Every time I solo, I get seduced by a fancy schmancy ego gift and I end up picking the crab rave theme pack. Remember, never pick the crab pack when soloing, cuz if the damage type doesn't end you, the rupture build up will.
I got Fairy longlegs floor 5 during my solo TDon Quixote run, i kept dying on turn 3 until i've strategized a plan where i make don take enough bleed damage to trigger the passive on turn 2 end. I beat him after a couple of tries.