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5HT1A receptor is an autoreceptor so it stops the release of serotonin from the cell if there is high accumulation of serotonin accumulation in the synapsis. Please correct me if I am wrong. You said that 5HT1A receptor removes serotonin from the synapsis back into cell. This is job of SERT. Maybe I am just misunderstanding your way of explaining it but I wanted to clarify?
Thank you for pointing out my mistake. That was an unfortunate fumbling of words on my part. You’re correct that presynaptic 5HT1A autoreceptors do NOT function as reuptake pumps. They instead trigger a mechanism that inhibits further presynaptic release of 5HT.
Just have to comment again to say that you are ridiculously good at explaining this stuff, it's so easy to follow and understand - I really hope this channel gets the growth it deserves
This is great! I like the way you don't assume that people know exactly what you're talking about and provide context and links where required. Keep up the good work!
I had been searching how does few Serotonin Antagonist drugs help in increasing Serotonin levels, (but could not find it anywhere on internet) but you answered that specifically in your video. Thanks!
Good staff. But can you explain what happens during bipolar disorder syndrome? For example, a relative of mine is given leponex. The symptoms almost disappear. When the dose is reduced (leponex is co-given with haloperidol) the symptoms de-masked slowly. I have noticed that when he starts showing the initial symptoms slowly (not straight away in few days) he is acting like OCD with some signs of compulsions, like going out to have walk. What happens in such situation at that exact point? He has low serotonin or high (he is agitated a little)? Is there a possibility that his brain after usage of leponex and blockage of HT2 receptors starts to build up new HT2 receptors for compensation or making new serotonin. Thank you
I've been wanting to learn more about serotonin and this video literally gives everything I was trying to find out! Your videos are produced really well and the content is great, also you look so much like link from Good Mythical Morning! I've noticed you also post a lot of shorts, I think you'll find this video helpful: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-bmnVYwVEzpE.html
That's really great to hear! Thanks for checking it out and sending that video about yt shorts, I also post them on reels on IG, and they seem to do better there but I've definitely noticed less traffic on shorts lately. Also, that I look like Link is really funny. I had never heard of him before but I agree we could be long lost twins.
so happy I came across your channel! Definitely subscribed. I'm doing research for a research paper & presentation on the effectivity of SSRIs and MAOIs for one of my senior biochemistry theses. This series (and your references) has been so helpful, as I am have very little background in neurochemistry. Super organized, clear, and interesting, thank you and great work!!!
Thank you! For a full list of references, see the caption for this video. But, if I had to choose, I would say the most important paper is this one: pubmed.ncbi.nlm.nih.gov/32522572/
Brilliant video which explains basics of serotonin receptors (?Hats off to the creative brain behind ) - If a small area can include 5 HT1 A disinhibition, when explaining SSRI actions , that would pretty much cover basic psychopharmacology in connection to serotonin receptor function ( usually explained as the cause of delay in clinical response of most SSRI ‘s ) 👍👍👍👍
sex, digestion, LSD, emotions 4:00 neuromodulator. Relatively weak effects/ about 75 percent of serotonergic neurons also have glutamate receptors 15 subtypes of serotonine receptors 10:00 anti psychosis, antidepressant, antianxiety, sexual arousal in some women
Great video man , working with more diagrams would make it a plus maybe you could use an ipad to walk us through and you could include a few analogies to make us understand
Unfortunately, I haven't gotten to that topic in any detail yet (though I plan to eventually do a video on neurological development)... However, I VERY briefly discuss synaptic pruning in my video on neuroplasticity (ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-q-iQGoxmRkM.html)
