1st time in 2 years It did not wake me up. I couldn't believe it. I was also able to touch the area without feeling any pain which in the past was impossible as it was too painful. During that day and following days I noticed my brain fog had lifted. I my mind was clear and sharp. I could remember things days later that I had read. Names of movies I just saw or names of people that before I could not remember 5 minutes after I met someone or saw a movie. I tested myself and had no trouble remembering lists. My mind was clear as it used to be. I am 72 now and have trouble with names etc. for years. I have Scoliosis that was brought on by some bad Chiropractic adjustments. I had been walking stooped over for a while and was thinking that soon I would be in a wheel chair,Sitting at the computer after around 2 weeks on LDN, I got a very sharp pain in my spine and felt a shifting. I thought I was in big trouble. I stood up and to my surprise and delight, I was standing straight and have been doing so ever since. I think the muscles in my back were tight and pulling my spine crooked. I think they relaxed and let my spine straighten out. Over the past few years I have shrunk around 3". I now have regained some of my height.I have Asthma and Hashimotos which I have had since I was a small child. My lungs seem to have relaxed and are not tight as they were before. Breathing is easier and I am alert and able to do things I haven't done in years. I have energy and the will to do things that I could not do before. I am not exhausted at the end or middle of the day. I did not have to change my Synthroid dose as I had energy but was not hyper thyroid now.I am so happy my sister told me about it. It took me over a year to decide to try it. I did have to take info I printed out on it to my doctor and spent a half hour to get him to give me a prescription for it. I will be bringing him my results this week and hope he reads up on it more and I will direct him to this video. I have lost a large part of my life due to my having many autoimmune diseases. I am trying to make up for it now. I bless the researchers who found out what it is able to do.

I get my LDN for $28.50 a month!!! Been on it for 9 years for MS with only one flare in that time. This gave me my life back!!! Can't say enough good things about this drug that saved my quality of life.

I've been on 4.5 mg for 3 years now to help with Hashimotos thyroiditis, it has changed my life and I'm not waking up crying that I have to go another day at work and function.

It's been a life changing medication for my Hidradenitis Suppurativa, Psoriasis, and psoriatic arthritis. It took six months to see a significant improvement but once it did, wow.

Started taking LDN after having been on 25mg of methotrexate for 8 years for my severe Psoriatic Arthritis. I had to come off the methotrexate because I was showing signs of neuropathy and so decided to give LDN a try before getting on a biologic. It took 3 months to see full affect, but I now have normal ESR and CRP my antithyroid antibodies are also down and thyroid function is normal...I used to sleep 18-20 hours a day from extreme sleepiness, fibromialgia pain and depression, I can't say I'm 100% healed but I only take short naps a couple of times a week and take no pain meds at all. And my mental health doctor titrated me off antidepressants and I only take vitamin d for that now. I have one quarter size psoriasis spot and one pinky joint that is slightly inflamed! I had more symtoms on tje methotrexate! Here is to hoping I can stay off the toxic meds for good! 😊

I started LDN at 1 mg and the first day I took it it stopped my neuropathy totally. It’s been 3 years and i haven’t had any issues with it recurring. Also took my thyroid antibodies down to normal. Also got relief from joint pain. My dx are Hashimotos, Sjogrens and myositis.

Sheefa Pharmacy in east Orange NJ, once the Rx is received, they overnight it to your address so you receive it right the next day early in the morning! It costs as low as a $1/day!

One of the Better talks on LDN

I get it for $53 for 3 months from Belmar Pharmacy in Colorado.

thanks for sharing. very informative and certainly gives us hope considering out situation. keep going with this. lots of people need it.

I saw this in a discussion on Sjogren's when someone talked about taking plaquenil and made an appointment but then read about LDN.although I've gone to my doctor for 30 years I had to talk him into this. I actually had to call the pharmacist and get the directions for the RX and tell the doctor what to write. I should hope that I get this soon and helps. I just want to be a little bit normal. I will check back since I have Sjogren's, fibro, Raynauds, arthritis, hyperthyroidism, low blood pressure, difficulty eating and swallowing, no insomnia, some depression, dry everything and constant pain especially my SI joint and lower back, and hands. My doctor actually seemed strange about the fact that I didn't care if I can't take pain medicine well on this medication. I have always said that I just want to be somewhat normal again. I can't tell you how many times I asked him if there was something I could take and he never offeredme plaquenil! I am wondering if he gets a kickback on the pain med Rx?

Very helpful. Clear, concise and to the point. Thank you!

I feel like I've found the Holy Grail. Now I just need to get a doctor to prescribe it.

Chris Kresser is super!

Great information. Thank you so much for posting this. Nine years on from this video being posted, LDN is becoming more and more used to treat long Covid. I've been taking it for nine months and saw improvement at 3-4 months which decreased my long Covid fatigue. Some clinical trials are under way currently. It's a drug with a lot of promise for many conditions

Graet video, thanks I have graves and Im gonna try it

Hey Kris- Great video as always. Do you have any updates on LDN since this video is now 7yo? I am a 48yo male recently presenting with severe Polymyalgia Rheumatica symptoms. Would be nice to know if I should explore LDN further. Thanks for all your wonderful work.

Acupuncture weekly seems to increase my endorphins and helps my AI symptoms.

Anyone tried this and had success with Vitiligo and Chronic Leukemia. thanks

Should low-dose LDN be cycled or can it safely be taken continuously? Any neurotransmitter receptor down regulation with long term use? Any tolerance with continuous use or withdrawal symptoms upon cessation? Any benefit for hypertension?

Hello my daughter is 15 yo, has hashimoto but not thyroid problems yet. What is the recommended doses for her? She is 110 lb

Are there any studies that include the use of 6mg doses for colitis?

How is it for Ankolosing Spondylitis?

What book are you reading?

I have been taking it for almost a year. I have Lupus, RA and Sjogrens. Was hoping it would help my small fiber neuropathy but it’s not 😢

I am trying to get my Kaiser physician to prescribe ldin as I plan on being on it for the rest of my life. I obtained the tablets from Mexico at expensive price of $120 for 20 tablets. I take ldn4 my esophageal reflux and also as a cancer prophylaxis as both my parents had cancer.

It's Skip's Pharmacy :-)

Has anyone here found a decent pharmacy in California (San Diego) that has LDN for cheaper than $75 for 30 day supply? Thx for the help

My question would be...does the increase of endorphins make you feel rushes of euphoria? When inhibitors wear off?

I was told recently by a doctor that research will not recommend something if people have been harmed. I asked about the bad press Hopi ear candles get from the research. (they work for me) He said that research is based on safety and it records figures on hospital treatment of burned ears :-) . So its not about whether they work or not, its about supervision. . Go figure . Always use someone professional who knows the product and how to supervise your safety. I wish i could be allowed to try a tester of LDN but my doc wont .

How do I find a doctor to prescribe this for me???



How long does it take for someone with Rheumatoid Arthritis taking LDN to get relief?

If you stop taking the LDN, for whatever reason, is there a rebound effect like there is with other drugs?

I wonder if this too works for COVID-19? If it helps the our system it could help fight the infection

This video is strange. The guy in the upper left corner is a distraction. Both wearing ear phones? What is the purpose of this crazy arrangement?

Have been taking LDN since May, 2011 for ulcerative colitis. Started taking 4.5mg and switched to 3mg in Nov., 2013. My symptoms came back in Jan., 2015. Should I consider going back to 4.5mg? Or, should I reduce even further? How do you determine the best dose?

Is LDN synthetic drug?

I have CVID and cancer. Just started on 50mg naltrexone. Experienced a lot of pain. Don't know why.

Maybe it is just me but Steve always seems to look a little inflamed.

Is Kressler taking this? funny how all these doctors want to prescibe pharmaceutics and not get down to the core cause